Incidental Mutation 'R8383:Or5t5'
ID 647006
Institutional Source Beutler Lab
Gene Symbol Or5t5
Ensembl Gene ENSMUSG00000047969
Gene Name olfactory receptor family 5 subfamily T member 5
Synonyms MOR179-6, Olfr1093, GA_x6K02T2Q125-48278396-48279364
MMRRC Submission 067749-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.452) question?
Stock # R8383 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 86612889-86617135 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 86616874 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 267 (I267V)
Ref Sequence ENSEMBL: ENSMUSP00000149944 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055273] [ENSMUST00000213354] [ENSMUST00000219561]
AlphaFold Q8VF14
Predicted Effect probably benign
Transcript: ENSMUST00000055273
AA Change: I267V

PolyPhen 2 Score 0.053 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000049733
Gene: ENSMUSG00000047969
AA Change: I267V

DomainStartEndE-ValueType
Pfam:7tm_4 43 319 2.4e-49 PFAM
Pfam:7tm_1 53 302 1.3e-16 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213354
AA Change: I267V

PolyPhen 2 Score 0.053 (Sensitivity: 0.94; Specificity: 0.84)
Predicted Effect probably benign
Transcript: ENSMUST00000219561
AA Change: I267V

PolyPhen 2 Score 0.053 (Sensitivity: 0.94; Specificity: 0.84)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acad12 A T 5: 121,745,436 (GRCm39) M285K probably damaging Het
Adcyap1r1 T C 6: 55,456,985 (GRCm39) S239P probably damaging Het
Alpk1 A T 3: 127,518,085 (GRCm39) M72K probably benign Het
Alpk2 G T 18: 65,438,469 (GRCm39) R975S probably benign Het
Ankrd7 A T 6: 18,868,410 (GRCm39) K177N possibly damaging Het
Asxl1 A G 2: 153,235,639 (GRCm39) T272A probably damaging Het
Ccdc175 A G 12: 72,155,952 (GRCm39) Y666H possibly damaging Het
Cyp2j11 T C 4: 96,236,695 (GRCm39) N37S probably benign Het
Dglucy A G 12: 100,801,588 (GRCm39) D81G probably benign Het
Dysf T A 6: 83,996,565 (GRCm39) D22E probably damaging Het
Glg1 T C 8: 111,896,194 (GRCm39) T177A possibly damaging Het
Gm3415 C T 5: 146,495,228 (GRCm39) P210L probably benign Het
Gm7995 A G 14: 42,133,321 (GRCm39) H66R Het
Habp2 G A 19: 56,304,768 (GRCm39) V388M probably damaging Het
Hey2 A G 10: 30,716,665 (GRCm39) S33P probably benign Het
Hmbs C T 9: 44,249,240 (GRCm39) R195H probably damaging Het
Hrnr A T 3: 93,239,653 (GRCm39) Y3297F unknown Het
Hspg2 T A 4: 137,271,681 (GRCm39) H2482Q possibly damaging Het
Ifi207 GAAGTTGCATGTGGAGCCAGGAGGTTGCTAGATGTTGTTGATAGAGTTGCATGTGGAGCCAGGAGGTTGCTAGATGTTGTTGATAGAGTTGCATGTGGAGCCAGGAGGTTGCTAGATGCTGTTGATACAGTTGCTTGTGGAGCCAGGAGGTTGCTAGATGCTGTTGATAGAGTTGCATATGGAGCCAGGAGGATGCTATATGTTGTTGATGAAGTTGCATGTGGAGCCAGGAG GGAGTTGCATGTGGAGCCAGGAGGTTGCTAGATGTTGTTGATAGAGTTGCATGTGGAGCCAGGAGGTTGCTAGATGCTGTTGATACAGTTGCTTGTGGAGCCAGGAGGTTGCTAGATGCTGTTGATAGAGTTGCATATGGAGCCAGGAGGATGCTATATGTTGTTGATGAAGTTGCATGTGGAGCCAGGAG 1: 173,556,770 (GRCm39) probably benign Het
Ifi208 T A 1: 173,511,075 (GRCm39) V410E possibly damaging Het
Igkv3-7 A G 6: 70,584,734 (GRCm39) T25A probably damaging Het
Il22ra1 A G 4: 135,461,451 (GRCm39) Q72R probably damaging Het
Ip6k1 T A 9: 107,921,926 (GRCm39) F207I possibly damaging Het
Kdm6b A G 11: 69,296,876 (GRCm39) S464P probably benign Het
Kirrel3 G T 9: 34,941,179 (GRCm39) M601I probably null Het
Klk1b1 C T 7: 43,619,767 (GRCm39) R109C possibly damaging Het
Kmt2e A G 5: 23,690,539 (GRCm39) N518S probably benign Het
Myo5b A G 18: 74,777,049 (GRCm39) S370G probably benign Het
Nrn1l T C 8: 106,621,058 (GRCm39) L50P probably damaging Het
Nrxn2 A G 19: 6,522,343 (GRCm39) Y411C probably damaging Het
Obsl1 G T 1: 75,480,501 (GRCm39) F374L possibly damaging Het
Or1j15 A T 2: 36,459,014 (GRCm39) I135F probably benign Het
Or1j20 A G 2: 36,760,343 (GRCm39) Y255C probably damaging Het
Panx3 T A 9: 37,578,049 (GRCm39) probably null Het
Piezo2 A T 18: 63,217,759 (GRCm39) F1139L probably damaging Het
Pld2 G A 11: 70,442,255 (GRCm39) D380N possibly damaging Het
Plekha7 A C 7: 115,744,154 (GRCm39) N715K probably damaging Het
Pom121l12 T A 11: 14,549,353 (GRCm39) S20T probably benign Het
Rasal1 C T 5: 120,804,420 (GRCm39) R431C probably benign Het
Rdh8 G A 9: 20,734,081 (GRCm39) probably null Het
Rgl3 G A 9: 21,888,529 (GRCm39) T427I probably damaging Het
Rnf17 TG T 14: 56,661,999 (GRCm39) 132 probably null Het
Sclt1 A C 3: 41,696,450 (GRCm39) I5S probably benign Het
Seh1l A G 18: 67,908,126 (GRCm39) H16R possibly damaging Het
Sgca G A 11: 94,863,068 (GRCm39) P95L probably benign Het
Spag17 T G 3: 99,992,708 (GRCm39) S1735A probably damaging Het
Tdrd3 T C 14: 87,743,744 (GRCm39) I564T probably benign Het
Tob1 ACAGCAGCAGCAGCAGCAGCAGC ACAGCAGCAGCAGCAGCAGC 11: 94,105,203 (GRCm39) probably benign Het
Trpv3 T G 11: 73,180,127 (GRCm39) F524V probably benign Het
Ttc41 A G 10: 86,555,390 (GRCm39) N282S probably benign Het
Txnrd2 T C 16: 18,291,614 (GRCm39) L421P possibly damaging Het
Tyr A T 7: 87,133,200 (GRCm39) C289S probably damaging Het
Ubn1 A G 16: 4,895,222 (GRCm39) E756G possibly damaging Het
Vps13a A T 19: 16,701,069 (GRCm39) M700K possibly damaging Het
Zfhx2 A G 14: 55,311,528 (GRCm39) S389P possibly damaging Het
Zfp667 T C 7: 6,308,370 (GRCm39) L346P probably damaging Het
Zfp945 A G 17: 23,070,798 (GRCm39) M388T probably benign Het
Zfp992 A G 4: 146,551,133 (GRCm39) I285V probably benign Het
Other mutations in Or5t5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02147:Or5t5 APN 2 86,616,494 (GRCm39) missense probably benign 0.19
IGL02337:Or5t5 APN 2 86,616,518 (GRCm39) missense probably damaging 1.00
IGL02734:Or5t5 APN 2 86,616,712 (GRCm39) missense probably benign 0.13
R0379:Or5t5 UTSW 2 86,616,079 (GRCm39) missense probably benign
R0526:Or5t5 UTSW 2 86,616,691 (GRCm39) missense possibly damaging 0.67
R3959:Or5t5 UTSW 2 86,616,340 (GRCm39) missense probably benign 0.04
R5635:Or5t5 UTSW 2 86,616,070 (GRCm39) splice site probably null
R5951:Or5t5 UTSW 2 86,616,571 (GRCm39) missense probably benign
R6932:Or5t5 UTSW 2 86,616,499 (GRCm39) missense probably damaging 1.00
R7289:Or5t5 UTSW 2 86,617,034 (GRCm39) missense probably benign
R7432:Or5t5 UTSW 2 86,616,565 (GRCm39) nonsense probably null
R9235:Or5t5 UTSW 2 86,616,548 (GRCm39) missense probably benign 0.00
R9688:Or5t5 UTSW 2 86,617,005 (GRCm39) missense probably damaging 1.00
Z1088:Or5t5 UTSW 2 86,616,817 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AATGAGCTTCTAGTCTTGTACTTGG -3'
(R):5'- ACCAGGGCATGTTTGTAATTTGTAG -3'

Sequencing Primer
(F):5'- GTGGGCTTGATTGAGATTGTTACC -3'
(R):5'- GGCATGTTTGTAATTTGTAGCAATG -3'
Posted On 2020-09-02