Mutagenetix > Incidental Mutation

Incidental Mutation 'R8385:Vmn2r102'

647141

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r102

Ensembl Gene

ENSMUSG00000095961

Gene Name

vomeronasal 2, receptor 102

Synonyms

EG224572

MMRRC Submission

067751-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R8385 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

19880661-19915010 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 19914088 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 551 (Y551C)

Ref Sequence

ENSEMBL: ENSMUSP00000126559 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000171741]

AlphaFold

L7N279

Predicted Effect

possibly damaging
Transcript: ENSMUST00000171741
AA Change: Y551C

PolyPhen 2 Score 0.886 (Sensitivity: 0.82; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000126559
Gene: ENSMUSG00000095961
AA Change: Y551C

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	82	448	5.2e-38	PFAM
Pfam:NCD3G	509	562	1.1e-21	PFAM
Pfam:7tm_3	595	830	1.8e-53	PFAM

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 99.0%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Brap	C	T	5: 121,823,197 (GRCm39)	T473I	probably benign	Het
Cacna1e	T	A	1: 154,319,687 (GRCm39)	M1400L	probably damaging	Het
Catsper2	A	G	2: 121,240,621 (GRCm39)	I127T	possibly damaging	Het
Dbt	A	T	3: 116,317,039 (GRCm39)	I72F	probably damaging	Het
Ddhd2	T	C	8: 26,225,041 (GRCm39)	H592R	probably damaging	Het
Disp2	T	A	2: 118,620,891 (GRCm39)	M541K	probably damaging	Het
Dnai7	C	T	6: 145,120,918 (GRCm39)	E685K	probably damaging	Het
Dnmbp	T	C	19: 43,878,090 (GRCm39)	D327G	probably benign	Het
Dvl1	A	G	4: 155,940,037 (GRCm39)	S390G	possibly damaging	Het
Fbxo22	A	G	9: 55,121,233 (GRCm39)	D106G	probably damaging	Het
Gfm2	A	G	13: 97,301,519 (GRCm39)	T441A	probably benign	Het
Gm5431	T	C	11: 48,780,347 (GRCm39)	I192V	probably damaging	Het
Gosr1	T	A	11: 76,620,967 (GRCm39)	T241S	possibly damaging	Het
Hk2	T	C	6: 82,706,527 (GRCm39)	S792G	probably benign	Het
Itsn1	A	C	16: 91,690,699 (GRCm39)	K1302Q	unknown	Het
Kif16b	T	C	2: 142,554,258 (GRCm39)	K847E	probably benign	Het
Lfng	G	A	5: 140,598,981 (GRCm39)	E297K	probably damaging	Het
Mark3	A	G	12: 111,621,808 (GRCm39)	D650G	possibly damaging	Het
Mgat4f	A	G	1: 134,318,376 (GRCm39)	K383E	probably benign	Het
Mob3b	T	C	4: 34,985,980 (GRCm39)	Y186C	probably damaging	Het
Mphosph9	T	C	5: 124,450,785 (GRCm39)	K329E	probably benign	Het
Mta1	A	T	12: 113,095,085 (GRCm39)	M448L	probably benign	Het
Mterf1a	A	T	5: 3,941,384 (GRCm39)	N161K	probably damaging	Het
Myo10	T	A	15: 25,804,484 (GRCm39)	I1593N	probably damaging	Het
Naca	A	G	10: 127,878,307 (GRCm39)	N1113S	unknown	Het
Or2w4	T	C	13: 21,795,522 (GRCm39)	I206V	probably benign	Het
Or5e1	T	G	7: 108,354,511 (GRCm39)	Y149*	probably null	Het
Pcdhga1	A	T	18: 37,795,149 (GRCm39)	D51V	probably damaging	Het
Peg3	T	C	7: 6,711,082 (GRCm39)	E1380G	probably damaging	Het
Pkd1	G	A	17: 24,794,702 (GRCm39)	V2130M	possibly damaging	Het
Pla2g4c	C	T	7: 13,063,589 (GRCm39)	P19S	probably benign	Het
Popdc2	G	A	16: 38,183,262 (GRCm39)	V82I	probably benign	Het
Ppfibp2	A	G	7: 107,296,894 (GRCm39)	R203G	probably benign	Het
Rab19	T	A	6: 39,360,892 (GRCm39)	N13K	probably benign	Het
Raet1d	T	A	10: 22,246,817 (GRCm39)	D48E	probably benign	Het
Rell1	T	A	5: 64,087,861 (GRCm39)	K136*	probably null	Het
Slc38a4	A	G	15: 96,897,393 (GRCm39)	I474T	probably damaging	Het
Slf1	T	C	13: 77,254,109 (GRCm39)	M243V	probably benign	Het
Spata31f1a	C	T	4: 42,850,509 (GRCm39)	R549H	possibly damaging	Het
Speer4c2	A	T	5: 15,857,669 (GRCm39)	S203T	unknown	Het
Spg11	A	T	2: 121,927,802 (GRCm39)	S661T	probably benign	Het
Thra	C	G	11: 98,659,177 (GRCm39)	S435R	probably benign	Het
Tmem181a	T	C	17: 6,339,274 (GRCm39)	I61T	probably benign	Het
Ttpa	G	A	4: 20,028,483 (GRCm39)	G247S	probably damaging	Het
Usp17lb	C	T	7: 104,489,830 (GRCm39)	V366I	possibly damaging	Het
Vit	A	T	17: 78,927,066 (GRCm39)	Q337L	probably benign	Het
Vps52	T	C	17: 34,181,791 (GRCm39)	L539P	probably damaging	Het
Ythdc1	C	A	5: 86,975,961 (GRCm39)	P529T	possibly damaging	Het
Zdhhc13	T	C	7: 48,455,444 (GRCm39)		probably null	Het
Zfp282	A	T	6: 47,882,023 (GRCm39)	Y570F	possibly damaging	Het
Zfp872	A	T	9: 22,111,407 (GRCm39)	K295N	probably damaging	Het

Other mutations in Vmn2r102

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00944:Vmn2r102	APN	17	19,899,154 (GRCm39)	missense	probably damaging	1.00
IGL00974:Vmn2r102	APN	17	19,897,771 (GRCm39)	missense	possibly damaging	0.93
IGL00978:Vmn2r102	APN	17	19,899,185 (GRCm39)	splice site	probably null
IGL01589:Vmn2r102	APN	17	19,899,066 (GRCm39)	missense	probably benign
IGL01738:Vmn2r102	APN	17	19,898,020 (GRCm39)	missense	probably damaging	1.00
IGL01994:Vmn2r102	APN	17	19,880,731 (GRCm39)	missense	probably benign	0.00
IGL02066:Vmn2r102	APN	17	19,914,191 (GRCm39)	missense	probably benign	0.01
IGL02525:Vmn2r102	APN	17	19,901,447 (GRCm39)	missense	probably benign
IGL02589:Vmn2r102	APN	17	19,901,480 (GRCm39)	missense	probably damaging	1.00
IGL02814:Vmn2r102	APN	17	19,898,170 (GRCm39)	missense	probably damaging	1.00
IGL03028:Vmn2r102	APN	17	19,914,328 (GRCm39)	missense	possibly damaging	0.92
IGL03162:Vmn2r102	APN	17	19,914,286 (GRCm39)	missense	probably damaging	1.00
PIT4431001:Vmn2r102	UTSW	17	19,896,958 (GRCm39)	missense	possibly damaging	0.68
R0042:Vmn2r102	UTSW	17	19,880,851 (GRCm39)	missense	probably damaging	0.98
R0131:Vmn2r102	UTSW	17	19,899,025 (GRCm39)	missense	probably benign	0.42
R0131:Vmn2r102	UTSW	17	19,899,025 (GRCm39)	missense	probably benign	0.42
R0132:Vmn2r102	UTSW	17	19,899,025 (GRCm39)	missense	probably benign	0.42
R0268:Vmn2r102	UTSW	17	19,898,112 (GRCm39)	missense	probably benign	0.00
R0441:Vmn2r102	UTSW	17	19,914,630 (GRCm39)	missense	probably damaging	1.00
R0583:Vmn2r102	UTSW	17	19,897,043 (GRCm39)	missense	probably benign	0.01
R0600:Vmn2r102	UTSW	17	19,898,277 (GRCm39)	missense	probably benign	0.00
R0606:Vmn2r102	UTSW	17	19,899,106 (GRCm39)	missense	possibly damaging	0.93
R0674:Vmn2r102	UTSW	17	19,898,129 (GRCm39)	missense	probably benign	0.00
R0709:Vmn2r102	UTSW	17	19,897,881 (GRCm39)	missense	probably benign	0.01
R0879:Vmn2r102	UTSW	17	19,914,454 (GRCm39)	missense	probably damaging	1.00
R1349:Vmn2r102	UTSW	17	19,880,887 (GRCm39)	splice site	probably benign
R1473:Vmn2r102	UTSW	17	19,914,843 (GRCm39)	missense	probably benign	0.00
R1630:Vmn2r102	UTSW	17	19,899,032 (GRCm39)	missense	possibly damaging	0.60
R1727:Vmn2r102	UTSW	17	19,897,770 (GRCm39)	missense	probably damaging	0.99
R1759:Vmn2r102	UTSW	17	19,914,755 (GRCm39)	missense	probably damaging	1.00
R1809:Vmn2r102	UTSW	17	19,897,881 (GRCm39)	missense	probably benign	0.01
R2013:Vmn2r102	UTSW	17	19,897,006 (GRCm39)	missense	probably benign	0.03
R2086:Vmn2r102	UTSW	17	19,896,949 (GRCm39)	missense	probably damaging	1.00
R2241:Vmn2r102	UTSW	17	19,897,003 (GRCm39)	missense	probably benign	0.00
R2378:Vmn2r102	UTSW	17	19,914,930 (GRCm39)	missense	probably damaging	1.00
R3814:Vmn2r102	UTSW	17	19,899,093 (GRCm39)	missense	probably damaging	0.98
R3827:Vmn2r102	UTSW	17	19,914,787 (GRCm39)	missense	probably damaging	1.00
R4159:Vmn2r102	UTSW	17	19,898,088 (GRCm39)	missense	probably damaging	1.00
R4505:Vmn2r102	UTSW	17	19,880,845 (GRCm39)	missense	probably benign	0.00
R4515:Vmn2r102	UTSW	17	19,901,475 (GRCm39)	missense	probably damaging	1.00
R4517:Vmn2r102	UTSW	17	19,901,475 (GRCm39)	missense	probably damaging	1.00
R4534:Vmn2r102	UTSW	17	19,914,975 (GRCm39)	missense	probably benign
R4535:Vmn2r102	UTSW	17	19,914,975 (GRCm39)	missense	probably benign
R4662:Vmn2r102	UTSW	17	19,901,424 (GRCm39)	missense	probably damaging	1.00
R4708:Vmn2r102	UTSW	17	19,914,576 (GRCm39)	missense	probably benign	0.00
R4734:Vmn2r102	UTSW	17	19,897,795 (GRCm39)	missense	probably damaging	1.00
R4834:Vmn2r102	UTSW	17	19,898,203 (GRCm39)	missense	probably damaging	0.99
R4927:Vmn2r102	UTSW	17	19,880,661 (GRCm39)	start codon destroyed	probably benign	0.00
R5077:Vmn2r102	UTSW	17	19,897,834 (GRCm39)	missense	probably benign	0.20
R5181:Vmn2r102	UTSW	17	19,897,003 (GRCm39)	missense	probably benign	0.00
R5277:Vmn2r102	UTSW	17	19,914,393 (GRCm39)	missense	possibly damaging	0.49
R5418:Vmn2r102	UTSW	17	19,914,415 (GRCm39)	missense	probably damaging	1.00
R5810:Vmn2r102	UTSW	17	19,897,804 (GRCm39)	missense	probably benign	0.20
R5864:Vmn2r102	UTSW	17	19,914,943 (GRCm39)	missense	possibly damaging	0.55
R6168:Vmn2r102	UTSW	17	19,914,402 (GRCm39)	missense	possibly damaging	0.83
R6266:Vmn2r102	UTSW	17	19,899,007 (GRCm39)	missense	probably benign
R6432:Vmn2r102	UTSW	17	19,901,483 (GRCm39)	missense	possibly damaging	0.61
R6487:Vmn2r102	UTSW	17	19,898,169 (GRCm39)	missense	probably damaging	1.00
R6597:Vmn2r102	UTSW	17	19,914,450 (GRCm39)	missense	probably damaging	0.99
R6797:Vmn2r102	UTSW	17	19,880,694 (GRCm39)	nonsense	probably null
R7009:Vmn2r102	UTSW	17	19,914,456 (GRCm39)	missense	probably damaging	0.99
R7098:Vmn2r102	UTSW	17	19,914,670 (GRCm39)	missense	probably damaging	1.00
R7134:Vmn2r102	UTSW	17	19,897,749 (GRCm39)	missense	probably benign	0.01
R7463:Vmn2r102	UTSW	17	19,896,886 (GRCm39)	missense	probably damaging	1.00
R7511:Vmn2r102	UTSW	17	19,901,405 (GRCm39)	missense	probably damaging	1.00
R7512:Vmn2r102	UTSW	17	19,914,363 (GRCm39)	missense	probably damaging	1.00
R7556:Vmn2r102	UTSW	17	19,898,093 (GRCm39)	missense	probably benign
R8126:Vmn2r102	UTSW	17	19,880,712 (GRCm39)	missense	probably benign	0.02
R8410:Vmn2r102	UTSW	17	19,898,196 (GRCm39)	missense	possibly damaging	0.85
R9045:Vmn2r102	UTSW	17	19,880,841 (GRCm39)	missense	probably benign	0.00
R9267:Vmn2r102	UTSW	17	19,896,928 (GRCm39)	missense	probably damaging	1.00
R9325:Vmn2r102	UTSW	17	19,897,558 (GRCm39)	missense	probably damaging	1.00
R9363:Vmn2r102	UTSW	17	19,897,614 (GRCm39)	missense	probably benign	0.04
R9524:Vmn2r102	UTSW	17	19,897,564 (GRCm39)	missense	possibly damaging	0.74
R9747:Vmn2r102	UTSW	17	19,898,129 (GRCm39)	missense	probably benign	0.00
Z1176:Vmn2r102	UTSW	17	19,914,305 (GRCm39)	nonsense	probably null

Predicted Primers

PCR Primer
(F):5'- TGGCTCTAATGAATGAACAAAGTGG -3'
(R):5'- ACAATCGGAGTGTCTCGGTG -3'

Sequencing Primer
(F):5'- GGAAGCAACAAAGTTCAGTTTATC -3'
(R):5'- CGGTGTTTCACAAAGATGCC -3'

Posted On

2020-09-02