Incidental Mutation 'R8386:Ndufb11b'
ID 647174
Institutional Source Beutler Lab
Gene Symbol Ndufb11b
Ensembl Gene ENSMUSG00000061633
Gene Name NADH:ubiquinone oxidoreductase subunit B11B
Synonyms 1700029P11Rik
MMRRC Submission 067752-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.154) question?
Stock # R8386 (G1)
Quality Score 225.009
Status Not validated
Chromosome 15
Chromosomal Location 81864741-81865764 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 81864830 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Phenylalanine at position 24 (L24F)
Ref Sequence ENSEMBL: ENSMUSP00000074190 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074608]
AlphaFold Q9CQ68
Predicted Effect probably damaging
Transcript: ENSMUST00000074608
AA Change: L24F

PolyPhen 2 Score 0.983 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000074190
Gene: ENSMUSG00000061633
AA Change: L24F

DomainStartEndE-ValueType
Pfam:ESSS 19 130 6.9e-40 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca9 G T 11: 110,021,518 (GRCm39) A1064D probably damaging Het
Adgb A G 10: 10,226,048 (GRCm39) I1390T probably damaging Het
Aktip G A 8: 91,857,674 (GRCm39) R13C probably benign Het
Arnt2 T A 7: 83,996,747 (GRCm39) I71F probably damaging Het
Casr T A 16: 36,335,950 (GRCm39) I120F probably damaging Het
Cilp G A 9: 65,186,286 (GRCm39) G794S probably damaging Het
Cntnap1 A T 11: 101,073,029 (GRCm39) R544S probably damaging Het
Cse1l T C 2: 166,761,604 (GRCm39) S53P probably benign Het
Cyfip1 T C 7: 55,527,488 (GRCm39) S207P probably damaging Het
Fam120b G A 17: 15,643,246 (GRCm39) S675N probably benign Het
Fcna C T 2: 25,516,027 (GRCm39) W163* probably null Het
Gast A G 11: 100,227,691 (GRCm39) D91G probably damaging Het
Igkv6-14 T C 6: 70,411,966 (GRCm39) Y106C probably damaging Het
Lin28b A G 10: 45,345,140 (GRCm39) V62A probably damaging Het
Malrd1 T A 2: 15,701,655 (GRCm39) S757T unknown Het
Ms4a15 A T 19: 10,970,546 (GRCm39) C3S unknown Het
Muc5ac G A 7: 141,361,371 (GRCm39) V1561I possibly damaging Het
Or4c11c G A 2: 88,661,633 (GRCm39) M57I possibly damaging Het
Or5p70 TTTCTTCTTCT TTTCTTCT 7: 107,994,555 (GRCm39) probably benign Het
Pi16 C A 17: 29,538,208 (GRCm39) P7Q possibly damaging Het
Ppp1r3c T C 19: 36,711,338 (GRCm39) D144G probably damaging Het
Setd1b T A 5: 123,282,319 (GRCm39) V149D unknown Het
Shcbp1 A C 8: 4,817,951 (GRCm39) W115G probably damaging Het
Shroom1 A T 11: 53,357,230 (GRCm39) K631M probably damaging Het
Sipa1l2 A T 8: 126,218,832 (GRCm39) S168R probably damaging Het
Slc12a4 A T 8: 106,678,250 (GRCm39) N314K probably damaging Het
Syngap1 T A 17: 27,179,465 (GRCm39) M755K possibly damaging Het
Tnik A G 3: 28,317,823 (GRCm39) D11G unknown Het
Trim80 A G 11: 115,335,900 (GRCm39) D274G probably damaging Het
Ush2a A G 1: 188,460,403 (GRCm39) T2555A possibly damaging Het
Vps13a A T 19: 16,678,483 (GRCm39) probably null Het
Wnt7a C T 6: 91,343,270 (GRCm39) G204D probably damaging Het
Zfp420 A T 7: 29,575,043 (GRCm39) Y421F probably benign Het
Zfp882 A G 8: 72,667,962 (GRCm39) H263R probably benign Het
Other mutations in Ndufb11b
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1836:Ndufb11b UTSW 15 81,865,068 (GRCm39) missense probably damaging 0.97
R5581:Ndufb11b UTSW 15 81,865,037 (GRCm39) missense probably damaging 1.00
R5888:Ndufb11b UTSW 15 81,864,872 (GRCm39) missense probably benign 0.03
R6556:Ndufb11b UTSW 15 81,864,939 (GRCm39) missense probably damaging 0.99
R8317:Ndufb11b UTSW 15 81,864,978 (GRCm39) missense probably damaging 1.00
R9074:Ndufb11b UTSW 15 81,865,011 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ATCTCGGAGGATGTCAGTGC -3'
(R):5'- GCGTGCATATTCAAGGCATC -3'

Sequencing Primer
(F):5'- GTTAAGGGAAGCTATTCTCCACAC -3'
(R):5'- AGGCATCCACCTTCGGG -3'
Posted On 2020-09-02