Incidental Mutation 'R8388:Or4s2'
ID 647228
Institutional Source Beutler Lab
Gene Symbol Or4s2
Ensembl Gene ENSMUSG00000081948
Gene Name olfactory receptor family 4 subfamily S member 2
Synonyms Olfr1191, GA_x6K02T2Q125-50121628-50122030, MOR230-9, GA_x6K02T2PRF0-44595-45531, Olfr526-ps1
MMRRC Submission 067753-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.097) question?
Stock # R8388 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 88473113-88474048 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 88473305 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Threonine at position 65 (S65T)
Ref Sequence ENSEMBL: ENSMUSP00000150282 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000120598] [ENSMUST00000217379]
AlphaFold A0A1L1STD5
Predicted Effect probably damaging
Transcript: ENSMUST00000120598
AA Change: S65T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000217379
AA Change: S65T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9430015G10Rik T A 4: 156,209,888 (GRCm39) Y173N probably damaging Het
A2ml1 T C 6: 128,548,937 (GRCm39) T282A probably benign Het
Adamdec1 A T 14: 68,810,684 (GRCm39) Y157* probably null Het
Adgre5 A G 8: 84,456,815 (GRCm39) Y189H probably damaging Het
Alg11 G A 8: 22,552,050 (GRCm39) V65I probably benign Het
Bach1 G A 16: 87,516,179 (GRCm39) R240Q probably benign Het
Camk2b C T 11: 5,939,026 (GRCm39) V278M probably damaging Het
Ccdc57 G A 11: 120,717,744 (GRCm39) P950L probably benign Het
Cep68 A T 11: 20,180,582 (GRCm39) V683D probably damaging Het
Chd6 A T 2: 160,861,571 (GRCm39) I493N probably damaging Het
Cyfip1 A G 7: 55,521,873 (GRCm39) Y59C probably damaging Het
Dclk3 A G 9: 111,311,813 (GRCm39) E685G probably damaging Het
Edaradd A T 13: 12,498,484 (GRCm39) S78T probably benign Het
Edc4 T C 8: 106,614,139 (GRCm39) V430A probably damaging Het
Efr3a T C 15: 65,738,671 (GRCm39) S767P probably benign Het
Enkd1 T C 8: 106,431,025 (GRCm39) Q234R probably damaging Het
Ercc6 ACGGTACCG ACGGTACCGGTACCG 14: 32,292,297 (GRCm39) probably benign Het
Hipk2 T A 6: 38,722,630 (GRCm39) Y468F probably damaging Het
Ifi207 GTT GT 1: 173,557,016 (GRCm39) probably null Het
Kcna5 A G 6: 126,511,588 (GRCm39) V180A probably benign Het
Kcnb1 T C 2: 166,947,217 (GRCm39) I544V probably benign Het
Kif21a A G 15: 90,843,327 (GRCm39) S1119P possibly damaging Het
Klk13 T C 7: 43,373,235 (GRCm39) C190R probably damaging Het
Mga T C 2: 119,794,562 (GRCm39) S2749P probably benign Het
Mpeg1 T C 19: 12,440,278 (GRCm39) S579P probably damaging Het
Msh3 A T 13: 92,359,784 (GRCm39) I903K probably damaging Het
Ptx4 T C 17: 25,339,897 (GRCm39) S25P probably damaging Het
Sipa1l1 G T 12: 82,216,259 (GRCm39) probably benign Het
Slfn9 G C 11: 82,878,112 (GRCm39) T339R probably benign Het
Srsf12 C G 4: 33,226,070 (GRCm39) P111R probably damaging Het
Tex15 A G 8: 34,065,237 (GRCm39) I1556V probably benign Het
Ttc14 A G 3: 33,854,735 (GRCm39) N21D probably benign Het
Other mutations in Or4s2
AlleleSourceChrCoordTypePredicted EffectPPH Score
R6293:Or4s2 UTSW 2 88,473,624 (GRCm39) missense possibly damaging 0.87
R6885:Or4s2 UTSW 2 88,473,941 (GRCm39) missense probably damaging 0.96
R7087:Or4s2 UTSW 2 88,473,197 (GRCm39) missense probably damaging 1.00
R7475:Or4s2 UTSW 2 88,473,554 (GRCm39) missense probably benign
R7552:Or4s2 UTSW 2 88,473,752 (GRCm39) missense probably benign 0.00
R7591:Or4s2 UTSW 2 88,473,811 (GRCm39) missense probably damaging 1.00
R8483:Or4s2 UTSW 2 88,473,678 (GRCm39) missense probably benign 0.12
R8756:Or4s2 UTSW 2 88,473,183 (GRCm39) missense possibly damaging 0.74
R9181:Or4s2 UTSW 2 88,473,348 (GRCm39) missense probably benign 0.07
R9745:Or4s2 UTSW 2 88,473,310 (GRCm39) missense probably benign 0.03
Z1177:Or4s2 UTSW 2 88,473,399 (GRCm39) missense probably damaging 0.96
Predicted Primers PCR Primer
(F):5'- ATGGCCTCAAGGACTTATTCC -3'
(R):5'- GTGGAGAGGTTTACAAATGGCC -3'

Sequencing Primer
(F):5'- TCCATGGAAGAAGTAAATAATGTCAC -3'
(R):5'- TGGCCACATATCTATCATAGGCCATG -3'
Posted On 2020-09-02