Incidental Mutation 'R8391:Iqcf3'
ID 647389
Institutional Source Beutler Lab
Gene Symbol Iqcf3
Ensembl Gene ENSMUSG00000023577
Gene Name IQ motif containing F3
Synonyms 1700012F17Rik
MMRRC Submission 067756-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.059) question?
Stock # R8391 (G1)
Quality Score 225.009
Status Not validated
Chromosome 9
Chromosomal Location 106420585-106438830 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 106438175 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Alanine at position 16 (E16A)
Ref Sequence ENSEMBL: ENSMUSP00000054276 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062917] [ENSMUST00000186668] [ENSMUST00000189407] [ENSMUST00000190975]
AlphaFold no structure available at present
Predicted Effect unknown
Transcript: ENSMUST00000062917
AA Change: E16A
SMART Domains Protein: ENSMUSP00000054276
Gene: ENSMUSG00000023577
AA Change: E16A

DomainStartEndE-ValueType
low complexity region 8 21 N/A INTRINSIC
low complexity region 30 39 N/A INTRINSIC
internal_repeat_1 48 61 1.14e-11 PROSPERO
low complexity region 65 74 N/A INTRINSIC
internal_repeat_1 83 96 1.14e-11 PROSPERO
IQ 128 150 8.58e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000186668
AA Change: E16A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000140327
Gene: ENSMUSG00000023577
AA Change: E16A

DomainStartEndE-ValueType
low complexity region 8 21 N/A INTRINSIC
low complexity region 30 39 N/A INTRINSIC
internal_repeat_1 48 60 1.04e-10 PROSPERO
low complexity region 65 74 N/A INTRINSIC
internal_repeat_1 83 95 1.04e-10 PROSPERO
IQ 99 121 4.3e-3 SMART
Predicted Effect unknown
Transcript: ENSMUST00000189407
AA Change: E16A
SMART Domains Protein: ENSMUSP00000140880
Gene: ENSMUSG00000023577
AA Change: E16A

DomainStartEndE-ValueType
coiled coil region 13 47 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000190975
AA Change: E16A
SMART Domains Protein: ENSMUSP00000141002
Gene: ENSMUSG00000023577
AA Change: E16A

DomainStartEndE-ValueType
low complexity region 8 21 N/A INTRINSIC
low complexity region 29 38 N/A INTRINSIC
internal_repeat_1 47 60 5.99e-12 PROSPERO
low complexity region 64 73 N/A INTRINSIC
internal_repeat_1 82 95 5.99e-12 PROSPERO
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcf3 T C 16: 20,368,968 (GRCm39) S155P possibly damaging Het
Akr1c21 C T 13: 4,626,278 (GRCm39) R101W probably damaging Het
Angpt1 T A 15: 42,375,794 (GRCm39) N154I probably damaging Het
Aoc1l2 T C 6: 48,909,602 (GRCm39) W616R probably damaging Het
Atp2a1 T A 7: 126,047,888 (GRCm39) I641F possibly damaging Het
Bach1 G A 16: 87,516,179 (GRCm39) R240Q probably benign Het
Bltp3b T C 10: 89,645,605 (GRCm39) V1226A possibly damaging Het
Cacna1b G A 2: 24,596,212 (GRCm39) A493V probably damaging Het
Cacna1h G A 17: 25,596,204 (GRCm39) A1939V probably benign Het
Cacna2d4 A G 6: 119,325,706 (GRCm39) I1027V probably benign Het
Cbln3 G A 14: 56,120,523 (GRCm39) R170C probably damaging Het
Cemip T C 7: 83,604,517 (GRCm39) S842G probably damaging Het
Cep164 T A 9: 45,718,491 (GRCm39) Q284L unknown Het
Crybg2 T C 4: 133,803,035 (GRCm39) F889L probably damaging Het
Fhip1a T C 3: 85,595,788 (GRCm39) N366D probably damaging Het
Gars1 T A 6: 55,025,127 (GRCm39) Y124N probably damaging Het
Gbp2b T C 3: 142,309,894 (GRCm39) F228S probably damaging Het
Gm5565 C A 5: 146,096,962 (GRCm39) R59L probably benign Het
Gm8947 A T 1: 151,068,737 (GRCm39) D190V probably benign Het
Grid2ip T C 5: 143,365,951 (GRCm39) M543T probably damaging Het
Gucy2c A G 6: 136,681,213 (GRCm39) L957P probably damaging Het
Hint1 T C 11: 54,757,368 (GRCm39) I18T possibly damaging Het
Il23r T C 6: 67,429,374 (GRCm39) S323G probably benign Het
Kcnj1 A T 9: 32,308,028 (GRCm39) T151S probably damaging Het
Kdm1a G T 4: 136,281,154 (GRCm39) T685K probably benign Het
Lipo4 T A 19: 33,488,965 (GRCm39) H206L probably benign Het
Lrp5 A G 19: 3,654,185 (GRCm39) Y1081H probably damaging Het
Masp1 A T 16: 23,289,128 (GRCm39) H557Q possibly damaging Het
Nhsl1 C T 10: 18,400,691 (GRCm39) T605I possibly damaging Het
Or1af1 T A 2: 37,110,277 (GRCm39) Y259N probably damaging Het
Or1j21 C T 2: 36,684,096 (GRCm39) P283S probably damaging Het
Pkmyt1 C T 17: 23,954,013 (GRCm39) R307C probably damaging Het
Plppr4 T C 3: 117,129,060 (GRCm39) I136V probably benign Het
Ppp1r12c A C 7: 4,500,431 (GRCm39) Y150D probably damaging Het
Qrich2 C G 11: 116,356,403 (GRCm39) V149L probably benign Het
R3hdm1 T C 1: 128,121,215 (GRCm39) F176L Het
Ric8a T A 7: 140,437,916 (GRCm39) S52T probably benign Het
Romo1 G T 2: 155,986,340 (GRCm39) probably benign Het
Rps6ka1 G A 4: 133,591,346 (GRCm39) H318Y probably damaging Het
Slc43a3 A G 2: 84,768,151 (GRCm39) N41S probably benign Het
Srrm4 T G 5: 116,582,755 (GRCm39) T567P unknown Het
Srsf12 C G 4: 33,226,070 (GRCm39) P111R probably damaging Het
St6galnac4 G T 2: 32,484,086 (GRCm39) D95Y probably damaging Het
Sult2a6 T C 7: 13,956,516 (GRCm39) probably null Het
Synj2 A G 17: 5,991,796 (GRCm39) E24G probably damaging Het
Try10 T G 6: 41,334,306 (GRCm39) L166R probably damaging Het
Ttn A G 2: 76,562,544 (GRCm39) V28767A probably damaging Het
Ttn T A 2: 76,604,822 (GRCm39) I18371F probably damaging Het
Zc3h13 T A 14: 75,568,625 (GRCm39) L1306Q probably damaging Het
Zp2 T A 7: 119,726,179 (GRCm39) T674S probably benign Het
Zscan4-ps3 A G 7: 11,346,801 (GRCm39) Y279C probably benign Het
Other mutations in Iqcf3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02974:Iqcf3 APN 9 106,430,844 (GRCm39) nonsense probably null
R4766:Iqcf3 UTSW 9 106,438,148 (GRCm39) critical splice donor site probably null
R4820:Iqcf3 UTSW 9 106,430,788 (GRCm39) unclassified probably benign
R5333:Iqcf3 UTSW 9 106,430,860 (GRCm39) missense possibly damaging 0.46
R5417:Iqcf3 UTSW 9 106,431,413 (GRCm39) missense probably damaging 0.99
R5427:Iqcf3 UTSW 9 106,421,059 (GRCm39) critical splice acceptor site probably null
R6404:Iqcf3 UTSW 9 106,430,083 (GRCm39) missense probably benign 0.06
R7543:Iqcf3 UTSW 9 106,431,425 (GRCm39) missense possibly damaging 0.53
R8390:Iqcf3 UTSW 9 106,438,175 (GRCm39) missense unknown
R9792:Iqcf3 UTSW 9 106,434,714 (GRCm39) missense probably benign 0.00
R9793:Iqcf3 UTSW 9 106,434,714 (GRCm39) missense probably benign 0.00
Z1176:Iqcf3 UTSW 9 106,438,187 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- AACCTTTGGGGCTCATCATC -3'
(R):5'- ACCTTTGACCCAACTGTCAC -3'

Sequencing Primer
(F):5'- GGGCTCATCATCCCCACC -3'
(R):5'- CTCAGAGGTCTATGTATGGATCCAC -3'
Posted On 2020-09-02