Incidental Mutation 'R8394:Vmn2r27'
ID 647524
Institutional Source Beutler Lab
Gene Symbol Vmn2r27
Ensembl Gene ENSMUSG00000072778
Gene Name vomeronasal 2, receptor27
Synonyms EG232367
MMRRC Submission 067758-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.060) question?
Stock # R8394 (G1)
Quality Score 225.009
Status Not validated
Chromosome 6
Chromosomal Location 124168555-124208743 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 124168776 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 785 (T785A)
Ref Sequence ENSEMBL: ENSMUSP00000098528 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000100968]
AlphaFold D3YUK6
Predicted Effect possibly damaging
Transcript: ENSMUST00000100968
AA Change: T785A

PolyPhen 2 Score 0.710 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000098528
Gene: ENSMUSG00000072778
AA Change: T785A

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Pfam:ANF_receptor 81 475 1.1e-27 PFAM
Pfam:NCD3G 519 570 1.3e-18 PFAM
Pfam:7tm_3 603 838 2.6e-50 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700129C05Rik T C 14: 59,379,623 (GRCm39) N137S probably benign Het
4930505A04Rik T A 11: 30,404,880 (GRCm39) probably null Het
Abcc8 A G 7: 45,803,977 (GRCm39) I399T probably benign Het
Aldh3b2 A C 19: 4,029,461 (GRCm39) Q278P probably benign Het
Arl8b A G 6: 108,760,244 (GRCm39) D10G possibly damaging Het
Baiap3 T C 17: 25,469,096 (GRCm39) N229S probably benign Het
Chrdl2 T C 7: 99,666,292 (GRCm39) S71P possibly damaging Het
Cmbl A G 15: 31,585,541 (GRCm39) M142V possibly damaging Het
Cpt1b A G 15: 89,306,490 (GRCm39) probably null Het
Crybg3 T C 16: 59,378,651 (GRCm39) K868E probably benign Het
Efl1 A G 7: 82,411,986 (GRCm39) I792V probably benign Het
Evx2 A G 2: 74,486,321 (GRCm39) L356S probably benign Het
Hspa14 C T 2: 3,513,670 (GRCm39) probably null Het
Ighv5-8 C T 12: 113,618,813 (GRCm39) A76V unknown Het
Il7r A G 15: 9,516,504 (GRCm39) F99S probably damaging Het
Klra2 A T 6: 131,222,273 (GRCm39) V6D possibly damaging Het
Lce3c T C 3: 92,852,760 (GRCm39) S74P unknown Het
Nectin2 C T 7: 19,467,137 (GRCm39) probably null Het
Nfil3 A G 13: 53,121,849 (GRCm39) S352P probably benign Het
Nme6 T A 9: 109,664,394 (GRCm39) M1K probably null Het
Or52z13 A T 7: 103,247,404 (GRCm39) I294F probably damaging Het
Otogl A G 10: 107,722,326 (GRCm39) probably null Het
Plcb1 T C 2: 135,159,710 (GRCm39) V391A probably damaging Het
Ptf1a T A 2: 19,450,746 (GRCm39) D25E probably damaging Het
Ralbp1 C T 17: 66,159,748 (GRCm39) R505H probably benign Het
Scube1 T C 15: 83,492,492 (GRCm39) Y944C probably damaging Het
Sdk2 A G 11: 113,729,542 (GRCm39) I1039T probably benign Het
Senp7 G T 16: 55,990,190 (GRCm39) W646L possibly damaging Het
Sphkap A T 1: 83,253,797 (GRCm39) N1317K probably benign Het
Strc G T 2: 121,209,490 (GRCm39) Q278K probably benign Het
Tbc1d30 T A 10: 121,183,013 (GRCm39) R142* probably null Het
Tmtc3 T C 10: 100,282,808 (GRCm39) I916V probably damaging Het
Tomm40l A T 1: 171,048,776 (GRCm39) H79Q probably damaging Het
Txndc12 T A 4: 108,713,420 (GRCm39) probably null Het
Vmn2r2 T C 3: 64,044,858 (GRCm39) N96S probably damaging Het
Zfp217 G A 2: 169,961,571 (GRCm39) S252F possibly damaging Het
Zfp462 A G 4: 55,011,862 (GRCm39) D1276G probably damaging Het
Other mutations in Vmn2r27
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01285:Vmn2r27 APN 6 124,169,370 (GRCm39) missense possibly damaging 0.86
IGL01388:Vmn2r27 APN 6 124,200,791 (GRCm39) missense possibly damaging 0.55
IGL01923:Vmn2r27 APN 6 124,177,484 (GRCm39) missense probably benign 0.20
IGL01954:Vmn2r27 APN 6 124,169,207 (GRCm39) missense probably damaging 1.00
IGL02105:Vmn2r27 APN 6 124,174,308 (GRCm39) splice site probably benign
IGL02586:Vmn2r27 APN 6 124,201,434 (GRCm39) nonsense probably null
IGL03130:Vmn2r27 APN 6 124,169,276 (GRCm39) missense possibly damaging 0.82
IGL03330:Vmn2r27 APN 6 124,207,139 (GRCm39) nonsense probably null
R0124:Vmn2r27 UTSW 6 124,208,578 (GRCm39) missense probably benign
R0234:Vmn2r27 UTSW 6 124,208,578 (GRCm39) missense probably benign
R0234:Vmn2r27 UTSW 6 124,208,578 (GRCm39) missense probably benign
R0384:Vmn2r27 UTSW 6 124,200,871 (GRCm39) missense probably benign 0.01
R0582:Vmn2r27 UTSW 6 124,201,249 (GRCm39) missense probably benign 0.02
R0733:Vmn2r27 UTSW 6 124,169,147 (GRCm39) missense probably benign 0.18
R0738:Vmn2r27 UTSW 6 124,200,661 (GRCm39) missense possibly damaging 0.48
R0835:Vmn2r27 UTSW 6 124,177,583 (GRCm39) missense probably damaging 0.99
R1183:Vmn2r27 UTSW 6 124,177,491 (GRCm39) missense probably benign
R1401:Vmn2r27 UTSW 6 124,168,591 (GRCm39) nonsense probably null
R1484:Vmn2r27 UTSW 6 124,177,474 (GRCm39) missense probably damaging 0.96
R1536:Vmn2r27 UTSW 6 124,177,649 (GRCm39) missense probably damaging 1.00
R1539:Vmn2r27 UTSW 6 124,168,730 (GRCm39) missense probably damaging 1.00
R1565:Vmn2r27 UTSW 6 124,208,593 (GRCm39) missense probably benign
R1595:Vmn2r27 UTSW 6 124,208,574 (GRCm39) missense probably benign 0.00
R1614:Vmn2r27 UTSW 6 124,200,893 (GRCm39) missense probably benign 0.01
R1742:Vmn2r27 UTSW 6 124,177,636 (GRCm39) missense possibly damaging 0.48
R1816:Vmn2r27 UTSW 6 124,207,330 (GRCm39) nonsense probably null
R1822:Vmn2r27 UTSW 6 124,208,593 (GRCm39) missense probably benign
R1824:Vmn2r27 UTSW 6 124,208,593 (GRCm39) missense probably benign
R1870:Vmn2r27 UTSW 6 124,201,170 (GRCm39) missense probably benign 0.11
R1942:Vmn2r27 UTSW 6 124,200,722 (GRCm39) missense probably damaging 1.00
R1962:Vmn2r27 UTSW 6 124,200,793 (GRCm39) missense possibly damaging 0.70
R2069:Vmn2r27 UTSW 6 124,201,442 (GRCm39) missense probably damaging 1.00
R2075:Vmn2r27 UTSW 6 124,177,510 (GRCm39) missense possibly damaging 0.85
R2379:Vmn2r27 UTSW 6 124,201,342 (GRCm39) missense possibly damaging 0.89
R3748:Vmn2r27 UTSW 6 124,207,351 (GRCm39) missense probably benign 0.35
R4384:Vmn2r27 UTSW 6 124,201,115 (GRCm39) missense probably benign 0.05
R4392:Vmn2r27 UTSW 6 124,207,135 (GRCm39) missense probably benign 0.01
R4758:Vmn2r27 UTSW 6 124,208,596 (GRCm39) missense possibly damaging 0.87
R5018:Vmn2r27 UTSW 6 124,201,141 (GRCm39) missense probably benign 0.02
R5235:Vmn2r27 UTSW 6 124,169,013 (GRCm39) missense probably damaging 0.99
R5718:Vmn2r27 UTSW 6 124,169,103 (GRCm39) missense possibly damaging 0.66
R5859:Vmn2r27 UTSW 6 124,177,647 (GRCm39) missense probably damaging 1.00
R5958:Vmn2r27 UTSW 6 124,208,686 (GRCm39) missense probably benign 0.00
R6044:Vmn2r27 UTSW 6 124,208,731 (GRCm39) missense probably benign
R6086:Vmn2r27 UTSW 6 124,168,958 (GRCm39) missense probably damaging 1.00
R6396:Vmn2r27 UTSW 6 124,201,125 (GRCm39) nonsense probably null
R6546:Vmn2r27 UTSW 6 124,169,369 (GRCm39) missense possibly damaging 0.49
R6746:Vmn2r27 UTSW 6 124,177,552 (GRCm39) missense possibly damaging 0.47
R6976:Vmn2r27 UTSW 6 124,201,312 (GRCm39) nonsense probably null
R7091:Vmn2r27 UTSW 6 124,200,904 (GRCm39) missense possibly damaging 0.85
R7145:Vmn2r27 UTSW 6 124,168,711 (GRCm39) missense probably benign
R7176:Vmn2r27 UTSW 6 124,168,995 (GRCm39) missense probably benign 0.01
R7382:Vmn2r27 UTSW 6 124,174,276 (GRCm39) missense probably damaging 1.00
R7482:Vmn2r27 UTSW 6 124,201,220 (GRCm39) missense probably damaging 1.00
R7853:Vmn2r27 UTSW 6 124,168,980 (GRCm39) missense probably damaging 1.00
R7859:Vmn2r27 UTSW 6 124,201,201 (GRCm39) missense probably benign 0.00
R7959:Vmn2r27 UTSW 6 124,169,040 (GRCm39) missense probably benign
R8266:Vmn2r27 UTSW 6 124,168,937 (GRCm39) missense probably benign 0.00
R8353:Vmn2r27 UTSW 6 124,169,404 (GRCm39) missense probably damaging 0.99
R8463:Vmn2r27 UTSW 6 124,169,168 (GRCm39) missense probably damaging 1.00
R8477:Vmn2r27 UTSW 6 124,201,200 (GRCm39) missense probably benign 0.11
R8705:Vmn2r27 UTSW 6 124,207,188 (GRCm39) missense probably damaging 1.00
R8752:Vmn2r27 UTSW 6 124,201,018 (GRCm39) missense probably benign 0.00
R9109:Vmn2r27 UTSW 6 124,174,224 (GRCm39) missense possibly damaging 0.95
R9140:Vmn2r27 UTSW 6 124,169,207 (GRCm39) missense probably damaging 1.00
R9157:Vmn2r27 UTSW 6 124,201,244 (GRCm39) missense probably benign 0.09
R9431:Vmn2r27 UTSW 6 124,168,856 (GRCm39) missense probably damaging 1.00
R9477:Vmn2r27 UTSW 6 124,168,910 (GRCm39) missense probably damaging 0.99
R9758:Vmn2r27 UTSW 6 124,168,637 (GRCm39) missense possibly damaging 0.89
Z1177:Vmn2r27 UTSW 6 124,168,860 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTCTTTTGTCTTACGGAGAAACC -3'
(R):5'- CCCTGATGTTGACATGCACTC -3'

Sequencing Primer
(F):5'- AGAACTTCTTTCTCGAATAGCCAC -3'
(R):5'- ACATGCACTCAGAGTTTGGTC -3'
Posted On 2020-09-02