Incidental Mutation 'R0022:Cracdl'
ID 64774
Institutional Source Beutler Lab
Gene Symbol Cracdl
Ensembl Gene ENSMUSG00000026090
Gene Name capping protein inhibiting regulator of actin like
Synonyms 2010300C02Rik
MMRRC Submission 038317-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0022 (G1)
Quality Score 166
Status Validated
Chromosome 1
Chromosomal Location 37650758-37758905 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 37667326 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Glutamine at position 240 (R240Q)
Ref Sequence ENSEMBL: ENSMUSP00000123803 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000162875]
AlphaFold E9Q3M9
Predicted Effect probably benign
Transcript: ENSMUST00000160023
SMART Domains Protein: ENSMUSP00000125015
Gene: ENSMUSG00000026090

DomainStartEndE-ValueType
internal_repeat_1 2 65 4.52e-24 PROSPERO
internal_repeat_1 65 128 4.52e-24 PROSPERO
low complexity region 181 194 N/A INTRINSIC
low complexity region 223 237 N/A INTRINSIC
low complexity region 263 279 N/A INTRINSIC
low complexity region 441 465 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000162875
AA Change: R240Q

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000123803
Gene: ENSMUSG00000026090
AA Change: R240Q

DomainStartEndE-ValueType
low complexity region 13 43 N/A INTRINSIC
Pfam:DUF4592 130 243 1.8e-33 PFAM
low complexity region 347 366 N/A INTRINSIC
internal_repeat_2 387 461 2.31e-5 PROSPERO
internal_repeat_3 404 474 3.67e-5 PROSPERO
internal_repeat_1 411 526 3.02e-34 PROSPERO
internal_repeat_2 485 559 2.31e-5 PROSPERO
internal_repeat_1 537 652 3.02e-34 PROSPERO
internal_repeat_3 570 698 3.67e-5 PROSPERO
low complexity region 705 718 N/A INTRINSIC
low complexity region 747 761 N/A INTRINSIC
low complexity region 787 803 N/A INTRINSIC
low complexity region 965 989 N/A INTRINSIC
Meta Mutation Damage Score 0.0973 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.0%
  • 20x: 93.8%
Validation Efficiency 100% (68/68)
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agl A T 3: 116,587,485 (GRCm39) probably null Het
Arhgap29 G A 3: 121,782,586 (GRCm39) V91I possibly damaging Het
Aste1 T A 9: 105,273,823 (GRCm39) L21* probably null Het
Bpifb5 A T 2: 154,072,268 (GRCm39) D325V probably damaging Het
Btbd10 G A 7: 112,924,988 (GRCm39) Q287* probably null Het
Cdc20 T A 4: 118,292,686 (GRCm39) H354L probably damaging Het
Cdhr3 G A 12: 33,132,263 (GRCm39) T120I probably damaging Het
Col5a2 G A 1: 45,422,843 (GRCm39) R1125* probably null Het
Col9a3 A G 2: 180,261,549 (GRCm39) D613G probably damaging Het
Coro7 C T 16: 4,451,168 (GRCm39) R507H probably benign Het
Crebbp A T 16: 3,903,092 (GRCm39) V2049E probably damaging Het
Cryga T C 1: 65,142,382 (GRCm39) I4V probably damaging Het
D930020B18Rik A G 10: 121,507,675 (GRCm39) T138A probably damaging Het
Dclre1b G T 3: 103,710,464 (GRCm39) H482Q probably benign Het
Dpy19l2 A G 9: 24,607,420 (GRCm39) S14P probably benign Het
Elavl3 C A 9: 21,948,167 (GRCm39) probably benign Het
Ephb6 T C 6: 41,591,503 (GRCm39) V220A probably damaging Het
Exoc7 A T 11: 116,188,408 (GRCm39) I297N possibly damaging Het
Gdpd4 A T 7: 97,632,082 (GRCm39) N332Y probably damaging Het
Ggct C A 6: 54,962,887 (GRCm39) E175* probably null Het
Gm5316 T C 6: 122,877,354 (GRCm39) noncoding transcript Het
Hoxa7 T C 6: 52,194,363 (GRCm39) N8S probably damaging Het
Ifi208 A G 1: 173,510,612 (GRCm39) T256A possibly damaging Het
Il12rb2 A G 6: 67,275,903 (GRCm39) F630S probably damaging Het
Kit A G 5: 75,783,657 (GRCm39) N378S probably benign Het
Lmntd1 T A 6: 145,375,716 (GRCm39) Y74F probably benign Het
Lrp1b A T 2: 40,888,050 (GRCm39) probably benign Het
Ltbp1 T A 17: 75,671,355 (GRCm39) V1194D probably damaging Het
Mc5r T G 18: 68,471,853 (GRCm39) S71A probably benign Het
Mcm7 T C 5: 138,162,981 (GRCm39) *390W probably null Het
Myo18a T C 11: 77,734,059 (GRCm39) probably null Het
Naa25 C A 5: 121,556,039 (GRCm39) L276M probably damaging Het
Nlrp1a T G 11: 71,014,207 (GRCm39) T348P probably damaging Het
Nlrp1b T G 11: 71,052,755 (GRCm39) K888T possibly damaging Het
Or4f53 A G 2: 111,087,994 (GRCm39) Y178C probably benign Het
Pabpc6 A T 17: 9,888,145 (GRCm39) N135K probably benign Het
Pdzd2 G A 15: 12,371,691 (GRCm39) A2568V possibly damaging Het
Pik3r2 A G 8: 71,223,545 (GRCm39) F346S probably damaging Het
Pkd1 T C 17: 24,813,793 (GRCm39) W4086R probably damaging Het
Plekhb2 G A 1: 34,905,320 (GRCm39) probably benign Het
Plxnb2 A G 15: 89,047,479 (GRCm39) probably null Het
Pmfbp1 C T 8: 110,252,039 (GRCm39) R395W probably damaging Het
Pnldc1 A G 17: 13,109,006 (GRCm39) Y497H probably damaging Het
Ppp1ca T G 19: 4,244,580 (GRCm39) V213G possibly damaging Het
Rapgef2 G A 3: 78,995,207 (GRCm39) R814C probably damaging Het
Relch T A 1: 105,619,627 (GRCm39) probably benign Het
Rnasel A T 1: 153,636,521 (GRCm39) I634F probably damaging Het
Rnf157 A T 11: 116,240,276 (GRCm39) probably benign Het
Ryr3 A G 2: 112,471,011 (GRCm39) S4567P probably damaging Het
Smcr8 T A 11: 60,671,185 (GRCm39) W778R probably damaging Het
Stat1 T A 1: 52,179,789 (GRCm39) L333Q probably damaging Het
Strc A G 2: 121,198,874 (GRCm39) L1391P probably damaging Het
Tek G A 4: 94,725,509 (GRCm39) V592M probably damaging Het
Top1 A C 2: 160,544,719 (GRCm39) K278N possibly damaging Het
Utrn C T 10: 12,585,700 (GRCm39) probably benign Het
Wdr7 T C 18: 63,910,705 (GRCm39) I699T probably damaging Het
Zfp30 A G 7: 29,491,860 (GRCm39) E119G possibly damaging Het
Other mutations in Cracdl
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01376:Cracdl APN 1 37,667,425 (GRCm39) missense probably damaging 0.99
IGL01413:Cracdl APN 1 37,651,387 (GRCm39) missense possibly damaging 0.85
IGL01812:Cracdl APN 1 37,664,446 (GRCm39) missense probably benign 0.06
IGL02183:Cracdl APN 1 37,664,459 (GRCm39) missense possibly damaging 0.93
IGL02498:Cracdl APN 1 37,662,926 (GRCm39) missense probably benign
IGL02713:Cracdl APN 1 37,663,218 (GRCm39) missense possibly damaging 0.72
IGL02736:Cracdl APN 1 37,676,954 (GRCm39) missense probably damaging 1.00
FR4449:Cracdl UTSW 1 37,664,117 (GRCm39) nonsense probably null
FR4449:Cracdl UTSW 1 37,664,116 (GRCm39) missense probably benign 0.40
FR4548:Cracdl UTSW 1 37,664,183 (GRCm39) missense probably damaging 0.96
FR4548:Cracdl UTSW 1 37,664,116 (GRCm39) missense probably benign 0.40
FR4548:Cracdl UTSW 1 37,664,117 (GRCm39) nonsense probably null
FR4737:Cracdl UTSW 1 37,664,117 (GRCm39) nonsense probably null
FR4737:Cracdl UTSW 1 37,664,116 (GRCm39) missense probably benign 0.40
FR4976:Cracdl UTSW 1 37,664,183 (GRCm39) missense probably damaging 0.96
FR4976:Cracdl UTSW 1 37,664,116 (GRCm39) missense probably benign 0.40
FR4976:Cracdl UTSW 1 37,664,117 (GRCm39) nonsense probably null
R0022:Cracdl UTSW 1 37,667,326 (GRCm39) missense probably damaging 1.00
R0055:Cracdl UTSW 1 37,663,337 (GRCm39) missense probably benign 0.18
R0153:Cracdl UTSW 1 37,663,720 (GRCm39) missense probably benign
R0523:Cracdl UTSW 1 37,683,710 (GRCm39) start codon destroyed probably null 0.94
R0699:Cracdl UTSW 1 37,651,411 (GRCm39) missense possibly damaging 0.85
R0928:Cracdl UTSW 1 37,663,663 (GRCm39) missense possibly damaging 0.85
R1457:Cracdl UTSW 1 37,665,093 (GRCm39) nonsense probably null
R1759:Cracdl UTSW 1 37,664,791 (GRCm39) missense probably benign 0.00
R1888:Cracdl UTSW 1 37,663,364 (GRCm39) missense possibly damaging 0.53
R1888:Cracdl UTSW 1 37,663,364 (GRCm39) missense possibly damaging 0.53
R2289:Cracdl UTSW 1 37,651,342 (GRCm39) missense possibly damaging 0.53
R2421:Cracdl UTSW 1 37,652,556 (GRCm39) missense probably benign 0.33
R2422:Cracdl UTSW 1 37,652,556 (GRCm39) missense probably benign 0.33
R2509:Cracdl UTSW 1 37,664,381 (GRCm39) missense probably benign
R2510:Cracdl UTSW 1 37,664,381 (GRCm39) missense probably benign
R2511:Cracdl UTSW 1 37,664,381 (GRCm39) missense probably benign
R3893:Cracdl UTSW 1 37,670,539 (GRCm39) missense probably benign 0.00
R4351:Cracdl UTSW 1 37,663,993 (GRCm39) missense probably benign
R4454:Cracdl UTSW 1 37,663,834 (GRCm39) missense probably damaging 1.00
R4788:Cracdl UTSW 1 37,670,556 (GRCm39) missense probably damaging 1.00
R4798:Cracdl UTSW 1 37,664,046 (GRCm39) missense probably benign 0.12
R5599:Cracdl UTSW 1 37,652,424 (GRCm39) missense possibly damaging 0.53
R5920:Cracdl UTSW 1 37,677,062 (GRCm39) missense probably damaging 1.00
R6051:Cracdl UTSW 1 37,663,306 (GRCm39) missense probably damaging 0.98
R6106:Cracdl UTSW 1 37,652,493 (GRCm39) missense possibly damaging 0.53
R6794:Cracdl UTSW 1 37,676,936 (GRCm39) splice site probably null
R6828:Cracdl UTSW 1 37,663,898 (GRCm39) missense possibly damaging 0.53
R6930:Cracdl UTSW 1 37,664,026 (GRCm39) missense possibly damaging 0.73
R7044:Cracdl UTSW 1 37,651,361 (GRCm39) missense possibly damaging 0.85
R7069:Cracdl UTSW 1 37,670,982 (GRCm39) missense probably damaging 1.00
R7149:Cracdl UTSW 1 37,651,352 (GRCm39) nonsense probably null
R7296:Cracdl UTSW 1 37,653,699 (GRCm39) missense possibly damaging 0.53
R7698:Cracdl UTSW 1 37,664,452 (GRCm39) missense probably benign 0.12
R7714:Cracdl UTSW 1 37,663,858 (GRCm39) missense probably benign 0.33
R8071:Cracdl UTSW 1 37,663,010 (GRCm39) nonsense probably null
R8205:Cracdl UTSW 1 37,664,047 (GRCm39) missense probably benign 0.06
R8443:Cracdl UTSW 1 37,652,537 (GRCm39) missense probably benign 0.33
R8720:Cracdl UTSW 1 37,652,522 (GRCm39) missense possibly damaging 0.53
R8917:Cracdl UTSW 1 37,676,993 (GRCm39) missense probably damaging 0.99
R9056:Cracdl UTSW 1 37,663,553 (GRCm39) missense possibly damaging 0.91
R9158:Cracdl UTSW 1 37,670,442 (GRCm39) missense probably damaging 0.99
R9290:Cracdl UTSW 1 37,663,634 (GRCm39) missense probably damaging 0.97
R9483:Cracdl UTSW 1 37,670,496 (GRCm39) missense probably damaging 1.00
R9641:Cracdl UTSW 1 37,663,592 (GRCm39) missense possibly damaging 0.85
X0025:Cracdl UTSW 1 37,664,026 (GRCm39) missense probably benign 0.33
Predicted Primers PCR Primer
(F):5'- AGTCCTCAGTGTGAGCCATTGTCC -3'
(R):5'- ACGAAGATCCTAGTGTCCTCGTCC -3'

Sequencing Primer
(F):5'- CACACGATACTGTGGATTCTTG -3'
(R):5'- GTCCCGGCCACAGTCTC -3'
Posted On 2013-08-06