Mutagenetix > Incidental Mutation

Incidental Mutation 'R8400:Vmn2r79'

647811

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r79

Ensembl Gene

ENSMUSG00000090362

Gene Name

vomeronasal 2, receptor 79

Synonyms

EG621430

MMRRC Submission

067763-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.093) question?

Stock #

R8400 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

86996465-87037968 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 87002100 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 236 (T236A)

Ref Sequence

ENSEMBL: ENSMUSP00000132478 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000164462]

AlphaFold

E9Q067

Predicted Effect

probably benign
Transcript: ENSMUST00000164462
AA Change: T236A

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

SMART Domains

Protein: ENSMUSP00000132478
Gene: ENSMUSG00000090362
AA Change: T236A

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	75	464	1.9e-31	PFAM
Pfam:NCD3G	506	559	3.1e-21	PFAM
Pfam:7tm_3	592	827	2.8e-53	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.0%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca13	T	C	11: 9,298,218 (GRCm38)	I2655T	probably damaging	Het
Abca13	G	A	11: 9,293,925 (GRCm38)	M1929I	probably benign	Het
Acad10	A	G	5: 121,626,205 (GRCm38)	V887A	possibly damaging	Het
Acot10	T	C	15: 20,666,172 (GRCm38)	E161G	possibly damaging	Het
Astn1	C	T	1: 158,657,100 (GRCm38)	P919L	probably benign	Het
Atp1a4	T	A	1: 172,234,494 (GRCm38)	D688V	probably damaging	Het
C4bp	C	A	1: 130,636,747 (GRCm38)	C400F	probably damaging	Het
Col6a6	A	C	9: 105,774,796 (GRCm38)	D1005E	probably damaging	Het
Csnk1g3	C	T	18: 53,953,288 (GRCm38)	R422C	probably benign	Het
Cutc	T	C	19: 43,753,205 (GRCm38)	S15P	probably benign	Het
Dgkb	T	C	12: 38,602,838 (GRCm38)		probably null	Het
Disc1	T	C	8: 125,232,993 (GRCm38)	V748A	probably benign	Het
Dmbt1	C	G	7: 131,082,587 (GRCm38)	D778E	unknown	Het
Dmxl2	T	C	9: 54,383,753 (GRCm38)	Y2471C	probably benign	Het
Fam185a	T	A	5: 21,438,816 (GRCm38)	N243K	probably benign	Het
Fchsd2	A	T	7: 101,253,573 (GRCm38)	Q386L	possibly damaging	Het
Gm904	C	A	13: 50,643,417 (GRCm38)	P49Q	probably damaging	Het
H2-Q10	C	T	17: 35,470,477 (GRCm38)	R59C	probably damaging	Het
Ier5l	A	G	2: 30,473,093 (GRCm38)	Y307H	possibly damaging	Het
Kmt2e	C	A	5: 23,497,092 (GRCm38)	T906K	probably benign	Het
Kndc1	C	T	7: 139,913,518 (GRCm38)	R467W	probably damaging	Het
Muc5ac	C	A	7: 141,810,476 (GRCm38)	T2508K	probably damaging	Het
Nlrp9a	A	T	7: 26,565,006 (GRCm38)	M784L	probably benign	Het
Nlrp9b	T	A	7: 20,024,012 (GRCm38)	C391*	probably null	Het
Nubp2	A	C	17: 24,884,465 (GRCm38)	M146R	probably damaging	Het
Or10q3	T	A	19: 11,871,214 (GRCm38)	M1L	probably damaging	Het
Or1a1b	C	T	11: 74,206,395 (GRCm38)	V274M	possibly damaging	Het
Or2ag1b	T	A	7: 106,689,669 (GRCm38)	S21C	probably benign	Het
Or2b2	G	A	13: 21,703,915 (GRCm38)	V305M	probably benign	Het
Or4k45	A	T	2: 111,565,402 (GRCm38)	L14H	probably damaging	Het
Or7e166	A	T	9: 19,713,093 (GRCm38)	N89Y	probably benign	Het
Otud1	T	C	2: 19,658,378 (GRCm38)	V106A	possibly damaging	Het
Pcdhac1	T	A	18: 37,092,400 (GRCm38)	Y755*	probably null	Het
Pkd1l3	C	T	8: 109,623,888 (GRCm38)	P455L	possibly damaging	Het
Ptprb	GAGACCCTCGGGAGCACTGCAGAGACCCTCAGGAACACTGCAAAGACCCTCGGGAGCACTGCAGAGACCCTCAGGAACACTGCAAAGACCCTCGGGAGCACTGCAGAGACCCTCGGGAGCACTGCAAAGACCCTCGGGAGCACTGCAAAGACCCTCGGGAGCACTGCAAAGACCCTCGGGAGCACT	GAGACCCTCGGGAGCACTGCAGAGACCCTCAGGAACACTGCAAAGACCCTCGGGAGCACTGCAGAGACCCTCGGGAGCACTGCAAAGACCCTCGGGAGCACTGCAAAGACCCTCGGGAGCACTGCAAAGACCCTCGGGAGCACT	10: 116,283,572 (GRCm38)		probably benign	Het
Samhd1	T	C	2: 157,099,433 (GRCm38)	E648G	probably benign	Het
Smarca5	T	C	8: 80,709,127 (GRCm38)	T794A	probably benign	Het
Spc24	A	T	9: 21,757,730 (GRCm38)	L87H	probably damaging	Het
Sppl2b	TGTCACAGGT	TGT	10: 80,866,069 (GRCm38)		probably null	Het
Stra6l	G	A	4: 45,864,905 (GRCm38)	R77Q	probably damaging	Het
Tdrd1	G	A	19: 56,848,649 (GRCm38)	V472M	probably benign	Het
Tsc2	A	T	17: 24,604,987 (GRCm38)	I948K	possibly damaging	Het
Ttc39d	T	C	17: 80,216,005 (GRCm38)	V31A	probably benign	Het
Vmn1r158	A	T	7: 22,789,880 (GRCm38)	C301*	probably null	Het
Vmn2r22	A	T	6: 123,637,527 (GRCm38)	L368*	probably null	Het
Vwa1	T	C	4: 155,772,768 (GRCm38)	H191R	probably benign	Het
Zdbf2	T	A	1: 63,304,976 (GRCm38)	V838E	possibly damaging	Het

Other mutations in Vmn2r79

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01401:Vmn2r79	APN	7	87,037,273 (GRCm38)	missense	probably benign	0.01
IGL01675:Vmn2r79	APN	7	86,996,648 (GRCm38)	missense	probably benign	0.01
IGL01760:Vmn2r79	APN	7	87,002,158 (GRCm38)	missense	probably benign
IGL01834:Vmn2r79	APN	7	87,037,146 (GRCm38)	missense	probably benign	0.01
IGL01843:Vmn2r79	APN	7	87,037,277 (GRCm38)	missense	probably damaging	1.00
IGL01914:Vmn2r79	APN	7	87,037,363 (GRCm38)	missense	probably benign	0.14
IGL01980:Vmn2r79	APN	7	87,037,082 (GRCm38)	missense	possibly damaging	0.49
IGL02438:Vmn2r79	APN	7	87,002,536 (GRCm38)	missense	probably damaging	0.98
IGL02740:Vmn2r79	APN	7	87,004,158 (GRCm38)	missense	probably benign	0.00
IGL03052:Vmn2r79	UTSW	7	87,003,591 (GRCm38)	missense	probably benign	0.00
PIT4445001:Vmn2r79	UTSW	7	87,002,200 (GRCm38)	missense	possibly damaging	0.46
R0096:Vmn2r79	UTSW	7	87,037,319 (GRCm38)	missense	probably damaging	1.00
R0096:Vmn2r79	UTSW	7	87,037,319 (GRCm38)	missense	probably damaging	1.00
R0270:Vmn2r79	UTSW	7	87,003,386 (GRCm38)	missense	probably benign	0.00
R0336:Vmn2r79	UTSW	7	87,002,079 (GRCm38)	missense	probably benign	0.15
R0418:Vmn2r79	UTSW	7	87,002,403 (GRCm38)	missense	probably benign	0.18
R1070:Vmn2r79	UTSW	7	87,003,473 (GRCm38)	missense	probably damaging	1.00
R1234:Vmn2r79	UTSW	7	87,004,099 (GRCm38)	missense	possibly damaging	0.71
R1459:Vmn2r79	UTSW	7	87,037,794 (GRCm38)	missense	probably benign	0.01
R1513:Vmn2r79	UTSW	7	87,037,444 (GRCm38)	missense	probably benign	0.01
R1624:Vmn2r79	UTSW	7	87,004,039 (GRCm38)	critical splice acceptor site	probably null
R1633:Vmn2r79	UTSW	7	87,037,834 (GRCm38)	missense	possibly damaging	0.52
R1676:Vmn2r79	UTSW	7	87,002,631 (GRCm38)	missense	probably benign
R1781:Vmn2r79	UTSW	7	87,002,347 (GRCm38)	missense	probably benign	0.00
R1794:Vmn2r79	UTSW	7	87,001,413 (GRCm38)	missense	probably benign	0.37
R1823:Vmn2r79	UTSW	7	87,037,872 (GRCm38)	missense	probably damaging	1.00
R2013:Vmn2r79	UTSW	7	87,004,081 (GRCm38)	missense	possibly damaging	0.50
R2018:Vmn2r79	UTSW	7	87,002,426 (GRCm38)	missense	probably benign	0.07
R2019:Vmn2r79	UTSW	7	87,002,426 (GRCm38)	missense	probably benign	0.07
R2177:Vmn2r79	UTSW	7	86,996,631 (GRCm38)	missense	possibly damaging	0.94
R2984:Vmn2r79	UTSW	7	87,001,891 (GRCm38)	missense	possibly damaging	0.85
R3719:Vmn2r79	UTSW	7	87,002,037 (GRCm38)	missense	probably benign	0.05
R3798:Vmn2r79	UTSW	7	87,002,194 (GRCm38)	missense	possibly damaging	0.88
R3969:Vmn2r79	UTSW	7	87,003,593 (GRCm38)	missense	probably damaging	1.00
R4182:Vmn2r79	UTSW	7	87,001,891 (GRCm38)	missense	possibly damaging	0.85
R4183:Vmn2r79	UTSW	7	87,001,891 (GRCm38)	missense	possibly damaging	0.85
R4245:Vmn2r79	UTSW	7	87,002,416 (GRCm38)	missense	possibly damaging	0.73
R4301:Vmn2r79	UTSW	7	87,001,891 (GRCm38)	missense	possibly damaging	0.85
R4391:Vmn2r79	UTSW	7	87,001,891 (GRCm38)	missense	possibly damaging	0.85
R4393:Vmn2r79	UTSW	7	87,001,891 (GRCm38)	missense	possibly damaging	0.85
R4394:Vmn2r79	UTSW	7	87,001,891 (GRCm38)	missense	possibly damaging	0.85
R4396:Vmn2r79	UTSW	7	87,001,891 (GRCm38)	missense	possibly damaging	0.85
R4397:Vmn2r79	UTSW	7	87,001,891 (GRCm38)	missense	possibly damaging	0.85
R4592:Vmn2r79	UTSW	7	87,004,111 (GRCm38)	missense	possibly damaging	0.86
R4697:Vmn2r79	UTSW	7	87,037,960 (GRCm38)	missense	probably damaging	0.98
R4897:Vmn2r79	UTSW	7	87,001,467 (GRCm38)	missense	probably benign
R5016:Vmn2r79	UTSW	7	87,037,340 (GRCm38)	missense	probably benign	0.00
R5058:Vmn2r79	UTSW	7	87,002,215 (GRCm38)	missense	probably damaging	0.98
R5177:Vmn2r79	UTSW	7	87,001,969 (GRCm38)	missense	probably damaging	0.97
R6078:Vmn2r79	UTSW	7	87,004,111 (GRCm38)	missense	possibly damaging	0.86
R6079:Vmn2r79	UTSW	7	87,004,111 (GRCm38)	missense	possibly damaging	0.86
R6138:Vmn2r79	UTSW	7	87,004,111 (GRCm38)	missense	possibly damaging	0.86
R6257:Vmn2r79	UTSW	7	87,002,570 (GRCm38)	missense	probably benign	0.27
R6260:Vmn2r79	UTSW	7	87,037,157 (GRCm38)	missense	probably benign	0.00
R6307:Vmn2r79	UTSW	7	87,037,768 (GRCm38)	missense	probably damaging	1.00
R6323:Vmn2r79	UTSW	7	87,001,314 (GRCm38)	missense	probably benign	0.05
R6374:Vmn2r79	UTSW	7	87,002,290 (GRCm38)	missense	probably benign	0.02
R6530:Vmn2r79	UTSW	7	87,002,044 (GRCm38)	missense	possibly damaging	0.91
R6546:Vmn2r79	UTSW	7	87,003,533 (GRCm38)	missense	probably benign	0.01
R6682:Vmn2r79	UTSW	7	87,004,162 (GRCm38)	missense	possibly damaging	0.69
R6858:Vmn2r79	UTSW	7	87,037,372 (GRCm38)	missense	probably benign
R6965:Vmn2r79	UTSW	7	87,001,892 (GRCm38)	missense	probably benign	0.10
R7130:Vmn2r79	UTSW	7	87,002,266 (GRCm38)	missense	probably damaging	0.99
R7156:Vmn2r79	UTSW	7	87,037,643 (GRCm38)	missense	probably damaging	0.98
R7604:Vmn2r79	UTSW	7	87,003,384 (GRCm38)	critical splice acceptor site	probably null
R7691:Vmn2r79	UTSW	7	87,037,903 (GRCm38)	missense	probably damaging	0.96
R8055:Vmn2r79	UTSW	7	87,037,333 (GRCm38)	missense	possibly damaging	0.94
R8070:Vmn2r79	UTSW	7	87,002,128 (GRCm38)	missense	probably benign
R8073:Vmn2r79	UTSW	7	87,002,254 (GRCm38)	missense	probably benign	0.00
R8145:Vmn2r79	UTSW	7	87,037,654 (GRCm38)	missense	probably benign	0.02
R8263:Vmn2r79	UTSW	7	87,037,518 (GRCm38)	missense	possibly damaging	0.89
R8350:Vmn2r79	UTSW	7	87,037,533 (GRCm38)	nonsense	probably null
R8814:Vmn2r79	UTSW	7	87,002,506 (GRCm38)	missense	probably benign	0.00
R8862:Vmn2r79	UTSW	7	86,996,504 (GRCm38)	missense	probably benign	0.23
R9146:Vmn2r79	UTSW	7	87,001,473 (GRCm38)	nonsense	probably null
R9276:Vmn2r79	UTSW	7	87,037,837 (GRCm38)	missense	probably damaging	1.00
R9361:Vmn2r79	UTSW	7	87,003,614 (GRCm38)	critical splice donor site	probably null
R9676:Vmn2r79	UTSW	7	87,037,244 (GRCm38)	missense	probably damaging	1.00
U15987:Vmn2r79	UTSW	7	87,004,111 (GRCm38)	missense	possibly damaging	0.86
X0054:Vmn2r79	UTSW	7	87,004,062 (GRCm38)	missense	probably benign	0.01
Z1088:Vmn2r79	UTSW	7	87,002,341 (GRCm38)	missense	probably damaging	1.00
Z1176:Vmn2r79	UTSW	7	87,037,169 (GRCm38)	missense	probably benign
Z1176:Vmn2r79	UTSW	7	87,002,318 (GRCm38)	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- TCTCTACCAGATGACTCCCAAG -3'
(R):5'- TCCATGCACAGAGTTAAGCATG -3'

Sequencing Primer
(F):5'- GATGACTCCCAAGGACACATCTC -3'
(R):5'- CCATGCACAGAGTTAAGCATGAATTC -3'

Posted On

2020-09-02