Mutagenetix > Incidental Mutation

Incidental Mutation 'R8400:Vmn2r79'

647811

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r79

Ensembl Gene

ENSMUSG00000090362

Gene Name

vomeronasal 2, receptor 79

Synonyms

EG621430

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.084) question?

Stock #

R8400 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

86996465-87037968 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 87002100 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 236 (T236A)

Ref Sequence

ENSEMBL: ENSMUSP00000132478 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000164462]

AlphaFold

E9Q067

Predicted Effect

probably benign
Transcript: ENSMUST00000164462
AA Change: T236A

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

SMART Domains

Protein: ENSMUSP00000132478
Gene: ENSMUSG00000090362
AA Change: T236A

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	75	464	1.9e-31	PFAM
Pfam:NCD3G	506	559	3.1e-21	PFAM
Pfam:7tm_3	592	827	2.8e-53	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.0%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca13	G	A	11: 9,293,925	M1929I	probably benign	Het
Abca13	T	C	11: 9,298,218	I2655T	probably damaging	Het
Acad10	A	G	5: 121,626,205	V887A	possibly damaging	Het
Acot10	T	C	15: 20,666,172	E161G	possibly damaging	Het
Astn1	C	T	1: 158,657,100	P919L	probably benign	Het
Atp1a4	T	A	1: 172,234,494	D688V	probably damaging	Het
C4bp	C	A	1: 130,636,747	C400F	probably damaging	Het
Col6a6	A	C	9: 105,774,796	D1005E	probably damaging	Het
Csnk1g3	C	T	18: 53,953,288	R422C	probably benign	Het
Cutc	T	C	19: 43,753,205	S15P	probably benign	Het
Dgkb	T	C	12: 38,602,838		probably null	Het
Disc1	T	C	8: 125,232,993	V748A	probably benign	Het
Dmbt1	C	G	7: 131,082,587	D778E	unknown	Het
Dmxl2	T	C	9: 54,383,753	Y2471C	probably benign	Het
Fam185a	T	A	5: 21,438,816	N243K	probably benign	Het
Fchsd2	A	T	7: 101,253,573	Q386L	possibly damaging	Het
Gm904	C	A	13: 50,643,417	P49Q	probably damaging	Het
H2-Q10	C	T	17: 35,470,477	R59C	probably damaging	Het
Ier5l	A	G	2: 30,473,093	Y307H	possibly damaging	Het
Kmt2e	C	A	5: 23,497,092	T906K	probably benign	Het
Kndc1	C	T	7: 139,913,518	R467W	probably damaging	Het
Muc5ac	C	A	7: 141,810,476	T2508K	probably damaging	Het
Nlrp9a	A	T	7: 26,565,006	M784L	probably benign	Het
Nlrp9b	T	A	7: 20,024,012	C391*	probably null	Het
Nubp2	A	C	17: 24,884,465	M146R	probably damaging	Het
Olfr1295	A	T	2: 111,565,402	L14H	probably damaging	Het
Olfr1359	G	A	13: 21,703,915	V305M	probably benign	Het
Olfr1419	T	A	19: 11,871,214	M1L	probably damaging	Het
Olfr43	C	T	11: 74,206,395	V274M	possibly damaging	Het
Olfr694	T	A	7: 106,689,669	S21C	probably benign	Het
Olfr857	A	T	9: 19,713,093	N89Y	probably benign	Het
Otud1	T	C	2: 19,658,378	V106A	possibly damaging	Het
Pcdhac1	T	A	18: 37,092,400	Y755*	probably null	Het
Pkd1l3	C	T	8: 109,623,888	P455L	possibly damaging	Het
Ptprb	GAGACCCTCGGGAGCACTGCAGAGACCCTCAGGAACACTGCAAAGACCCTCGGGAGCACTGCAGAGACCCTCAGGAACACTGCAAAGACCCTCGGGAGCACTGCAGAGACCCTCGGGAGCACTGCAAAGACCCTCGGGAGCACTGCAAAGACCCTCGGGAGCACTGCAAAGACCCTCGGGAGCACT	GAGACCCTCGGGAGCACTGCAGAGACCCTCAGGAACACTGCAAAGACCCTCGGGAGCACTGCAGAGACCCTCGGGAGCACTGCAAAGACCCTCGGGAGCACTGCAAAGACCCTCGGGAGCACTGCAAAGACCCTCGGGAGCACT	10: 116,283,572		probably benign	Het
Samhd1	T	C	2: 157,099,433	E648G	probably benign	Het
Smarca5	T	C	8: 80,709,127	T794A	probably benign	Het
Spc24	A	T	9: 21,757,730	L87H	probably damaging	Het
Sppl2b	TGTCACAGGT	TGT	10: 80,866,069		probably null	Het
Stra6l	G	A	4: 45,864,905	R77Q	probably damaging	Het
Tdrd1	G	A	19: 56,848,649	V472M	probably benign	Het
Tsc2	A	T	17: 24,604,987	I948K	possibly damaging	Het
Ttc39d	T	C	17: 80,216,005	V31A	probably benign	Het
Vmn1r158	A	T	7: 22,789,880	C301*	probably null	Het
Vmn2r22	A	T	6: 123,637,527	L368*	probably null	Het
Vwa1	T	C	4: 155,772,768	H191R	probably benign	Het
Zdbf2	T	A	1: 63,304,976	V838E	possibly damaging	Het

Other mutations in Vmn2r79

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01401:Vmn2r79	APN	7	87037273	missense	probably benign	0.01
IGL01675:Vmn2r79	APN	7	86996648	missense	probably benign	0.01
IGL01760:Vmn2r79	APN	7	87002158	missense	probably benign
IGL01834:Vmn2r79	APN	7	87037146	missense	probably benign	0.01
IGL01843:Vmn2r79	APN	7	87037277	missense	probably damaging	1.00
IGL01914:Vmn2r79	APN	7	87037363	missense	probably benign	0.14
IGL01980:Vmn2r79	APN	7	87037082	missense	possibly damaging	0.49
IGL02438:Vmn2r79	APN	7	87002536	missense	probably damaging	0.98
IGL02740:Vmn2r79	APN	7	87004158	missense	probably benign	0.00
IGL03052:Vmn2r79	UTSW	7	87003591	missense	probably benign	0.00
PIT4445001:Vmn2r79	UTSW	7	87002200	missense	possibly damaging	0.46
R0096:Vmn2r79	UTSW	7	87037319	missense	probably damaging	1.00
R0096:Vmn2r79	UTSW	7	87037319	missense	probably damaging	1.00
R0270:Vmn2r79	UTSW	7	87003386	missense	probably benign	0.00
R0336:Vmn2r79	UTSW	7	87002079	missense	probably benign	0.15
R0418:Vmn2r79	UTSW	7	87002403	missense	probably benign	0.18
R1070:Vmn2r79	UTSW	7	87003473	missense	probably damaging	1.00
R1234:Vmn2r79	UTSW	7	87004099	missense	possibly damaging	0.71
R1459:Vmn2r79	UTSW	7	87037794	missense	probably benign	0.01
R1513:Vmn2r79	UTSW	7	87037444	missense	probably benign	0.01
R1624:Vmn2r79	UTSW	7	87004039	critical splice acceptor site	probably null
R1633:Vmn2r79	UTSW	7	87037834	missense	possibly damaging	0.52
R1676:Vmn2r79	UTSW	7	87002631	missense	probably benign
R1781:Vmn2r79	UTSW	7	87002347	missense	probably benign	0.00
R1794:Vmn2r79	UTSW	7	87001413	missense	probably benign	0.37
R1823:Vmn2r79	UTSW	7	87037872	missense	probably damaging	1.00
R2013:Vmn2r79	UTSW	7	87004081	missense	possibly damaging	0.50
R2018:Vmn2r79	UTSW	7	87002426	missense	probably benign	0.07
R2019:Vmn2r79	UTSW	7	87002426	missense	probably benign	0.07
R2177:Vmn2r79	UTSW	7	86996631	missense	possibly damaging	0.94
R2984:Vmn2r79	UTSW	7	87001891	missense	possibly damaging	0.85
R3719:Vmn2r79	UTSW	7	87002037	missense	probably benign	0.05
R3798:Vmn2r79	UTSW	7	87002194	missense	possibly damaging	0.88
R3969:Vmn2r79	UTSW	7	87003593	missense	probably damaging	1.00
R4182:Vmn2r79	UTSW	7	87001891	missense	possibly damaging	0.85
R4183:Vmn2r79	UTSW	7	87001891	missense	possibly damaging	0.85
R4245:Vmn2r79	UTSW	7	87002416	missense	possibly damaging	0.73
R4301:Vmn2r79	UTSW	7	87001891	missense	possibly damaging	0.85
R4391:Vmn2r79	UTSW	7	87001891	missense	possibly damaging	0.85
R4393:Vmn2r79	UTSW	7	87001891	missense	possibly damaging	0.85
R4394:Vmn2r79	UTSW	7	87001891	missense	possibly damaging	0.85
R4396:Vmn2r79	UTSW	7	87001891	missense	possibly damaging	0.85
R4397:Vmn2r79	UTSW	7	87001891	missense	possibly damaging	0.85
R4592:Vmn2r79	UTSW	7	87004111	missense	possibly damaging	0.86
R4697:Vmn2r79	UTSW	7	87037960	missense	probably damaging	0.98
R4897:Vmn2r79	UTSW	7	87001467	missense	probably benign
R5016:Vmn2r79	UTSW	7	87037340	missense	probably benign	0.00
R5058:Vmn2r79	UTSW	7	87002215	missense	probably damaging	0.98
R5177:Vmn2r79	UTSW	7	87001969	missense	probably damaging	0.97
R6078:Vmn2r79	UTSW	7	87004111	missense	possibly damaging	0.86
R6079:Vmn2r79	UTSW	7	87004111	missense	possibly damaging	0.86
R6138:Vmn2r79	UTSW	7	87004111	missense	possibly damaging	0.86
R6257:Vmn2r79	UTSW	7	87002570	missense	probably benign	0.27
R6260:Vmn2r79	UTSW	7	87037157	missense	probably benign	0.00
R6307:Vmn2r79	UTSW	7	87037768	missense	probably damaging	1.00
R6323:Vmn2r79	UTSW	7	87001314	missense	probably benign	0.05
R6374:Vmn2r79	UTSW	7	87002290	missense	probably benign	0.02
R6530:Vmn2r79	UTSW	7	87002044	missense	possibly damaging	0.91
R6546:Vmn2r79	UTSW	7	87003533	missense	probably benign	0.01
R6682:Vmn2r79	UTSW	7	87004162	missense	possibly damaging	0.69
R6858:Vmn2r79	UTSW	7	87037372	missense	probably benign
R6965:Vmn2r79	UTSW	7	87001892	missense	probably benign	0.10
R7130:Vmn2r79	UTSW	7	87002266	missense	probably damaging	0.99
R7156:Vmn2r79	UTSW	7	87037643	missense	probably damaging	0.98
R7604:Vmn2r79	UTSW	7	87003384	critical splice acceptor site	probably null
R7691:Vmn2r79	UTSW	7	87037903	missense	probably damaging	0.96
R8055:Vmn2r79	UTSW	7	87037333	missense	possibly damaging	0.94
R8070:Vmn2r79	UTSW	7	87002128	missense	probably benign
R8073:Vmn2r79	UTSW	7	87002254	missense	probably benign	0.00
R8145:Vmn2r79	UTSW	7	87037654	missense	probably benign	0.02
R8263:Vmn2r79	UTSW	7	87037518	missense	possibly damaging	0.89
R8350:Vmn2r79	UTSW	7	87037533	nonsense	probably null
R8814:Vmn2r79	UTSW	7	87002506	missense	probably benign	0.00
R8862:Vmn2r79	UTSW	7	86996504	missense	probably benign	0.23
R9146:Vmn2r79	UTSW	7	87001473	nonsense	probably null
R9276:Vmn2r79	UTSW	7	87037837	missense	probably damaging	1.00
R9361:Vmn2r79	UTSW	7	87003614	critical splice donor site	probably null
R9676:Vmn2r79	UTSW	7	87037244	missense	probably damaging	1.00
U15987:Vmn2r79	UTSW	7	87004111	missense	possibly damaging	0.86
X0054:Vmn2r79	UTSW	7	87004062	missense	probably benign	0.01
Z1088:Vmn2r79	UTSW	7	87002341	missense	probably damaging	1.00
Z1176:Vmn2r79	UTSW	7	87002318	missense	probably benign	0.00
Z1176:Vmn2r79	UTSW	7	87037169	missense	probably benign

Predicted Primers

PCR Primer
(F):5'- TCTCTACCAGATGACTCCCAAG -3'
(R):5'- TCCATGCACAGAGTTAAGCATG -3'

Sequencing Primer
(F):5'- GATGACTCCCAAGGACACATCTC -3'
(R):5'- CCATGCACAGAGTTAAGCATGAATTC -3'

Posted On

2020-09-02