|Institutional Source||Beutler Lab|
|Gene Name||diacylglycerol kinase, beta|
|Essential gene?||Probably non essential (E-score: 0.126)|
|Stock #||R8400 (G1)|
|Chromosomal Location||37817726-38634239 bp(+) (GRCm38)|
|Type of Mutation||critical splice donor site (2 bp from exon)|
|DNA Base Change (assembly)||T to C at 38602838 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000037900 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000040500] [ENSMUST00000220990]|
|AlphaFold||no structure available at present|
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Diacylglycerol kinases (DGKs) are regulators of the intracellular concentration of the second messenger diacylglycerol (DAG) and thus play a key role in cellular processes. Nine mammalian isotypes have been identified, which are encoded by separate genes. Mammalian DGK isozymes contain a conserved catalytic (kinase) domain and a cysteine-rich domain (CRD). The protein encoded by this gene is a diacylglycerol kinase, beta isotype. Two alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a transposon distruption have defects in long term potentiation, synapase morphology, and in spatial reference and working memory. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Dgkb||
(F):5'- TGGACATGTGCATGCACTG -3'
(R):5'- CTCATCTACCCTGAGCAAAGG -3'
(F):5'- GTGCATGCACTGTAATTGACCAC -3'
(R):5'- CCTGATAGGAAGTAGCTGTTAAGAC -3'