Incidental Mutation 'R7916:Mst1r'
ID 648087
Institutional Source Beutler Lab
Gene Symbol Mst1r
Ensembl Gene ENSMUSG00000032584
Gene Name macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
Synonyms Fv2, Ron, STK, friend virus susceptibility 2, CDw136, Fv-2, PTK8
MMRRC Submission 045964-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.261) question?
Stock # R7916 (G1)
Quality Score 225.009
Status Not validated
Chromosome 9
Chromosomal Location 107784072-107797582 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 107784777 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Serine at position 145 (F145S)
Ref Sequence ENSEMBL: ENSMUSP00000035203 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000035202] [ENSMUST00000035203] [ENSMUST00000191906] [ENSMUST00000195617]
AlphaFold Q62190
Predicted Effect probably benign
Transcript: ENSMUST00000035202
SMART Domains Protein: ENSMUSP00000035202
Gene: ENSMUSG00000032583

DomainStartEndE-ValueType
Pfam:Mon1 151 555 1.2e-142 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000035203
AA Change: F145S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000035203
Gene: ENSMUSG00000032584
AA Change: F145S

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
Sema 57 510 9.03e-116 SMART
PSI 528 570 8.72e-4 SMART
IPT 570 684 1.63e-18 SMART
IPT 685 769 4.03e-23 SMART
IPT 771 873 8.41e-12 SMART
IPT 878 972 5.36e0 SMART
TyrKc 1059 1318 8.2e-134 SMART
low complexity region 1349 1360 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000191906
SMART Domains Protein: ENSMUSP00000141516
Gene: ENSMUSG00000032583

DomainStartEndE-ValueType
Pfam:Mon1 146 461 1.1e-138 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000195617
AA Change: F145S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000142201
Gene: ENSMUSG00000032584
AA Change: F145S

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
Sema 57 442 3.5e-63 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a precursor protein that is proteolytically cleaved to yield an alpha chain and a beta chain which form a membrane-spanning heterodimer. The encoded protein belongs to a family of cell-surface receptor tyrosine kinases involved in signaling from the cell surface to the intracellular environment. The binding of the encoded protein to its ligand, macrophage-stimulating protein, mediates several biological activities including wound healing, tumor immunity, macrophage activation and hematopoiesis as well as cell growth, motility, survival and adhesion. The protein encoded by this gene also functions in early development and the macrophage-mediated inflammatory response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
PHENOTYPE: This locus controls susceptibility to splenomegaly or spleen focus formation induced by inoculation with Friend leukemia virus. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 69 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930562C15Rik T A 16: 4,682,454 (GRCm39) L195* probably null Het
Ahnak T G 19: 8,983,196 (GRCm39) D1493E possibly damaging Het
Alox12e C A 11: 70,212,111 (GRCm39) R162L probably benign Het
Bax T G 7: 45,115,539 (GRCm39) Q32P probably benign Het
Cand1 A G 10: 119,052,493 (GRCm39) M204T probably benign Het
Chd9 T A 8: 91,761,684 (GRCm39) Y2256* probably null Het
Chuk A G 19: 44,085,420 (GRCm39) I242T probably damaging Het
Cic T C 7: 24,987,715 (GRCm39) S1468P probably damaging Het
Col27a1 A G 4: 63,142,789 (GRCm39) H159R probably damaging Het
Cux1 T C 5: 136,311,815 (GRCm39) K1174E probably damaging Het
Dnah2 C A 11: 69,311,974 (GRCm39) probably null Het
Dpp3 C A 19: 4,967,052 (GRCm39) E351* probably null Het
Dyrk1a A G 16: 94,474,200 (GRCm39) Y319C probably damaging Het
E130308A19Rik T C 4: 59,719,841 (GRCm39) S458P probably damaging Het
Ehmt1 G A 2: 24,746,708 (GRCm39) L425F probably damaging Het
Emp2 C A 16: 10,102,437 (GRCm39) R125L possibly damaging Het
Farsb A G 1: 78,435,200 (GRCm39) probably null Het
Frk A T 10: 34,360,021 (GRCm39) R7S possibly damaging Het
Glb1l2 T C 9: 26,678,720 (GRCm39) T483A probably benign Het
Gm5773 T C 3: 93,680,586 (GRCm39) V86A possibly damaging Het
Gm7324 T G 14: 43,952,003 (GRCm39) D215E probably benign Het
Gng13 A T 17: 25,937,932 (GRCm39) K44* probably null Het
Gprin1 C T 13: 54,887,263 (GRCm39) G337D possibly damaging Het
Ighv1-84 G T 12: 115,944,609 (GRCm39) Q22K probably benign Het
Il20rb T C 9: 100,348,304 (GRCm39) H210R probably benign Het
Iqcm C T 8: 76,304,578 (GRCm39) S113L probably benign Het
Kat6b AGAGGAGGAGGAGGAGGAGGA AGAGGAGGAGGAGGAGGA 14: 21,712,417 (GRCm39) probably benign Het
Kmo G T 1: 175,487,236 (GRCm39) G430W probably damaging Het
Kti12 A C 4: 108,705,443 (GRCm39) E119A probably benign Het
Kti12 G T 4: 108,705,444 (GRCm39) E119D probably benign Het
Ldhd T G 8: 112,356,023 (GRCm39) D120A possibly damaging Het
Lyst T C 13: 13,821,657 (GRCm39) S1344P possibly damaging Het
Mb T A 15: 76,900,257 (GRCm39) I112F probably damaging Het
Mbd5 G A 2: 49,147,118 (GRCm39) V443M probably damaging Het
Milr1 A G 11: 106,654,688 (GRCm39) K180R possibly damaging Het
Mthfd2 A T 6: 83,286,455 (GRCm39) I251K possibly damaging Het
Nfx1 T A 4: 40,977,142 (GRCm39) M272K probably benign Het
Nlrp3 A G 11: 59,442,689 (GRCm39) D747G probably benign Het
Odr4 C T 1: 150,260,249 (GRCm39) R123K probably benign Het
Or2y1 A T 11: 49,385,543 (GRCm39) Y61F probably benign Het
Or5p60 C A 7: 107,724,329 (GRCm39) S47I possibly damaging Het
Or8k18 A T 2: 86,085,202 (GRCm39) Y278* probably null Het
Pcdha11 A G 18: 37,140,441 (GRCm39) E690G probably benign Het
Pcdhga4 T A 18: 37,818,502 (GRCm39) I17N probably benign Het
Peg10 T TCCG 6: 4,756,451 (GRCm39) probably benign Het
Phf20 A G 2: 156,129,858 (GRCm39) K477E probably damaging Het
Pik3c2b T A 1: 133,028,642 (GRCm39) I1377N probably benign Het
Polr3h T C 15: 81,806,613 (GRCm39) K69E probably benign Het
Rpgrip1 A G 14: 52,368,641 (GRCm39) H280R possibly damaging Het
Rpp40 C A 13: 36,086,034 (GRCm39) R132L probably benign Het
Ryr1 G A 7: 28,790,364 (GRCm39) Q1488* probably null Het
Sh3bp1 A G 15: 78,791,421 (GRCm39) M403V probably benign Het
Slc20a1 G A 2: 129,049,757 (GRCm39) D340N probably benign Het
Snrnp200 T A 2: 127,074,979 (GRCm39) N1517K possibly damaging Het
Srek1ip1 T A 13: 104,973,981 (GRCm39) H129Q possibly damaging Het
Thumpd2 A T 17: 81,334,116 (GRCm39) C491S probably benign Het
Tle3 A T 9: 61,314,410 (GRCm39) N204I probably benign Het
Tmem131 A G 1: 36,862,167 (GRCm39) V677A probably benign Het
Topaz1 T G 9: 122,576,499 (GRCm39) L30R probably benign Het
Trim35 T A 14: 66,546,309 (GRCm39) C359S probably damaging Het
Ttn A C 2: 76,774,865 (GRCm39) V2105G unknown Het
Ube2o A G 11: 116,471,884 (GRCm39) V119A probably benign Het
Ubr2 A T 17: 47,279,308 (GRCm39) probably null Het
Uhmk1 A G 1: 170,032,757 (GRCm39) V347A possibly damaging Het
Utp4 C T 8: 107,649,497 (GRCm39) P649S probably damaging Het
Vmn2r28 G A 7: 5,483,818 (GRCm39) T794I probably damaging Het
Vmn2r61 T G 7: 41,949,935 (GRCm39) F785C probably damaging Het
Xpot C A 10: 121,458,848 (GRCm39) probably benign Het
Zfp729a C T 13: 67,768,294 (GRCm39) R645H probably benign Het
Other mutations in Mst1r
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00429:Mst1r APN 9 107,790,449 (GRCm39) splice site probably benign
IGL01327:Mst1r APN 9 107,785,043 (GRCm39) missense probably benign 0.03
IGL01572:Mst1r APN 9 107,788,791 (GRCm39) missense probably damaging 1.00
IGL01968:Mst1r APN 9 107,794,005 (GRCm39) splice site probably null
IGL01983:Mst1r APN 9 107,794,475 (GRCm39) missense probably damaging 0.99
IGL02096:Mst1r APN 9 107,794,478 (GRCm39) missense probably damaging 0.97
IGL02203:Mst1r APN 9 107,785,068 (GRCm39) missense probably damaging 1.00
IGL02203:Mst1r APN 9 107,790,348 (GRCm39) missense possibly damaging 0.61
IGL02332:Mst1r APN 9 107,785,025 (GRCm39) nonsense probably null
IGL02402:Mst1r APN 9 107,794,026 (GRCm39) missense probably damaging 0.99
IGL02404:Mst1r APN 9 107,790,266 (GRCm39) splice site probably benign
IGL02942:Mst1r APN 9 107,790,352 (GRCm39) missense possibly damaging 0.89
IGL02951:Mst1r APN 9 107,785,403 (GRCm39) missense possibly damaging 0.88
IGL02975:Mst1r APN 9 107,790,379 (GRCm39) missense probably benign 0.20
IGL03005:Mst1r APN 9 107,791,748 (GRCm39) nonsense probably null
IGL03304:Mst1r APN 9 107,785,137 (GRCm39) missense probably damaging 1.00
R0386:Mst1r UTSW 9 107,794,003 (GRCm39) splice site probably null
R0833:Mst1r UTSW 9 107,791,975 (GRCm39) missense probably benign 0.00
R0833:Mst1r UTSW 9 107,790,366 (GRCm39) missense probably benign
R1139:Mst1r UTSW 9 107,797,168 (GRCm39) missense possibly damaging 0.93
R1371:Mst1r UTSW 9 107,794,424 (GRCm39) missense probably damaging 1.00
R1477:Mst1r UTSW 9 107,785,523 (GRCm39) missense probably benign
R1479:Mst1r UTSW 9 107,790,544 (GRCm39) splice site probably benign
R1541:Mst1r UTSW 9 107,794,562 (GRCm39) missense probably damaging 0.99
R1698:Mst1r UTSW 9 107,797,179 (GRCm39) missense probably benign 0.06
R1891:Mst1r UTSW 9 107,790,661 (GRCm39) missense probably damaging 1.00
R1971:Mst1r UTSW 9 107,790,411 (GRCm39) missense probably benign 0.06
R1974:Mst1r UTSW 9 107,793,132 (GRCm39) critical splice donor site probably null
R1974:Mst1r UTSW 9 107,791,962 (GRCm39) missense probably damaging 1.00
R2144:Mst1r UTSW 9 107,790,367 (GRCm39) missense probably benign
R2221:Mst1r UTSW 9 107,785,547 (GRCm39) missense probably damaging 1.00
R2356:Mst1r UTSW 9 107,795,069 (GRCm39) missense probably damaging 1.00
R3913:Mst1r UTSW 9 107,791,945 (GRCm39) missense probably benign
R4768:Mst1r UTSW 9 107,788,849 (GRCm39) missense probably damaging 1.00
R4793:Mst1r UTSW 9 107,797,124 (GRCm39) missense probably damaging 0.96
R5141:Mst1r UTSW 9 107,789,440 (GRCm39) missense probably damaging 0.99
R5191:Mst1r UTSW 9 107,788,750 (GRCm39) missense probably damaging 0.98
R5238:Mst1r UTSW 9 107,784,773 (GRCm39) missense probably damaging 1.00
R6024:Mst1r UTSW 9 107,785,350 (GRCm39) missense probably benign 0.00
R6220:Mst1r UTSW 9 107,784,547 (GRCm39) missense probably benign 0.11
R6256:Mst1r UTSW 9 107,794,465 (GRCm39) missense probably damaging 1.00
R6361:Mst1r UTSW 9 107,793,052 (GRCm39) missense probably benign
R6522:Mst1r UTSW 9 107,790,438 (GRCm39) missense probably benign 0.00
R6559:Mst1r UTSW 9 107,785,470 (GRCm39) missense possibly damaging 0.91
R6863:Mst1r UTSW 9 107,797,225 (GRCm39) missense probably benign
R6868:Mst1r UTSW 9 107,793,132 (GRCm39) critical splice donor site probably null
R6873:Mst1r UTSW 9 107,788,843 (GRCm39) missense possibly damaging 0.90
R6978:Mst1r UTSW 9 107,789,793 (GRCm39) missense probably benign 0.23
R7168:Mst1r UTSW 9 107,785,392 (GRCm39) missense probably benign 0.01
R7299:Mst1r UTSW 9 107,791,989 (GRCm39) missense possibly damaging 0.46
R7301:Mst1r UTSW 9 107,791,989 (GRCm39) missense possibly damaging 0.46
R7405:Mst1r UTSW 9 107,792,321 (GRCm39) missense possibly damaging 0.87
R7615:Mst1r UTSW 9 107,797,211 (GRCm39) missense probably benign 0.05
R7684:Mst1r UTSW 9 107,788,762 (GRCm39) missense probably benign 0.01
R7741:Mst1r UTSW 9 107,784,319 (GRCm39) start gained probably benign
R7987:Mst1r UTSW 9 107,789,997 (GRCm39) splice site probably null
R8177:Mst1r UTSW 9 107,784,784 (GRCm39) missense probably damaging 1.00
R8356:Mst1r UTSW 9 107,794,463 (GRCm39) missense probably damaging 1.00
R8494:Mst1r UTSW 9 107,791,718 (GRCm39) missense possibly damaging 0.90
R8692:Mst1r UTSW 9 107,792,050 (GRCm39) missense possibly damaging 0.82
R8979:Mst1r UTSW 9 107,792,478 (GRCm39) missense probably damaging 0.98
R9012:Mst1r UTSW 9 107,791,960 (GRCm39) missense probably benign 0.01
X0026:Mst1r UTSW 9 107,790,402 (GRCm39) missense probably damaging 0.97
Predicted Primers PCR Primer
(F):5'- CATAGAGAACCTGACCACTGGC -3'
(R):5'- CTTTAGACGACGGATGGACAC -3'

Sequencing Primer
(F):5'- TGACCACTGGCCCTATCG -3'
(R):5'- CCAACTCTGGGTCTAGCGAAGATG -3'
Posted On 2020-09-15