Incidental Mutation 'R7918:Vmn2r63'
| ID |
648184 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r63
|
| Ensembl Gene |
ENSMUSG00000090751 |
| Gene Name |
vomeronasal 2, receptor 63 |
| Synonyms |
EG435975 |
| MMRRC Submission |
045966-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.074)
|
| Stock # |
R7918 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
42552675-42583213 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to C
at 42552955 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Alanine to Glycine
at position 767
(A767G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129089
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000163803]
|
| AlphaFold |
E9Q0K5 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000163803
AA Change: A767G
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000129089
Gene: ENSMUSG00000090751
AA Change: A767G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
471 |
3.5e-43 |
PFAM |
|
Pfam:NCD3G
|
514 |
567 |
5.1e-23 |
PFAM |
|
Pfam:7tm_3
|
600 |
835 |
3.5e-51 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.8%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 47 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A330070K13Rik |
G |
A |
5: 130,413,269 (GRCm39) |
T30I |
unknown |
Het |
| Adam21 |
A |
G |
12: 81,607,378 (GRCm39) |
V128A |
possibly damaging |
Het |
| Adam26a |
T |
C |
8: 44,022,566 (GRCm39) |
Y308C |
probably damaging |
Het |
| Adam26b |
A |
G |
8: 43,974,138 (GRCm39) |
V288A |
probably benign |
Het |
| Ankrd29 |
A |
C |
18: 12,428,979 (GRCm39) |
L30R |
probably damaging |
Het |
| Bank1 |
A |
G |
3: 135,799,123 (GRCm39) |
I406T |
probably damaging |
Het |
| Cacna1g |
A |
G |
11: 94,334,856 (GRCm39) |
I817T |
probably benign |
Het |
| Catsperd |
T |
C |
17: 56,938,564 (GRCm39) |
F31L |
probably benign |
Het |
| Cep164 |
A |
G |
9: 45,690,986 (GRCm39) |
|
probably null |
Het |
| Clca4b |
T |
C |
3: 144,619,033 (GRCm39) |
Y702C |
probably damaging |
Het |
| Clstn1 |
A |
G |
4: 149,728,508 (GRCm39) |
I655V |
probably damaging |
Het |
| Dock1 |
A |
G |
7: 134,747,147 (GRCm39) |
E1486G |
probably damaging |
Het |
| Epha8 |
A |
G |
4: 136,661,877 (GRCm39) |
F573L |
probably benign |
Het |
| Exoc1 |
A |
G |
5: 76,691,840 (GRCm39) |
N323S |
probably benign |
Het |
| Exoc6b |
C |
T |
6: 85,046,332 (GRCm39) |
R19Q |
probably damaging |
Het |
| Gcsam |
T |
C |
16: 45,440,502 (GRCm39) |
*182R |
probably null |
Het |
| Ighv9-2 |
T |
C |
12: 114,072,911 (GRCm39) |
I21V |
probably benign |
Het |
| Ints2 |
G |
A |
11: 86,113,043 (GRCm39) |
T825M |
probably damaging |
Het |
| Kti12 |
A |
C |
4: 108,705,443 (GRCm39) |
E119A |
probably benign |
Het |
| Kti12 |
G |
T |
4: 108,705,444 (GRCm39) |
E119D |
probably benign |
Het |
| Lad1 |
A |
G |
1: 135,757,454 (GRCm39) |
T398A |
probably benign |
Het |
| Lrfn2 |
T |
C |
17: 49,378,212 (GRCm39) |
V431A |
probably damaging |
Het |
| Mast2 |
T |
C |
4: 116,292,732 (GRCm39) |
I79M |
possibly damaging |
Het |
| Nup107 |
A |
G |
10: 117,617,905 (GRCm39) |
V171A |
probably benign |
Het |
| Or1e1c |
T |
C |
11: 73,265,923 (GRCm39) |
F119S |
probably damaging |
Het |
| Or8b101 |
T |
A |
9: 38,020,103 (GRCm39) |
Y35* |
probably null |
Het |
| Or8g37 |
C |
A |
9: 39,731,406 (GRCm39) |
T157K |
probably damaging |
Het |
| Pde4dip |
T |
A |
3: 97,622,539 (GRCm39) |
K1557* |
probably null |
Het |
| Plat |
C |
T |
8: 23,263,655 (GRCm39) |
P185S |
probably damaging |
Het |
| Plcg1 |
T |
G |
2: 160,595,585 (GRCm39) |
V511G |
probably damaging |
Het |
| Plxnb3 |
C |
T |
X: 72,811,251 (GRCm39) |
A1258V |
probably benign |
Het |
| Rnf223 |
T |
C |
4: 156,217,240 (GRCm39) |
V205A |
probably benign |
Het |
| Slc13a1 |
G |
C |
6: 24,118,065 (GRCm39) |
T224R |
probably benign |
Het |
| Slc39a10 |
T |
A |
1: 46,874,912 (GRCm39) |
H130L |
possibly damaging |
Het |
| Sucnr1 |
T |
A |
3: 59,993,790 (GRCm39) |
I106N |
probably damaging |
Het |
| Syde2 |
T |
C |
3: 145,708,170 (GRCm39) |
|
probably null |
Het |
| Syne1 |
T |
C |
10: 5,309,078 (GRCm39) |
I644V |
possibly damaging |
Het |
| Tbc1d8 |
A |
C |
1: 39,441,809 (GRCm39) |
F261C |
probably damaging |
Het |
| Tmem132e |
A |
G |
11: 82,336,116 (GRCm39) |
Y1066C |
probably damaging |
Het |
| Trip12 |
A |
C |
1: 84,722,784 (GRCm39) |
I1322S |
probably damaging |
Het |
| Tsnaxip1 |
A |
G |
8: 106,571,167 (GRCm39) |
I676V |
probably benign |
Het |
| Vmn1r231 |
A |
T |
17: 21,110,236 (GRCm39) |
Y226* |
probably null |
Het |
| Wdr5b |
A |
G |
16: 35,862,192 (GRCm39) |
T104A |
probably damaging |
Het |
| Zbed5 |
T |
C |
5: 129,930,504 (GRCm39) |
V151A |
possibly damaging |
Het |
| Zc3h7b |
T |
C |
15: 81,653,189 (GRCm39) |
F31S |
probably damaging |
Het |
| Zfp874b |
A |
T |
13: 67,622,279 (GRCm39) |
C340S |
possibly damaging |
Het |
| Zmym4 |
T |
A |
4: 126,804,797 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Vmn2r63 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01399:Vmn2r63
|
APN |
7 |
42,553,543 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01765:Vmn2r63
|
APN |
7 |
42,552,788 (GRCm39) |
missense |
probably benign |
|
|
IGL02203:Vmn2r63
|
APN |
7 |
42,553,432 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02825:Vmn2r63
|
APN |
7 |
42,576,274 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03155:Vmn2r63
|
APN |
7 |
42,552,878 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03260:Vmn2r63
|
APN |
7 |
42,578,616 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03411:Vmn2r63
|
APN |
7 |
42,577,368 (GRCm39) |
missense |
probably benign |
0.42 |
|
PIT4280001:Vmn2r63
|
UTSW |
7 |
42,553,409 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0066:Vmn2r63
|
UTSW |
7 |
42,576,514 (GRCm39) |
splice site |
probably benign |
|
|
R0328:Vmn2r63
|
UTSW |
7 |
42,552,699 (GRCm39) |
missense |
probably benign |
0.09 |
|
R0344:Vmn2r63
|
UTSW |
7 |
42,553,042 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0554:Vmn2r63
|
UTSW |
7 |
42,583,129 (GRCm39) |
nonsense |
probably null |
|
|
R0555:Vmn2r63
|
UTSW |
7 |
42,577,952 (GRCm39) |
nonsense |
probably null |
|
|
R0685:Vmn2r63
|
UTSW |
7 |
42,577,434 (GRCm39) |
missense |
probably benign |
0.13 |
|
R0751:Vmn2r63
|
UTSW |
7 |
42,577,459 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1349:Vmn2r63
|
UTSW |
7 |
42,578,642 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1372:Vmn2r63
|
UTSW |
7 |
42,578,642 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1416:Vmn2r63
|
UTSW |
7 |
42,577,339 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1502:Vmn2r63
|
UTSW |
7 |
42,578,015 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R1563:Vmn2r63
|
UTSW |
7 |
42,553,550 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1652:Vmn2r63
|
UTSW |
7 |
42,577,635 (GRCm39) |
missense |
probably benign |
0.32 |
|
R1693:Vmn2r63
|
UTSW |
7 |
42,577,743 (GRCm39) |
missense |
probably benign |
|
|
R1698:Vmn2r63
|
UTSW |
7 |
42,583,038 (GRCm39) |
missense |
probably benign |
|
|
R1753:Vmn2r63
|
UTSW |
7 |
42,577,669 (GRCm39) |
nonsense |
probably null |
|
|
R2136:Vmn2r63
|
UTSW |
7 |
42,576,297 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2175:Vmn2r63
|
UTSW |
7 |
42,583,004 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2261:Vmn2r63
|
UTSW |
7 |
42,578,031 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2262:Vmn2r63
|
UTSW |
7 |
42,578,031 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2263:Vmn2r63
|
UTSW |
7 |
42,578,031 (GRCm39) |
missense |
probably benign |
0.02 |
|
R3413:Vmn2r63
|
UTSW |
7 |
42,576,406 (GRCm39) |
missense |
probably benign |
0.04 |
|
R3426:Vmn2r63
|
UTSW |
7 |
42,576,406 (GRCm39) |
missense |
probably benign |
0.04 |
|
R3427:Vmn2r63
|
UTSW |
7 |
42,576,406 (GRCm39) |
missense |
probably benign |
0.04 |
|
R3802:Vmn2r63
|
UTSW |
7 |
42,552,829 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4319:Vmn2r63
|
UTSW |
7 |
42,576,406 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4321:Vmn2r63
|
UTSW |
7 |
42,576,406 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4323:Vmn2r63
|
UTSW |
7 |
42,576,406 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4346:Vmn2r63
|
UTSW |
7 |
42,577,537 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R4568:Vmn2r63
|
UTSW |
7 |
42,583,250 (GRCm39) |
splice site |
probably null |
|
|
R4649:Vmn2r63
|
UTSW |
7 |
42,553,114 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R4653:Vmn2r63
|
UTSW |
7 |
42,553,114 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R4679:Vmn2r63
|
UTSW |
7 |
42,577,544 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4734:Vmn2r63
|
UTSW |
7 |
42,577,544 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4741:Vmn2r63
|
UTSW |
7 |
42,577,544 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4748:Vmn2r63
|
UTSW |
7 |
42,577,544 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4806:Vmn2r63
|
UTSW |
7 |
42,576,314 (GRCm39) |
missense |
probably benign |
0.34 |
|
R4933:Vmn2r63
|
UTSW |
7 |
42,553,402 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5198:Vmn2r63
|
UTSW |
7 |
42,553,169 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5399:Vmn2r63
|
UTSW |
7 |
42,577,701 (GRCm39) |
missense |
probably benign |
|
|
R5400:Vmn2r63
|
UTSW |
7 |
42,577,635 (GRCm39) |
missense |
probably benign |
0.32 |
|
R6158:Vmn2r63
|
UTSW |
7 |
42,583,104 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6185:Vmn2r63
|
UTSW |
7 |
42,578,435 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6267:Vmn2r63
|
UTSW |
7 |
42,578,059 (GRCm39) |
splice site |
probably null |
|
|
R6362:Vmn2r63
|
UTSW |
7 |
42,552,721 (GRCm39) |
missense |
probably benign |
|
|
R6706:Vmn2r63
|
UTSW |
7 |
42,578,001 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6764:Vmn2r63
|
UTSW |
7 |
42,552,695 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7104:Vmn2r63
|
UTSW |
7 |
42,577,959 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R7503:Vmn2r63
|
UTSW |
7 |
42,583,014 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7506:Vmn2r63
|
UTSW |
7 |
42,576,391 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7525:Vmn2r63
|
UTSW |
7 |
42,576,406 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R7658:Vmn2r63
|
UTSW |
7 |
42,574,693 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7663:Vmn2r63
|
UTSW |
7 |
42,576,466 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7702:Vmn2r63
|
UTSW |
7 |
42,577,553 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R8826:Vmn2r63
|
UTSW |
7 |
42,576,441 (GRCm39) |
missense |
probably benign |
0.38 |
|
R8973:Vmn2r63
|
UTSW |
7 |
42,577,919 (GRCm39) |
missense |
probably benign |
0.19 |
|
R9024:Vmn2r63
|
UTSW |
7 |
42,577,874 (GRCm39) |
missense |
probably benign |
0.14 |
|
R9154:Vmn2r63
|
UTSW |
7 |
42,576,413 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9731:Vmn2r63
|
UTSW |
7 |
42,553,361 (GRCm39) |
missense |
probably benign |
0.32 |
|
Z1088:Vmn2r63
|
UTSW |
7 |
42,577,983 (GRCm39) |
missense |
probably benign |
0.09 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTATACTGGAAGCCAAGACCG -3'
(R):5'- TCCAGCTAGAATGGTGAAGTGG -3'
Sequencing Primer
(F):5'- TTATACTGGAAGCCAAGACCGACAAG -3'
(R):5'- ATAGGGGCCCCAAATCTCATTATTC -3'
|
| Posted On |
2020-09-15 |
Incidental Mutation