Incidental Mutation 'R7918:Or8g37'
ID 648191
Institutional Source Beutler Lab
Gene Symbol Or8g37
Ensembl Gene ENSMUSG00000095774
Gene Name olfactory receptor family 8 subfamily G member 37
Synonyms Olfr970, GA_x6K02T2PVTD-33517322-33518257, MOR171-16
MMRRC Submission 045966-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.318) question?
Stock # R7918 (G1)
Quality Score 225.009
Status Not validated
Chromosome 9
Chromosomal Location 39730937-39731872 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 39731406 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Lysine at position 157 (T157K)
Ref Sequence ENSEMBL: ENSMUSP00000150325 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071132] [ENSMUST00000213975] [ENSMUST00000215922]
AlphaFold Q8VFN3
Predicted Effect probably damaging
Transcript: ENSMUST00000071132
AA Change: T157K

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000071132
Gene: ENSMUSG00000095774
AA Change: T157K

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 5.2e-53 PFAM
Pfam:7tm_1 41 290 1.6e-22 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213975
AA Change: T157K

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
Predicted Effect probably damaging
Transcript: ENSMUST00000215922
AA Change: T157K

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A330070K13Rik G A 5: 130,413,269 (GRCm39) T30I unknown Het
Adam21 A G 12: 81,607,378 (GRCm39) V128A possibly damaging Het
Adam26a T C 8: 44,022,566 (GRCm39) Y308C probably damaging Het
Adam26b A G 8: 43,974,138 (GRCm39) V288A probably benign Het
Ankrd29 A C 18: 12,428,979 (GRCm39) L30R probably damaging Het
Bank1 A G 3: 135,799,123 (GRCm39) I406T probably damaging Het
Cacna1g A G 11: 94,334,856 (GRCm39) I817T probably benign Het
Catsperd T C 17: 56,938,564 (GRCm39) F31L probably benign Het
Cep164 A G 9: 45,690,986 (GRCm39) probably null Het
Clca4b T C 3: 144,619,033 (GRCm39) Y702C probably damaging Het
Clstn1 A G 4: 149,728,508 (GRCm39) I655V probably damaging Het
Dock1 A G 7: 134,747,147 (GRCm39) E1486G probably damaging Het
Epha8 A G 4: 136,661,877 (GRCm39) F573L probably benign Het
Exoc1 A G 5: 76,691,840 (GRCm39) N323S probably benign Het
Exoc6b C T 6: 85,046,332 (GRCm39) R19Q probably damaging Het
Gcsam T C 16: 45,440,502 (GRCm39) *182R probably null Het
Ighv9-2 T C 12: 114,072,911 (GRCm39) I21V probably benign Het
Ints2 G A 11: 86,113,043 (GRCm39) T825M probably damaging Het
Kti12 A C 4: 108,705,443 (GRCm39) E119A probably benign Het
Kti12 G T 4: 108,705,444 (GRCm39) E119D probably benign Het
Lad1 A G 1: 135,757,454 (GRCm39) T398A probably benign Het
Lrfn2 T C 17: 49,378,212 (GRCm39) V431A probably damaging Het
Mast2 T C 4: 116,292,732 (GRCm39) I79M possibly damaging Het
Nup107 A G 10: 117,617,905 (GRCm39) V171A probably benign Het
Or1e1c T C 11: 73,265,923 (GRCm39) F119S probably damaging Het
Or8b101 T A 9: 38,020,103 (GRCm39) Y35* probably null Het
Pde4dip T A 3: 97,622,539 (GRCm39) K1557* probably null Het
Plat C T 8: 23,263,655 (GRCm39) P185S probably damaging Het
Plcg1 T G 2: 160,595,585 (GRCm39) V511G probably damaging Het
Plxnb3 C T X: 72,811,251 (GRCm39) A1258V probably benign Het
Rnf223 T C 4: 156,217,240 (GRCm39) V205A probably benign Het
Slc13a1 G C 6: 24,118,065 (GRCm39) T224R probably benign Het
Slc39a10 T A 1: 46,874,912 (GRCm39) H130L possibly damaging Het
Sucnr1 T A 3: 59,993,790 (GRCm39) I106N probably damaging Het
Syde2 T C 3: 145,708,170 (GRCm39) probably null Het
Syne1 T C 10: 5,309,078 (GRCm39) I644V possibly damaging Het
Tbc1d8 A C 1: 39,441,809 (GRCm39) F261C probably damaging Het
Tmem132e A G 11: 82,336,116 (GRCm39) Y1066C probably damaging Het
Trip12 A C 1: 84,722,784 (GRCm39) I1322S probably damaging Het
Tsnaxip1 A G 8: 106,571,167 (GRCm39) I676V probably benign Het
Vmn1r231 A T 17: 21,110,236 (GRCm39) Y226* probably null Het
Vmn2r63 G C 7: 42,552,955 (GRCm39) A767G probably damaging Het
Wdr5b A G 16: 35,862,192 (GRCm39) T104A probably damaging Het
Zbed5 T C 5: 129,930,504 (GRCm39) V151A possibly damaging Het
Zc3h7b T C 15: 81,653,189 (GRCm39) F31S probably damaging Het
Zfp874b A T 13: 67,622,279 (GRCm39) C340S possibly damaging Het
Zmym4 T A 4: 126,804,797 (GRCm39) probably null Het
Other mutations in Or8g37
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01388:Or8g37 APN 9 39,731,298 (GRCm39) missense probably damaging 1.00
IGL02674:Or8g37 APN 9 39,730,934 (GRCm39) splice site probably null
R0659:Or8g37 UTSW 9 39,731,112 (GRCm39) missense possibly damaging 0.78
R0686:Or8g37 UTSW 9 39,730,964 (GRCm39) missense probably damaging 0.98
R1952:Or8g37 UTSW 9 39,731,363 (GRCm39) missense probably benign 0.09
R2068:Or8g37 UTSW 9 39,731,846 (GRCm39) missense probably benign 0.00
R4472:Or8g37 UTSW 9 39,731,870 (GRCm39) makesense probably null
R4798:Or8g37 UTSW 9 39,731,193 (GRCm39) missense probably benign 0.13
R5035:Or8g37 UTSW 9 39,731,390 (GRCm39) missense possibly damaging 0.82
R5339:Or8g37 UTSW 9 39,731,229 (GRCm39) missense probably damaging 0.97
R6751:Or8g37 UTSW 9 39,731,193 (GRCm39) missense probably benign 0.13
R7211:Or8g37 UTSW 9 39,731,154 (GRCm39) missense possibly damaging 0.76
R7471:Or8g37 UTSW 9 39,731,423 (GRCm39) missense probably benign 0.00
R7609:Or8g37 UTSW 9 39,731,583 (GRCm39) missense probably benign
R7638:Or8g37 UTSW 9 39,731,189 (GRCm39) missense probably damaging 1.00
R7890:Or8g37 UTSW 9 39,731,310 (GRCm39) missense probably damaging 0.99
R8548:Or8g37 UTSW 9 39,731,537 (GRCm39) missense probably benign 0.00
R8817:Or8g37 UTSW 9 39,730,939 (GRCm39) start codon destroyed probably null 0.40
R8868:Or8g37 UTSW 9 39,731,252 (GRCm39) missense probably benign
R9689:Or8g37 UTSW 9 39,731,801 (GRCm39) missense possibly damaging 0.95
Z1176:Or8g37 UTSW 9 39,731,651 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ATCCTGAATGTATGACTCAGCTCTAC -3'
(R):5'- TTTGGACCTGCCTTCAGTGG -3'

Sequencing Primer
(F):5'- GCAATCTGTAACCCCTTG -3'
(R):5'- GGACCTGCCTTCAGTGGATTTAATC -3'
Posted On 2020-09-15