Mutagenetix > Incidental Mutation

Incidental Mutation 'R7921:Flnb'

648394

Institutional Source

Beutler Lab

Gene Symbol

Flnb

Ensembl Gene

ENSMUSG00000025278

Gene Name

filamin, beta

Synonyms

MMRRC Submission

045968-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R7921 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

7817957-7951588 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 7933800 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 2152 (S2152P)

Ref Sequence

ENSEMBL: ENSMUSP00000052020 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000052678]

AlphaFold

Q80X90

Predicted Effect

possibly damaging
Transcript: ENSMUST00000052678
AA Change: S2152P

PolyPhen 2 Score 0.572 (Sensitivity: 0.88; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000052020
Gene: ENSMUSG00000025278
AA Change: S2152P

Domain	Start	End	E-Value	Type
CH	18	120	2.38e-26	SMART
CH	141	237	1.83e-18	SMART
IG_FLMN	253	350	1.17e-33	SMART
IG_FLMN	353	449	2.08e-34	SMART
IG_FLMN	451	546	3.42e-35	SMART
IG_FLMN	548	639	6.06e-27	SMART
IG_FLMN	644	739	1.94e-34	SMART
IG_FLMN	741	842	4.25e-31	SMART
IG_FLMN	844	941	5.16e-30	SMART
IG_FLMN	943	1037	5.12e-25	SMART
IG_FLMN	1039	1130	5.31e-41	SMART
IG_FLMN	1132	1225	1.4e-31	SMART
IG_FLMN	1227	1325	1.42e-32	SMART
IG_FLMN	1327	1418	5.19e-35	SMART
IG_FLMN	1420	1514	2.48e-41	SMART
IG_FLMN	1516	1611	3.15e-34	SMART
IG_FLMN	1613	1707	4.99e-37	SMART
IG_FLMN	1730	1819	4.44e-11	SMART
IG_FLMN	1820	1911	5.82e-38	SMART
IG_FLMN	1914	1997	5.68e-9	SMART
IG_FLMN	2001	2092	4.45e-34	SMART
IG_FLMN	2101	2188	1.24e-9	SMART
IG_FLMN	2192	2283	4.48e-39	SMART
IG_FLMN	2286	2378	2.94e-25	SMART
IG_FLMN	2383	2474	5.66e-27	SMART
IG_FLMN	2511	2602	1.63e-27	SMART

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.0%

Validation Efficiency

95% (84/88)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the filamin family. The encoded protein interacts with glycoprotein Ib alpha as part of the process to repair vascular injuries. The platelet glycoprotein Ib complex includes glycoprotein Ib alpha, and it binds the actin cytoskeleton. Mutations in this gene have been found in several conditions: atelosteogenesis type 1 and type 3; boomerang dysplasia; autosomal dominant Larsen syndrome; and spondylocarpotarsal synostosis syndrome. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Nov 2009]
PHENOTYPE: Mutations in this gene cause skeletal defects including runting, premature mineralization, and bone fusion. Nullizygous mice show a delay and reduction in long bone growth. Truncation mutations cause early fusion of spinal vertebrae due to enhanced chondrocyte hypertrophy and early differentiation. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 94 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A2m	T	G	6: 121,677,995 (GRCm38)	M1426R	probably benign	Het
Adh7	A	T	3: 138,224,010 (GRCm38)	Y149F	probably damaging	Het
Ankdd1b	C	A	13: 96,424,780 (GRCm38)	V319F	possibly damaging	Het
Ankrd13d	T	C	19: 4,271,030 (GRCm38)	D483G	probably damaging	Het
Anks4b	A	T	7: 120,182,769 (GRCm38)	E341V	probably benign	Het
Aqp12	A	G	1: 93,012,008 (GRCm38)	H253R	probably benign	Het
Atp2c1	A	G	9: 105,414,687 (GRCm38)	I892T	probably damaging	Het
Atp8b3	A	T	10: 80,530,603 (GRCm38)	N275K	probably damaging	Het
Carmil2	C	A	8: 105,691,104 (GRCm38)	N610K	probably damaging	Het
Cd96	GCCCAAAC	G	16: 46,038,480 (GRCm38)		probably null	Het
Cdh10	A	T	15: 18,991,956 (GRCm38)	I434F	probably damaging	Het
Celf1	A	T	2: 90,998,747 (GRCm38)	Q53L	probably benign	Het
Cers4	T	A	8: 4,515,704 (GRCm38)	V50E	probably damaging	Het
Chd9	T	C	8: 91,042,281 (GRCm38)		probably null	Het
Cir1	A	G	2: 73,310,455 (GRCm38)		probably null	Het
Ckap5	A	G	2: 91,548,940 (GRCm38)	Y75C	probably damaging	Het
Cndp1	A	G	18: 84,622,258 (GRCm38)	M274T	probably benign	Het
Col22a1	A	T	15: 71,981,962 (GRCm38)		probably null	Het
Col24a1	G	T	3: 145,474,238 (GRCm38)	G1162C	probably damaging	Het
Cr2	A	T	1: 195,151,667 (GRCm38)	L938Q	possibly damaging	Het
Cubn	G	A	2: 13,424,727 (GRCm38)	T1321I	probably benign	Het
Cyp3a44	G	A	5: 145,791,688 (GRCm38)	P242L	probably damaging	Het
Ddx4	A	T	13: 112,601,507 (GRCm38)	D539E	probably benign	Het
Dennd1b	G	A	1: 139,062,873 (GRCm38)	E192K	probably damaging	Het
Dgkd	G	T	1: 87,924,084 (GRCm38)	V403L	probably damaging	Het
Dnah2	T	A	11: 69,520,834 (GRCm38)	M321L	probably benign	Het
Dpy19l1	A	T	9: 24,422,338 (GRCm38)	M433K	possibly damaging	Het
Enoph1	A	G	5: 100,061,133 (GRCm38)	K116E	probably benign	Het
Exd1	C	A	2: 119,530,099 (GRCm38)	C174F	probably damaging	Het
Exoc7	A	T	11: 116,297,682 (GRCm38)		probably null	Het
Fam183b	T	C	11: 58,801,781 (GRCm38)	H40R	possibly damaging	Het
Fam50b	G	A	13: 34,747,101 (GRCm38)	E187K	possibly damaging	Het
Farp2	G	C	1: 93,567,515 (GRCm38)		probably null	Het
Fbxo22	A	T	9: 55,218,353 (GRCm38)	I167L	probably benign	Het
Fchsd2	A	G	7: 101,250,542 (GRCm38)	N365S	probably benign	Het
Fgr	T	G	4: 132,986,521 (GRCm38)		probably null	Het
Fkbp9	A	G	6: 56,851,385 (GRCm38)	D194G	probably damaging	Het
Flnc	A	G	6: 29,447,770 (GRCm38)	I1191V	possibly damaging	Het
Fpr-rs7	A	T	17: 20,113,405 (GRCm38)	N274K	probably benign	Het
Fuca1	A	G	4: 135,929,910 (GRCm38)	D211G	probably damaging	Het
Glb1l2	C	T	9: 26,773,968 (GRCm38)		probably null	Het
Gm13088	T	C	4: 143,656,565 (GRCm38)	E28G	probably damaging	Het
Gm48552	T	C	10: 81,390,992 (GRCm38)	*136R	probably null	Het
Hdgfl2	T	C	17: 56,093,724 (GRCm38)		probably null	Het
Icmt	T	G	4: 152,303,158 (GRCm38)	V270G	probably damaging	Het
Icosl	A	T	10: 78,073,740 (GRCm38)	D173V	probably benign	Het
Icosl	G	A	10: 78,073,952 (GRCm38)	V244I	probably benign	Het
Iqsec1	C	T	6: 90,667,941 (GRCm38)	R903H	probably damaging	Het
Lrtm2	G	A	6: 119,317,367 (GRCm38)	P268S	possibly damaging	Het
Methig1	T	A	15: 100,353,370 (GRCm38)	L54Q	probably benign	Het
Mga	T	A	2: 119,919,678 (GRCm38)	L686H	probably damaging	Het
Mki67	A	T	7: 135,695,204 (GRCm38)	S2700R	probably benign	Het
Muc16	T	A	9: 18,659,318 (GRCm38)	D635V	unknown	Het
Muc4	G	A	16: 32,751,321 (GRCm38)	V400I	possibly damaging	Het
Muc5ac	G	C	7: 141,809,687 (GRCm38)		probably benign	Het
Myh8	T	C	11: 67,283,818 (GRCm38)	I253T	probably damaging	Het
Myo15b	A	T	11: 115,887,178 (GRCm38)	K852*	probably null	Het
Myo19	C	T	11: 84,908,238 (GRCm38)	T799I	possibly damaging	Het
Naca	T	G	10: 128,043,049 (GRCm38)	S1317A	unknown	Het
Nipa1	T	C	7: 55,979,810 (GRCm38)	Y185C	probably damaging	Het
Nlrc5	T	A	8: 94,487,664 (GRCm38)	N910K	probably damaging	Het
Nucks1	G	T	1: 131,910,736 (GRCm38)	M1I	probably null	Het
Nudt13	T	C	14: 20,304,072 (GRCm38)	V68A	probably benign	Het
Oacyl	A	T	18: 65,725,383 (GRCm38)	M260L	probably benign	Het
Olfr106-ps	C	T	17: 37,395,442 (GRCm38)	L301F	possibly damaging	Het
Olfr524	A	T	7: 140,202,299 (GRCm38)	I157N	probably damaging	Het
Olfr586	A	T	7: 103,122,428 (GRCm38)	S115T	probably damaging	Het
Osbpl6	A	G	2: 76,585,097 (GRCm38)	N601S	probably damaging	Het
Pcdh9	A	G	14: 93,015,565 (GRCm38)	S1221P	probably benign	Het
Pcdhb16	T	C	18: 37,478,245 (GRCm38)	L86P	probably damaging	Het
Pclo	A	C	5: 14,669,234 (GRCm38)	Q1128H	unknown	Het
Pcnx2	T	A	8: 125,837,863 (GRCm38)	Y1097F	probably benign	Het
Per1	T	A	11: 69,100,779 (GRCm38)	D46E	probably damaging	Het
Plce1	T	A	19: 38,620,553 (GRCm38)	D435E	probably benign	Het
Prkaa1	C	A	15: 5,177,151 (GRCm38)	Q461K	probably damaging	Het
Proc	C	T	18: 32,123,417 (GRCm38)	G399D	probably damaging	Het
Rbak	G	T	5: 143,174,262 (GRCm38)	S345R	probably damaging	Het
Rsph3b	T	C	17: 6,905,091 (GRCm38)	I325V	probably benign	Het
Sbf1	A	T	15: 89,306,223 (GRCm38)	L323Q	probably damaging	Het
Scd3	G	A	19: 44,235,892 (GRCm38)	R188H	possibly damaging	Het
Setdb1	T	G	3: 95,326,399 (GRCm38)	N1067H	possibly damaging	Het
Spopl	G	A	2: 23,545,478 (GRCm38)	T15I	probably benign	Het
Sptbn2	C	G	19: 4,749,012 (GRCm38)	R2037G	probably benign	Het
Stk39	A	G	2: 68,307,039 (GRCm38)		probably null	Het
Syt13	G	T	2: 92,953,646 (GRCm38)	M420I	probably damaging	Het
Tas1r1	A	T	4: 152,028,661 (GRCm38)	I645N	possibly damaging	Het
Tbx3	G	T	5: 119,680,870 (GRCm38)	Q523H	probably benign	Het
Tbx3	A	T	5: 119,680,869 (GRCm38)	Q523L	possibly damaging	Het
Tcf23	C	T	5: 30,970,150 (GRCm38)	Q99*	probably null	Het
Tfip11	T	A	5: 112,335,576 (GRCm38)	M619K	probably benign	Het
Tg	A	T	15: 66,683,793 (GRCm38)	H778L	probably benign	Het
Utp3	A	G	5: 88,554,896 (GRCm38)	S95G	probably benign	Het
Zfp458	T	A	13: 67,256,116 (GRCm38)	*753L	probably null	Het
Zfp9	T	C	6: 118,465,071 (GRCm38)	Y210C	possibly damaging	Het

Other mutations in Flnb

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01017:Flnb	APN	14	7,917,390 (GRCm38)	splice site	probably benign
IGL01063:Flnb	APN	14	7,926,518 (GRCm38)	splice site	probably benign
IGL01135:Flnb	APN	14	7,909,736 (GRCm38)	missense	probably benign
IGL01139:Flnb	APN	14	7,945,989 (GRCm38)	missense	probably damaging	1.00
IGL01364:Flnb	APN	14	7,934,562 (GRCm38)	critical splice acceptor site	probably null
IGL01417:Flnb	APN	14	7,905,513 (GRCm38)	missense	probably damaging	0.99
IGL01505:Flnb	APN	14	7,902,003 (GRCm38)	critical splice donor site	probably null
IGL01560:Flnb	APN	14	7,893,829 (GRCm38)	missense	probably benign	0.07
IGL01621:Flnb	APN	14	7,950,470 (GRCm38)	missense	probably damaging	1.00
IGL01656:Flnb	APN	14	7,902,010 (GRCm38)	splice site	probably benign
IGL01889:Flnb	APN	14	7,935,967 (GRCm38)	missense	possibly damaging	0.85
IGL01987:Flnb	APN	14	7,922,748 (GRCm38)	critical splice donor site	probably null
IGL02322:Flnb	APN	14	7,894,676 (GRCm38)	missense	probably damaging	1.00
IGL02496:Flnb	APN	14	7,930,919 (GRCm38)	splice site	probably benign
IGL02752:Flnb	APN	14	7,917,338 (GRCm38)	missense	probably benign
IGL03001:Flnb	APN	14	7,934,680 (GRCm38)	missense	probably damaging	0.99
IGL03076:Flnb	APN	14	7,901,988 (GRCm38)	missense	probably benign	0.01
IGL03085:Flnb	APN	14	7,882,211 (GRCm38)	missense	probably benign
IGL03170:Flnb	APN	14	7,818,261 (GRCm38)	missense	possibly damaging	0.90
IGL03373:Flnb	APN	14	7,890,867 (GRCm38)	critical splice donor site	probably null
Boomerang	UTSW	14	7,901,945 (GRCm38)	missense	probably damaging	1.00
Queensland	UTSW	14	7,927,352 (GRCm38)	missense	probably damaging	1.00
R3437_Flnb_252	UTSW	14	7,942,057 (GRCm38)	missense	probably damaging	0.97
R8441_Flnb_221	UTSW	14	7,896,488 (GRCm38)	missense	probably benign	0.15
Rhodelinda	UTSW	14	7,887,682 (GRCm38)	splice site	probably benign
saul	UTSW	14	7,889,183 (GRCm38)	missense	probably damaging	0.99
Xerxes	UTSW	14	7,867,551 (GRCm38)	missense	probably damaging	1.00
R0068:Flnb	UTSW	14	7,915,290 (GRCm38)	missense	possibly damaging	0.49
R0068:Flnb	UTSW	14	7,915,290 (GRCm38)	missense	possibly damaging	0.49
R0084:Flnb	UTSW	14	7,935,979 (GRCm38)	missense	probably benign
R0128:Flnb	UTSW	14	7,901,951 (GRCm38)	missense	probably damaging	0.99
R0130:Flnb	UTSW	14	7,901,951 (GRCm38)	missense	probably damaging	0.99
R0148:Flnb	UTSW	14	7,939,077 (GRCm38)	missense	probably benign	0.01
R0166:Flnb	UTSW	14	7,896,115 (GRCm38)	missense	probably damaging	1.00
R0376:Flnb	UTSW	14	7,946,014 (GRCm38)	critical splice donor site	probably null
R0547:Flnb	UTSW	14	7,912,943 (GRCm38)	splice site	probably null
R0612:Flnb	UTSW	14	7,887,682 (GRCm38)	splice site	probably benign
R0656:Flnb	UTSW	14	7,927,352 (GRCm38)	missense	probably damaging	1.00
R0691:Flnb	UTSW	14	7,890,810 (GRCm38)	missense	probably benign	0.16
R1241:Flnb	UTSW	14	7,896,503 (GRCm38)	missense	probably benign	0.06
R1572:Flnb	UTSW	14	7,883,908 (GRCm38)	missense	probably damaging	0.97
R1682:Flnb	UTSW	14	7,913,121 (GRCm38)	missense	probably benign	0.04
R1807:Flnb	UTSW	14	7,934,645 (GRCm38)	missense	probably benign	0.26
R1848:Flnb	UTSW	14	7,892,113 (GRCm38)	missense	probably damaging	1.00
R1959:Flnb	UTSW	14	7,884,735 (GRCm38)	nonsense	probably null
R2078:Flnb	UTSW	14	7,927,466 (GRCm38)	missense	probably damaging	1.00
R2132:Flnb	UTSW	14	7,873,376 (GRCm38)	missense	probably benign	0.04
R2209:Flnb	UTSW	14	7,905,507 (GRCm38)	nonsense	probably null
R2212:Flnb	UTSW	14	7,881,652 (GRCm38)	small deletion	probably benign
R2213:Flnb	UTSW	14	7,881,652 (GRCm38)	small deletion	probably benign
R2363:Flnb	UTSW	14	7,945,950 (GRCm38)	missense	possibly damaging	0.95
R2415:Flnb	UTSW	14	7,929,932 (GRCm38)	missense	probably benign	0.07
R2983:Flnb	UTSW	14	7,882,250 (GRCm38)	missense	probably damaging	1.00
R3001:Flnb	UTSW	14	7,907,162 (GRCm38)	missense	probably benign	0.22
R3002:Flnb	UTSW	14	7,907,162 (GRCm38)	missense	probably benign	0.22
R3436:Flnb	UTSW	14	7,942,057 (GRCm38)	missense	probably damaging	0.97
R3437:Flnb	UTSW	14	7,942,057 (GRCm38)	missense	probably damaging	0.97
R3778:Flnb	UTSW	14	7,915,353 (GRCm38)	missense	probably benign	0.06
R3783:Flnb	UTSW	14	7,889,236 (GRCm38)	missense	probably benign	0.04
R4162:Flnb	UTSW	14	7,915,374 (GRCm38)	missense	possibly damaging	0.81
R4163:Flnb	UTSW	14	7,915,374 (GRCm38)	missense	possibly damaging	0.81
R4164:Flnb	UTSW	14	7,915,374 (GRCm38)	missense	possibly damaging	0.81
R4356:Flnb	UTSW	14	7,922,700 (GRCm38)	missense	probably benign
R4369:Flnb	UTSW	14	7,942,216 (GRCm38)	missense	probably benign
R4783:Flnb	UTSW	14	7,905,701 (GRCm38)	missense	probably benign	0.12
R4785:Flnb	UTSW	14	7,905,701 (GRCm38)	missense	probably benign	0.12
R4790:Flnb	UTSW	14	7,905,661 (GRCm38)	missense	probably benign	0.34
R4828:Flnb	UTSW	14	7,919,238 (GRCm38)	missense	probably benign	0.13
R4882:Flnb	UTSW	14	7,929,936 (GRCm38)	missense	possibly damaging	0.56
R5002:Flnb	UTSW	14	7,945,882 (GRCm38)	missense	probably damaging	1.00
R5058:Flnb	UTSW	14	7,924,262 (GRCm38)	nonsense	probably null
R5184:Flnb	UTSW	14	7,901,945 (GRCm38)	missense	probably damaging	1.00
R5186:Flnb	UTSW	14	7,909,748 (GRCm38)	missense	probably damaging	1.00
R5395:Flnb	UTSW	14	7,883,881 (GRCm38)	missense	probably benign	0.02
R5421:Flnb	UTSW	14	7,926,494 (GRCm38)	missense	probably damaging	1.00
R5667:Flnb	UTSW	14	7,890,843 (GRCm38)	missense	probably benign	0.00
R5671:Flnb	UTSW	14	7,890,843 (GRCm38)	missense	probably benign	0.00
R5714:Flnb	UTSW	14	7,929,073 (GRCm38)	missense	probably damaging	1.00
R5860:Flnb	UTSW	14	7,931,135 (GRCm38)	missense	probably damaging	1.00
R5892:Flnb	UTSW	14	7,907,183 (GRCm38)	missense	probably damaging	1.00
R5924:Flnb	UTSW	14	7,890,765 (GRCm38)	missense	probably benign	0.00
R6131:Flnb	UTSW	14	7,894,635 (GRCm38)	missense	possibly damaging	0.79
R6244:Flnb	UTSW	14	7,892,092 (GRCm38)	missense	probably damaging	1.00
R6489:Flnb	UTSW	14	7,867,551 (GRCm38)	missense	probably damaging	1.00
R6582:Flnb	UTSW	14	7,892,275 (GRCm38)	critical splice donor site	probably null
R6586:Flnb	UTSW	14	7,929,138 (GRCm38)	missense	possibly damaging	0.93
R6611:Flnb	UTSW	14	7,915,318 (GRCm38)	missense	probably damaging	1.00
R6626:Flnb	UTSW	14	7,929,012 (GRCm38)	missense	probably damaging	1.00
R6700:Flnb	UTSW	14	7,892,189 (GRCm38)	missense	probably damaging	0.99
R6738:Flnb	UTSW	14	7,904,536 (GRCm38)	missense	probably benign	0.01
R6864:Flnb	UTSW	14	7,905,640 (GRCm38)	missense	possibly damaging	0.84
R6916:Flnb	UTSW	14	7,907,171 (GRCm38)	missense	probably damaging	0.99
R7117:Flnb	UTSW	14	7,894,214 (GRCm38)	missense	probably benign	0.02
R7164:Flnb	UTSW	14	7,915,944 (GRCm38)	splice site	probably null
R7328:Flnb	UTSW	14	7,894,660 (GRCm38)	nonsense	probably null
R7328:Flnb	UTSW	14	7,883,788 (GRCm38)	missense	possibly damaging	0.95
R7687:Flnb	UTSW	14	7,924,224 (GRCm38)	missense	probably damaging	1.00
R7716:Flnb	UTSW	14	7,917,274 (GRCm38)	missense	possibly damaging	0.64
R7763:Flnb	UTSW	14	7,926,478 (GRCm38)	missense	probably benign	0.00
R7821:Flnb	UTSW	14	7,939,113 (GRCm38)	missense	probably benign	0.00
R8008:Flnb	UTSW	14	7,892,155 (GRCm38)	missense	probably damaging	1.00
R8075:Flnb	UTSW	14	7,913,048 (GRCm38)	missense	probably benign	0.00
R8084:Flnb	UTSW	14	7,907,243 (GRCm38)	missense	probably benign	0.00
R8259:Flnb	UTSW	14	7,889,183 (GRCm38)	missense	probably damaging	0.99
R8441:Flnb	UTSW	14	7,896,488 (GRCm38)	missense	probably benign	0.15
R8493:Flnb	UTSW	14	7,869,822 (GRCm38)	missense	probably damaging	0.97
R8508:Flnb	UTSW	14	7,950,394 (GRCm38)	missense	probably damaging	0.98
R8531:Flnb	UTSW	14	7,929,939 (GRCm38)	missense	probably damaging	1.00
R8812:Flnb	UTSW	14	7,887,624 (GRCm38)	missense	probably benign	0.06
R8814:Flnb	UTSW	14	7,927,409 (GRCm38)	missense	probably damaging	1.00
R8825:Flnb	UTSW	14	7,887,566 (GRCm38)	missense	probably damaging	1.00
R8868:Flnb	UTSW	14	7,908,671 (GRCm38)	missense	probably benign	0.02
R8955:Flnb	UTSW	14	7,904,688 (GRCm38)	nonsense	probably null
R8955:Flnb	UTSW	14	7,892,874 (GRCm38)	missense	probably damaging	1.00
R8976:Flnb	UTSW	14	7,901,882 (GRCm38)	critical splice acceptor site	probably null
R9055:Flnb	UTSW	14	7,908,553 (GRCm38)	missense	probably benign	0.00
R9148:Flnb	UTSW	14	7,817,996 (GRCm38)	start gained	probably benign
R9179:Flnb	UTSW	14	7,887,541 (GRCm38)	nonsense	probably null
R9180:Flnb	UTSW	14	7,818,219 (GRCm38)	missense	probably damaging	1.00
R9189:Flnb	UTSW	14	7,892,976 (GRCm38)	missense	possibly damaging	0.90
R9286:Flnb	UTSW	14	7,873,414 (GRCm38)	missense	probably damaging	0.98
R9288:Flnb	UTSW	14	7,904,498 (GRCm38)	missense	probably benign	0.43
R9354:Flnb	UTSW	14	7,818,411 (GRCm38)	missense	probably benign	0.13
R9484:Flnb	UTSW	14	7,929,004 (GRCm38)	missense	probably benign	0.06
R9505:Flnb	UTSW	14	7,904,665 (GRCm38)	missense	probably benign
R9525:Flnb	UTSW	14	7,905,481 (GRCm38)	missense	probably damaging	1.00
R9621:Flnb	UTSW	14	7,926,421 (GRCm38)	missense	probably damaging	0.99
R9630:Flnb	UTSW	14	7,926,438 (GRCm38)	nonsense	probably null
R9739:Flnb	UTSW	14	7,935,954 (GRCm38)	nonsense	probably null
R9760:Flnb	UTSW	14	7,929,846 (GRCm38)	missense	probably damaging	0.98
X0066:Flnb	UTSW	14	7,908,636 (GRCm38)	missense	probably damaging	1.00
Z1088:Flnb	UTSW	14	7,905,871 (GRCm38)	missense	probably benign	0.04
Z1176:Flnb	UTSW	14	7,942,066 (GRCm38)	missense	probably benign	0.25

Predicted Primers

PCR Primer
(F):5'- AACCTTCTCTGCGTGACCTG -3'
(R):5'- CTCTTTAGAGCAATGGGTACAGTTG -3'

Sequencing Primer
(F):5'- ACCTGTGTGCCCTGCATG -3'
(R):5'- GTGAGTCCAGTTAAAACTTGGCCC -3'

Posted On

2020-09-15