Incidental Mutation 'R7936:Dusp2'
ID 648716
Institutional Source Beutler Lab
Gene Symbol Dusp2
Ensembl Gene ENSMUSG00000027368
Gene Name dual specificity phosphatase 2
Synonyms PAC1
MMRRC Submission 045982-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7936 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 127178079-127180296 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 127178812 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 172 (Y172*)
Ref Sequence ENSEMBL: ENSMUSP00000028846 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028846] [ENSMUST00000059839] [ENSMUST00000089673] [ENSMUST00000179618]
AlphaFold Q05922
Predicted Effect probably null
Transcript: ENSMUST00000028846
AA Change: Y172*
SMART Domains Protein: ENSMUSP00000028846
Gene: ENSMUSG00000027368
AA Change: Y172*

DomainStartEndE-ValueType
RHOD 17 145 6.72e-10 SMART
DSPc 176 314 1.49e-61 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000059839
SMART Domains Protein: ENSMUSP00000054456
Gene: ENSMUSG00000050468

DomainStartEndE-ValueType
Blast:ZnMc 31 60 4e-8 BLAST
ZnMc 69 213 1.13e-39 SMART
low complexity region 292 308 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000089673
SMART Domains Protein: ENSMUSP00000087102
Gene: ENSMUSG00000050468

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
Blast:ZnMc 52 81 5e-8 BLAST
ZnMc 90 234 1.13e-39 SMART
low complexity region 313 329 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000179618
SMART Domains Protein: ENSMUSP00000135987
Gene: ENSMUSG00000050468

DomainStartEndE-ValueType
Blast:ZnMc 31 60 4e-8 BLAST
ZnMc 69 213 1.13e-39 SMART
low complexity region 292 308 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 100% (64/64)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1 and ERK2, is predominantly expressed in hematopoietic tissues, and is localized in the nucleus. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous mutation of this gene results in reduced inflammatory responses in induced rheumatoid arthritis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 70 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930590J08Rik T A 6: 91,900,445 (GRCm39) L438* probably null Het
Adamts18 T A 8: 114,493,760 (GRCm39) I460F probably damaging Het
Api5 C T 2: 94,268,392 (GRCm39) probably benign Het
Arap2 A G 5: 62,888,048 (GRCm39) S433P probably damaging Het
Arhgap26 T C 18: 39,338,340 (GRCm39) Y371H probably damaging Het
Asf1b T C 8: 84,695,848 (GRCm39) I163T probably benign Het
Cacna2d2 A G 9: 107,401,326 (GRCm39) N696S probably damaging Het
Carns1 A C 19: 4,216,152 (GRCm39) S677A probably benign Het
Cd276 G A 9: 58,448,113 (GRCm39) probably benign Het
Cdk8 T A 5: 146,236,644 (GRCm39) M353K possibly damaging Het
Cfap57 C T 4: 118,472,128 (GRCm39) V84I probably benign Het
Chsy3 A G 18: 59,542,418 (GRCm39) I519V probably damaging Het
Chtop T C 3: 90,414,658 (GRCm39) probably benign Het
Clstn3 T A 6: 124,408,972 (GRCm39) D892V possibly damaging Het
Col16a1 A T 4: 129,990,664 (GRCm39) probably null Het
Dnah5 A G 15: 28,345,983 (GRCm39) E2441G possibly damaging Het
Dpy19l2 T G 9: 24,469,454 (GRCm39) D734A probably damaging Het
Efcab3 A G 11: 104,890,524 (GRCm39) N4202S possibly damaging Het
Efcab3 G A 11: 104,937,385 (GRCm39) probably null Het
Eml4 G A 17: 83,781,115 (GRCm39) R771Q possibly damaging Het
Fat2 T A 11: 55,200,993 (GRCm39) M694L probably benign Het
Fat2 C A 11: 55,201,986 (GRCm39) E363* probably null Het
Gdpgp1 A G 7: 79,888,826 (GRCm39) I286V probably damaging Het
Gps1 T A 11: 120,677,199 (GRCm39) V166E probably damaging Het
H60b T A 10: 22,162,055 (GRCm39) N93K probably benign Het
Imp4 C T 1: 34,482,114 (GRCm39) T79I probably benign Het
Kank3 A G 17: 34,037,841 (GRCm39) S485G probably benign Het
Kcnv2 A G 19: 27,300,167 (GRCm39) N6S probably benign Het
Krba1 A T 6: 48,388,603 (GRCm39) Q534L probably damaging Het
Lgr4 A G 2: 109,836,863 (GRCm39) N399S probably damaging Het
Lgr5 A G 10: 115,288,952 (GRCm39) V564A probably damaging Het
Lrtm2 A G 6: 119,297,394 (GRCm39) F216L probably benign Het
Lsm8 T A 6: 18,849,658 (GRCm39) M22K probably benign Het
Mboat2 C T 12: 25,005,392 (GRCm39) T389M probably damaging Het
Mcoln1 T G 8: 3,555,924 (GRCm39) I73S probably damaging Het
Myh7 T A 14: 55,216,920 (GRCm39) I1146F possibly damaging Het
Naa16 G A 14: 79,578,486 (GRCm39) T666I possibly damaging Het
Ncoa1 A G 12: 4,385,873 (GRCm39) S88P possibly damaging Het
Obscn T C 11: 58,941,334 (GRCm39) T4496A possibly damaging Het
Or13a28 T C 7: 140,217,652 (GRCm39) F13L probably damaging Het
Or7a35 T A 10: 78,853,872 (GRCm39) F239I probably damaging Het
Pdxk G T 10: 78,277,012 (GRCm39) A262D possibly damaging Het
Pebp4 T A 14: 70,089,082 (GRCm39) L68Q probably damaging Het
Pfdn5 C T 15: 102,236,978 (GRCm39) H77Y possibly damaging Het
Pld1 T C 3: 28,130,651 (GRCm39) Y484H probably damaging Het
Pou3f3 C A 1: 42,736,560 (GRCm39) N85K unknown Het
Ppm1m C A 9: 106,075,144 (GRCm39) A134S probably damaging Het
Prdm11 A T 2: 92,806,106 (GRCm39) S281R possibly damaging Het
Prdm2 C A 4: 142,862,434 (GRCm39) L285F probably damaging Het
Ptchd3 C T 11: 121,721,939 (GRCm39) R271* probably null Het
Ptprq A C 10: 107,488,572 (GRCm39) V955G probably damaging Het
Pygb A T 2: 150,657,589 (GRCm39) M351L probably benign Het
Rcl1 G A 19: 29,095,805 (GRCm39) probably null Het
Sgip1 A T 4: 102,786,097 (GRCm39) T351S possibly damaging Het
Slc22a5 T C 11: 53,760,215 (GRCm39) N367S probably damaging Het
Sox6 A G 7: 115,143,830 (GRCm39) V437A probably benign Het
Spata16 T A 3: 26,721,572 (GRCm39) M31K possibly damaging Het
Stab1 C A 14: 30,879,372 (GRCm39) V703F possibly damaging Het
Tbc1d4 C T 14: 101,703,190 (GRCm39) G752R probably damaging Het
Tent4b G A 8: 88,978,913 (GRCm39) G505R probably null Het
Tes3-ps C T 13: 49,647,460 (GRCm39) A112V probably benign Het
Tnfrsf19 T C 14: 61,208,382 (GRCm39) T380A probably benign Het
Trim75 C T 8: 65,435,190 (GRCm39) G420E probably damaging Het
Txlnb A G 10: 17,703,712 (GRCm39) D290G probably benign Het
Unc5c T A 3: 141,534,238 (GRCm39) F920I possibly damaging Het
Vmn1r233 T A 17: 21,214,237 (GRCm39) R238* probably null Het
Vmn2r113 A G 17: 23,176,917 (GRCm39) E567G probably benign Het
Vmn2r97 T A 17: 19,150,662 (GRCm39) I503K probably damaging Het
Wdr62 A G 7: 29,964,584 (GRCm39) W387R probably damaging Het
Zfp36l2 A T 17: 84,495,090 (GRCm39) D11E probably benign Het
Other mutations in Dusp2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01545:Dusp2 APN 2 127,179,695 (GRCm39) missense probably benign 0.00
R4353:Dusp2 UTSW 2 127,179,256 (GRCm39) missense probably damaging 1.00
R5973:Dusp2 UTSW 2 127,179,208 (GRCm39) missense probably damaging 1.00
R9211:Dusp2 UTSW 2 127,179,311 (GRCm39) missense probably benign
R9396:Dusp2 UTSW 2 127,179,638 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ATGAAAGCAGCGCGTCTGTG -3'
(R):5'- CACATATGCCTTAAAGTCTGTATGAGG -3'

Sequencing Primer
(F):5'- TTCTTGCGAGGTGAGCCC -3'
(R):5'- TGAGGATATATACACGTTCACACC -3'
Posted On 2020-09-15