Incidental Mutation 'R7936:Tent4b'
ID 648740
Institutional Source Beutler Lab
Gene Symbol Tent4b
Ensembl Gene ENSMUSG00000036779
Gene Name terminal nucleotidyltransferase 4B
Synonyms 5730445M16Rik, Papd5
MMRRC Submission 045982-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.904) question?
Stock # R7936 (G1)
Quality Score 225.009
Status Validated
Chromosome 8
Chromosomal Location 88925841-88986350 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 88978913 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Arginine at position 505 (G505R)
Ref Sequence ENSEMBL: ENSMUSP00000112608 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000066748] [ENSMUST00000118952] [ENSMUST00000119033] [ENSMUST00000154115]
AlphaFold no structure available at present
Predicted Effect probably null
Transcript: ENSMUST00000066748
AA Change: G462R

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000067971
Gene: ENSMUSG00000036779
AA Change: G462R

DomainStartEndE-ValueType
low complexity region 21 47 N/A INTRINSIC
low complexity region 83 117 N/A INTRINSIC
low complexity region 148 162 N/A INTRINSIC
Pfam:NTP_transf_2 206 315 1.6e-16 PFAM
Pfam:PAP_assoc 326 386 2.4e-18 PFAM
low complexity region 496 526 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000118952
AA Change: G505R

PolyPhen 2 Score 0.049 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000112608
Gene: ENSMUSG00000036779
AA Change: G505R

DomainStartEndE-ValueType
low complexity region 21 47 N/A INTRINSIC
low complexity region 83 117 N/A INTRINSIC
low complexity region 148 162 N/A INTRINSIC
Pfam:NTP_transf_2 206 317 1.1e-16 PFAM
Pfam:PAP_assoc 369 429 1.1e-17 PFAM
low complexity region 539 569 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000119033
AA Change: G505R

PolyPhen 2 Score 0.049 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000112766
Gene: ENSMUSG00000036779
AA Change: G505R

DomainStartEndE-ValueType
low complexity region 21 47 N/A INTRINSIC
low complexity region 83 117 N/A INTRINSIC
low complexity region 148 162 N/A INTRINSIC
Pfam:NTP_transf_2 206 318 4.6e-18 PFAM
Pfam:PAP_assoc 369 429 4.8e-17 PFAM
low complexity region 539 569 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000154115
AA Change: G72S

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000120503
Gene: ENSMUSG00000036779
AA Change: G72S

DomainStartEndE-ValueType
low complexity region 74 92 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 100% (64/64)
Allele List at MGI
Other mutations in this stock
Total: 70 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930590J08Rik T A 6: 91,900,445 (GRCm39) L438* probably null Het
Adamts18 T A 8: 114,493,760 (GRCm39) I460F probably damaging Het
Api5 C T 2: 94,268,392 (GRCm39) probably benign Het
Arap2 A G 5: 62,888,048 (GRCm39) S433P probably damaging Het
Arhgap26 T C 18: 39,338,340 (GRCm39) Y371H probably damaging Het
Asf1b T C 8: 84,695,848 (GRCm39) I163T probably benign Het
Cacna2d2 A G 9: 107,401,326 (GRCm39) N696S probably damaging Het
Carns1 A C 19: 4,216,152 (GRCm39) S677A probably benign Het
Cd276 G A 9: 58,448,113 (GRCm39) probably benign Het
Cdk8 T A 5: 146,236,644 (GRCm39) M353K possibly damaging Het
Cfap57 C T 4: 118,472,128 (GRCm39) V84I probably benign Het
Chsy3 A G 18: 59,542,418 (GRCm39) I519V probably damaging Het
Chtop T C 3: 90,414,658 (GRCm39) probably benign Het
Clstn3 T A 6: 124,408,972 (GRCm39) D892V possibly damaging Het
Col16a1 A T 4: 129,990,664 (GRCm39) probably null Het
Dnah5 A G 15: 28,345,983 (GRCm39) E2441G possibly damaging Het
Dpy19l2 T G 9: 24,469,454 (GRCm39) D734A probably damaging Het
Dusp2 T A 2: 127,178,812 (GRCm39) Y172* probably null Het
Efcab3 A G 11: 104,890,524 (GRCm39) N4202S possibly damaging Het
Efcab3 G A 11: 104,937,385 (GRCm39) probably null Het
Eml4 G A 17: 83,781,115 (GRCm39) R771Q possibly damaging Het
Fat2 T A 11: 55,200,993 (GRCm39) M694L probably benign Het
Fat2 C A 11: 55,201,986 (GRCm39) E363* probably null Het
Gdpgp1 A G 7: 79,888,826 (GRCm39) I286V probably damaging Het
Gps1 T A 11: 120,677,199 (GRCm39) V166E probably damaging Het
H60b T A 10: 22,162,055 (GRCm39) N93K probably benign Het
Imp4 C T 1: 34,482,114 (GRCm39) T79I probably benign Het
Kank3 A G 17: 34,037,841 (GRCm39) S485G probably benign Het
Kcnv2 A G 19: 27,300,167 (GRCm39) N6S probably benign Het
Krba1 A T 6: 48,388,603 (GRCm39) Q534L probably damaging Het
Lgr4 A G 2: 109,836,863 (GRCm39) N399S probably damaging Het
Lgr5 A G 10: 115,288,952 (GRCm39) V564A probably damaging Het
Lrtm2 A G 6: 119,297,394 (GRCm39) F216L probably benign Het
Lsm8 T A 6: 18,849,658 (GRCm39) M22K probably benign Het
Mboat2 C T 12: 25,005,392 (GRCm39) T389M probably damaging Het
Mcoln1 T G 8: 3,555,924 (GRCm39) I73S probably damaging Het
Myh7 T A 14: 55,216,920 (GRCm39) I1146F possibly damaging Het
Naa16 G A 14: 79,578,486 (GRCm39) T666I possibly damaging Het
Ncoa1 A G 12: 4,385,873 (GRCm39) S88P possibly damaging Het
Obscn T C 11: 58,941,334 (GRCm39) T4496A possibly damaging Het
Or13a28 T C 7: 140,217,652 (GRCm39) F13L probably damaging Het
Or7a35 T A 10: 78,853,872 (GRCm39) F239I probably damaging Het
Pdxk G T 10: 78,277,012 (GRCm39) A262D possibly damaging Het
Pebp4 T A 14: 70,089,082 (GRCm39) L68Q probably damaging Het
Pfdn5 C T 15: 102,236,978 (GRCm39) H77Y possibly damaging Het
Pld1 T C 3: 28,130,651 (GRCm39) Y484H probably damaging Het
Pou3f3 C A 1: 42,736,560 (GRCm39) N85K unknown Het
Ppm1m C A 9: 106,075,144 (GRCm39) A134S probably damaging Het
Prdm11 A T 2: 92,806,106 (GRCm39) S281R possibly damaging Het
Prdm2 C A 4: 142,862,434 (GRCm39) L285F probably damaging Het
Ptchd3 C T 11: 121,721,939 (GRCm39) R271* probably null Het
Ptprq A C 10: 107,488,572 (GRCm39) V955G probably damaging Het
Pygb A T 2: 150,657,589 (GRCm39) M351L probably benign Het
Rcl1 G A 19: 29,095,805 (GRCm39) probably null Het
Sgip1 A T 4: 102,786,097 (GRCm39) T351S possibly damaging Het
Slc22a5 T C 11: 53,760,215 (GRCm39) N367S probably damaging Het
Sox6 A G 7: 115,143,830 (GRCm39) V437A probably benign Het
Spata16 T A 3: 26,721,572 (GRCm39) M31K possibly damaging Het
Stab1 C A 14: 30,879,372 (GRCm39) V703F possibly damaging Het
Tbc1d4 C T 14: 101,703,190 (GRCm39) G752R probably damaging Het
Tes3-ps C T 13: 49,647,460 (GRCm39) A112V probably benign Het
Tnfrsf19 T C 14: 61,208,382 (GRCm39) T380A probably benign Het
Trim75 C T 8: 65,435,190 (GRCm39) G420E probably damaging Het
Txlnb A G 10: 17,703,712 (GRCm39) D290G probably benign Het
Unc5c T A 3: 141,534,238 (GRCm39) F920I possibly damaging Het
Vmn1r233 T A 17: 21,214,237 (GRCm39) R238* probably null Het
Vmn2r113 A G 17: 23,176,917 (GRCm39) E567G probably benign Het
Vmn2r97 T A 17: 19,150,662 (GRCm39) I503K probably damaging Het
Wdr62 A G 7: 29,964,584 (GRCm39) W387R probably damaging Het
Zfp36l2 A T 17: 84,495,090 (GRCm39) D11E probably benign Het
Other mutations in Tent4b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00502:Tent4b APN 8 88,978,886 (GRCm39) nonsense probably null
R0079:Tent4b UTSW 8 88,926,631 (GRCm39) missense possibly damaging 0.86
R0158:Tent4b UTSW 8 88,977,371 (GRCm39) missense probably damaging 1.00
R1175:Tent4b UTSW 8 88,978,635 (GRCm39) missense probably damaging 1.00
R1351:Tent4b UTSW 8 88,927,002 (GRCm39) nonsense probably null
R1381:Tent4b UTSW 8 88,969,937 (GRCm39) missense possibly damaging 0.95
R1541:Tent4b UTSW 8 88,972,227 (GRCm39) missense probably damaging 1.00
R1801:Tent4b UTSW 8 88,977,416 (GRCm39) missense probably benign 0.25
R1994:Tent4b UTSW 8 88,973,112 (GRCm39) missense probably damaging 1.00
R2013:Tent4b UTSW 8 88,972,223 (GRCm39) splice site probably null
R2290:Tent4b UTSW 8 88,978,603 (GRCm39) missense probably damaging 1.00
R3791:Tent4b UTSW 8 88,969,957 (GRCm39) missense probably damaging 1.00
R3845:Tent4b UTSW 8 88,977,292 (GRCm39) missense possibly damaging 0.60
R3886:Tent4b UTSW 8 88,927,043 (GRCm39) missense probably benign 0.03
R5041:Tent4b UTSW 8 88,981,878 (GRCm39) small deletion probably benign
R5253:Tent4b UTSW 8 88,926,651 (GRCm39) missense possibly damaging 0.63
R6881:Tent4b UTSW 8 88,977,416 (GRCm39) missense possibly damaging 0.91
R7792:Tent4b UTSW 8 88,979,182 (GRCm39) missense probably benign
R8054:Tent4b UTSW 8 88,974,186 (GRCm39) missense probably damaging 1.00
R8997:Tent4b UTSW 8 88,979,023 (GRCm39) missense probably benign 0.12
R8998:Tent4b UTSW 8 88,977,350 (GRCm39) missense probably benign 0.09
X0024:Tent4b UTSW 8 88,973,103 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGTAAAAGTCTAGCCCAGGC -3'
(R):5'- TTCCGAGGCGTTACTTCTAC -3'

Sequencing Primer
(F):5'- CCAGCCTGTGTGTTGAGAG -3'
(R):5'- GAGGCGTTACTTCTACATTTTCCAAG -3'
Posted On 2020-09-15