Incidental Mutation 'R7937:Or4f14b'
ID 648789
Institutional Source Beutler Lab
Gene Symbol Or4f14b
Ensembl Gene ENSMUSG00000094747
Gene Name olfactory receptor family 4 subfamily F member 14B
Synonyms GA_x6K02T2Q125-72988111-72987173, MOR245-19P, Olfr1307
MMRRC Submission 045983-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.118) question?
Stock # R7937 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 111774861-111775799 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 111774875 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Glycine at position 309 (R309G)
Ref Sequence ENSEMBL: ENSMUSP00000097199 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099604] [ENSMUST00000099606]
AlphaFold Q7TQX1
Predicted Effect probably benign
Transcript: ENSMUST00000099604
AA Change: R309G

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000097199
Gene: ENSMUSG00000094747
AA Change: R309G

DomainStartEndE-ValueType
Pfam:7tm_4 38 311 1.5e-36 PFAM
Pfam:7tm_1 49 295 6.5e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000099606
AA Change: R309G

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000097201
Gene: ENSMUSG00000094747
AA Change: R309G

DomainStartEndE-ValueType
Pfam:7tm_4 30 305 2.2e-42 PFAM
Pfam:7tm_1 41 287 6.7e-23 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb11 GTTGATCCATACA G 2: 69,154,217 (GRCm39) probably benign Het
Ano6 C A 15: 95,870,470 (GRCm39) T875K probably damaging Het
Armc8 G A 9: 99,418,272 (GRCm39) T94I probably damaging Het
Ash1l C T 3: 88,977,624 (GRCm39) R2685* probably null Het
Bri3bp A T 5: 125,531,395 (GRCm39) N114Y probably damaging Het
Camkk2 G T 5: 122,902,097 (GRCm39) Q71K probably benign Het
Cc2d2b T C 19: 40,765,736 (GRCm39) F49S Het
Cdh10 A G 15: 18,964,335 (GRCm39) T166A probably benign Het
Chd8 A G 14: 52,464,963 (GRCm39) F633L probably benign Het
Clec2m A G 6: 129,307,974 (GRCm39) W32R possibly damaging Het
Cntn5 G A 9: 9,748,450 (GRCm39) T477I probably damaging Het
Cyp2c37 T A 19: 39,982,202 (GRCm39) Y68N probably damaging Het
Dnah2 A T 11: 69,408,511 (GRCm39) L53* probably null Het
Dnajc11 A G 4: 152,034,909 (GRCm39) D44G probably damaging Het
Elovl3 T C 19: 46,123,168 (GRCm39) F248S probably damaging Het
Etfdh A G 3: 79,517,123 (GRCm39) L422P probably benign Het
Fam184a C A 10: 53,509,802 (GRCm39) E126* probably null Het
Fgd4 A G 16: 16,287,637 (GRCm39) Y355H probably damaging Het
Fgfr2 A G 7: 129,820,823 (GRCm39) M237T probably damaging Het
Gdap1 A T 1: 17,230,177 (GRCm39) K203N probably benign Het
Glis1 A G 4: 107,484,723 (GRCm39) D594G possibly damaging Het
Gm4787 T A 12: 81,424,679 (GRCm39) H493L probably benign Het
Gpatch3 G T 4: 133,310,308 (GRCm39) V418L probably damaging Het
Greb1 T C 12: 16,766,670 (GRCm39) N376S probably damaging Het
Hspg2 A G 4: 137,278,243 (GRCm39) Q3010R probably benign Het
Ice2 T A 9: 69,318,067 (GRCm39) F223I possibly damaging Het
Marchf11 A G 15: 26,409,323 (GRCm39) T341A probably damaging Het
Mllt10 A G 2: 18,210,895 (GRCm39) K770E probably damaging Het
Mug1 A G 6: 121,838,128 (GRCm39) T453A probably benign Het
Myh15 C T 16: 48,976,009 (GRCm39) T1359I probably benign Het
Nbn A G 4: 15,958,080 (GRCm39) K3E probably damaging Het
Nlrp4a T C 7: 26,163,571 (GRCm39) F913L probably benign Het
Nlrx1 G T 9: 44,176,086 (GRCm39) A48D probably damaging Het
Noc3l C G 19: 38,783,447 (GRCm39) G643A possibly damaging Het
Or8c17 T A 9: 38,180,344 (GRCm39) N170K probably benign Het
Pde6b G T 5: 108,567,639 (GRCm39) probably null Het
Phactr1 A G 13: 43,231,205 (GRCm39) I247V unknown Het
Pid1 G T 1: 84,093,745 (GRCm39) Q48K probably benign Het
Ppfia2 A G 10: 106,699,233 (GRCm39) N794S probably benign Het
Ppox G A 1: 171,107,546 (GRCm39) S123L possibly damaging Het
Ptprd A C 4: 76,013,772 (GRCm39) D778E probably benign Het
Rgs13 A G 1: 144,016,600 (GRCm39) Y48H probably damaging Het
Rgs17 T A 10: 5,783,078 (GRCm39) M190L probably benign Het
Rictor C T 15: 6,801,635 (GRCm39) S441L probably benign Het
Scaf8 C T 17: 3,247,482 (GRCm39) P935L probably damaging Het
Slc22a6 T C 19: 8,601,253 (GRCm39) I435T probably benign Het
Slc34a1 A G 13: 23,996,648 (GRCm39) H51R probably benign Het
Snx4 T C 16: 33,112,199 (GRCm39) L378P probably damaging Het
Spns1 A G 7: 125,973,226 (GRCm39) L155P probably damaging Het
St8sia4 T C 1: 95,581,320 (GRCm39) T141A possibly damaging Het
Syt10 A T 15: 89,666,820 (GRCm39) S510R probably damaging Het
Tmprss11d A T 5: 86,457,349 (GRCm39) F241L probably benign Het
Tnfrsf21 A T 17: 43,348,816 (GRCm39) T143S probably benign Het
Trim72 A G 7: 127,609,491 (GRCm39) N431S probably benign Het
Usp43 A G 11: 67,746,615 (GRCm39) S1031P probably damaging Het
Wdr75 A G 1: 45,858,799 (GRCm39) Y656C probably benign Het
Zfp28 T C 7: 6,396,785 (GRCm39) C407R probably damaging Het
Zfp804b C T 5: 6,821,866 (GRCm39) R399Q possibly damaging Het
Zfp949 T A 9: 88,451,323 (GRCm39) C298S probably damaging Het
Other mutations in Or4f14b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01501:Or4f14b APN 2 111,774,863 (GRCm39) makesense probably null
IGL01947:Or4f14b APN 2 111,775,339 (GRCm39) missense probably benign 0.26
IGL02373:Or4f14b APN 2 111,775,178 (GRCm39) missense probably benign 0.01
IGL02682:Or4f14b APN 2 111,775,285 (GRCm39) missense probably damaging 1.00
R0714:Or4f14b UTSW 2 111,774,898 (GRCm39) missense probably benign 0.01
R1670:Or4f14b UTSW 2 111,775,264 (GRCm39) missense probably damaging 1.00
R1730:Or4f14b UTSW 2 111,775,633 (GRCm39) missense probably benign 0.45
R1733:Or4f14b UTSW 2 111,775,625 (GRCm39) missense probably benign 0.13
R1773:Or4f14b UTSW 2 111,775,204 (GRCm39) missense possibly damaging 0.55
R1783:Or4f14b UTSW 2 111,775,633 (GRCm39) missense probably benign 0.45
R2180:Or4f14b UTSW 2 111,775,348 (GRCm39) missense probably benign 0.39
R2197:Or4f14b UTSW 2 111,775,658 (GRCm39) missense possibly damaging 0.64
R2207:Or4f14b UTSW 2 111,775,270 (GRCm39) missense probably damaging 1.00
R2377:Or4f14b UTSW 2 111,774,988 (GRCm39) missense probably damaging 1.00
R4425:Or4f14b UTSW 2 111,775,534 (GRCm39) missense probably benign 0.00
R4595:Or4f14b UTSW 2 111,774,997 (GRCm39) missense possibly damaging 0.86
R4859:Or4f14b UTSW 2 111,775,156 (GRCm39) missense probably damaging 0.98
R4910:Or4f14b UTSW 2 111,775,423 (GRCm39) missense possibly damaging 0.69
R5167:Or4f14b UTSW 2 111,775,447 (GRCm39) missense probably damaging 1.00
R5537:Or4f14b UTSW 2 111,775,393 (GRCm39) missense probably damaging 1.00
R6328:Or4f14b UTSW 2 111,775,739 (GRCm39) missense probably null 0.41
R6877:Or4f14b UTSW 2 111,775,184 (GRCm39) missense probably benign 0.16
R7011:Or4f14b UTSW 2 111,775,031 (GRCm39) missense probably benign 0.01
R7177:Or4f14b UTSW 2 111,775,501 (GRCm39) missense probably damaging 1.00
R8792:Or4f14b UTSW 2 111,775,073 (GRCm39) missense probably damaging 1.00
R9290:Or4f14b UTSW 2 111,774,967 (GRCm39) missense possibly damaging 0.91
R9358:Or4f14b UTSW 2 111,775,429 (GRCm39) missense probably benign 0.31
Predicted Primers PCR Primer
(F):5'- TCCTTGGGAATGTAGGTTACAG -3'
(R):5'- TGCTCACATCACTGTAGTGTTC -3'

Sequencing Primer
(F):5'- TCCTGCCTGAGTAGATGA -3'
(R):5'- ACTGTAGTGTTCTTATTCTTTGGTCC -3'
Posted On 2020-09-15