Mutagenetix > Incidental Mutation

Incidental Mutation 'R7937:Cyp2c37'

648838

Institutional Source

Beutler Lab

Gene Symbol

Cyp2c37

Ensembl Gene

ENSMUSG00000042248

Gene Name

cytochrome P450, family 2. subfamily c, polypeptide 37

Synonyms

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.092) question?

Stock #

R7937 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

39992424-40012243 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 39993758 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Asparagine at position 68 (Y68N)

Ref Sequence

ENSEMBL: ENSMUSP00000045362 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000049178]

AlphaFold

P56654

Predicted Effect

probably damaging
Transcript: ENSMUST00000049178
AA Change: Y68N

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000045362
Gene: ENSMUSG00000042248
AA Change: Y68N

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
Pfam:p450	30	487	5e-160	PFAM

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 99.0%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 59 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4922502D21Rik	A	G	6: 129,331,011	W32R	possibly damaging	Het
Abcb11	GTTGATCCATACA	G	2: 69,323,873		probably benign	Het
Ano6	C	A	15: 95,972,589	T875K	probably damaging	Het
Armc8	G	A	9: 99,536,219	T94I	probably damaging	Het
Ash1l	C	T	3: 89,070,317	R2685*	probably null	Het
Bri3bp	A	T	5: 125,454,331	N114Y	probably damaging	Het
Camkk2	G	T	5: 122,764,034	Q71K	probably benign	Het
Cc2d2b	T	C	19: 40,777,292	F49S		Het
Cdh10	A	G	15: 18,964,249	T166A	probably benign	Het
Chd8	A	G	14: 52,227,506	F633L	probably benign	Het
Cntn5	G	A	9: 9,748,445	T477I	probably damaging	Het
Dnah2	A	T	11: 69,517,685	L53*	probably null	Het
Dnajc11	A	G	4: 151,950,452	D44G	probably damaging	Het
Elovl3	T	C	19: 46,134,729	F248S	probably damaging	Het
Etfdh	A	G	3: 79,609,816	L422P	probably benign	Het
Fam184a	C	A	10: 53,633,706	E126*	probably null	Het
Fgd4	A	G	16: 16,469,773	Y355H	probably damaging	Het
Fgfr2	A	G	7: 130,219,093	M237T	probably damaging	Het
Gdap1	A	T	1: 17,159,953	K203N	probably benign	Het
Glis1	A	G	4: 107,627,526	D594G	possibly damaging	Het
Gm4787	T	A	12: 81,377,905	H493L	probably benign	Het
Gpatch3	G	T	4: 133,582,997	V418L	probably damaging	Het
Greb1	T	C	12: 16,716,669	N376S	probably damaging	Het
Hspg2	A	G	4: 137,550,932	Q3010R	probably benign	Het
Ice2	T	A	9: 69,410,785	F223I	possibly damaging	Het
March11	A	G	15: 26,409,237	T341A	probably damaging	Het
Mllt10	A	G	2: 18,206,084	K770E	probably damaging	Het
Mug1	A	G	6: 121,861,169	T453A	probably benign	Het
Myh15	C	T	16: 49,155,646	T1359I	probably benign	Het
Nbn	A	G	4: 15,958,080	K3E	probably damaging	Het
Nlrp4a	T	C	7: 26,464,146	F913L	probably benign	Het
Nlrx1	G	T	9: 44,264,789	A48D	probably damaging	Het
Noc3l	C	G	19: 38,795,003	G643A	possibly damaging	Het
Olfr1307	T	C	2: 111,944,530	R309G	probably benign	Het
Olfr895	T	A	9: 38,269,048	N170K	probably benign	Het
Pde6b	G	T	5: 108,419,773		probably null	Het
Phactr1	A	G	13: 43,077,729	I247V	unknown	Het
Pid1	G	T	1: 84,116,024	Q48K	probably benign	Het
Ppfia2	A	G	10: 106,863,372	N794S	probably benign	Het
Ppox	G	A	1: 171,279,972	S123L	possibly damaging	Het
Ptprd	A	C	4: 76,095,535	D778E	probably benign	Het
Rgs13	A	G	1: 144,140,862	Y48H	probably damaging	Het
Rgs17	T	A	10: 5,833,078	M190L	probably benign	Het
Rictor	C	T	15: 6,772,154	S441L	probably benign	Het
Scaf8	C	T	17: 3,197,207	P935L	probably damaging	Het
Slc17a2	A	G	13: 23,812,665	H51R	probably benign	Het
Slc22a6	T	C	19: 8,623,889	I435T	probably benign	Het
Snx4	T	C	16: 33,291,829	L378P	probably damaging	Het
Spns1	A	G	7: 126,374,054	L155P	probably damaging	Het
St8sia4	T	C	1: 95,653,595	T141A	possibly damaging	Het
Syt10	A	T	15: 89,782,617	S510R	probably damaging	Het
Tmprss11d	A	T	5: 86,309,490	F241L	probably benign	Het
Tnfrsf21	A	T	17: 43,037,925	T143S	probably benign	Het
Trim72	A	G	7: 128,010,319	N431S	probably benign	Het
Usp43	A	G	11: 67,855,789	S1031P	probably damaging	Het
Wdr75	A	G	1: 45,819,639	Y656C	probably benign	Het
Zfp28	T	C	7: 6,393,786	C407R	probably damaging	Het
Zfp804b	C	T	5: 6,771,866	R399Q	possibly damaging	Het
Zfp949	T	A	9: 88,569,270	C298S	probably damaging	Het

Other mutations in Cyp2c37

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00465:Cyp2c37	APN	19	40001997	missense	probably benign	0.00
IGL01307:Cyp2c37	APN	19	39992579	missense	probably benign	0.00
IGL01959:Cyp2c37	APN	19	39995833	nonsense	probably null
IGL02580:Cyp2c37	APN	19	39994498	missense	probably damaging	1.00
IGL02611:Cyp2c37	APN	19	39993865	missense	probably benign	0.00
R0124:Cyp2c37	UTSW	19	39994102	missense	probably damaging	1.00
R0391:Cyp2c37	UTSW	19	39994506	missense	probably damaging	1.00
R0420:Cyp2c37	UTSW	19	39995794	missense	probably benign	0.00
R0782:Cyp2c37	UTSW	19	39993825	missense	probably benign	0.00
R1413:Cyp2c37	UTSW	19	39994098	missense	probably benign	0.21
R1637:Cyp2c37	UTSW	19	40001982	nonsense	probably null
R1688:Cyp2c37	UTSW	19	39994443	splice site	probably null
R2258:Cyp2c37	UTSW	19	39995859	missense	possibly damaging	0.49
R4353:Cyp2c37	UTSW	19	40000545	missense	possibly damaging	0.66
R4640:Cyp2c37	UTSW	19	40011832	missense	possibly damaging	0.67
R4965:Cyp2c37	UTSW	19	40011762	missense	possibly damaging	0.79
R5053:Cyp2c37	UTSW	19	40001887	missense	probably benign	0.00
R5645:Cyp2c37	UTSW	19	39994152	missense	probably benign	0.04
R5847:Cyp2c37	UTSW	19	40011732	missense	probably damaging	0.98
R6487:Cyp2c37	UTSW	19	39994581	missense	probably benign
R6631:Cyp2c37	UTSW	19	40009843	missense	probably damaging	1.00
R7062:Cyp2c37	UTSW	19	39995546	splice site	probably null
R9640:Cyp2c37	UTSW	19	40011736	missense	probably benign	0.01
R9779:Cyp2c37	UTSW	19	40009879	missense	probably benign	0.09
R9784:Cyp2c37	UTSW	19	40000499	missense	possibly damaging	0.85

Predicted Primers

PCR Primer
(F):5'- TGTGTGGTCTCTTGTCACAC -3'
(R):5'- AGATGCCTGGTTGTAGCCATAG -3'

Sequencing Primer
(F):5'- GTGGTCTCTTGTCACACTATAGATC -3'
(R):5'- ATGCCTGGTTGTAGCCATAGAATCC -3'

Posted On

2020-09-15