|Institutional Source||Beutler Lab|
|Gene Name||MAP kinase-activated protein kinase 2|
|Synonyms||MAPKAP kinase 2, Rps6kc1, MK2|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R0015 (G1)|
|Chromosomal Location||131053700-131097826 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||A to G at 131097326 bp|
|Amino Acid Change||Isoleucine to Threonine at position 67 (I67T)|
|Ref Sequence||ENSEMBL: ENSMUSP00000016672 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000016672]|
|Predicted Effect||possibly damaging
AA Change: I67T
PolyPhen 2 Score 0.788 (Sensitivity: 0.85; Specificity: 0.93)
AA Change: I67T
|Meta Mutation Damage Score||0.3009|
|Coding Region Coverage||
|Validation Efficiency||97% (71/73)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Inactivation of this locus affects the inflammatory response. Homozygous null mice show an increased susceptibility to bacterial infection. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Mapkapk2||
(F):5'- GTAAAGCGAGCAGAGGCCGTCC -3'
(R):5'- GTACTTCTCGGCGCGGCGATTC -3'
(F):5'- TCCGGGTCCCAAGAGTG -3'
(R):5'- GAGCAAACTTcgccgcc -3'