Incidental Mutation 'R7940:Or8c15'
ID 649009
Institutional Source Beutler Lab
Gene Symbol Or8c15
Ensembl Gene ENSMUSG00000093901
Gene Name olfactory receptor family 8 subfamily C member 15
Synonyms GA_x6K02T2PVTD-31889215-31890153, Olfr893, MOR170-11
MMRRC Submission 045986-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.176) question?
Stock # R7940 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 38208365-38211598 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 38209200 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 47 (V47A)
Ref Sequence ENSEMBL: ENSMUSP00000148719 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000093867] [ENSMUST00000211975]
AlphaFold K7N678
Predicted Effect probably benign
Transcript: ENSMUST00000093867
AA Change: V49A

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000091390
Gene: ENSMUSG00000093901
AA Change: V49A

Pfam:7tm_4 33 309 1.2e-45 PFAM
Pfam:7tm_1 43 292 8e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000211975
AA Change: V47A

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Predicted Effect probably benign
Transcript: ENSMUST00000212815
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 98% (56/57)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310057M21Rik A G 7: 131,351,038 (GRCm38) M238T probably benign Het
Acacb C T 5: 114,166,047 (GRCm38) S177F possibly damaging Het
Afap1l2 A G 19: 56,914,165 (GRCm38) V822A probably damaging Het
Akap2 A G 4: 57,883,026 (GRCm38) K790E probably damaging Het
Alpk3 C T 7: 81,093,945 (GRCm38) P1170L probably damaging Het
Aox3 A G 1: 58,188,437 (GRCm38) I1234V probably damaging Het
Ascc1 G A 10: 60,012,559 (GRCm38) V103M probably null Het
Brca2 C G 5: 150,538,733 (GRCm38) T654S probably benign Het
Cblb T C 16: 52,152,536 (GRCm38) F410S probably damaging Het
Cep95 T A 11: 106,796,148 (GRCm38) N94K probably benign Het
Cfap57 C T 4: 118,614,931 (GRCm38) V84I probably benign Het
Cpe T A 8: 64,594,911 (GRCm38) S440C probably damaging Het
Cspg4 C T 9: 56,888,097 (GRCm38) Q1039* probably null Het
Cul5 A T 9: 53,623,769 (GRCm38) S612T probably benign Het
Dapl1 T C 2: 59,484,768 (GRCm38) probably null Het
Deptor C T 15: 55,208,848 (GRCm38) T241M probably benign Het
Dnaaf1 A G 8: 119,582,715 (GRCm38) T181A possibly damaging Het
Dnajc11 G T 4: 151,968,588 (GRCm38) Q156H probably benign Het
Dst T C 1: 34,167,676 (GRCm38) V975A possibly damaging Het
Elf3 T A 1: 135,257,128 (GRCm38) S107C probably damaging Het
Enpp2 T A 15: 54,906,928 (GRCm38) D105V probably damaging Het
Fgd6 G A 10: 94,120,482 (GRCm38) V1008I probably benign Het
Frmpd2 C T 14: 33,554,893 (GRCm38) R1157* probably null Het
Gabrg2 A C 11: 41,967,647 (GRCm38) V218G probably benign Het
Gdpgp1 C T 7: 80,239,205 (GRCm38) A328V probably damaging Het
Glis1 A T 4: 107,632,375 (GRCm38) N720Y probably damaging Het
Glis1 C G 4: 107,632,374 (GRCm38) F719L probably damaging Het
Grin2c G T 11: 115,255,281 (GRCm38) A546D probably damaging Het
Gtf3c5 G A 2: 28,568,580 (GRCm38) T433I possibly damaging Het
Jmjd6 C A 11: 116,843,229 (GRCm38) probably benign Het
Kctd14 T C 7: 97,457,684 (GRCm38) S49P probably damaging Het
Lamc2 T A 1: 153,130,775 (GRCm38) K877* probably null Het
Lgr4 T A 2: 110,006,513 (GRCm38) S397R probably damaging Het
Lrp2 A T 2: 69,432,197 (GRCm38) I4420N possibly damaging Het
Lyn A G 4: 3,783,089 (GRCm38) K441E possibly damaging Het
Minpp1 A T 19: 32,485,959 (GRCm38) S7C possibly damaging Het
Mrps9 T A 1: 42,862,648 (GRCm38) D105E probably damaging Het
Ncoa1 C A 12: 4,313,095 (GRCm38) A247S possibly damaging Het
Olfr548-ps1 G A 7: 102,542,308 (GRCm38) R124H possibly damaging Het
Pabir1 G A 19: 24,477,188 (GRCm38) R57W probably benign Het
Pcdh15 G A 10: 74,594,190 (GRCm38) V1250I probably damaging Het
Pcdha12 A T 18: 37,020,356 (GRCm38) T43S probably damaging Het
Pkn2 G A 3: 142,810,719 (GRCm38) R549C probably benign Het
Plscr4 C T 9: 92,490,790 (GRCm38) R322* probably null Het
Polq T A 16: 37,060,642 (GRCm38) M1056K probably benign Het
Ppp1r12b A T 1: 134,876,055 (GRCm38) N455K probably benign Het
Rhbdf1 T A 11: 32,216,258 (GRCm38) M1L possibly damaging Het
Rspry1 G T 8: 94,623,007 (GRCm38) V8L probably benign Het
Slc6a20b A G 9: 123,607,601 (GRCm38) V249A probably damaging Het
Smok2b A T 17: 13,236,159 (GRCm38) H402L possibly damaging Het
Supt20 A T 3: 54,713,199 (GRCm38) N393I probably benign Het
Tcp11l1 T C 2: 104,698,648 (GRCm38) K102E probably damaging Het
Tpbgl T C 7: 99,625,591 (GRCm38) Y353C probably damaging Het
Usp24 A T 4: 106,430,544 (GRCm38) Q2465L probably damaging Het
Vmn2r116 T A 17: 23,386,972 (GRCm38) M286K probably damaging Het
Wnt16 C A 6: 22,291,189 (GRCm38) N205K possibly damaging Het
Xkr7 C A 2: 153,032,215 (GRCm38) F67L probably damaging Het
Zfp473 T G 7: 44,734,576 (GRCm38) E111A probably damaging Het
Zfp74 T C 7: 29,932,442 (GRCm38) K126E probably benign Het
Other mutations in Or8c15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00331:Or8c15 APN 9 38,209,238 (GRCm38) missense probably damaging 1.00
IGL00914:Or8c15 APN 9 38,209,799 (GRCm38) splice site probably null
IGL01563:Or8c15 APN 9 38,209,701 (GRCm38) missense probably damaging 1.00
IGL01696:Or8c15 APN 9 38,209,049 (GRCm38) unclassified probably benign
IGL02064:Or8c15 APN 9 38,209,578 (GRCm38) missense probably damaging 1.00
IGL02605:Or8c15 APN 9 38,209,236 (GRCm38) missense probably damaging 0.99
R0415:Or8c15 UTSW 9 38,209,973 (GRCm38) missense probably benign
R0463:Or8c15 UTSW 9 38,209,064 (GRCm38) missense probably benign 0.00
R0843:Or8c15 UTSW 9 38,209,283 (GRCm38) missense possibly damaging 0.81
R1441:Or8c15 UTSW 9 38,209,481 (GRCm38) missense probably damaging 1.00
R1939:Or8c15 UTSW 9 38,209,429 (GRCm38) nonsense probably null
R2512:Or8c15 UTSW 9 38,209,374 (GRCm38) missense probably damaging 1.00
R4890:Or8c15 UTSW 9 38,209,290 (GRCm38) missense probably benign 0.00
R5439:Or8c15 UTSW 9 38,209,754 (GRCm38) missense probably benign 0.00
R6918:Or8c15 UTSW 9 38,209,652 (GRCm38) missense possibly damaging 0.95
R7621:Or8c15 UTSW 9 38,209,151 (GRCm38) missense probably benign 0.09
R7715:Or8c15 UTSW 9 38,209,479 (GRCm38) missense probably benign 0.30
R8710:Or8c15 UTSW 9 38,209,770 (GRCm38) missense possibly damaging 0.60
R8712:Or8c15 UTSW 9 38,209,803 (GRCm38) missense probably benign 0.39
R8882:Or8c15 UTSW 9 38,209,165 (GRCm38) nonsense probably null
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2020-09-15