Mutagenetix > Incidental Mutation

Incidental Mutation 'R7941:Or5w11'

649039

Institutional Source

Beutler Lab

Gene Symbol

Or5w11

Ensembl Gene

ENSMUSG00000068819

Gene Name

olfactory receptor family 5 subfamily W member 11

Synonyms

GA_x6K02T2Q125-49133664-49134593, MOR177-4, Olfr1131

MMRRC Submission

045987-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.073) question?

Stock #

R7941 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

87458809-87459738 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 87459248 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 31 (V31A)

Ref Sequence

ENSEMBL: ENSMUSP00000148881 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000090712] [ENSMUST00000213302] [ENSMUST00000216082] [ENSMUST00000216756]

AlphaFold

Q7TR45

Predicted Effect

probably benign
Transcript: ENSMUST00000090712
AA Change: V147A

PolyPhen 2 Score 0.059 (Sensitivity: 0.94; Specificity: 0.84)

SMART Domains

Protein: ENSMUSP00000088214
Gene: ENSMUSG00000068819
AA Change: V147A

Domain	Start	End	E-Value	Type
Pfam:7tm_4	30	307	5.2e-47	PFAM
Pfam:7tm_1	40	289	1.7e-18	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000213302
AA Change: V147A

PolyPhen 2 Score 0.059 (Sensitivity: 0.94; Specificity: 0.84)

Predicted Effect

probably benign
Transcript: ENSMUST00000216082

Predicted Effect

probably benign
Transcript: ENSMUST00000216756
AA Change: V31A

PolyPhen 2 Score 0.059 (Sensitivity: 0.94; Specificity: 0.84)

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 98.9%

Validation Efficiency

98% (43/44)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abl1	T	C	2: 31,579,691 (GRCm39)		probably benign	Het
AI467606	A	G	7: 126,691,593 (GRCm39)	E56G	probably damaging	Het
Ak9	C	T	10: 41,285,133 (GRCm39)	P1403S	unknown	Het
Akr1c14	A	G	13: 4,109,713 (GRCm39)	K28E	probably benign	Het
Ampd2	C	A	3: 107,987,432 (GRCm39)	V134L	probably benign	Het
Anks1b	A	T	10: 90,413,017 (GRCm39)	N55I	probably damaging	Het
Cabyr	T	C	18: 12,877,825 (GRCm39)	L54P	probably damaging	Het
Cachd1	A	T	4: 100,845,370 (GRCm39)	N954I	probably damaging	Het
Cenpf	A	G	1: 189,389,483 (GRCm39)	S1450P	probably damaging	Het
Chst10	T	A	1: 38,910,772 (GRCm39)	I131L	probably damaging	Het
Cluh	A	T	11: 74,550,583 (GRCm39)	M270L	probably benign	Het
Dagla	T	C	19: 10,248,867 (GRCm39)	H29R	probably damaging	Het
Dusp5	A	G	19: 53,525,964 (GRCm39)	N202S	probably benign	Het
Elavl3	A	G	9: 21,947,612 (GRCm39)	I110T	possibly damaging	Het
Fam222b	G	T	11: 78,045,885 (GRCm39)	G482V	possibly damaging	Het
Fbxl7	A	G	15: 26,543,699 (GRCm39)	L316P	probably damaging	Het
Gad1	T	A	2: 70,424,929 (GRCm39)		probably null	Het
H2-K2	T	C	17: 34,218,305 (GRCm39)	T204A	probably benign	Het
Hmcn1	A	G	1: 150,525,835 (GRCm39)	V3296A	possibly damaging	Het
Hyal1	T	C	9: 107,455,299 (GRCm39)	F203S	probably damaging	Het
Il16	T	A	7: 83,332,037 (GRCm39)	D181V	probably damaging	Het
Ip6k1	T	C	9: 107,901,631 (GRCm39)	F69L	probably damaging	Het
Klf4	G	A	4: 55,531,755 (GRCm39)		probably benign	Het
Lsr	T	G	7: 30,672,520 (GRCm39)	I27L	probably benign	Het
Mettl4	A	T	17: 95,040,622 (GRCm39)		probably null	Het
Mpdz	A	G	4: 81,200,987 (GRCm39)	V1902A	probably benign	Het
Nfkbiz	C	T	16: 55,642,307 (GRCm39)	G37D	probably damaging	Het
Otogl	A	T	10: 107,642,663 (GRCm39)		probably null	Het
Pcdh1	T	C	18: 38,332,133 (GRCm39)	D429G	probably damaging	Het
Pramel34	A	T	5: 93,785,887 (GRCm39)	V131D	probably benign	Het
Prelid2	A	T	18: 42,065,816 (GRCm39)	L73*	probably null	Het
Psg20	T	A	7: 18,415,102 (GRCm39)		probably null	Het
Ptprb	GAGACCCTCGGGAGCACTGCAAAGACCCTCGGGAGCACTGCAAAGACCCTCGGGAGCACTGCAAAGACCCTCGGGAGCACT	GAGACCCTCGGGAGCACTGCAAAGACCCTCGGGAGCACTGCAAAGACCCTCGGGAGCACT	10: 116,119,582 (GRCm39)		probably benign	Het
Rab24	C	T	13: 55,468,120 (GRCm39)		probably null	Het
Rag1	T	G	2: 101,472,691 (GRCm39)	K817T	probably benign	Het
Rgl2	T	C	17: 34,150,713 (GRCm39)	V57A	probably benign	Het
Ric1	T	C	19: 29,510,659 (GRCm39)	M80T	probably damaging	Het
Sh3rf3	T	C	10: 58,842,883 (GRCm39)	I283T	probably damaging	Het
Skint2	C	A	4: 112,483,187 (GRCm39)	N197K	probably damaging	Het
Snapc4	A	G	2: 26,266,730 (GRCm39)	I126T	probably damaging	Het
Srcap	GTCCTCCTCCTCCTCCTCCTGCTCCTCCTCCTCCTCCT	GTCCTCCTCCTCCTCCTGCTCCTCCTCCTCCTCCT	7: 127,157,462 (GRCm39)		probably benign	Het
Svip	T	C	7: 51,653,161 (GRCm39)	K51R	probably benign	Het
Syndig1	T	A	2: 149,741,708 (GRCm39)	V98E	probably benign	Het
Tshz1	A	T	18: 84,033,517 (GRCm39)	M297K	possibly damaging	Het
Ttn	A	G	2: 76,749,694 (GRCm39)	V3785A	probably benign	Het
Usf3	T	C	16: 44,035,924 (GRCm39)	S135P	probably damaging	Het
Vmn2r10	A	T	5: 109,144,306 (GRCm39)	M548K	probably damaging	Het
Vmn2r92	T	C	17: 18,405,099 (GRCm39)	S748P	possibly damaging	Het
Zbtb39	A	G	10: 127,579,409 (GRCm39)	Y661C	probably damaging	Het
Zfp804b	A	G	5: 6,820,042 (GRCm39)	I1007T	probably benign	Het
Zscan4-ps2	A	G	7: 11,251,599 (GRCm39)	I212V	probably benign	Het

Other mutations in Or5w11

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01388:Or5w11	APN	2	87,458,973 (GRCm39)	missense	probably benign	0.03
IGL02186:Or5w11	APN	2	87,459,715 (GRCm39)	missense	probably benign	0.00
R0266:Or5w11	UTSW	2	87,459,626 (GRCm39)	missense	possibly damaging	0.79
R0849:Or5w11	UTSW	2	87,459,626 (GRCm39)	missense	possibly damaging	0.79
R1607:Or5w11	UTSW	2	87,459,321 (GRCm39)	missense	probably benign	0.14
R2077:Or5w11	UTSW	2	87,459,173 (GRCm39)	missense	probably damaging	1.00
R2105:Or5w11	UTSW	2	87,459,283 (GRCm39)	missense	probably benign	0.20
R2322:Or5w11	UTSW	2	87,459,118 (GRCm39)	missense	possibly damaging	0.86
R3434:Or5w11	UTSW	2	87,459,418 (GRCm39)	missense	probably benign	0.02
R4357:Or5w11	UTSW	2	87,458,810 (GRCm39)	start codon destroyed	probably null	1.00
R5139:Or5w11	UTSW	2	87,459,000 (GRCm39)	missense	probably benign	0.03
R5333:Or5w11	UTSW	2	87,459,458 (GRCm39)	missense	probably damaging	0.97
R5719:Or5w11	UTSW	2	87,459,475 (GRCm39)	splice site	probably null
R6449:Or5w11	UTSW	2	87,459,493 (GRCm39)	missense	possibly damaging	0.63
R7640:Or5w11	UTSW	2	87,459,436 (GRCm39)	missense	probably benign	0.01
R8110:Or5w11	UTSW	2	87,458,951 (GRCm39)	missense	possibly damaging	0.75
R8393:Or5w11	UTSW	2	87,459,197 (GRCm39)	missense	probably damaging	0.97
R8877:Or5w11	UTSW	2	87,459,212 (GRCm39)	missense	probably damaging	1.00
R9250:Or5w11	UTSW	2	87,459,278 (GRCm39)	missense	probably benign	0.02
R9290:Or5w11	UTSW	2	87,459,209 (GRCm39)	missense	probably benign	0.00
R9313:Or5w11	UTSW	2	87,459,076 (GRCm39)	missense	probably benign	0.03
R9666:Or5w11	UTSW	2	87,459,152 (GRCm39)	missense	possibly damaging	0.78
X0027:Or5w11	UTSW	2	87,459,647 (GRCm39)	missense	possibly damaging	0.96
Z1176:Or5w11	UTSW	2	87,459,659 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- CAATTGGTCCCAAGATGCTGC -3'
(R):5'- GTGCTCAGTTCAAGGAAGCC -3'

Sequencing Primer
(F):5'- GTCCCAAGATGCTGCTAGATATG -3'
(R):5'- CTCAGTTCAAGGAAGCCATAAATAG -3'

Posted On

2020-09-15