Incidental Mutation 'R0015:Or8b37'
ID 64904
Institutional Source Beutler Lab
Gene Symbol Or8b37
Ensembl Gene ENSMUSG00000095893
Gene Name olfactory receptor family 8 subfamily B member 37
Synonyms GA_x6K02T2PVTD-31726544-31727473, MOR162-9P, MOR162-11P, Olfr1550-ps1, MOR162-13, Olfr884, MOR162-11P
MMRRC Submission 038310-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.089) question?
Stock # R0015 (G1)
Quality Score 209
Status Validated
Chromosome 9
Chromosomal Location 37957851-37961433 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 37958963 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 148 (Y148*)
Ref Sequence ENSEMBL: ENSMUSP00000138035 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077732] [ENSMUST00000181088]
AlphaFold Q7TRE1
Predicted Effect probably null
Transcript: ENSMUST00000077732
AA Change: Y148*
SMART Domains Protein: ENSMUSP00000076912
Gene: ENSMUSG00000095893
AA Change: Y148*

DomainStartEndE-ValueType
Pfam:7tm_4 31 306 8e-51 PFAM
Pfam:7TM_GPCR_Srsx 35 300 1.5e-6 PFAM
Pfam:7tm_1 41 288 5.1e-24 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000181088
AA Change: Y148*
SMART Domains Protein: ENSMUSP00000138035
Gene: ENSMUSG00000095893
AA Change: Y148*

DomainStartEndE-ValueType
low complexity region 14 33 N/A INTRINSIC
Pfam:7TM_GPCR_Srsx 35 300 1.5e-6 PFAM
Pfam:7tm_1 41 288 4.6e-30 PFAM
Pfam:7tm_4 138 281 3.9e-45 PFAM
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.2%
Validation Efficiency 97% (71/73)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A130050O07Rik A G 1: 137,856,394 (GRCm39) Y23C unknown Het
Adcy3 G A 12: 4,245,260 (GRCm39) probably null Het
Aldh6a1 G A 12: 84,488,554 (GRCm39) L86F probably damaging Het
Arl10 G T 13: 54,723,770 (GRCm39) probably benign Het
Armc3 A G 2: 19,301,132 (GRCm39) probably null Het
Astn2 T G 4: 66,184,619 (GRCm39) probably null Het
Cacna1d G A 14: 29,836,928 (GRCm39) T804I probably benign Het
Ccny A C 18: 9,316,682 (GRCm39) probably benign Het
Cdh5 C T 8: 104,867,559 (GRCm39) T612I probably benign Het
Cfap58 A G 19: 48,017,539 (GRCm39) M800V probably benign Het
Clrn1 A T 3: 58,753,848 (GRCm39) I171K probably damaging Het
Cnp T A 11: 100,469,734 (GRCm39) probably null Het
Col12a1 T C 9: 79,558,667 (GRCm39) T1933A probably damaging Het
Cplane1 G A 15: 8,215,668 (GRCm39) R408H probably damaging Het
Cwf19l2 A G 9: 3,454,666 (GRCm39) S660G probably benign Het
Dync1i2 C A 2: 71,044,828 (GRCm39) R13S probably damaging Het
Eps8l1 A T 7: 4,480,556 (GRCm39) probably benign Het
Espn T C 4: 152,223,609 (GRCm39) T188A possibly damaging Het
F2 T C 2: 91,460,952 (GRCm39) E260G probably benign Het
Fat4 T A 3: 39,036,652 (GRCm39) S3435T probably damaging Het
Fchsd1 A G 18: 38,096,012 (GRCm39) C533R probably benign Het
Fstl5 G A 3: 76,229,498 (GRCm39) V100M probably damaging Het
Gls2 T G 10: 128,045,219 (GRCm39) L572R probably damaging Het
Gm20939 A T 17: 95,184,196 (GRCm39) E281D probably benign Het
Gpr35 T G 1: 92,910,954 (GRCm39) L222W probably damaging Het
Hsf5 C A 11: 87,548,161 (GRCm39) H615N probably benign Het
Id2 C T 12: 25,145,802 (GRCm39) D70N probably damaging Het
Ints2 T C 11: 86,140,113 (GRCm39) T240A probably damaging Het
Kcnn3 A C 3: 89,570,080 (GRCm39) D631A probably damaging Het
Klhdc8a A G 1: 132,230,743 (GRCm39) T203A probably damaging Het
Lama4 C T 10: 38,951,432 (GRCm39) T1059M possibly damaging Het
Lgals8 A G 13: 12,462,179 (GRCm39) L226P probably damaging Het
Lifr T A 15: 7,217,667 (GRCm39) probably null Het
Lonp1 T A 17: 56,925,406 (GRCm39) Q462L probably benign Het
Lypd1 A G 1: 125,838,175 (GRCm39) V48A possibly damaging Het
Mapkapk2 A G 1: 131,025,063 (GRCm39) I67T possibly damaging Het
Mbd3l1 A T 9: 18,396,154 (GRCm39) D93V probably benign Het
Mdh1b T C 1: 63,760,959 (GRCm39) probably benign Het
Myh7b C T 2: 155,464,206 (GRCm39) P569L probably damaging Het
Ncapd3 C A 9: 26,963,105 (GRCm39) A470E probably damaging Het
Ndrg2 A G 14: 52,147,902 (GRCm39) probably benign Het
Nprl2 A T 9: 107,421,618 (GRCm39) I209F probably damaging Het
Ntrk1 A G 3: 87,699,057 (GRCm39) probably benign Het
Olfm2 T C 9: 20,580,037 (GRCm39) E268G probably damaging Het
Pcf11 T A 7: 92,307,525 (GRCm39) H881L probably benign Het
Pde10a A G 17: 9,196,029 (GRCm39) D640G probably damaging Het
Pde9a G A 17: 31,605,330 (GRCm39) probably null Het
Pianp G T 6: 124,978,503 (GRCm39) G236V probably damaging Het
Polr2g A G 19: 8,771,016 (GRCm39) I160T probably damaging Het
Ppp1r3a A G 6: 14,717,660 (GRCm39) S1085P possibly damaging Het
Pter G A 2: 13,005,811 (GRCm39) G328D probably damaging Het
Rad51 T A 2: 118,946,808 (GRCm39) M5K probably benign Het
Rbm43 T A 2: 51,815,679 (GRCm39) I181F probably benign Het
Rgs12 T C 5: 35,180,120 (GRCm39) probably benign Het
Rnf213 A C 11: 119,332,432 (GRCm39) D2547A possibly damaging Het
Slc20a2 C A 8: 23,025,361 (GRCm39) A21E probably damaging Het
Stab2 A G 10: 86,679,481 (GRCm39) S2503P probably benign Het
Sv2b A T 7: 74,775,389 (GRCm39) F479L probably damaging Het
Sybu T C 15: 44,536,896 (GRCm39) R349G probably damaging Het
Tead3 T C 17: 28,560,325 (GRCm39) Y2C probably damaging Het
Tnrc6c T A 11: 117,612,284 (GRCm39) N307K probably damaging Het
Ubxn11 C G 4: 133,843,336 (GRCm39) probably null Het
Ust T C 10: 8,205,829 (GRCm39) probably benign Het
Vmn2r116 T A 17: 23,620,823 (GRCm39) N852K probably benign Het
Zgrf1 T C 3: 127,349,046 (GRCm39) probably benign Het
Other mutations in Or8b37
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00870:Or8b37 APN 9 37,959,036 (GRCm39) missense probably damaging 1.00
IGL02612:Or8b37 APN 9 37,958,662 (GRCm39) missense probably damaging 1.00
IGL02802:Or8b37 UTSW 9 37,959,345 (GRCm39) missense probably damaging 0.99
R0142:Or8b37 UTSW 9 37,959,406 (GRCm39) missense probably benign 0.37
R0559:Or8b37 UTSW 9 37,959,123 (GRCm39) missense probably benign 0.16
R0561:Or8b37 UTSW 9 37,959,123 (GRCm39) missense probably benign 0.16
R0715:Or8b37 UTSW 9 37,959,123 (GRCm39) missense probably benign 0.16
R0723:Or8b37 UTSW 9 37,959,123 (GRCm39) missense probably benign 0.16
R0729:Or8b37 UTSW 9 37,959,123 (GRCm39) missense probably benign 0.16
R1350:Or8b37 UTSW 9 37,959,111 (GRCm39) missense probably benign 0.02
R1869:Or8b37 UTSW 9 37,959,498 (GRCm39) splice site probably null
R3917:Or8b37 UTSW 9 37,958,841 (GRCm39) missense probably damaging 1.00
R4131:Or8b37 UTSW 9 37,959,170 (GRCm39) nonsense probably null
R4764:Or8b37 UTSW 9 37,959,436 (GRCm39) missense probably benign
R5857:Or8b37 UTSW 9 37,959,049 (GRCm39) missense probably benign 0.18
R5976:Or8b37 UTSW 9 37,958,997 (GRCm39) missense possibly damaging 0.80
R6329:Or8b37 UTSW 9 37,959,121 (GRCm39) missense probably benign 0.02
R7344:Or8b37 UTSW 9 37,959,253 (GRCm39) missense probably benign
R8289:Or8b37 UTSW 9 37,959,000 (GRCm39) missense probably benign 0.02
R8485:Or8b37 UTSW 9 37,959,253 (GRCm39) missense probably benign 0.00
R8973:Or8b37 UTSW 9 37,958,839 (GRCm39) missense possibly damaging 0.95
R9026:Or8b37 UTSW 9 37,958,885 (GRCm39) nonsense probably null
R9378:Or8b37 UTSW 9 37,958,775 (GRCm39) missense possibly damaging 0.67
R9395:Or8b37 UTSW 9 37,959,136 (GRCm39) missense probably damaging 0.99
R9655:Or8b37 UTSW 9 37,959,387 (GRCm39) missense probably benign 0.00
R9731:Or8b37 UTSW 9 37,958,892 (GRCm39) missense probably damaging 1.00
RF009:Or8b37 UTSW 9 37,959,043 (GRCm39) missense probably damaging 1.00
X0052:Or8b37 UTSW 9 37,958,995 (GRCm39) missense possibly damaging 0.53
Z1177:Or8b37 UTSW 9 37,959,111 (GRCm39) missense possibly damaging 0.95
Predicted Primers PCR Primer
(F):5'- CTATGTGGTCTCCATGTTGGGGAAC -3'
(R):5'- AAGAGAGTCAGGCTGGGCACTATC -3'

Sequencing Primer
(F):5'- CATAACCCCTAGAATGTTGGTGG -3'
(R):5'- GCTGGGCACTATCACATTGAC -3'
Posted On 2013-08-06