Incidental Mutation 'R7941:Vmn2r10'
ID |
649049 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r10
|
Ensembl Gene |
ENSMUSG00000067010 |
Gene Name |
vomeronasal 2, receptor 10 |
Synonyms |
VR16, V2r16 |
MMRRC Submission |
045987-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.085)
|
Stock # |
R7941 (G1)
|
Quality Score |
225.009 |
Status
|
Validated
|
Chromosome |
5 |
Chromosomal Location |
109141278-109154337 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to T
at 109144306 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Methionine to Lysine
at position 548
(M548K)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000078162
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000079163]
[ENSMUST00000176594]
|
AlphaFold |
K7N621 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000079163
AA Change: M548K
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
SMART Domains |
Protein: ENSMUSP00000078162 Gene: ENSMUSG00000067010 AA Change: M548K
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
75 |
464 |
8.5e-29 |
PFAM |
Pfam:NCD3G
|
506 |
560 |
3.8e-17 |
PFAM |
Pfam:7tm_3
|
593 |
828 |
4e-55 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000176594
|
SMART Domains |
Protein: ENSMUSP00000135274 Gene: ENSMUSG00000067010
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 98.9%
|
Validation Efficiency |
98% (43/44) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 51 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Abl1 |
T |
C |
2: 31,579,691 (GRCm39) |
|
probably benign |
Het |
AI467606 |
A |
G |
7: 126,691,593 (GRCm39) |
E56G |
probably damaging |
Het |
Ak9 |
C |
T |
10: 41,285,133 (GRCm39) |
P1403S |
unknown |
Het |
Akr1c14 |
A |
G |
13: 4,109,713 (GRCm39) |
K28E |
probably benign |
Het |
Ampd2 |
C |
A |
3: 107,987,432 (GRCm39) |
V134L |
probably benign |
Het |
Anks1b |
A |
T |
10: 90,413,017 (GRCm39) |
N55I |
probably damaging |
Het |
Cabyr |
T |
C |
18: 12,877,825 (GRCm39) |
L54P |
probably damaging |
Het |
Cachd1 |
A |
T |
4: 100,845,370 (GRCm39) |
N954I |
probably damaging |
Het |
Cenpf |
A |
G |
1: 189,389,483 (GRCm39) |
S1450P |
probably damaging |
Het |
Chst10 |
T |
A |
1: 38,910,772 (GRCm39) |
I131L |
probably damaging |
Het |
Cluh |
A |
T |
11: 74,550,583 (GRCm39) |
M270L |
probably benign |
Het |
Dagla |
T |
C |
19: 10,248,867 (GRCm39) |
H29R |
probably damaging |
Het |
Dusp5 |
A |
G |
19: 53,525,964 (GRCm39) |
N202S |
probably benign |
Het |
Elavl3 |
A |
G |
9: 21,947,612 (GRCm39) |
I110T |
possibly damaging |
Het |
Fam222b |
G |
T |
11: 78,045,885 (GRCm39) |
G482V |
possibly damaging |
Het |
Fbxl7 |
A |
G |
15: 26,543,699 (GRCm39) |
L316P |
probably damaging |
Het |
Gad1 |
T |
A |
2: 70,424,929 (GRCm39) |
|
probably null |
Het |
H2-K2 |
T |
C |
17: 34,218,305 (GRCm39) |
T204A |
probably benign |
Het |
Hmcn1 |
A |
G |
1: 150,525,835 (GRCm39) |
V3296A |
possibly damaging |
Het |
Hyal1 |
T |
C |
9: 107,455,299 (GRCm39) |
F203S |
probably damaging |
Het |
Il16 |
T |
A |
7: 83,332,037 (GRCm39) |
D181V |
probably damaging |
Het |
Ip6k1 |
T |
C |
9: 107,901,631 (GRCm39) |
F69L |
probably damaging |
Het |
Klf4 |
G |
A |
4: 55,531,755 (GRCm39) |
|
probably benign |
Het |
Lsr |
T |
G |
7: 30,672,520 (GRCm39) |
I27L |
probably benign |
Het |
Mettl4 |
A |
T |
17: 95,040,622 (GRCm39) |
|
probably null |
Het |
Mpdz |
A |
G |
4: 81,200,987 (GRCm39) |
V1902A |
probably benign |
Het |
Nfkbiz |
C |
T |
16: 55,642,307 (GRCm39) |
G37D |
probably damaging |
Het |
Or5w11 |
T |
C |
2: 87,459,248 (GRCm39) |
V31A |
probably benign |
Het |
Otogl |
A |
T |
10: 107,642,663 (GRCm39) |
|
probably null |
Het |
Pcdh1 |
T |
C |
18: 38,332,133 (GRCm39) |
D429G |
probably damaging |
Het |
Pramel34 |
A |
T |
5: 93,785,887 (GRCm39) |
V131D |
probably benign |
Het |
Prelid2 |
A |
T |
18: 42,065,816 (GRCm39) |
L73* |
probably null |
Het |
Psg20 |
T |
A |
7: 18,415,102 (GRCm39) |
|
probably null |
Het |
Ptprb |
GAGACCCTCGGGAGCACTGCAAAGACCCTCGGGAGCACTGCAAAGACCCTCGGGAGCACTGCAAAGACCCTCGGGAGCACT |
GAGACCCTCGGGAGCACTGCAAAGACCCTCGGGAGCACTGCAAAGACCCTCGGGAGCACT |
10: 116,119,582 (GRCm39) |
|
probably benign |
Het |
Rab24 |
C |
T |
13: 55,468,120 (GRCm39) |
|
probably null |
Het |
Rag1 |
T |
G |
2: 101,472,691 (GRCm39) |
K817T |
probably benign |
Het |
Rgl2 |
T |
C |
17: 34,150,713 (GRCm39) |
V57A |
probably benign |
Het |
Ric1 |
T |
C |
19: 29,510,659 (GRCm39) |
M80T |
probably damaging |
Het |
Sh3rf3 |
T |
C |
10: 58,842,883 (GRCm39) |
I283T |
probably damaging |
Het |
Skint2 |
C |
A |
4: 112,483,187 (GRCm39) |
N197K |
probably damaging |
Het |
Snapc4 |
A |
G |
2: 26,266,730 (GRCm39) |
I126T |
probably damaging |
Het |
Srcap |
GTCCTCCTCCTCCTCCTCCTGCTCCTCCTCCTCCTCCT |
GTCCTCCTCCTCCTCCTGCTCCTCCTCCTCCTCCT |
7: 127,157,462 (GRCm39) |
|
probably benign |
Het |
Svip |
T |
C |
7: 51,653,161 (GRCm39) |
K51R |
probably benign |
Het |
Syndig1 |
T |
A |
2: 149,741,708 (GRCm39) |
V98E |
probably benign |
Het |
Tshz1 |
A |
T |
18: 84,033,517 (GRCm39) |
M297K |
possibly damaging |
Het |
Ttn |
A |
G |
2: 76,749,694 (GRCm39) |
V3785A |
probably benign |
Het |
Usf3 |
T |
C |
16: 44,035,924 (GRCm39) |
S135P |
probably damaging |
Het |
Vmn2r92 |
T |
C |
17: 18,405,099 (GRCm39) |
S748P |
possibly damaging |
Het |
Zbtb39 |
A |
G |
10: 127,579,409 (GRCm39) |
Y661C |
probably damaging |
Het |
Zfp804b |
A |
G |
5: 6,820,042 (GRCm39) |
I1007T |
probably benign |
Het |
Zscan4-ps2 |
A |
G |
7: 11,251,599 (GRCm39) |
I212V |
probably benign |
Het |
|
Other mutations in Vmn2r10 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00816:Vmn2r10
|
APN |
5 |
109,150,451 (GRCm39) |
missense |
possibly damaging |
0.75 |
IGL01618:Vmn2r10
|
APN |
5 |
109,150,345 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01624:Vmn2r10
|
APN |
5 |
109,154,112 (GRCm39) |
missense |
possibly damaging |
0.83 |
IGL01941:Vmn2r10
|
APN |
5 |
109,143,820 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01959:Vmn2r10
|
APN |
5 |
109,145,571 (GRCm39) |
missense |
probably benign |
0.00 |
IGL01973:Vmn2r10
|
APN |
5 |
109,143,543 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01985:Vmn2r10
|
APN |
5 |
109,154,125 (GRCm39) |
missense |
probably benign |
0.21 |
IGL02451:Vmn2r10
|
APN |
5 |
109,143,788 (GRCm39) |
nonsense |
probably null |
|
IGL02503:Vmn2r10
|
APN |
5 |
109,151,341 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03275:Vmn2r10
|
APN |
5 |
109,151,243 (GRCm39) |
missense |
probably benign |
0.00 |
R0035:Vmn2r10
|
UTSW |
5 |
109,145,467 (GRCm39) |
splice site |
probably benign |
|
R0395:Vmn2r10
|
UTSW |
5 |
109,149,859 (GRCm39) |
missense |
probably damaging |
1.00 |
R0454:Vmn2r10
|
UTSW |
5 |
109,151,327 (GRCm39) |
missense |
probably benign |
0.25 |
R0648:Vmn2r10
|
UTSW |
5 |
109,143,782 (GRCm39) |
missense |
probably benign |
0.00 |
R1251:Vmn2r10
|
UTSW |
5 |
109,143,890 (GRCm39) |
missense |
probably benign |
0.01 |
R1580:Vmn2r10
|
UTSW |
5 |
109,154,117 (GRCm39) |
missense |
possibly damaging |
0.82 |
R1845:Vmn2r10
|
UTSW |
5 |
109,149,861 (GRCm39) |
nonsense |
probably null |
|
R1986:Vmn2r10
|
UTSW |
5 |
109,154,120 (GRCm39) |
nonsense |
probably null |
|
R2137:Vmn2r10
|
UTSW |
5 |
109,151,410 (GRCm39) |
missense |
possibly damaging |
0.87 |
R2495:Vmn2r10
|
UTSW |
5 |
109,143,961 (GRCm39) |
missense |
probably damaging |
1.00 |
R3932:Vmn2r10
|
UTSW |
5 |
109,150,088 (GRCm39) |
missense |
possibly damaging |
0.47 |
R3933:Vmn2r10
|
UTSW |
5 |
109,150,088 (GRCm39) |
missense |
possibly damaging |
0.47 |
R4899:Vmn2r10
|
UTSW |
5 |
109,151,324 (GRCm39) |
missense |
probably damaging |
1.00 |
R4992:Vmn2r10
|
UTSW |
5 |
109,145,592 (GRCm39) |
missense |
possibly damaging |
0.89 |
R5124:Vmn2r10
|
UTSW |
5 |
109,154,286 (GRCm39) |
missense |
probably benign |
0.01 |
R5145:Vmn2r10
|
UTSW |
5 |
109,143,761 (GRCm39) |
missense |
possibly damaging |
0.64 |
R5156:Vmn2r10
|
UTSW |
5 |
109,143,466 (GRCm39) |
missense |
probably benign |
0.11 |
R5265:Vmn2r10
|
UTSW |
5 |
109,143,586 (GRCm39) |
missense |
probably damaging |
1.00 |
R5311:Vmn2r10
|
UTSW |
5 |
109,154,121 (GRCm39) |
missense |
probably damaging |
1.00 |
R5321:Vmn2r10
|
UTSW |
5 |
109,143,505 (GRCm39) |
missense |
probably damaging |
1.00 |
R5666:Vmn2r10
|
UTSW |
5 |
109,146,910 (GRCm39) |
nonsense |
probably null |
|
R5670:Vmn2r10
|
UTSW |
5 |
109,146,910 (GRCm39) |
nonsense |
probably null |
|
R5872:Vmn2r10
|
UTSW |
5 |
109,151,377 (GRCm39) |
missense |
possibly damaging |
0.84 |
R6004:Vmn2r10
|
UTSW |
5 |
109,146,944 (GRCm39) |
missense |
probably benign |
0.30 |
R6108:Vmn2r10
|
UTSW |
5 |
109,143,667 (GRCm39) |
missense |
probably damaging |
1.00 |
R6332:Vmn2r10
|
UTSW |
5 |
109,151,328 (GRCm39) |
missense |
probably damaging |
1.00 |
R6599:Vmn2r10
|
UTSW |
5 |
109,143,944 (GRCm39) |
missense |
probably benign |
0.09 |
R6651:Vmn2r10
|
UTSW |
5 |
109,143,488 (GRCm39) |
missense |
probably null |
0.22 |
R6891:Vmn2r10
|
UTSW |
5 |
109,149,845 (GRCm39) |
missense |
probably damaging |
1.00 |
R7023:Vmn2r10
|
UTSW |
5 |
109,149,894 (GRCm39) |
missense |
probably damaging |
0.96 |
R7146:Vmn2r10
|
UTSW |
5 |
109,151,200 (GRCm39) |
missense |
probably damaging |
1.00 |
R8058:Vmn2r10
|
UTSW |
5 |
109,149,955 (GRCm39) |
missense |
probably benign |
0.00 |
R8478:Vmn2r10
|
UTSW |
5 |
109,143,636 (GRCm39) |
missense |
probably damaging |
1.00 |
R8526:Vmn2r10
|
UTSW |
5 |
109,145,572 (GRCm39) |
missense |
possibly damaging |
0.51 |
R8698:Vmn2r10
|
UTSW |
5 |
109,151,390 (GRCm39) |
missense |
probably benign |
0.00 |
R8796:Vmn2r10
|
UTSW |
5 |
109,143,917 (GRCm39) |
missense |
possibly damaging |
0.74 |
R8854:Vmn2r10
|
UTSW |
5 |
109,144,126 (GRCm39) |
missense |
probably benign |
0.20 |
R8871:Vmn2r10
|
UTSW |
5 |
109,146,899 (GRCm39) |
missense |
possibly damaging |
0.67 |
R8893:Vmn2r10
|
UTSW |
5 |
109,143,677 (GRCm39) |
missense |
probably benign |
0.09 |
R8907:Vmn2r10
|
UTSW |
5 |
109,149,791 (GRCm39) |
missense |
probably benign |
|
R8957:Vmn2r10
|
UTSW |
5 |
109,149,780 (GRCm39) |
missense |
possibly damaging |
0.60 |
R8976:Vmn2r10
|
UTSW |
5 |
109,145,479 (GRCm39) |
missense |
probably damaging |
1.00 |
R9155:Vmn2r10
|
UTSW |
5 |
109,144,212 (GRCm39) |
missense |
probably benign |
0.10 |
R9308:Vmn2r10
|
UTSW |
5 |
109,145,476 (GRCm39) |
nonsense |
probably null |
|
R9800:Vmn2r10
|
UTSW |
5 |
109,150,404 (GRCm39) |
missense |
probably damaging |
0.99 |
Z1088:Vmn2r10
|
UTSW |
5 |
109,143,979 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1176:Vmn2r10
|
UTSW |
5 |
109,149,854 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- AATGCGGTTATTGGCCTTCAC -3'
(R):5'- GCTCAATCAGAAAGCACAGG -3'
Sequencing Primer
(F):5'- CGGTTATTGGCCTTCACAATAG -3'
(R):5'- TCAATCAGAAAGCACAGGTTGATAC -3'
|
Posted On |
2020-09-15 |