Incidental Mutation 'R7941:Vmn2r10'
ID 649049
Institutional Source Beutler Lab
Gene Symbol Vmn2r10
Ensembl Gene ENSMUSG00000067010
Gene Name vomeronasal 2, receptor 10
Synonyms VR16, V2r16
MMRRC Submission 045987-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.085) question?
Stock # R7941 (G1)
Quality Score 225.009
Status Validated
Chromosome 5
Chromosomal Location 109141278-109154337 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 109144306 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 548 (M548K)
Ref Sequence ENSEMBL: ENSMUSP00000078162 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079163] [ENSMUST00000176594]
AlphaFold K7N621
Predicted Effect probably damaging
Transcript: ENSMUST00000079163
AA Change: M548K

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000078162
Gene: ENSMUSG00000067010
AA Change: M548K

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Pfam:ANF_receptor 75 464 8.5e-29 PFAM
Pfam:NCD3G 506 560 3.8e-17 PFAM
Pfam:7tm_3 593 828 4e-55 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000176594
SMART Domains Protein: ENSMUSP00000135274
Gene: ENSMUSG00000067010

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 98% (43/44)
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abl1 T C 2: 31,579,691 (GRCm39) probably benign Het
AI467606 A G 7: 126,691,593 (GRCm39) E56G probably damaging Het
Ak9 C T 10: 41,285,133 (GRCm39) P1403S unknown Het
Akr1c14 A G 13: 4,109,713 (GRCm39) K28E probably benign Het
Ampd2 C A 3: 107,987,432 (GRCm39) V134L probably benign Het
Anks1b A T 10: 90,413,017 (GRCm39) N55I probably damaging Het
Cabyr T C 18: 12,877,825 (GRCm39) L54P probably damaging Het
Cachd1 A T 4: 100,845,370 (GRCm39) N954I probably damaging Het
Cenpf A G 1: 189,389,483 (GRCm39) S1450P probably damaging Het
Chst10 T A 1: 38,910,772 (GRCm39) I131L probably damaging Het
Cluh A T 11: 74,550,583 (GRCm39) M270L probably benign Het
Dagla T C 19: 10,248,867 (GRCm39) H29R probably damaging Het
Dusp5 A G 19: 53,525,964 (GRCm39) N202S probably benign Het
Elavl3 A G 9: 21,947,612 (GRCm39) I110T possibly damaging Het
Fam222b G T 11: 78,045,885 (GRCm39) G482V possibly damaging Het
Fbxl7 A G 15: 26,543,699 (GRCm39) L316P probably damaging Het
Gad1 T A 2: 70,424,929 (GRCm39) probably null Het
H2-K2 T C 17: 34,218,305 (GRCm39) T204A probably benign Het
Hmcn1 A G 1: 150,525,835 (GRCm39) V3296A possibly damaging Het
Hyal1 T C 9: 107,455,299 (GRCm39) F203S probably damaging Het
Il16 T A 7: 83,332,037 (GRCm39) D181V probably damaging Het
Ip6k1 T C 9: 107,901,631 (GRCm39) F69L probably damaging Het
Klf4 G A 4: 55,531,755 (GRCm39) probably benign Het
Lsr T G 7: 30,672,520 (GRCm39) I27L probably benign Het
Mettl4 A T 17: 95,040,622 (GRCm39) probably null Het
Mpdz A G 4: 81,200,987 (GRCm39) V1902A probably benign Het
Nfkbiz C T 16: 55,642,307 (GRCm39) G37D probably damaging Het
Or5w11 T C 2: 87,459,248 (GRCm39) V31A probably benign Het
Otogl A T 10: 107,642,663 (GRCm39) probably null Het
Pcdh1 T C 18: 38,332,133 (GRCm39) D429G probably damaging Het
Pramel34 A T 5: 93,785,887 (GRCm39) V131D probably benign Het
Prelid2 A T 18: 42,065,816 (GRCm39) L73* probably null Het
Psg20 T A 7: 18,415,102 (GRCm39) probably null Het
Ptprb GAGACCCTCGGGAGCACTGCAAAGACCCTCGGGAGCACTGCAAAGACCCTCGGGAGCACTGCAAAGACCCTCGGGAGCACT GAGACCCTCGGGAGCACTGCAAAGACCCTCGGGAGCACTGCAAAGACCCTCGGGAGCACT 10: 116,119,582 (GRCm39) probably benign Het
Rab24 C T 13: 55,468,120 (GRCm39) probably null Het
Rag1 T G 2: 101,472,691 (GRCm39) K817T probably benign Het
Rgl2 T C 17: 34,150,713 (GRCm39) V57A probably benign Het
Ric1 T C 19: 29,510,659 (GRCm39) M80T probably damaging Het
Sh3rf3 T C 10: 58,842,883 (GRCm39) I283T probably damaging Het
Skint2 C A 4: 112,483,187 (GRCm39) N197K probably damaging Het
Snapc4 A G 2: 26,266,730 (GRCm39) I126T probably damaging Het
Srcap GTCCTCCTCCTCCTCCTCCTGCTCCTCCTCCTCCTCCT GTCCTCCTCCTCCTCCTGCTCCTCCTCCTCCTCCT 7: 127,157,462 (GRCm39) probably benign Het
Svip T C 7: 51,653,161 (GRCm39) K51R probably benign Het
Syndig1 T A 2: 149,741,708 (GRCm39) V98E probably benign Het
Tshz1 A T 18: 84,033,517 (GRCm39) M297K possibly damaging Het
Ttn A G 2: 76,749,694 (GRCm39) V3785A probably benign Het
Usf3 T C 16: 44,035,924 (GRCm39) S135P probably damaging Het
Vmn2r92 T C 17: 18,405,099 (GRCm39) S748P possibly damaging Het
Zbtb39 A G 10: 127,579,409 (GRCm39) Y661C probably damaging Het
Zfp804b A G 5: 6,820,042 (GRCm39) I1007T probably benign Het
Zscan4-ps2 A G 7: 11,251,599 (GRCm39) I212V probably benign Het
Other mutations in Vmn2r10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00816:Vmn2r10 APN 5 109,150,451 (GRCm39) missense possibly damaging 0.75
IGL01618:Vmn2r10 APN 5 109,150,345 (GRCm39) missense probably damaging 1.00
IGL01624:Vmn2r10 APN 5 109,154,112 (GRCm39) missense possibly damaging 0.83
IGL01941:Vmn2r10 APN 5 109,143,820 (GRCm39) missense probably damaging 1.00
IGL01959:Vmn2r10 APN 5 109,145,571 (GRCm39) missense probably benign 0.00
IGL01973:Vmn2r10 APN 5 109,143,543 (GRCm39) missense probably damaging 1.00
IGL01985:Vmn2r10 APN 5 109,154,125 (GRCm39) missense probably benign 0.21
IGL02451:Vmn2r10 APN 5 109,143,788 (GRCm39) nonsense probably null
IGL02503:Vmn2r10 APN 5 109,151,341 (GRCm39) missense probably damaging 1.00
IGL03275:Vmn2r10 APN 5 109,151,243 (GRCm39) missense probably benign 0.00
R0035:Vmn2r10 UTSW 5 109,145,467 (GRCm39) splice site probably benign
R0395:Vmn2r10 UTSW 5 109,149,859 (GRCm39) missense probably damaging 1.00
R0454:Vmn2r10 UTSW 5 109,151,327 (GRCm39) missense probably benign 0.25
R0648:Vmn2r10 UTSW 5 109,143,782 (GRCm39) missense probably benign 0.00
R1251:Vmn2r10 UTSW 5 109,143,890 (GRCm39) missense probably benign 0.01
R1580:Vmn2r10 UTSW 5 109,154,117 (GRCm39) missense possibly damaging 0.82
R1845:Vmn2r10 UTSW 5 109,149,861 (GRCm39) nonsense probably null
R1986:Vmn2r10 UTSW 5 109,154,120 (GRCm39) nonsense probably null
R2137:Vmn2r10 UTSW 5 109,151,410 (GRCm39) missense possibly damaging 0.87
R2495:Vmn2r10 UTSW 5 109,143,961 (GRCm39) missense probably damaging 1.00
R3932:Vmn2r10 UTSW 5 109,150,088 (GRCm39) missense possibly damaging 0.47
R3933:Vmn2r10 UTSW 5 109,150,088 (GRCm39) missense possibly damaging 0.47
R4899:Vmn2r10 UTSW 5 109,151,324 (GRCm39) missense probably damaging 1.00
R4992:Vmn2r10 UTSW 5 109,145,592 (GRCm39) missense possibly damaging 0.89
R5124:Vmn2r10 UTSW 5 109,154,286 (GRCm39) missense probably benign 0.01
R5145:Vmn2r10 UTSW 5 109,143,761 (GRCm39) missense possibly damaging 0.64
R5156:Vmn2r10 UTSW 5 109,143,466 (GRCm39) missense probably benign 0.11
R5265:Vmn2r10 UTSW 5 109,143,586 (GRCm39) missense probably damaging 1.00
R5311:Vmn2r10 UTSW 5 109,154,121 (GRCm39) missense probably damaging 1.00
R5321:Vmn2r10 UTSW 5 109,143,505 (GRCm39) missense probably damaging 1.00
R5666:Vmn2r10 UTSW 5 109,146,910 (GRCm39) nonsense probably null
R5670:Vmn2r10 UTSW 5 109,146,910 (GRCm39) nonsense probably null
R5872:Vmn2r10 UTSW 5 109,151,377 (GRCm39) missense possibly damaging 0.84
R6004:Vmn2r10 UTSW 5 109,146,944 (GRCm39) missense probably benign 0.30
R6108:Vmn2r10 UTSW 5 109,143,667 (GRCm39) missense probably damaging 1.00
R6332:Vmn2r10 UTSW 5 109,151,328 (GRCm39) missense probably damaging 1.00
R6599:Vmn2r10 UTSW 5 109,143,944 (GRCm39) missense probably benign 0.09
R6651:Vmn2r10 UTSW 5 109,143,488 (GRCm39) missense probably null 0.22
R6891:Vmn2r10 UTSW 5 109,149,845 (GRCm39) missense probably damaging 1.00
R7023:Vmn2r10 UTSW 5 109,149,894 (GRCm39) missense probably damaging 0.96
R7146:Vmn2r10 UTSW 5 109,151,200 (GRCm39) missense probably damaging 1.00
R8058:Vmn2r10 UTSW 5 109,149,955 (GRCm39) missense probably benign 0.00
R8478:Vmn2r10 UTSW 5 109,143,636 (GRCm39) missense probably damaging 1.00
R8526:Vmn2r10 UTSW 5 109,145,572 (GRCm39) missense possibly damaging 0.51
R8698:Vmn2r10 UTSW 5 109,151,390 (GRCm39) missense probably benign 0.00
R8796:Vmn2r10 UTSW 5 109,143,917 (GRCm39) missense possibly damaging 0.74
R8854:Vmn2r10 UTSW 5 109,144,126 (GRCm39) missense probably benign 0.20
R8871:Vmn2r10 UTSW 5 109,146,899 (GRCm39) missense possibly damaging 0.67
R8893:Vmn2r10 UTSW 5 109,143,677 (GRCm39) missense probably benign 0.09
R8907:Vmn2r10 UTSW 5 109,149,791 (GRCm39) missense probably benign
R8957:Vmn2r10 UTSW 5 109,149,780 (GRCm39) missense possibly damaging 0.60
R8976:Vmn2r10 UTSW 5 109,145,479 (GRCm39) missense probably damaging 1.00
R9155:Vmn2r10 UTSW 5 109,144,212 (GRCm39) missense probably benign 0.10
R9308:Vmn2r10 UTSW 5 109,145,476 (GRCm39) nonsense probably null
R9800:Vmn2r10 UTSW 5 109,150,404 (GRCm39) missense probably damaging 0.99
Z1088:Vmn2r10 UTSW 5 109,143,979 (GRCm39) missense probably damaging 1.00
Z1176:Vmn2r10 UTSW 5 109,149,854 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AATGCGGTTATTGGCCTTCAC -3'
(R):5'- GCTCAATCAGAAAGCACAGG -3'

Sequencing Primer
(F):5'- CGGTTATTGGCCTTCACAATAG -3'
(R):5'- TCAATCAGAAAGCACAGGTTGATAC -3'
Posted On 2020-09-15