|Institutional Source||Beutler Lab|
|Gene Name||CD4 antigen|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R7943 (G1)|
|Chromosomal Location||124864692-124888221 bp(-) (GRCm38)|
|Type of Mutation||critical splice donor site (1 bp from exon)|
|DNA Base Change (assembly)||C to T at 124870244 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000024044 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000024044]|
|Predicted Effect||probably null
|Meta Mutation Damage Score||0.9492|
|Coding Region Coverage||
|Validation Efficiency||100% (68/68)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010]
PHENOTYPE: Mice homozygous for knock-out alleles exhibit abnormal immune system morphology and physiology. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Cd4||
(F):5'- AATTCAGAGCCAGCTCAGG -3'
(R):5'- TGTCCGTACAAAAGTCCACC -3'
(F):5'- CTGCTCAGCAATAGAGTTTGTAC -3'
(R):5'- GTCCGTACAAAAGTCCACCAAAGAC -3'