Incidental Mutation 'R0018:Or1p1c'
ID 64945
Institutional Source Beutler Lab
Gene Symbol Or1p1c
Ensembl Gene ENSMUSG00000070375
Gene Name olfactory receptor family 1 subfamily P member 1C
Synonyms Olfr406, MOR133-1, Olfr406-ps, GA_x6K02T2P1NL-4415162-4416133
MMRRC Submission 038313-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.055) question?
Stock # R0018 (G1)
Quality Score 123
Status Validated
Chromosome 11
Chromosomal Location 74160217-74161188 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 74160934 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Proline at position 240 (T240P)
Ref Sequence ENSEMBL: ENSMUSP00000148929 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000133561] [ENSMUST00000214303] [ENSMUST00000217016]
AlphaFold Q7TRX0
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127098
Predicted Effect probably benign
Transcript: ENSMUST00000133561
AA Change: T240P

PolyPhen 2 Score 0.390 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000125963
Gene: ENSMUSG00000070375
AA Change: T240P

DomainStartEndE-ValueType
Pfam:7tm_4 31 310 3.5e-56 PFAM
Pfam:7tm_1 41 292 3e-27 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214303
AA Change: T240P

PolyPhen 2 Score 0.390 (Sensitivity: 0.90; Specificity: 0.89)
Predicted Effect probably benign
Transcript: ENSMUST00000217016
AA Change: T240P

PolyPhen 2 Score 0.390 (Sensitivity: 0.90; Specificity: 0.89)
Meta Mutation Damage Score 0.4744 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 99.0%
  • 10x: 97.9%
  • 20x: 96.6%
Validation Efficiency 100% (64/64)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca17 T C 17: 24,532,162 (GRCm39) probably null Het
Afp A C 5: 90,654,600 (GRCm39) Q546P probably damaging Het
Api5 A T 2: 94,251,329 (GRCm39) probably null Het
Atp2b4 T A 1: 133,645,609 (GRCm39) I982F probably damaging Het
BC024139 G A 15: 76,005,087 (GRCm39) Q592* probably null Het
Capn7 T A 14: 31,076,069 (GRCm39) C290* probably null Het
Ccn1 A G 3: 145,355,186 (GRCm39) L23P probably damaging Het
Celsr1 T A 15: 85,915,243 (GRCm39) D910V possibly damaging Het
Chga T C 12: 102,524,764 (GRCm39) S45P probably damaging Het
Cpne2 T A 8: 95,282,681 (GRCm39) C59S possibly damaging Het
Cyp2b13 G A 7: 25,785,375 (GRCm39) R248H probably benign Het
Dennd1a T A 2: 37,748,472 (GRCm39) T336S possibly damaging Het
Drc7 A G 8: 95,800,862 (GRCm39) Y628C probably damaging Het
Dse A G 10: 34,029,464 (GRCm39) V542A probably benign Het
Dspp A T 5: 104,326,096 (GRCm39) S820C unknown Het
Efcab3 G A 11: 104,612,378 (GRCm39) probably null Het
Eif5b T C 1: 38,057,970 (GRCm39) S91P unknown Het
Epop A G 11: 97,519,017 (GRCm39) V364A probably benign Het
Ext2 G A 2: 93,626,037 (GRCm39) P341L probably damaging Het
Galns T C 8: 123,311,724 (GRCm39) T429A probably benign Het
Gsx2 A G 5: 75,237,828 (GRCm39) K260R probably damaging Het
H2-M10.6 A C 17: 37,124,941 (GRCm39) H286P probably damaging Het
Hectd4 A G 5: 121,392,242 (GRCm39) N169D possibly damaging Het
Helz2 C A 2: 180,874,552 (GRCm39) G1981C probably damaging Het
Hmcn1 T C 1: 150,528,302 (GRCm39) D3282G probably benign Het
Hnmt T A 2: 23,893,640 (GRCm39) N285Y possibly damaging Het
Hr A G 14: 70,795,717 (GRCm39) R450G probably benign Het
Kat6a A G 8: 23,419,289 (GRCm39) D684G possibly damaging Het
Kif27 T G 13: 58,435,867 (GRCm39) I1309L probably benign Het
Mab21l4 T A 1: 93,082,327 (GRCm39) D264V probably benign Het
Man2b1 T A 8: 85,824,118 (GRCm39) V1005E probably damaging Het
Me2 A T 18: 73,924,923 (GRCm39) F265I possibly damaging Het
Myo9a A T 9: 59,779,007 (GRCm39) T1588S probably benign Het
Neu4 T A 1: 93,953,060 (GRCm39) D476E probably benign Het
Nlrp9c T A 7: 26,071,423 (GRCm39) Q895L possibly damaging Het
Or1e35 T C 11: 73,797,452 (GRCm39) I289V probably damaging Het
Pdzd8 C T 19: 59,289,105 (GRCm39) R765H probably damaging Het
Plk1 T C 7: 121,768,208 (GRCm39) probably null Het
Ppfia2 A G 10: 106,678,647 (GRCm39) probably benign Het
Prkdc T C 16: 15,544,406 (GRCm39) Y1799H probably benign Het
Psmc1 T C 12: 100,082,951 (GRCm39) probably benign Het
Ptchd3 A C 11: 121,733,170 (GRCm39) I687L probably benign Het
Ptprh A G 7: 4,604,845 (GRCm39) probably null Het
Pus3 A G 9: 35,477,920 (GRCm39) D384G probably benign Het
Rab44 C T 17: 29,358,354 (GRCm39) P181S probably benign Het
Rasa2 A G 9: 96,454,016 (GRCm39) S307P probably damaging Het
Rbpms2 A G 9: 65,558,360 (GRCm39) D142G probably damaging Het
Reln A T 5: 22,130,369 (GRCm39) D2647E probably benign Het
Ryr2 G A 13: 11,610,109 (GRCm39) T4239I possibly damaging Het
Sctr C A 1: 119,971,286 (GRCm39) probably benign Het
Serpinb6e A T 13: 34,021,828 (GRCm39) Y167N probably damaging Het
Slc13a5 T C 11: 72,157,301 (GRCm39) I31V probably benign Het
Slc15a4 A T 5: 127,679,074 (GRCm39) I422N probably damaging Het
Stk24 G A 14: 121,545,419 (GRCm39) probably benign Het
Vmn1r213 T A 13: 23,196,311 (GRCm39) V298D probably damaging Het
Xdh C T 17: 74,232,020 (GRCm39) R230H probably benign Het
Zfp418 A T 7: 7,185,449 (GRCm39) S471C probably benign Het
Other mutations in Or1p1c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01370:Or1p1c APN 11 74,160,325 (GRCm39) missense probably benign 0.01
IGL01480:Or1p1c APN 11 74,160,427 (GRCm39) missense possibly damaging 0.64
IGL02138:Or1p1c APN 11 74,160,544 (GRCm39) missense probably benign 0.01
IGL02986:Or1p1c APN 11 74,160,928 (GRCm39) missense possibly damaging 0.82
R1822:Or1p1c UTSW 11 74,161,066 (GRCm39) missense probably benign 0.11
R1823:Or1p1c UTSW 11 74,161,043 (GRCm39) missense probably damaging 1.00
R1956:Or1p1c UTSW 11 74,160,670 (GRCm39) missense probably damaging 1.00
R2017:Or1p1c UTSW 11 74,161,159 (GRCm39) missense probably benign
R2879:Or1p1c UTSW 11 74,161,049 (GRCm39) missense probably damaging 1.00
R3854:Or1p1c UTSW 11 74,161,105 (GRCm39) nonsense probably null
R4750:Or1p1c UTSW 11 74,160,246 (GRCm39) missense probably benign 0.00
R6076:Or1p1c UTSW 11 74,161,088 (GRCm39) missense probably damaging 1.00
R6257:Or1p1c UTSW 11 74,160,833 (GRCm39) missense probably damaging 1.00
R6431:Or1p1c UTSW 11 74,160,235 (GRCm39) missense possibly damaging 0.95
R7032:Or1p1c UTSW 11 74,160,428 (GRCm39) missense possibly damaging 0.95
R7216:Or1p1c UTSW 11 74,160,550 (GRCm39) missense probably damaging 1.00
R7429:Or1p1c UTSW 11 74,160,579 (GRCm39) missense probably damaging 1.00
R8144:Or1p1c UTSW 11 74,160,384 (GRCm39) missense probably damaging 0.98
R8161:Or1p1c UTSW 11 74,160,544 (GRCm39) missense probably benign 0.01
R8847:Or1p1c UTSW 11 74,160,443 (GRCm39) missense probably damaging 1.00
R8872:Or1p1c UTSW 11 74,160,120 (GRCm39) splice site probably benign
R8977:Or1p1c UTSW 11 74,160,304 (GRCm39) missense probably benign 0.02
R9049:Or1p1c UTSW 11 74,161,115 (GRCm39) missense possibly damaging 0.80
R9336:Or1p1c UTSW 11 74,160,743 (GRCm39) missense probably damaging 0.98
R9596:Or1p1c UTSW 11 74,160,289 (GRCm39) missense probably benign
R9771:Or1p1c UTSW 11 74,160,635 (GRCm39) missense probably benign 0.05
Predicted Primers PCR Primer
(F):5'- ATGAGCTTCCAACGCTGCTCAC -3'
(R):5'- TGTTTCGCAGGCTGTAAATGAAGGG -3'

Sequencing Primer
(F):5'- GCTCTCAGAAGGTCATTCCAG -3'
(R):5'- GGTTCAGCAAGGGAGTCACC -3'
Posted On 2013-08-06