Incidental Mutation 'R7949:Or2f2'
ID 649457
Institutional Source Beutler Lab
Gene Symbol Or2f2
Ensembl Gene ENSMUSG00000094192
Gene Name olfactory receptor family 2 subfamily F member 2
Synonyms MOR257-5P, GA_x6K02T2P3E9-4769843-4768890, Olfr452
MMRRC Submission 045994-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.178) question?
Stock # R7949 (G1)
Quality Score 225.009
Status Validated
Chromosome 6
Chromosomal Location 42766975-42767928 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 42767588 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 205 (V205A)
Ref Sequence ENSEMBL: ENSMUSP00000151882 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075468] [ENSMUST00000214465] [ENSMUST00000215719] [ENSMUST00000217701]
AlphaFold Q7TRV8
Predicted Effect possibly damaging
Transcript: ENSMUST00000075468
AA Change: V205A

PolyPhen 2 Score 0.794 (Sensitivity: 0.85; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000074914
Gene: ENSMUSG00000094192
AA Change: V205A

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 2.8e-52 PFAM
Pfam:7tm_1 41 290 2.3e-24 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000214465
AA Change: V205A

PolyPhen 2 Score 0.794 (Sensitivity: 0.85; Specificity: 0.93)
Predicted Effect possibly damaging
Transcript: ENSMUST00000215719
AA Change: V205A

PolyPhen 2 Score 0.794 (Sensitivity: 0.85; Specificity: 0.93)
Predicted Effect possibly damaging
Transcript: ENSMUST00000217701
AA Change: V205A

PolyPhen 2 Score 0.794 (Sensitivity: 0.85; Specificity: 0.93)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 100% (47/47)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrv1 G A 13: 81,303,353 (GRCm39) T6111M probably damaging Het
Adprhl1 T G 8: 13,274,225 (GRCm39) R844S possibly damaging Het
Aldh1b1 A G 4: 45,802,807 (GRCm39) E115G possibly damaging Het
Anp32a A G 9: 62,280,948 (GRCm39) E170G unknown Het
Arhgap27 A G 11: 103,228,595 (GRCm39) S349P probably damaging Het
Asns T A 6: 7,685,328 (GRCm39) I110F probably damaging Het
Atad3a T C 4: 155,833,152 (GRCm39) H437R possibly damaging Het
Atl2 C A 17: 80,167,289 (GRCm39) R244L probably damaging Het
Bcl2l14 A T 6: 134,407,083 (GRCm39) D222V probably damaging Het
Ccdc102a G T 8: 95,631,913 (GRCm39) Q498K probably damaging Het
Cdc14b T C 13: 64,338,212 (GRCm39) probably null Het
Cdcp3 G A 7: 130,895,324 (GRCm39) probably null Het
Cep162 T A 9: 87,088,901 (GRCm39) M994L probably benign Het
Ddx18 A G 1: 121,483,047 (GRCm39) Y580H probably damaging Het
Entpd6 C A 2: 150,612,197 (GRCm39) probably null Het
Fer T A 17: 64,440,503 (GRCm39) S707T probably damaging Het
Gabra6 A G 11: 42,207,826 (GRCm39) V215A probably benign Het
Gm20671 A G 5: 32,977,288 (GRCm39) V142A probably benign Het
Gtf3c1 G T 7: 125,250,253 (GRCm39) N1439K probably benign Het
Igbp1b T C 6: 138,635,414 (GRCm39) K10R probably benign Het
Ighv5-8 TATATATATATATATATATATATA TATATATATATATATATATATATATA 12: 113,618,563 (GRCm39) probably null Het
Igkv12-44 A T 6: 69,791,874 (GRCm39) S30T probably benign Het
Immt A T 6: 71,851,327 (GRCm39) R563* probably null Het
Jakmip1 A T 5: 37,339,492 (GRCm39) Q1231L probably damaging Het
Jsrp1 T C 10: 80,647,906 (GRCm39) T51A probably benign Het
Krtap31-1 A G 11: 99,799,144 (GRCm39) T116A possibly damaging Het
Lrp8 T A 4: 107,660,524 (GRCm39) D61E probably damaging Het
Mark2 T C 19: 7,262,081 (GRCm39) D311G probably benign Het
Men1 C T 19: 6,388,323 (GRCm39) S314L possibly damaging Het
Nxpe2 T C 9: 48,234,397 (GRCm39) N290S possibly damaging Het
Or5b105 T A 19: 13,080,610 (GRCm39) probably null Het
Pcolce2 A T 9: 95,576,688 (GRCm39) T320S probably benign Het
Phc2 C T 4: 128,603,401 (GRCm39) T177M probably damaging Het
Phf21b G T 15: 84,676,036 (GRCm39) P337H probably damaging Het
Pinlyp G T 7: 24,245,375 (GRCm39) T15K probably damaging Het
Ppox A T 1: 171,105,521 (GRCm39) S307R probably benign Het
Ptk7 T A 17: 46,897,387 (GRCm39) E315V possibly damaging Het
Pxk T C 14: 8,144,233 (GRCm38) I327T probably damaging Het
Rabgap1 A T 2: 37,453,491 (GRCm39) K973I probably benign Het
Rbbp8 A T 18: 11,851,892 (GRCm39) I238L probably benign Het
Runx2 T A 17: 45,046,442 (GRCm39) D109V possibly damaging Het
Serpinb6a G A 13: 34,107,003 (GRCm39) S183L probably benign Het
Slco1a8 C A 6: 141,939,991 (GRCm39) G171C probably damaging Het
Sptlc3 T C 2: 139,467,795 (GRCm39) I451T possibly damaging Het
Sugp1 A T 8: 70,509,153 (GRCm39) Y142F possibly damaging Het
Sumf2 T C 5: 129,881,759 (GRCm39) F98S probably damaging Het
Tmem120a C T 5: 135,771,220 (GRCm39) E39K possibly damaging Het
Tnxb C T 17: 34,936,103 (GRCm39) P2680L probably damaging Het
Zfp78 C G 7: 6,382,365 (GRCm39) R472G possibly damaging Het
Other mutations in Or2f2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01097:Or2f2 APN 6 42,767,077 (GRCm39) missense probably damaging 1.00
IGL02134:Or2f2 APN 6 42,767,398 (GRCm39) missense probably benign
IGL02900:Or2f2 APN 6 42,767,808 (GRCm39) nonsense probably null
IGL03115:Or2f2 APN 6 42,767,599 (GRCm39) missense probably benign 0.07
R0441:Or2f2 UTSW 6 42,767,108 (GRCm39) missense probably damaging 0.99
R0504:Or2f2 UTSW 6 42,767,530 (GRCm39) nonsense probably null
R1191:Or2f2 UTSW 6 42,767,451 (GRCm39) missense probably benign 0.00
R1912:Or2f2 UTSW 6 42,767,411 (GRCm39) missense probably benign 0.01
R4579:Or2f2 UTSW 6 42,767,458 (GRCm39) missense probably benign 0.04
R4911:Or2f2 UTSW 6 42,767,138 (GRCm39) missense probably damaging 1.00
R7003:Or2f2 UTSW 6 42,767,399 (GRCm39) missense probably benign 0.18
R8420:Or2f2 UTSW 6 42,767,644 (GRCm39) missense possibly damaging 0.73
R9061:Or2f2 UTSW 6 42,767,141 (GRCm39) missense probably damaging 1.00
R9508:Or2f2 UTSW 6 42,767,928 (GRCm39) makesense probably null
X0028:Or2f2 UTSW 6 42,767,453 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ATACAGGGCTCTGCACAAGG -3'
(R):5'- CTTCTCTTGAAGGACTGAGGG -3'

Sequencing Primer
(F):5'- AAGGCTGGTCATCACATCGTG -3'
(R):5'- CTTGAAGGACTGAGGGGCTGG -3'
Posted On 2020-09-15