Incidental Mutation 'R7955:Or6z1'
ID 649765
Institutional Source Beutler Lab
Gene Symbol Or6z1
Ensembl Gene ENSMUSG00000093877
Gene Name olfactory receptor family 6 subfamily Z member 1
Synonyms GA_x6K02T2QGBW-3232059-3231121, MOR103-9, Olfr1348
MMRRC Submission 045999-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.127) question?
Stock # R7955 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 6504285-6505223 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 6505078 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 49 (I49T)
Ref Sequence ENSEMBL: ENSMUSP00000147205 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086319] [ENSMUST00000207055] [ENSMUST00000207339] [ENSMUST00000207624] [ENSMUST00000208066] [ENSMUST00000208207] [ENSMUST00000208623] [ENSMUST00000209097] [ENSMUST00000209029] [ENSMUST00000209055] [ENSMUST00000213549] [ENSMUST00000214383]
AlphaFold F6VB59
Predicted Effect possibly damaging
Transcript: ENSMUST00000086319
AA Change: I55T

PolyPhen 2 Score 0.907 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000083499
Gene: ENSMUSG00000093877
AA Change: I55T

DomainStartEndE-ValueType
Pfam:7tm_4 41 317 4.9e-50 PFAM
Pfam:7tm_1 51 300 2.6e-21 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000207055
AA Change: I49T

PolyPhen 2 Score 0.907 (Sensitivity: 0.81; Specificity: 0.94)
Predicted Effect probably benign
Transcript: ENSMUST00000207339
Predicted Effect possibly damaging
Transcript: ENSMUST00000207624
AA Change: I49T

PolyPhen 2 Score 0.907 (Sensitivity: 0.81; Specificity: 0.94)
Predicted Effect possibly damaging
Transcript: ENSMUST00000208066
AA Change: I49T

PolyPhen 2 Score 0.907 (Sensitivity: 0.81; Specificity: 0.94)
Predicted Effect possibly damaging
Transcript: ENSMUST00000208207
AA Change: I49T

PolyPhen 2 Score 0.907 (Sensitivity: 0.81; Specificity: 0.94)
Predicted Effect possibly damaging
Transcript: ENSMUST00000208623
AA Change: I49T

PolyPhen 2 Score 0.907 (Sensitivity: 0.81; Specificity: 0.94)
Predicted Effect possibly damaging
Transcript: ENSMUST00000209097
AA Change: I49T

PolyPhen 2 Score 0.907 (Sensitivity: 0.81; Specificity: 0.94)
Predicted Effect possibly damaging
Transcript: ENSMUST00000209029
AA Change: I49T

PolyPhen 2 Score 0.907 (Sensitivity: 0.81; Specificity: 0.94)
Predicted Effect probably benign
Transcript: ENSMUST00000209055
Predicted Effect possibly damaging
Transcript: ENSMUST00000213549
AA Change: I49T

PolyPhen 2 Score 0.907 (Sensitivity: 0.81; Specificity: 0.94)
Predicted Effect possibly damaging
Transcript: ENSMUST00000214383
AA Change: I49T

PolyPhen 2 Score 0.907 (Sensitivity: 0.81; Specificity: 0.94)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency 100% (43/43)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts10 T A 17: 33,764,613 (GRCm39) V711D probably damaging Het
Adgrg5 G A 8: 95,664,325 (GRCm39) V312M Het
Ankrd53 A G 6: 83,744,845 (GRCm39) T352A probably benign Het
Ano4 T A 10: 88,831,088 (GRCm39) M512L probably null Het
AW551984 A G 9: 39,507,960 (GRCm39) F392S probably damaging Het
Chrna7 T G 7: 62,753,541 (GRCm39) K326T possibly damaging Het
Cldnd2 G T 7: 43,091,120 (GRCm39) L17F possibly damaging Het
Clvs2 T C 10: 33,471,808 (GRCm39) N166D possibly damaging Het
Cox10 A T 11: 63,884,750 (GRCm39) N218K probably benign Het
Crygs C T 16: 22,624,082 (GRCm39) R175H probably damaging Het
Daxx T A 17: 34,131,229 (GRCm39) Y385* probably null Het
Dnmbp T C 19: 43,890,762 (GRCm39) E335G probably benign Het
Erich3 C T 3: 154,444,951 (GRCm39) Q376* probably null Het
Flot2 A G 11: 77,949,769 (GRCm39) probably null Het
Ganc A G 2: 120,261,181 (GRCm39) T289A probably damaging Het
Gm19668 G A 10: 77,634,630 (GRCm39) T113I unknown Het
Gpm6a A G 8: 55,511,840 (GRCm39) N238S probably damaging Het
Hps1 T C 19: 42,759,221 (GRCm39) T124A probably damaging Het
Larp4b T C 13: 9,186,816 (GRCm39) V48A probably benign Het
Magi2 A G 5: 20,594,070 (GRCm39) H205R probably damaging Het
Map2 T A 1: 66,452,875 (GRCm39) S588R probably damaging Het
Mocos A G 18: 24,799,216 (GRCm39) D150G probably damaging Het
Msl2 A G 9: 100,979,354 (GRCm39) D576G possibly damaging Het
Mybpc3 A G 2: 90,956,401 (GRCm39) probably null Het
Myo3b A T 2: 69,925,623 (GRCm39) Y58F probably benign Het
Ndst3 T G 3: 123,400,586 (GRCm39) K440T probably benign Het
Ndst4 T A 3: 125,231,831 (GRCm39) Y133* probably null Het
Nrcam G A 12: 44,631,737 (GRCm39) V1097M probably benign Het
Rabep1 A G 11: 70,808,267 (GRCm39) T408A probably damaging Het
Rims1 A T 1: 22,507,322 (GRCm39) D609E probably damaging Het
Sh2d4a A G 8: 68,781,907 (GRCm39) K172E probably benign Het
Slc12a9 A C 5: 137,323,808 (GRCm39) L369R probably damaging Het
Slc30a1 T C 1: 191,639,395 (GRCm39) C93R probably damaging Het
Tex35 C T 1: 156,927,742 (GRCm39) D143N probably damaging Het
Tgm3 A T 2: 129,880,400 (GRCm39) Y402F probably benign Het
Tmem17 T A 11: 22,468,490 (GRCm39) I143K possibly damaging Het
Tmprss11f A C 5: 86,692,682 (GRCm39) S81A probably benign Het
Trp53bp1 G A 2: 121,066,225 (GRCm39) P834S possibly damaging Het
Trpm4 C A 7: 44,968,683 (GRCm39) G417W probably damaging Het
Trpm6 A T 19: 18,831,654 (GRCm39) R1506S probably benign Het
Tspan18 A G 2: 93,040,305 (GRCm39) V150A possibly damaging Het
Ttc39d T C 17: 80,523,352 (GRCm39) F4L probably benign Het
Zdhhc4 A T 5: 143,307,619 (GRCm39) L134H probably damaging Het
Zfp407 A T 18: 84,577,416 (GRCm39) S1232R probably benign Het
Zswim2 A C 2: 83,747,227 (GRCm39) F353V probably benign Het
Other mutations in Or6z1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01785:Or6z1 APN 7 6,504,899 (GRCm39) missense probably benign 0.00
IGL03157:Or6z1 APN 7 6,504,892 (GRCm39) missense probably damaging 1.00
R0006:Or6z1 UTSW 7 6,504,610 (GRCm39) missense possibly damaging 0.58
R1763:Or6z1 UTSW 7 6,504,440 (GRCm39) missense probably benign 0.07
R2178:Or6z1 UTSW 7 6,504,487 (GRCm39) missense probably damaging 0.98
R5787:Or6z1 UTSW 7 6,504,989 (GRCm39) missense probably damaging 1.00
R5884:Or6z1 UTSW 7 6,504,842 (GRCm39) missense probably benign 0.02
R6248:Or6z1 UTSW 7 6,504,675 (GRCm39) nonsense probably null
R7026:Or6z1 UTSW 7 6,504,820 (GRCm39) missense probably damaging 0.97
R7635:Or6z1 UTSW 7 6,504,581 (GRCm39) missense probably benign 0.06
R8443:Or6z1 UTSW 7 6,504,734 (GRCm39) missense probably damaging 1.00
R9474:Or6z1 UTSW 7 6,505,150 (GRCm39) missense probably benign
R9719:Or6z1 UTSW 7 6,504,999 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- CACTCTGTGCAGATGAGGAC -3'
(R):5'- AACTTGCTCAAGGTGTAAAGC -3'

Sequencing Primer
(F):5'- CTCTGTGCAGATGAGGACTATAAAG -3'
(R):5'- AGAACAGATGATAACAATTGGCTTG -3'
Posted On 2020-09-15