Incidental Mutation 'R0322:Arl9'
ID64982
Institutional Source Beutler Lab
Gene Symbol Arl9
Ensembl Gene ENSMUSG00000063820
Gene NameADP-ribosylation factor-like 9
Synonyms
MMRRC Submission 038532-MU
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #R0322 (G1)
Quality Score152
Status Validated
Chromosome5
Chromosomal Location77004055-77010606 bp(+) (GRCm38)
Type of Mutationintron
DNA Base Change (assembly) A to G at 77007190 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000122846 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071199] [ENSMUST00000134197]
Predicted Effect probably benign
Transcript: ENSMUST00000071199
SMART Domains Protein: ENSMUSP00000071188
Gene: ENSMUSG00000063820

DomainStartEndE-ValueType
Pfam:Arf 5 132 1.1e-30 PFAM
Pfam:SRPRB 16 132 3.5e-10 PFAM
Pfam:Roc 20 128 2.4e-11 PFAM
Pfam:Ras 20 130 7.4e-9 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129353
Predicted Effect probably benign
Transcript: ENSMUST00000134197
SMART Domains Protein: ENSMUSP00000122846
Gene: ENSMUSG00000063820

DomainStartEndE-ValueType
Pfam:SRPRB 1 166 3.1e-13 PFAM
Pfam:Arf 2 162 1e-38 PFAM
Pfam:Roc 5 115 1.1e-12 PFAM
Pfam:Gtr1_RagA 5 141 8.5e-8 PFAM
Pfam:Ras 5 160 4.4e-12 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 98.7%
  • 3x: 97.5%
  • 10x: 93.8%
  • 20x: 84.3%
Validation Efficiency 98% (58/59)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] ARL9 is a member of the small GTPase protein family with a high degree of similarity to ARF (MIM 103180) proteins of the RAS superfamily.[supplied by OMIM, Nov 2008]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9130401M01Rik A T 15: 58,025,372 S275T possibly damaging Het
Adam34 G T 8: 43,651,921 T229N probably benign Het
Adgrb3 C A 1: 25,221,748 probably benign Het
Ankhd1 T A 18: 36,658,008 Y2478* probably null Het
Bub1b G A 2: 118,639,618 probably benign Het
Chl1 A T 6: 103,701,883 probably benign Het
Cobl T A 11: 12,267,072 E465V probably damaging Het
Cobll1 A T 2: 65,102,098 M520K possibly damaging Het
Dll3 A G 7: 28,296,368 V336A possibly damaging Het
Dnmbp T C 19: 43,854,846 H1193R probably damaging Het
Fbxo43 T C 15: 36,152,192 probably benign Het
Gart G A 16: 91,623,037 probably benign Het
Gjc3 A T 5: 137,957,498 M175K possibly damaging Het
Gm9008 T C 6: 76,496,418 Y405C probably benign Het
Gpc5 T A 14: 115,399,151 N415K probably benign Het
Idh2 C T 7: 80,098,257 A232T probably damaging Het
Il7r A T 15: 9,510,215 F251I probably benign Het
Insc A G 7: 114,792,265 E141G probably damaging Het
Itm2c C T 1: 85,907,030 T160M probably damaging Het
Mboat1 T C 13: 30,232,080 probably benign Het
Mdm2 G T 10: 117,702,204 H96Q possibly damaging Het
Mettl13 A G 1: 162,544,176 probably benign Het
Mfsd4b3 T C 10: 39,947,530 N245D probably damaging Het
Mroh2a C T 1: 88,230,680 R150* probably null Het
Mtmr3 T C 11: 4,487,505 Y982C possibly damaging Het
Mymk A T 2: 27,067,406 L66Q probably damaging Het
Myo18a T C 11: 77,829,800 S767P probably damaging Het
Ndufa8 T C 2: 36,036,622 D134G probably benign Het
Noxa1 A G 2: 25,092,554 F83S probably damaging Het
Npc1l1 T A 11: 6,229,042 I123L probably benign Het
Ogdhl A G 14: 32,337,577 T394A probably benign Het
Olfr1193 T C 2: 88,678,667 S264P probably damaging Het
Olfr290 A G 7: 84,916,313 Y178C probably damaging Het
Pcdh20 T C 14: 88,468,947 T306A probably benign Het
Pcid2 G A 8: 13,090,775 probably benign Het
Phyhip G A 14: 70,463,396 V108M possibly damaging Het
Pnpla5 G T 15: 84,120,719 L144M probably damaging Het
Psmb4 A G 3: 94,886,091 Y160H probably benign Het
Riox2 A T 16: 59,489,389 K369* probably null Het
Sh3tc1 G A 5: 35,706,561 P761S possibly damaging Het
Slc6a3 T A 13: 73,560,926 V323D possibly damaging Het
Smg7 A G 1: 152,849,873 probably null Het
Srrt G A 5: 137,296,608 R370C probably damaging Het
Stc1 T C 14: 69,029,409 V7A probably benign Het
Svep1 G T 4: 58,057,996 probably benign Het
Tbpl2 A G 2: 24,094,979 V51A probably benign Het
Tecr A G 8: 83,572,243 Y248H probably damaging Het
Tenm3 A G 8: 48,236,912 probably benign Het
Tia1 C T 6: 86,420,387 A114V probably damaging Het
Tmprss11f A T 5: 86,591,416 M2K probably benign Het
Tnfsf8 T C 4: 63,834,166 T221A probably damaging Het
Tubgcp5 G A 7: 55,814,978 G536S probably damaging Het
Tyr A T 7: 87,492,917 I145N probably benign Het
Ubr4 T A 4: 139,422,418 V1809E probably damaging Het
Vmn2r65 A T 7: 84,946,548 N309K probably benign Het
Other mutations in Arl9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00538:Arl9 APN 5 77004056 start codon destroyed probably null 0.02
IGL01327:Arl9 APN 5 77006554 missense possibly damaging 0.63
IGL01557:Arl9 APN 5 77004101 critical splice donor site probably null
IGL03068:Arl9 APN 5 77007378 missense possibly damaging 0.60
R0038:Arl9 UTSW 5 77006475 missense probably benign 0.00
R0195:Arl9 UTSW 5 77006494 missense probably damaging 1.00
R0540:Arl9 UTSW 5 77007271 missense possibly damaging 0.91
R1614:Arl9 UTSW 5 77010565 missense probably benign
R1735:Arl9 UTSW 5 77006626 missense probably damaging 1.00
R3547:Arl9 UTSW 5 77010479 missense probably benign 0.01
R4296:Arl9 UTSW 5 77006549 missense probably damaging 1.00
R5520:Arl9 UTSW 5 77006593 missense probably damaging 1.00
R5731:Arl9 UTSW 5 77006527 missense possibly damaging 0.95
R6018:Arl9 UTSW 5 77007406 missense probably damaging 1.00
R6547:Arl9 UTSW 5 77010410 critical splice acceptor site probably null
R7203:Arl9 UTSW 5 77007271 missense possibly damaging 0.91
R7468:Arl9 UTSW 5 77010429 nonsense probably null
Predicted Primers PCR Primer
(F):5'- GATCCTGTGTGGCAATACTGTCCC -3'
(R):5'- ACAATCCTGAAAGCTAGGCAAGGTG -3'

Sequencing Primer
(F):5'- TGGCAATACTGTCCCACCTAC -3'
(R):5'- GCACAGATTCTTACCTGTTTGTTG -3'
Posted On2013-08-08