Incidental Mutation 'R0322:Tmprss11f'
ID 64983
Institutional Source Beutler Lab
Gene Symbol Tmprss11f
Ensembl Gene ENSMUSG00000048764
Gene Name transmembrane protease, serine 11f
Synonyms 4732406D01Rik
MMRRC Submission 038532-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.069) question?
Stock # R0322 (G1)
Quality Score 160
Status Validated
Chromosome 5
Chromosomal Location 86669757-86780283 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 86739275 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 2 (M2K)
Ref Sequence ENSEMBL: ENSMUSP00000112252 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000116553]
AlphaFold Q8BHM9
Predicted Effect probably benign
Transcript: ENSMUST00000116553
AA Change: M2K

PolyPhen 2 Score 0.061 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000112252
Gene: ENSMUSG00000048764
AA Change: M2K

DomainStartEndE-ValueType
transmembrane domain 31 53 N/A INTRINSIC
SEA 56 168 4.62e-2 SMART
low complexity region 192 203 N/A INTRINSIC
Tryp_SPc 206 433 8.7e-84 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000161625
Predicted Effect noncoding transcript
Transcript: ENSMUST00000173259
Meta Mutation Damage Score 0.1439 question?
Coding Region Coverage
  • 1x: 98.7%
  • 3x: 97.5%
  • 10x: 93.8%
  • 20x: 84.3%
Validation Efficiency 98% (58/59)
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9130401M01Rik A T 15: 57,888,768 (GRCm39) S275T possibly damaging Het
Adam34 G T 8: 44,104,958 (GRCm39) T229N probably benign Het
Adgrb3 C A 1: 25,260,829 (GRCm39) probably benign Het
Ankhd1 T A 18: 36,791,061 (GRCm39) Y2478* probably null Het
Arl9 A G 5: 77,155,037 (GRCm39) probably benign Het
Bub1b G A 2: 118,470,099 (GRCm39) probably benign Het
Chl1 A T 6: 103,678,844 (GRCm39) probably benign Het
Cobl T A 11: 12,217,072 (GRCm39) E465V probably damaging Het
Cobll1 A T 2: 64,932,442 (GRCm39) M520K possibly damaging Het
Dll3 A G 7: 27,995,793 (GRCm39) V336A possibly damaging Het
Dnmbp T C 19: 43,843,285 (GRCm39) H1193R probably damaging Het
Fbxo43 T C 15: 36,152,338 (GRCm39) probably benign Het
Gart G A 16: 91,419,925 (GRCm39) probably benign Het
Gjc3 A T 5: 137,955,760 (GRCm39) M175K possibly damaging Het
Gpc5 T A 14: 115,636,563 (GRCm39) N415K probably benign Het
Idh2 C T 7: 79,748,005 (GRCm39) A232T probably damaging Het
Il7r A T 15: 9,510,301 (GRCm39) F251I probably benign Het
Insc A G 7: 114,391,500 (GRCm39) E141G probably damaging Het
Itm2c C T 1: 85,834,751 (GRCm39) T160M probably damaging Het
Mboat1 T C 13: 30,416,063 (GRCm39) probably benign Het
Mdm2 G T 10: 117,538,109 (GRCm39) H96Q possibly damaging Het
Mettl13 A G 1: 162,371,745 (GRCm39) probably benign Het
Mfsd4b3-ps T C 10: 39,823,526 (GRCm39) N245D probably damaging Het
Mroh2a C T 1: 88,158,402 (GRCm39) R150* probably null Het
Mtmr3 T C 11: 4,437,505 (GRCm39) Y982C possibly damaging Het
Mymk A T 2: 26,957,418 (GRCm39) L66Q probably damaging Het
Myo18a T C 11: 77,720,626 (GRCm39) S767P probably damaging Het
Ndufa8 T C 2: 35,926,634 (GRCm39) D134G probably benign Het
Noxa1 A G 2: 24,982,566 (GRCm39) F83S probably damaging Het
Npc1l1 T A 11: 6,179,042 (GRCm39) I123L probably benign Het
Ogdhl A G 14: 32,059,534 (GRCm39) T394A probably benign Het
Or4s2b T C 2: 88,509,011 (GRCm39) S264P probably damaging Het
Or5ae1 A G 7: 84,565,521 (GRCm39) Y178C probably damaging Het
Pcdh20 T C 14: 88,706,383 (GRCm39) T306A probably benign Het
Pcid2 G A 8: 13,140,775 (GRCm39) probably benign Het
Phyhip G A 14: 70,700,836 (GRCm39) V108M possibly damaging Het
Pnpla5 G T 15: 84,004,920 (GRCm39) L144M probably damaging Het
Psmb4 A G 3: 94,793,402 (GRCm39) Y160H probably benign Het
Riox2 A T 16: 59,309,752 (GRCm39) K369* probably null Het
Rnf26rt T C 6: 76,473,401 (GRCm39) Y405C probably benign Het
Sh3tc1 G A 5: 35,863,905 (GRCm39) P761S possibly damaging Het
Slc6a3 T A 13: 73,709,045 (GRCm39) V323D possibly damaging Het
Smg7 A G 1: 152,725,624 (GRCm39) probably null Het
Srrt G A 5: 137,294,870 (GRCm39) R370C probably damaging Het
Stc1 T C 14: 69,266,858 (GRCm39) V7A probably benign Het
Svep1 G T 4: 58,057,996 (GRCm39) probably benign Het
Tbpl2 A G 2: 23,984,991 (GRCm39) V51A probably benign Het
Tecr A G 8: 84,298,872 (GRCm39) Y248H probably damaging Het
Tenm3 A G 8: 48,689,947 (GRCm39) probably benign Het
Tia1 C T 6: 86,397,369 (GRCm39) A114V probably damaging Het
Tnfsf8 T C 4: 63,752,403 (GRCm39) T221A probably damaging Het
Tubgcp5 G A 7: 55,464,726 (GRCm39) G536S probably damaging Het
Tyr A T 7: 87,142,125 (GRCm39) I145N probably benign Het
Ubr4 T A 4: 139,149,729 (GRCm39) V1809E probably damaging Het
Vmn2r65 A T 7: 84,595,756 (GRCm39) N309K probably benign Het
Other mutations in Tmprss11f
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00777:Tmprss11f APN 5 86,671,924 (GRCm39) missense probably damaging 1.00
IGL01453:Tmprss11f APN 5 86,692,691 (GRCm39) nonsense probably null
IGL02406:Tmprss11f APN 5 86,681,525 (GRCm39) missense probably damaging 1.00
IGL03294:Tmprss11f APN 5 86,685,966 (GRCm39) missense probably damaging 1.00
R0122:Tmprss11f UTSW 5 86,681,484 (GRCm39) splice site probably benign
R0418:Tmprss11f UTSW 5 86,704,870 (GRCm39) missense probably benign 0.16
R1936:Tmprss11f UTSW 5 86,692,723 (GRCm39) missense probably benign 0.23
R2002:Tmprss11f UTSW 5 86,687,627 (GRCm39) splice site probably benign
R2008:Tmprss11f UTSW 5 86,739,265 (GRCm39) splice site probably null
R2260:Tmprss11f UTSW 5 86,739,269 (GRCm39) missense probably benign 0.22
R4109:Tmprss11f UTSW 5 86,677,795 (GRCm39) missense possibly damaging 0.89
R4584:Tmprss11f UTSW 5 86,687,553 (GRCm39) critical splice donor site probably null
R4983:Tmprss11f UTSW 5 86,685,858 (GRCm39) missense probably benign 0.06
R5034:Tmprss11f UTSW 5 86,739,243 (GRCm39) intron probably benign
R5116:Tmprss11f UTSW 5 86,687,555 (GRCm39) missense probably benign 0.01
R5254:Tmprss11f UTSW 5 86,685,892 (GRCm39) missense probably benign 0.00
R5324:Tmprss11f UTSW 5 86,704,837 (GRCm39) missense possibly damaging 0.95
R5410:Tmprss11f UTSW 5 86,677,965 (GRCm39) missense probably damaging 0.99
R5441:Tmprss11f UTSW 5 86,676,062 (GRCm39) missense probably damaging 1.00
R6143:Tmprss11f UTSW 5 86,687,558 (GRCm39) missense probably benign
R6178:Tmprss11f UTSW 5 86,704,837 (GRCm39) missense probably benign 0.00
R6239:Tmprss11f UTSW 5 86,681,636 (GRCm39) missense probably damaging 0.99
R6447:Tmprss11f UTSW 5 86,676,086 (GRCm39) missense probably damaging 1.00
R6817:Tmprss11f UTSW 5 86,704,793 (GRCm39) missense probably benign
R7243:Tmprss11f UTSW 5 86,677,975 (GRCm39) missense probably damaging 1.00
R7314:Tmprss11f UTSW 5 86,671,912 (GRCm39) missense possibly damaging 0.55
R7623:Tmprss11f UTSW 5 86,672,019 (GRCm39) missense probably damaging 1.00
R7708:Tmprss11f UTSW 5 86,672,028 (GRCm39) missense probably damaging 1.00
R7776:Tmprss11f UTSW 5 86,681,605 (GRCm39) missense probably benign 0.21
R7955:Tmprss11f UTSW 5 86,692,682 (GRCm39) missense probably benign 0.13
R8046:Tmprss11f UTSW 5 86,676,132 (GRCm39) missense probably damaging 1.00
R8147:Tmprss11f UTSW 5 86,677,769 (GRCm39) missense probably damaging 1.00
R8209:Tmprss11f UTSW 5 86,687,566 (GRCm39) missense probably damaging 1.00
R8219:Tmprss11f UTSW 5 86,677,878 (GRCm39) missense probably damaging 1.00
R8343:Tmprss11f UTSW 5 86,681,666 (GRCm39) missense probably benign 0.25
R8873:Tmprss11f UTSW 5 86,692,733 (GRCm39) missense probably damaging 0.98
R8889:Tmprss11f UTSW 5 86,687,618 (GRCm39) missense possibly damaging 0.86
R8892:Tmprss11f UTSW 5 86,687,618 (GRCm39) missense possibly damaging 0.86
R9465:Tmprss11f UTSW 5 86,685,876 (GRCm39) missense probably damaging 0.97
Z1176:Tmprss11f UTSW 5 86,676,054 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCTGCTGTTGGTAAGAAAGTTGGAGA -3'
(R):5'- GGCTGGGACCAAATAGACCATGC -3'

Sequencing Primer
(F):5'- GCTGTCATCCTTTTACTTGGAATG -3'
(R):5'- CAAATAGACCATGCTTCTATCTGGC -3'
Posted On 2013-08-08