|Institutional Source||Beutler Lab|
|Gene Name||netrin 4|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R7957 (G1)|
|Chromosomal Location||93640681-93747207 bp(+) (GRCm38)|
|Type of Mutation||splice site|
|DNA Base Change (assembly)||T to C at 93644473 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000123306 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000020204] [ENSMUST00000147080]|
|Predicted Effect||probably benign
|Coding Region Coverage||
|Validation Efficiency||98% (46/47)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the netrin family of proteins, which function in various biological processes including axon guidance, tumorogenesis, and angiogenesis. Netrins are laminin-related proteins that have an N-terminal laminin-type domain, epidermal growth factor-like repeat domain, and a positively charged heparin-binding domain at the C-terminus. The protein encoded by this gene is involved in processes including neurite growth and migration, angiogenesis and mural cell adhesion to endothelial cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased cell proliferation in the cornea without an increase in corneal thickness and increased microvessel branching in the middle levels of the retina. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Ntn4||
(F):5'- GCACTCGTGAACACATTATCATC -3'
(R):5'- CATTTATCACACTTGGGCTGCC -3'
(F):5'- CGTGAACACATTATCATCTATCGAGC -3'
(R):5'- CGGCAAGTGAGGTCAGCATTC -3'