|Institutional Source||Beutler Lab|
|Gene Name||dual specificity phosphatase 9|
|Is this an essential gene?||Probably non essential (E-score: 0.163)|
|Stock #||R7958 (G1)|
|Chromosomal Location||73639419-73643514 bp(+) (GRCm38)|
|Type of Mutation||small deletion (16 aa in frame mutation)|
|DNA Base Change (assembly)||TAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCTAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCTAAAGCGGAGGCCAAAGCGGAGGCCAAAG to TAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCTAAAGCGGAGGCCAAAGCGGAGGCCAAAG at 73640611 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000019701 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000019701]|
|Predicted Effect||probably benign
|Meta Mutation Damage Score||0.0846|
|Coding Region Coverage||
|Validation Efficiency||100% (55/55)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product shows selectivity for members of the ERK family of MAP kinases and is localized to the cytoplasm and nucleus. Aberrant expression of this gene is associated with type 2 diabetes and cancer progression in several cell types. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
PHENOTYPE: Hemizygous null male and heterozygous null female mice display embryonic lethality during organogenesis with abnormal placental labyrinth morphology when the allele is maternally inherited. Tetraploid rescue produces viable heterozygous and hemizygous mice. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Dusp9||
(F):5'- GAGAGTCTGAGTCGGTCATG -3'
(R):5'- TGACCCTCACTTACCCTGTAGG -3'
(F):5'- AGCTGTATGAGTCGGCGC -3'
(R):5'- CCCTGTAGGTAGTATGCTGGG -3'