Incidental Mutation 'R7960:Nrp2'
| ID |
650021 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Nrp2
|
| Ensembl Gene |
ENSMUSG00000025969 |
| Gene Name |
neuropilin 2 |
| Synonyms |
1110048P06Rik, NP-2, Npn-2, NP2, Npn2 |
| MMRRC Submission |
046004-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.958)
|
| Stock # |
R7960 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
62742476-62857851 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 62784567 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Cysteine
at position 239
(R239C)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000109794
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000027112]
[ENSMUST00000063594]
[ENSMUST00000075144]
[ENSMUST00000102822]
[ENSMUST00000114155]
[ENSMUST00000114157]
|
| AlphaFold |
O35375 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000027112
AA Change: R239C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000027112
Gene: ENSMUSG00000025969
AA Change: R239C
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
CUB
|
28 |
142 |
3.4e-45 |
SMART |
|
CUB
|
149 |
267 |
1.04e-40 |
SMART |
|
FA58C
|
276 |
427 |
1.63e-45 |
SMART |
|
FA58C
|
433 |
592 |
9.33e-14 |
SMART |
|
MAM
|
641 |
802 |
2.31e-60 |
SMART |
|
Pfam:DUF3481
|
822 |
906 |
1.4e-35 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000063594
AA Change: R239C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000069379
Gene: ENSMUSG00000025969
AA Change: R239C
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
CUB
|
28 |
142 |
3.4e-45 |
SMART |
|
CUB
|
149 |
267 |
1.04e-40 |
SMART |
|
FA58C
|
276 |
427 |
1.63e-45 |
SMART |
|
FA58C
|
433 |
592 |
9.33e-14 |
SMART |
|
MAM
|
641 |
802 |
2.31e-60 |
SMART |
|
low complexity region
|
816 |
831 |
N/A |
INTRINSIC |
|
Pfam:DUF3481
|
839 |
923 |
1.6e-25 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000075144
AA Change: R239C
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000074642
Gene: ENSMUSG00000025969
AA Change: R239C
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
CUB
|
28 |
142 |
3.4e-45 |
SMART |
|
CUB
|
149 |
267 |
1.04e-40 |
SMART |
|
FA58C
|
276 |
427 |
1.63e-45 |
SMART |
|
FA58C
|
433 |
592 |
9.33e-14 |
SMART |
|
MAM
|
641 |
802 |
2.31e-60 |
SMART |
|
Pfam:DUF3481
|
827 |
911 |
2.3e-25 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000102822
AA Change: R239C
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000099886
Gene: ENSMUSG00000025969
AA Change: R239C
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
CUB
|
28 |
142 |
3.4e-45 |
SMART |
|
CUB
|
149 |
267 |
1.04e-40 |
SMART |
|
FA58C
|
276 |
427 |
1.63e-45 |
SMART |
|
FA58C
|
433 |
592 |
9.33e-14 |
SMART |
|
MAM
|
641 |
802 |
2.31e-60 |
SMART |
|
Pfam:DUF3481
|
822 |
906 |
2.3e-25 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000114155
AA Change: R239C
PolyPhen 2
Score 0.413 (Sensitivity: 0.89; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000109792
Gene: ENSMUSG00000025969
AA Change: R239C
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
CUB
|
28 |
142 |
3.4e-45 |
SMART |
|
CUB
|
149 |
267 |
1.04e-40 |
SMART |
|
FA58C
|
276 |
427 |
1.63e-45 |
SMART |
|
FA58C
|
433 |
592 |
9.33e-14 |
SMART |
|
MAM
|
641 |
802 |
2.31e-60 |
SMART |
|
Pfam:DUF3481
|
817 |
901 |
9.4e-36 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000114157
AA Change: R239C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000109794
Gene: ENSMUSG00000025969
AA Change: R239C
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
CUB
|
28 |
142 |
3.4e-45 |
SMART |
|
CUB
|
149 |
267 |
1.04e-40 |
SMART |
|
FA58C
|
276 |
427 |
1.63e-45 |
SMART |
|
FA58C
|
433 |
592 |
9.33e-14 |
SMART |
|
MAM
|
641 |
802 |
2.31e-60 |
SMART |
|
low complexity region
|
821 |
836 |
N/A |
INTRINSIC |
|
Pfam:DUF3481
|
844 |
928 |
2.4e-25 |
PFAM |
|
| Meta Mutation Damage Score |
0.3354 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
99% (71/72) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Nullizygous mice may exhibit pre- or postnatal lethality, reduced fertility, hydrocephalus, aberrant sensory innervation, reduced interneuron count, seizure susceptibility and abnormal lymphangiogenesis. Homozygotes for a gene trap allele show abnormal neuronal development and axonal trajectories. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 76 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1110004F10Rik |
T |
C |
7: 115,702,481 (GRCm39) |
S82P |
possibly damaging |
Het |
| Ablim2 |
A |
C |
5: 36,014,493 (GRCm39) |
E450A |
probably benign |
Het |
| Acacb |
G |
T |
5: 114,368,922 (GRCm39) |
M1713I |
probably benign |
Het |
| Acbd6 |
C |
A |
1: 155,562,766 (GRCm39) |
Q256K |
probably benign |
Het |
| Agbl2 |
A |
T |
2: 90,621,975 (GRCm39) |
N154I |
probably benign |
Het |
| Ahcyl2 |
A |
G |
6: 29,870,626 (GRCm39) |
N181D |
probably benign |
Het |
| Aldh18a1 |
A |
T |
19: 40,546,264 (GRCm39) |
D544E |
probably benign |
Het |
| Anapc1 |
A |
T |
2: 128,516,513 (GRCm39) |
L407Q |
probably damaging |
Het |
| Arhgap26 |
T |
A |
18: 39,362,980 (GRCm39) |
V34D |
|
Het |
| Brd3 |
A |
T |
2: 27,342,945 (GRCm39) |
S516T |
probably benign |
Het |
| Bsn |
A |
G |
9: 107,992,747 (GRCm39) |
S1002P |
probably damaging |
Het |
| C4b |
G |
T |
17: 34,960,252 (GRCm39) |
|
probably null |
Het |
| Camta1 |
T |
C |
4: 151,232,990 (GRCm39) |
T228A |
probably benign |
Het |
| Cct6b |
T |
C |
11: 82,632,221 (GRCm39) |
K256E |
possibly damaging |
Het |
| Cep85l |
T |
A |
10: 53,172,403 (GRCm39) |
Q552L |
probably benign |
Het |
| Col6a5 |
A |
G |
9: 105,823,049 (GRCm39) |
F103L |
unknown |
Het |
| Copb2 |
A |
G |
9: 98,462,407 (GRCm39) |
Q464R |
possibly damaging |
Het |
| Dlc1 |
G |
T |
8: 37,404,989 (GRCm39) |
H267N |
probably benign |
Het |
| Dnajb2 |
T |
C |
1: 75,218,055 (GRCm39) |
I184T |
|
Het |
| Dnajc9 |
C |
T |
14: 20,438,764 (GRCm39) |
E30K |
possibly damaging |
Het |
| Dock1 |
T |
C |
7: 134,678,917 (GRCm39) |
L1012P |
possibly damaging |
Het |
| Dtnbp1 |
T |
C |
13: 45,106,650 (GRCm39) |
K170R |
probably benign |
Het |
| F13b |
T |
A |
1: 139,431,509 (GRCm39) |
C26* |
probably null |
Het |
| Ficd |
G |
T |
5: 113,877,020 (GRCm39) |
E398D |
probably benign |
Het |
| G6pc1 |
G |
A |
11: 101,267,359 (GRCm39) |
G270R |
probably damaging |
Het |
| Garin4 |
T |
A |
1: 190,895,645 (GRCm39) |
T333S |
probably benign |
Het |
| Gm3604 |
T |
C |
13: 62,517,587 (GRCm39) |
Y257C |
probably damaging |
Het |
| Hmcn1 |
T |
A |
1: 150,531,606 (GRCm39) |
Y3221F |
probably damaging |
Het |
| Hs3st3b1 |
C |
T |
11: 63,812,694 (GRCm39) |
G7D |
possibly damaging |
Het |
| Htr3b |
A |
T |
9: 48,856,852 (GRCm39) |
S209T |
probably benign |
Het |
| Ift70a1 |
A |
T |
2: 75,811,188 (GRCm39) |
D298E |
probably benign |
Het |
| Iglon5 |
T |
A |
7: 43,126,326 (GRCm39) |
E192D |
probably benign |
Het |
| Inpp5f |
A |
G |
7: 128,295,638 (GRCm39) |
|
probably null |
Het |
| Kif26b |
T |
A |
1: 178,506,484 (GRCm39) |
C187S |
probably damaging |
Het |
| Klhl11 |
A |
G |
11: 100,354,805 (GRCm39) |
S339P |
probably benign |
Het |
| Klk14 |
G |
A |
7: 43,341,467 (GRCm39) |
A40T |
probably damaging |
Het |
| Kmt2c |
G |
A |
5: 25,520,194 (GRCm39) |
T1972I |
probably benign |
Het |
| Lama2 |
T |
C |
10: 26,869,094 (GRCm39) |
T2784A |
probably benign |
Het |
| Loxhd1 |
T |
A |
18: 77,472,746 (GRCm39) |
F1088I |
probably damaging |
Het |
| Map2k2 |
G |
A |
10: 80,954,968 (GRCm39) |
R185Q |
probably benign |
Het |
| Mbd5 |
G |
A |
2: 49,169,796 (GRCm39) |
|
probably null |
Het |
| Mdc1 |
A |
T |
17: 36,161,570 (GRCm39) |
R828* |
probably null |
Het |
| Or5g25 |
A |
G |
2: 85,478,417 (GRCm39) |
S83P |
possibly damaging |
Het |
| Parp4 |
C |
A |
14: 56,832,708 (GRCm39) |
|
probably null |
Het |
| Pbk |
T |
A |
14: 66,046,650 (GRCm39) |
|
probably null |
Het |
| Phip |
A |
T |
9: 82,775,401 (GRCm39) |
D1060E |
probably benign |
Het |
| Pik3c2b |
T |
A |
1: 133,031,587 (GRCm39) |
L1509Q |
probably damaging |
Het |
| Pik3r5 |
T |
A |
11: 68,386,796 (GRCm39) |
F808L |
probably benign |
Het |
| Plcl1 |
T |
A |
1: 55,736,443 (GRCm39) |
S595T |
possibly damaging |
Het |
| Plxna2 |
AT |
A |
1: 194,476,172 (GRCm39) |
|
probably null |
Het |
| Pole |
A |
G |
5: 110,437,727 (GRCm39) |
K95R |
possibly damaging |
Het |
| Poteg |
A |
G |
8: 27,946,888 (GRCm39) |
T259A |
probably benign |
Het |
| Pramel52-ps |
A |
G |
5: 94,531,739 (GRCm39) |
M208V |
probably benign |
Het |
| Ptpn12 |
G |
T |
5: 21,260,687 (GRCm39) |
P20Q |
probably benign |
Het |
| Ptpn5 |
T |
A |
7: 46,729,295 (GRCm39) |
T440S |
possibly damaging |
Het |
| Ptpru |
T |
C |
4: 131,515,820 (GRCm39) |
R845G |
probably benign |
Het |
| Rasgrp2 |
G |
T |
19: 6,464,839 (GRCm39) |
V596L |
probably benign |
Het |
| Rcbtb2 |
T |
G |
14: 73,399,384 (GRCm39) |
V16G |
probably benign |
Het |
| Rel |
T |
C |
11: 23,694,493 (GRCm39) |
N289S |
probably damaging |
Het |
| Rpn1 |
T |
A |
6: 88,079,068 (GRCm39) |
Y504N |
probably damaging |
Het |
| Rsf1 |
CGGCGGCGG |
CGGCGGCGGGGGCGGCGG |
7: 97,229,124 (GRCm39) |
|
probably benign |
Het |
| Scaf8 |
G |
A |
17: 3,221,397 (GRCm39) |
V295M |
unknown |
Het |
| Skic3 |
T |
C |
13: 76,260,318 (GRCm39) |
C87R |
probably benign |
Het |
| Slc25a48 |
T |
A |
13: 56,611,411 (GRCm39) |
Y173N |
probably damaging |
Het |
| Slc8a3 |
C |
T |
12: 81,263,506 (GRCm39) |
S627N |
probably benign |
Het |
| Snx8 |
T |
A |
5: 140,343,848 (GRCm39) |
M123L |
probably benign |
Het |
| Sri |
A |
T |
5: 8,114,586 (GRCm39) |
Q180H |
probably benign |
Het |
| Sycp2 |
T |
A |
2: 178,046,453 (GRCm39) |
R4S |
probably null |
Het |
| Tcstv1a |
G |
A |
13: 120,355,521 (GRCm39) |
T37I |
possibly damaging |
Het |
| Tnnc2 |
A |
T |
2: 164,619,704 (GRCm39) |
D87E |
probably benign |
Het |
| Trim7 |
A |
T |
11: 48,728,628 (GRCm39) |
N92I |
probably damaging |
Het |
| Trpv6 |
C |
T |
6: 41,604,612 (GRCm39) |
D97N |
probably benign |
Het |
| Ulk4 |
A |
G |
9: 121,102,022 (GRCm39) |
Y19H |
probably damaging |
Het |
| Vmn2r69 |
C |
T |
7: 85,055,973 (GRCm39) |
V722I |
probably benign |
Het |
| Zan |
T |
C |
5: 137,407,865 (GRCm39) |
D3643G |
unknown |
Het |
| Zan |
G |
A |
5: 137,463,154 (GRCm39) |
T675I |
unknown |
Het |
|
| Other mutations in Nrp2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00765:Nrp2
|
APN |
1 |
62,743,410 (GRCm39) |
nonsense |
probably null |
|
|
IGL01912:Nrp2
|
APN |
1 |
62,810,896 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01996:Nrp2
|
APN |
1 |
62,788,419 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02184:Nrp2
|
APN |
1 |
62,758,099 (GRCm39) |
nonsense |
probably null |
|
|
IGL02682:Nrp2
|
APN |
1 |
62,810,996 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02928:Nrp2
|
APN |
1 |
62,854,605 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03024:Nrp2
|
APN |
1 |
62,810,893 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Euphorbia
|
UTSW |
1 |
62,801,972 (GRCm39) |
missense |
probably benign |
0.02 |
|
Sabra
|
UTSW |
1 |
62,822,680 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0068:Nrp2
|
UTSW |
1 |
62,784,536 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R0068:Nrp2
|
UTSW |
1 |
62,784,536 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R0683:Nrp2
|
UTSW |
1 |
62,783,477 (GRCm39) |
missense |
probably benign |
0.41 |
|
R0789:Nrp2
|
UTSW |
1 |
62,784,609 (GRCm39) |
missense |
probably benign |
0.44 |
|
R1418:Nrp2
|
UTSW |
1 |
62,822,491 (GRCm39) |
nonsense |
probably null |
|
|
R1468:Nrp2
|
UTSW |
1 |
62,777,458 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1468:Nrp2
|
UTSW |
1 |
62,777,458 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1544:Nrp2
|
UTSW |
1 |
62,802,063 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1645:Nrp2
|
UTSW |
1 |
62,824,283 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1677:Nrp2
|
UTSW |
1 |
62,822,479 (GRCm39) |
missense |
probably benign |
0.18 |
|
R1752:Nrp2
|
UTSW |
1 |
62,777,600 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1840:Nrp2
|
UTSW |
1 |
62,777,498 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1916:Nrp2
|
UTSW |
1 |
62,801,906 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1962:Nrp2
|
UTSW |
1 |
62,758,090 (GRCm39) |
missense |
probably benign |
0.03 |
|
R2108:Nrp2
|
UTSW |
1 |
62,783,436 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2164:Nrp2
|
UTSW |
1 |
62,783,514 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2216:Nrp2
|
UTSW |
1 |
62,802,077 (GRCm39) |
nonsense |
probably null |
|
|
R2679:Nrp2
|
UTSW |
1 |
62,824,237 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4349:Nrp2
|
UTSW |
1 |
62,777,576 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4351:Nrp2
|
UTSW |
1 |
62,777,576 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4352:Nrp2
|
UTSW |
1 |
62,777,576 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4353:Nrp2
|
UTSW |
1 |
62,777,576 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4811:Nrp2
|
UTSW |
1 |
62,758,240 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5362:Nrp2
|
UTSW |
1 |
62,808,221 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5387:Nrp2
|
UTSW |
1 |
62,801,972 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5461:Nrp2
|
UTSW |
1 |
62,786,370 (GRCm39) |
nonsense |
probably null |
|
|
R5704:Nrp2
|
UTSW |
1 |
62,824,267 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6143:Nrp2
|
UTSW |
1 |
62,799,974 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6303:Nrp2
|
UTSW |
1 |
62,784,565 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6304:Nrp2
|
UTSW |
1 |
62,784,565 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6376:Nrp2
|
UTSW |
1 |
62,758,176 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R6945:Nrp2
|
UTSW |
1 |
62,799,947 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7347:Nrp2
|
UTSW |
1 |
62,784,663 (GRCm39) |
missense |
probably benign |
0.04 |
|
R7393:Nrp2
|
UTSW |
1 |
62,784,583 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7593:Nrp2
|
UTSW |
1 |
62,758,203 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7881:Nrp2
|
UTSW |
1 |
62,810,990 (GRCm39) |
missense |
probably benign |
0.42 |
|
R7882:Nrp2
|
UTSW |
1 |
62,822,680 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7948:Nrp2
|
UTSW |
1 |
62,784,567 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7958:Nrp2
|
UTSW |
1 |
62,784,567 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7959:Nrp2
|
UTSW |
1 |
62,784,567 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7961:Nrp2
|
UTSW |
1 |
62,784,567 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8009:Nrp2
|
UTSW |
1 |
62,784,567 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8012:Nrp2
|
UTSW |
1 |
62,784,567 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8014:Nrp2
|
UTSW |
1 |
62,784,567 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8015:Nrp2
|
UTSW |
1 |
62,784,567 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8068:Nrp2
|
UTSW |
1 |
62,784,567 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8069:Nrp2
|
UTSW |
1 |
62,784,567 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8070:Nrp2
|
UTSW |
1 |
62,784,567 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8071:Nrp2
|
UTSW |
1 |
62,784,567 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8206:Nrp2
|
UTSW |
1 |
62,786,374 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8791:Nrp2
|
UTSW |
1 |
62,788,356 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9090:Nrp2
|
UTSW |
1 |
62,784,670 (GRCm39) |
missense |
probably benign |
0.21 |
|
R9271:Nrp2
|
UTSW |
1 |
62,784,670 (GRCm39) |
missense |
probably benign |
0.21 |
|
R9287:Nrp2
|
UTSW |
1 |
62,835,014 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9469:Nrp2
|
UTSW |
1 |
62,804,030 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9646:Nrp2
|
UTSW |
1 |
62,777,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9752:Nrp2
|
UTSW |
1 |
62,851,726 (GRCm39) |
missense |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- AGCTCAGGGAAAGCACTTTTAATG -3'
(R):5'- GTCAGCCCTTTACCTGTACG -3'
Sequencing Primer
(F):5'- TCAGGGGGAATATCAGACATCATTC -3'
(R):5'- GTACGTACACCTGTCCCTAATGAG -3'
|
| Posted On |
2020-09-15 |
Incidental Mutation