Incidental Mutation 'R7960:Rcbtb2'
| ID |
650086 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Rcbtb2
|
| Ensembl Gene |
ENSMUSG00000022106 |
| Gene Name |
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 |
| Synonyms |
Rc/btb2, 2810420M18Rik, 2610028E02Rik, Chc1l |
| MMRRC Submission |
046004-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.322)
|
| Stock # |
R7960 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
14 |
| Chromosomal Location |
73376185-73421495 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to G
at 73399384 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Glycine
at position 16
(V16G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000131588
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000022702]
[ENSMUST00000110952]
[ENSMUST00000163339]
[ENSMUST00000163533]
[ENSMUST00000163797]
[ENSMUST00000164298]
[ENSMUST00000164822]
[ENSMUST00000165429]
[ENSMUST00000165567]
[ENSMUST00000165727]
[ENSMUST00000167021]
[ENSMUST00000167401]
[ENSMUST00000169479]
[ENSMUST00000169513]
[ENSMUST00000170368]
[ENSMUST00000170370]
[ENSMUST00000170677]
[ENSMUST00000171070]
[ENSMUST00000171767]
|
| AlphaFold |
Q99LJ7 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000022702
AA Change: V16G
PolyPhen 2
Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
|
| SMART Domains |
Protein: ENSMUSP00000022702
Gene: ENSMUSG00000022106
AA Change: V16G
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:RCC1
|
117 |
167 |
1.1e-16 |
PFAM |
|
Pfam:RCC1_2
|
154 |
183 |
7.1e-15 |
PFAM |
|
Pfam:RCC1
|
170 |
220 |
1.7e-14 |
PFAM |
|
Pfam:RCC1
|
223 |
272 |
7.1e-18 |
PFAM |
|
Pfam:RCC1_2
|
259 |
288 |
1.7e-12 |
PFAM |
|
Pfam:RCC1
|
275 |
324 |
8e-16 |
PFAM |
|
BTB
|
394 |
487 |
2.69e-21 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000110952
AA Change: V16G
PolyPhen 2
Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
|
| SMART Domains |
Protein: ENSMUSP00000106577
Gene: ENSMUSG00000022106
AA Change: V16G
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:RCC1
|
117 |
167 |
3e-16 |
PFAM |
|
Pfam:RCC1_2
|
154 |
183 |
7.8e-15 |
PFAM |
|
Pfam:RCC1
|
170 |
220 |
1.4e-15 |
PFAM |
|
Pfam:RCC1
|
223 |
272 |
9.4e-18 |
PFAM |
|
Pfam:RCC1_2
|
259 |
288 |
2.6e-11 |
PFAM |
|
Pfam:RCC1
|
275 |
324 |
1.2e-13 |
PFAM |
|
BTB
|
394 |
487 |
2.69e-21 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000163339
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000163533
AA Change: V16G
PolyPhen 2
Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
|
| SMART Domains |
Protein: ENSMUSP00000130828
Gene: ENSMUSG00000022106
AA Change: V16G
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:RCC1
|
117 |
150 |
4.3e-10 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000163797
AA Change: V2G
PolyPhen 2
Score 0.712 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000132125
Gene: ENSMUSG00000022106
AA Change: V2G
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:RCC1
|
136 |
174 |
7.7e-12 |
PFAM |
|
low complexity region
|
199 |
207 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000164298
AA Change: V2G
PolyPhen 2
Score 0.127 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000126651
Gene: ENSMUSG00000022106
AA Change: V2G
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:RCC1
|
103 |
153 |
2.9e-17 |
PFAM |
|
Pfam:RCC1_2
|
140 |
169 |
2.2e-15 |
PFAM |
|
Pfam:RCC1
|
156 |
206 |
4.4e-15 |
PFAM |
|
Pfam:RCC1
|
209 |
247 |
1.2e-11 |
PFAM |
|
low complexity region
|
272 |
280 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000164822
AA Change: V16G
PolyPhen 2
Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
|
| SMART Domains |
Protein: ENSMUSP00000131588
Gene: ENSMUSG00000022106
AA Change: V16G
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:RCC1
|
117 |
167 |
1.1e-16 |
PFAM |
|
Pfam:RCC1_2
|
154 |
183 |
7.1e-15 |
PFAM |
|
Pfam:RCC1
|
170 |
220 |
1.7e-14 |
PFAM |
|
Pfam:RCC1
|
223 |
272 |
7.1e-18 |
PFAM |
|
Pfam:RCC1_2
|
259 |
288 |
1.7e-12 |
PFAM |
|
Pfam:RCC1
|
275 |
324 |
8e-16 |
PFAM |
|
BTB
|
394 |
487 |
2.69e-21 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000165429
|
| SMART Domains |
Protein: ENSMUSP00000127258
Gene: ENSMUSG00000022106
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:RCC1
|
93 |
143 |
4.4e-17 |
PFAM |
|
Pfam:RCC1_2
|
130 |
157 |
5.2e-13 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000165567
AA Change: V16G
PolyPhen 2
Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
|
| SMART Domains |
Protein: ENSMUSP00000130240
Gene: ENSMUSG00000022106
AA Change: V16G
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:RCC1
|
117 |
167 |
5.3e-17 |
PFAM |
|
Pfam:RCC1_2
|
154 |
172 |
6.7e-7 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000165727
|
| SMART Domains |
Protein: ENSMUSP00000128479
Gene: ENSMUSG00000022106
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:RCC1
|
11 |
60 |
2.3e-14 |
PFAM |
|
Pfam:RCC1
|
63 |
90 |
6e-9 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000167021
AA Change: V16G
PolyPhen 2
Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000167401
AA Change: V16G
PolyPhen 2
Score 0.723 (Sensitivity: 0.86; Specificity: 0.92)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000169479
AA Change: V16G
PolyPhen 2
Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
|
| SMART Domains |
Protein: ENSMUSP00000126898
Gene: ENSMUSG00000022106
AA Change: V16G
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:RCC1
|
117 |
167 |
1.1e-16 |
PFAM |
|
Pfam:RCC1_2
|
154 |
183 |
7.1e-15 |
PFAM |
|
Pfam:RCC1
|
170 |
220 |
1.7e-14 |
PFAM |
|
Pfam:RCC1
|
223 |
272 |
7.1e-18 |
PFAM |
|
Pfam:RCC1_2
|
259 |
288 |
1.7e-12 |
PFAM |
|
Pfam:RCC1
|
275 |
324 |
8e-16 |
PFAM |
|
BTB
|
394 |
487 |
2.69e-21 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000169513
|
| SMART Domains |
Protein: ENSMUSP00000128579
Gene: ENSMUSG00000022106
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:RCC1
|
93 |
143 |
3.1e-16 |
PFAM |
|
Pfam:RCC1_2
|
130 |
159 |
1.9e-14 |
PFAM |
|
Pfam:RCC1
|
146 |
196 |
4.7e-14 |
PFAM |
|
Pfam:RCC1
|
199 |
248 |
1.9e-17 |
PFAM |
|
Pfam:RCC1_2
|
235 |
264 |
4.4e-12 |
PFAM |
|
Pfam:RCC1
|
251 |
300 |
2.2e-15 |
PFAM |
|
BTB
|
370 |
463 |
2.69e-21 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000170368
AA Change: V16G
PolyPhen 2
Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
|
| SMART Domains |
Protein: ENSMUSP00000126276
Gene: ENSMUSG00000022106
AA Change: V16G
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1a12a_
|
45 |
86 |
9e-3 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000170370
AA Change: V16G
PolyPhen 2
Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
|
| SMART Domains |
Protein: ENSMUSP00000130732
Gene: ENSMUSG00000022106
AA Change: V16G
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1a12a_
|
45 |
128 |
1e-14 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000170677
|
| SMART Domains |
Protein: ENSMUSP00000126510
Gene: ENSMUSG00000022106
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:RCC1
|
93 |
143 |
3.1e-16 |
PFAM |
|
Pfam:RCC1_2
|
130 |
159 |
1.9e-14 |
PFAM |
|
Pfam:RCC1
|
146 |
196 |
4.7e-14 |
PFAM |
|
Pfam:RCC1
|
199 |
248 |
1.9e-17 |
PFAM |
|
Pfam:RCC1_2
|
235 |
264 |
4.4e-12 |
PFAM |
|
Pfam:RCC1
|
251 |
300 |
2.2e-15 |
PFAM |
|
BTB
|
370 |
463 |
2.69e-21 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000171070
AA Change: V16G
PolyPhen 2
Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000171767
AA Change: V16G
PolyPhen 2
Score 0.116 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000127397
Gene: ENSMUSG00000022106
AA Change: V16G
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:RCC1
|
117 |
167 |
1.7e-16 |
PFAM |
|
Pfam:RCC1_2
|
154 |
183 |
4.9e-15 |
PFAM |
|
Pfam:RCC1
|
170 |
220 |
8.4e-16 |
PFAM |
|
Pfam:RCC1
|
223 |
272 |
5.5e-18 |
PFAM |
|
Pfam:RCC1_2
|
259 |
288 |
1.7e-11 |
PFAM |
|
Pfam:RCC1
|
275 |
324 |
6.8e-14 |
PFAM |
|
BTB
|
394 |
487 |
2.69e-21 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
99% (71/72) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein containing two C-terminal BTB/POZ domains that is related to regulator of chromosome condensation (RCC). The encoded protein may act as a guanine nucleotide exchange factor. This gene is observed to be lost or underexpressed in prostate cancers. There is a pseudogene of this gene on chromosome 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 76 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1110004F10Rik |
T |
C |
7: 115,702,481 (GRCm39) |
S82P |
possibly damaging |
Het |
| Ablim2 |
A |
C |
5: 36,014,493 (GRCm39) |
E450A |
probably benign |
Het |
| Acacb |
G |
T |
5: 114,368,922 (GRCm39) |
M1713I |
probably benign |
Het |
| Acbd6 |
C |
A |
1: 155,562,766 (GRCm39) |
Q256K |
probably benign |
Het |
| Agbl2 |
A |
T |
2: 90,621,975 (GRCm39) |
N154I |
probably benign |
Het |
| Ahcyl2 |
A |
G |
6: 29,870,626 (GRCm39) |
N181D |
probably benign |
Het |
| Aldh18a1 |
A |
T |
19: 40,546,264 (GRCm39) |
D544E |
probably benign |
Het |
| Anapc1 |
A |
T |
2: 128,516,513 (GRCm39) |
L407Q |
probably damaging |
Het |
| Arhgap26 |
T |
A |
18: 39,362,980 (GRCm39) |
V34D |
|
Het |
| Brd3 |
A |
T |
2: 27,342,945 (GRCm39) |
S516T |
probably benign |
Het |
| Bsn |
A |
G |
9: 107,992,747 (GRCm39) |
S1002P |
probably damaging |
Het |
| C4b |
G |
T |
17: 34,960,252 (GRCm39) |
|
probably null |
Het |
| Camta1 |
T |
C |
4: 151,232,990 (GRCm39) |
T228A |
probably benign |
Het |
| Cct6b |
T |
C |
11: 82,632,221 (GRCm39) |
K256E |
possibly damaging |
Het |
| Cep85l |
T |
A |
10: 53,172,403 (GRCm39) |
Q552L |
probably benign |
Het |
| Col6a5 |
A |
G |
9: 105,823,049 (GRCm39) |
F103L |
unknown |
Het |
| Copb2 |
A |
G |
9: 98,462,407 (GRCm39) |
Q464R |
possibly damaging |
Het |
| Dlc1 |
G |
T |
8: 37,404,989 (GRCm39) |
H267N |
probably benign |
Het |
| Dnajb2 |
T |
C |
1: 75,218,055 (GRCm39) |
I184T |
|
Het |
| Dnajc9 |
C |
T |
14: 20,438,764 (GRCm39) |
E30K |
possibly damaging |
Het |
| Dock1 |
T |
C |
7: 134,678,917 (GRCm39) |
L1012P |
possibly damaging |
Het |
| Dtnbp1 |
T |
C |
13: 45,106,650 (GRCm39) |
K170R |
probably benign |
Het |
| F13b |
T |
A |
1: 139,431,509 (GRCm39) |
C26* |
probably null |
Het |
| Ficd |
G |
T |
5: 113,877,020 (GRCm39) |
E398D |
probably benign |
Het |
| G6pc1 |
G |
A |
11: 101,267,359 (GRCm39) |
G270R |
probably damaging |
Het |
| Garin4 |
T |
A |
1: 190,895,645 (GRCm39) |
T333S |
probably benign |
Het |
| Gm3604 |
T |
C |
13: 62,517,587 (GRCm39) |
Y257C |
probably damaging |
Het |
| Hmcn1 |
T |
A |
1: 150,531,606 (GRCm39) |
Y3221F |
probably damaging |
Het |
| Hs3st3b1 |
C |
T |
11: 63,812,694 (GRCm39) |
G7D |
possibly damaging |
Het |
| Htr3b |
A |
T |
9: 48,856,852 (GRCm39) |
S209T |
probably benign |
Het |
| Ift70a1 |
A |
T |
2: 75,811,188 (GRCm39) |
D298E |
probably benign |
Het |
| Iglon5 |
T |
A |
7: 43,126,326 (GRCm39) |
E192D |
probably benign |
Het |
| Inpp5f |
A |
G |
7: 128,295,638 (GRCm39) |
|
probably null |
Het |
| Kif26b |
T |
A |
1: 178,506,484 (GRCm39) |
C187S |
probably damaging |
Het |
| Klhl11 |
A |
G |
11: 100,354,805 (GRCm39) |
S339P |
probably benign |
Het |
| Klk14 |
G |
A |
7: 43,341,467 (GRCm39) |
A40T |
probably damaging |
Het |
| Kmt2c |
G |
A |
5: 25,520,194 (GRCm39) |
T1972I |
probably benign |
Het |
| Lama2 |
T |
C |
10: 26,869,094 (GRCm39) |
T2784A |
probably benign |
Het |
| Loxhd1 |
T |
A |
18: 77,472,746 (GRCm39) |
F1088I |
probably damaging |
Het |
| Map2k2 |
G |
A |
10: 80,954,968 (GRCm39) |
R185Q |
probably benign |
Het |
| Mbd5 |
G |
A |
2: 49,169,796 (GRCm39) |
|
probably null |
Het |
| Mdc1 |
A |
T |
17: 36,161,570 (GRCm39) |
R828* |
probably null |
Het |
| Nrp2 |
C |
T |
1: 62,784,567 (GRCm39) |
R239C |
probably damaging |
Het |
| Or5g25 |
A |
G |
2: 85,478,417 (GRCm39) |
S83P |
possibly damaging |
Het |
| Parp4 |
C |
A |
14: 56,832,708 (GRCm39) |
|
probably null |
Het |
| Pbk |
T |
A |
14: 66,046,650 (GRCm39) |
|
probably null |
Het |
| Phip |
A |
T |
9: 82,775,401 (GRCm39) |
D1060E |
probably benign |
Het |
| Pik3c2b |
T |
A |
1: 133,031,587 (GRCm39) |
L1509Q |
probably damaging |
Het |
| Pik3r5 |
T |
A |
11: 68,386,796 (GRCm39) |
F808L |
probably benign |
Het |
| Plcl1 |
T |
A |
1: 55,736,443 (GRCm39) |
S595T |
possibly damaging |
Het |
| Plxna2 |
AT |
A |
1: 194,476,172 (GRCm39) |
|
probably null |
Het |
| Pole |
A |
G |
5: 110,437,727 (GRCm39) |
K95R |
possibly damaging |
Het |
| Poteg |
A |
G |
8: 27,946,888 (GRCm39) |
T259A |
probably benign |
Het |
| Pramel52-ps |
A |
G |
5: 94,531,739 (GRCm39) |
M208V |
probably benign |
Het |
| Ptpn12 |
G |
T |
5: 21,260,687 (GRCm39) |
P20Q |
probably benign |
Het |
| Ptpn5 |
T |
A |
7: 46,729,295 (GRCm39) |
T440S |
possibly damaging |
Het |
| Ptpru |
T |
C |
4: 131,515,820 (GRCm39) |
R845G |
probably benign |
Het |
| Rasgrp2 |
G |
T |
19: 6,464,839 (GRCm39) |
V596L |
probably benign |
Het |
| Rel |
T |
C |
11: 23,694,493 (GRCm39) |
N289S |
probably damaging |
Het |
| Rpn1 |
T |
A |
6: 88,079,068 (GRCm39) |
Y504N |
probably damaging |
Het |
| Rsf1 |
CGGCGGCGG |
CGGCGGCGGGGGCGGCGG |
7: 97,229,124 (GRCm39) |
|
probably benign |
Het |
| Scaf8 |
G |
A |
17: 3,221,397 (GRCm39) |
V295M |
unknown |
Het |
| Skic3 |
T |
C |
13: 76,260,318 (GRCm39) |
C87R |
probably benign |
Het |
| Slc25a48 |
T |
A |
13: 56,611,411 (GRCm39) |
Y173N |
probably damaging |
Het |
| Slc8a3 |
C |
T |
12: 81,263,506 (GRCm39) |
S627N |
probably benign |
Het |
| Snx8 |
T |
A |
5: 140,343,848 (GRCm39) |
M123L |
probably benign |
Het |
| Sri |
A |
T |
5: 8,114,586 (GRCm39) |
Q180H |
probably benign |
Het |
| Sycp2 |
T |
A |
2: 178,046,453 (GRCm39) |
R4S |
probably null |
Het |
| Tcstv1a |
G |
A |
13: 120,355,521 (GRCm39) |
T37I |
possibly damaging |
Het |
| Tnnc2 |
A |
T |
2: 164,619,704 (GRCm39) |
D87E |
probably benign |
Het |
| Trim7 |
A |
T |
11: 48,728,628 (GRCm39) |
N92I |
probably damaging |
Het |
| Trpv6 |
C |
T |
6: 41,604,612 (GRCm39) |
D97N |
probably benign |
Het |
| Ulk4 |
A |
G |
9: 121,102,022 (GRCm39) |
Y19H |
probably damaging |
Het |
| Vmn2r69 |
C |
T |
7: 85,055,973 (GRCm39) |
V722I |
probably benign |
Het |
| Zan |
T |
C |
5: 137,407,865 (GRCm39) |
D3643G |
unknown |
Het |
| Zan |
G |
A |
5: 137,463,154 (GRCm39) |
T675I |
unknown |
Het |
|
| Other mutations in Rcbtb2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01981:Rcbtb2
|
APN |
14 |
73,402,222 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02550:Rcbtb2
|
APN |
14 |
73,399,459 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02800:Rcbtb2
|
APN |
14 |
73,405,543 (GRCm39) |
nonsense |
probably null |
|
|
IGL02811:Rcbtb2
|
APN |
14 |
73,411,851 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0319:Rcbtb2
|
UTSW |
14 |
73,415,909 (GRCm39) |
missense |
probably benign |
0.04 |
|
R0390:Rcbtb2
|
UTSW |
14 |
73,415,987 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0448:Rcbtb2
|
UTSW |
14 |
73,415,869 (GRCm39) |
splice site |
probably benign |
|
|
R1298:Rcbtb2
|
UTSW |
14 |
73,399,828 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1567:Rcbtb2
|
UTSW |
14 |
73,399,902 (GRCm39) |
missense |
probably benign |
0.07 |
|
R2014:Rcbtb2
|
UTSW |
14 |
73,411,826 (GRCm39) |
splice site |
probably benign |
|
|
R2137:Rcbtb2
|
UTSW |
14 |
73,399,491 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2218:Rcbtb2
|
UTSW |
14 |
73,416,005 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4505:Rcbtb2
|
UTSW |
14 |
73,411,345 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5832:Rcbtb2
|
UTSW |
14 |
73,404,262 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5898:Rcbtb2
|
UTSW |
14 |
73,399,405 (GRCm39) |
nonsense |
probably null |
|
|
R6484:Rcbtb2
|
UTSW |
14 |
73,414,490 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7252:Rcbtb2
|
UTSW |
14 |
73,404,220 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7606:Rcbtb2
|
UTSW |
14 |
73,419,806 (GRCm39) |
splice site |
probably null |
|
|
R7654:Rcbtb2
|
UTSW |
14 |
73,411,941 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7762:Rcbtb2
|
UTSW |
14 |
73,415,906 (GRCm39) |
missense |
probably benign |
|
|
R7951:Rcbtb2
|
UTSW |
14 |
73,403,992 (GRCm39) |
nonsense |
probably null |
|
|
R8086:Rcbtb2
|
UTSW |
14 |
73,411,305 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8366:Rcbtb2
|
UTSW |
14 |
73,444,632 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8696:Rcbtb2
|
UTSW |
14 |
73,404,305 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9206:Rcbtb2
|
UTSW |
14 |
73,414,500 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9208:Rcbtb2
|
UTSW |
14 |
73,414,500 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9237:Rcbtb2
|
UTSW |
14 |
73,411,936 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACAGCATCAGATGTGGGTG -3'
(R):5'- TCAGGCAGCCTTCCTAAAGC -3'
Sequencing Primer
(F):5'- CATCAGATGTGGGTGACTCTCAGC -3'
(R):5'- CCATTACTAAACATATGGGTGGTTG -3'
|
| Posted On |
2020-09-15 |
Incidental Mutation