|Institutional Source||Beutler Lab|
|Gene Name||cyclin G1|
|Is this an essential gene?||Possibly non essential (E-score: 0.434)|
|Stock #||R7961 (G1)|
|Chromosomal Location||40748552-40755311 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||G to A at 40751269 bp|
|Amino Acid Change||Histidine to Tyrosine at position 229 (H229Y)|
|Ref Sequence||ENSEMBL: ENSMUSP00000020576 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000020576]|
|Predicted Effect||probably benign
AA Change: H229Y
PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
AA Change: H229Y
|Meta Mutation Damage Score||0.0977|
|Coding Region Coverage||
|Validation Efficiency||94% (44/47)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The protein encoded by this gene is a member of the cyclin family and contains the cyclin box. The encoded protein lacks the protein destabilizing (PEST) sequence that is present in other family members. Transcriptional activation of this gene can be induced by tumor protein p53. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Depending on the allele, homozygous mutants exhibit increased cellular sensitivity to gamma-irradiation or decreased incidence of induced hepatic tumors. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Ccng1||
(F):5'- GGTCAAATCTCGGCCACTTATC -3'
(R):5'- CTGCAGGATCATATTTTCTAAGGC -3'
(F):5'- AAATCTCGGCCACTTATCTGTAC -3'
(R):5'- CAGGATCATATTTTCTAAGGCAAAGG -3'