Incidental Mutation 'R7961:Ccng1'
ID 650125
Institutional Source Beutler Lab
Gene Symbol Ccng1
Ensembl Gene ENSMUSG00000020326
Gene Name cyclin G1
Synonyms cyclin G
MMRRC Submission 046005-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.274) question?
Stock # R7961 (G1)
Quality Score 225.009
Status Validated
Chromosome 11
Chromosomal Location 40639379-40646044 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 40642096 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Tyrosine at position 229 (H229Y)
Ref Sequence ENSEMBL: ENSMUSP00000020576 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000020576]
AlphaFold P51945
Predicted Effect probably benign
Transcript: ENSMUST00000020576
AA Change: H229Y

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000020576
Gene: ENSMUSG00000020326
AA Change: H229Y

DomainStartEndE-ValueType
CYCLIN 56 142 3.63e-17 SMART
Meta Mutation Damage Score 0.0977 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 94% (44/47)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The protein encoded by this gene is a member of the cyclin family and contains the cyclin box. The encoded protein lacks the protein destabilizing (PEST) sequence that is present in other family members. Transcriptional activation of this gene can be induced by tumor protein p53. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Depending on the allele, homozygous mutants exhibit increased cellular sensitivity to gamma-irradiation or decreased incidence of induced hepatic tumors. [provided by MGI curators]
Allele List at MGI

All alleles(7) : Targeted, knock-out(2) Targeted, other(1) Gene trapped(4)
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb1b T A 5: 8,878,870 (GRCm39) N751K possibly damaging Het
Bckdha G A 7: 25,330,903 (GRCm39) R288W probably damaging Het
Cenpn C A 8: 117,663,976 (GRCm39) T256N probably benign Het
Ciart A G 3: 95,788,629 (GRCm39) V70A possibly damaging Het
Clcc1 A G 3: 108,568,774 (GRCm39) N36S probably damaging Het
Cntnap1 G A 11: 101,069,121 (GRCm39) A192T probably benign Het
Dmrt1 T A 19: 25,523,245 (GRCm39) S199T possibly damaging Het
Dmrt3 T C 19: 25,588,272 (GRCm39) V37A possibly damaging Het
Dock1 T A 7: 134,346,786 (GRCm39) D239E possibly damaging Het
Dyrk3 A G 1: 131,063,995 (GRCm39) probably null Het
Engase A G 11: 118,377,686 (GRCm39) D571G possibly damaging Het
Gm45871 C T 18: 90,609,883 (GRCm39) H374Y probably damaging Het
Icam5 T C 9: 20,950,051 (GRCm39) V870A possibly damaging Het
Idh2 T C 7: 79,748,001 (GRCm39) H233R probably benign Het
Kcna5 A G 6: 126,510,517 (GRCm39) L537P probably benign Het
Krt71 T C 15: 101,643,877 (GRCm39) I454V probably damaging Het
Krtap5-4 C T 7: 141,857,671 (GRCm39) Q114* probably null Het
Loxl3 T C 6: 83,027,790 (GRCm39) F734S possibly damaging Het
Lpcat1 C T 13: 73,659,498 (GRCm39) T420I probably damaging Het
Mia2 T A 12: 59,206,425 (GRCm39) probably null Het
Neurod4 A T 10: 130,106,356 (GRCm39) V306D possibly damaging Het
Nkiras2 A T 11: 100,510,628 (GRCm39) probably benign Het
Nrp2 C T 1: 62,784,567 (GRCm39) R239C probably damaging Het
Ntrk3 T A 7: 78,103,076 (GRCm39) D408V probably benign Het
Nubpl T A 12: 52,228,080 (GRCm39) L168* probably null Het
Odf1 A G 15: 38,226,840 (GRCm39) I247V unknown Het
Or4c35 A G 2: 89,808,131 (GRCm39) Q3R probably benign Het
Or4k48 G A 2: 111,476,282 (GRCm39) S20F probably damaging Het
Or5d41 C A 2: 88,055,033 (GRCm39) M114I possibly damaging Het
Pcsk1 T C 13: 75,274,958 (GRCm39) S516P probably benign Het
Pikfyve A G 1: 65,294,293 (GRCm39) D1411G probably damaging Het
Polm T C 11: 5,780,155 (GRCm39) D294G possibly damaging Het
Ppcs A T 4: 119,276,262 (GRCm39) S281T probably benign Het
Pramel34 T C 5: 93,784,543 (GRCm39) D307G probably damaging Het
Pspc1 G A 14: 57,009,304 (GRCm39) Q177* probably null Het
Rbm33 G A 5: 28,599,606 (GRCm39) G185R Het
Satb2 A G 1: 56,910,917 (GRCm39) S243P probably benign Het
Serinc5 T C 13: 92,797,699 (GRCm39) probably null Het
Sgsm1 T C 5: 113,430,510 (GRCm39) T292A probably damaging Het
Smad3 G A 9: 63,557,564 (GRCm39) R420C possibly damaging Het
Sntg1 C T 1: 8,433,794 (GRCm39) V486I probably damaging Het
Tep1 A G 14: 51,061,687 (GRCm39) S2610P possibly damaging Het
Tmem200a A G 10: 25,869,904 (GRCm39) S122P probably damaging Het
Tnks2 T A 19: 36,829,901 (GRCm39) M194K probably benign Het
Trav14d-3-dv8 A C 14: 53,316,224 (GRCm39) Q28P probably damaging Het
Trpm5 T C 7: 142,634,106 (GRCm39) E700G probably benign Het
Ubqln3 T A 7: 103,791,797 (GRCm39) I98L probably benign Het
Usp25 A G 16: 76,856,150 (GRCm39) I248V probably damaging Het
Vmn1r28 T C 6: 58,242,178 (GRCm39) V7A probably benign Het
Zfp60 G A 7: 27,447,881 (GRCm39) G183D probably benign Het
Other mutations in Ccng1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00693:Ccng1 APN 11 40,644,885 (GRCm39) missense probably benign 0.00
IGL01875:Ccng1 APN 11 40,643,183 (GRCm39) missense probably benign 0.09
IGL02986:Ccng1 APN 11 40,641,690 (GRCm39) utr 3 prime probably benign
G5030:Ccng1 UTSW 11 40,644,629 (GRCm39) splice site probably benign
R1375:Ccng1 UTSW 11 40,642,941 (GRCm39) missense probably benign 0.02
R1377:Ccng1 UTSW 11 40,642,941 (GRCm39) missense probably benign 0.02
R1715:Ccng1 UTSW 11 40,642,941 (GRCm39) missense probably benign 0.02
R3620:Ccng1 UTSW 11 40,642,992 (GRCm39) missense probably benign 0.01
R3857:Ccng1 UTSW 11 40,644,660 (GRCm39) missense probably damaging 0.99
R3858:Ccng1 UTSW 11 40,644,660 (GRCm39) missense probably damaging 0.99
R5082:Ccng1 UTSW 11 40,643,015 (GRCm39) missense possibly damaging 0.77
R5172:Ccng1 UTSW 11 40,642,113 (GRCm39) missense probably benign
R5521:Ccng1 UTSW 11 40,643,093 (GRCm39) missense possibly damaging 0.87
R7431:Ccng1 UTSW 11 40,644,745 (GRCm39) missense possibly damaging 0.74
R8009:Ccng1 UTSW 11 40,642,096 (GRCm39) missense probably benign 0.00
R8794:Ccng1 UTSW 11 40,644,826 (GRCm39) missense probably benign
R9036:Ccng1 UTSW 11 40,643,078 (GRCm39) missense possibly damaging 0.55
R9530:Ccng1 UTSW 11 40,644,885 (GRCm39) missense probably benign 0.00
T0975:Ccng1 UTSW 11 40,644,871 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- GGTCAAATCTCGGCCACTTATC -3'
(R):5'- CTGCAGGATCATATTTTCTAAGGC -3'

Sequencing Primer
(F):5'- AAATCTCGGCCACTTATCTGTAC -3'
(R):5'- CAGGATCATATTTTCTAAGGCAAAGG -3'
Posted On 2020-09-15