Incidental Mutation 'R7963:Or5w1b'
ID 650207
Institutional Source Beutler Lab
Gene Symbol Or5w1b
Ensembl Gene ENSMUSG00000075155
Gene Name olfactory receptor family 5 subfamily W member 1B
Synonyms GA_x6K02T2Q125-49151278-49150337, Olfr1133, MOR176-2
MMRRC Submission 046006-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.061) question?
Stock # R7963 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 87475524-87476465 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 87475769 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Lysine at position 233 (E233K)
Ref Sequence ENSEMBL: ENSMUSP00000149460 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099855] [ENSMUST00000217368]
AlphaFold Q7TR44
Predicted Effect probably benign
Transcript: ENSMUST00000099855
AA Change: E233K

PolyPhen 2 Score 0.163 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000097441
Gene: ENSMUSG00000075155
AA Change: E233K

DomainStartEndE-ValueType
low complexity region 3 14 N/A INTRINSIC
Pfam:7tm_4 32 308 7e-51 PFAM
Pfam:7tm_1 42 291 1.8e-15 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000217368
AA Change: E233K

PolyPhen 2 Score 0.163 (Sensitivity: 0.92; Specificity: 0.87)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2210408I21Rik A G 13: 77,340,673 (GRCm39) K101E probably benign Het
4930407I10Rik A G 15: 81,948,137 (GRCm39) K678R possibly damaging Het
Akr1b10 G C 6: 34,364,643 (GRCm39) A35P possibly damaging Het
Arhgef10l T C 4: 140,306,736 (GRCm39) E106G probably damaging Het
Atp9a T C 2: 168,516,732 (GRCm39) Y445C probably damaging Het
Btbd18 T C 2: 84,498,239 (GRCm39) S626P probably benign Het
Cdh23 A T 10: 60,171,967 (GRCm39) N1738K probably damaging Het
Cdv3 T C 9: 103,241,210 (GRCm39) D119G probably damaging Het
Cep295 A G 9: 15,244,737 (GRCm39) F1240L possibly damaging Het
Cmtm1 CGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGT CGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGT 8: 105,036,102 (GRCm39) probably benign Het
Ctsr C A 13: 61,310,276 (GRCm39) V127L probably damaging Het
Dlg1 G A 16: 31,609,119 (GRCm39) R271Q probably null Het
Dnaaf11 A T 15: 66,252,366 (GRCm39) D433E probably damaging Het
Dnajc1 G A 2: 18,227,535 (GRCm39) T377I possibly damaging Het
F2rl3 T C 8: 73,489,333 (GRCm39) Y187H probably damaging Het
Fgf1 A T 18: 38,980,167 (GRCm39) V69E probably damaging Het
Garem1 T C 18: 21,281,844 (GRCm39) K171E probably damaging Het
H3c13 C A 3: 96,176,309 (GRCm39) Y100* probably null Het
Il2ra G A 2: 11,679,235 (GRCm39) R65H probably benign Het
Lrp1b T C 2: 40,817,947 (GRCm39) I2428V Het
Lrp3 G A 7: 34,902,404 (GRCm39) Q579* probably null Het
Ncoa6 G A 2: 155,247,916 (GRCm39) T1796I probably benign Het
Ncor1 T C 11: 62,225,359 (GRCm39) I747V probably benign Het
Nfkb2 C T 19: 46,298,358 (GRCm39) T554M possibly damaging Het
Nrde2 T C 12: 100,116,127 (GRCm39) D119G probably damaging Het
Odf2 C A 2: 29,816,112 (GRCm39) Q720K probably benign Het
Or4c52 T C 2: 89,846,003 (GRCm39) V243A possibly damaging Het
Or4k41 T A 2: 111,279,971 (GRCm39) L162Q possibly damaging Het
Or8k33 T C 2: 86,383,639 (GRCm39) I276M possibly damaging Het
Pcx T C 19: 4,652,034 (GRCm39) V94A probably damaging Het
Pdxdc1 A T 16: 13,694,030 (GRCm39) Y131N possibly damaging Het
Peg10 GC GCTCC 6: 4,756,452 (GRCm39) probably benign Het
Plod2 A G 9: 92,487,499 (GRCm39) H606R probably benign Het
Ptp4a2 A G 4: 129,733,237 (GRCm39) probably benign Het
Rsl1 A G 13: 67,330,173 (GRCm39) E207G probably damaging Het
Slc28a3 A G 13: 58,724,580 (GRCm39) Y225H probably damaging Het
Spag17 T A 3: 99,929,954 (GRCm39) M551K probably benign Het
Ssh2 C A 11: 77,312,182 (GRCm39) A231D possibly damaging Het
Stab2 A G 10: 86,683,887 (GRCm39) probably null Het
Stac2 T C 11: 97,932,403 (GRCm39) T197A probably benign Het
Syne2 T A 12: 76,067,174 (GRCm39) L4291Q probably benign Het
Vmn2r38 A T 7: 9,095,854 (GRCm39) D179E probably benign Het
Zfp597 T C 16: 3,689,022 (GRCm39) D51G probably benign Het
Zfp64 A T 2: 168,793,538 (GRCm39) F69L probably benign Het
Other mutations in Or5w1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02377:Or5w1b APN 2 87,475,630 (GRCm39) missense probably damaging 1.00
IGL03354:Or5w1b APN 2 87,475,939 (GRCm39) missense probably damaging 0.99
PIT4366001:Or5w1b UTSW 2 87,475,534 (GRCm39) nonsense probably null
R1375:Or5w1b UTSW 2 87,476,081 (GRCm39) missense probably damaging 1.00
R1413:Or5w1b UTSW 2 87,476,182 (GRCm39) missense probably benign 0.02
R2011:Or5w1b UTSW 2 87,476,233 (GRCm39) missense probably damaging 0.97
R2016:Or5w1b UTSW 2 87,476,396 (GRCm39) missense probably benign 0.18
R2026:Or5w1b UTSW 2 87,475,753 (GRCm39) missense probably damaging 1.00
R2106:Or5w1b UTSW 2 87,475,895 (GRCm39) missense probably damaging 1.00
R4393:Or5w1b UTSW 2 87,476,256 (GRCm39) nonsense probably null
R5292:Or5w1b UTSW 2 87,476,339 (GRCm39) missense probably damaging 1.00
R5562:Or5w1b UTSW 2 87,476,063 (GRCm39) missense probably benign 0.00
R5631:Or5w1b UTSW 2 87,475,952 (GRCm39) missense probably benign 0.16
R5632:Or5w1b UTSW 2 87,475,573 (GRCm39) missense probably damaging 1.00
R6801:Or5w1b UTSW 2 87,475,667 (GRCm39) missense probably benign 0.23
R7014:Or5w1b UTSW 2 87,476,320 (GRCm39) missense probably damaging 1.00
R8769:Or5w1b UTSW 2 87,475,960 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- TCTCAAACTGTAGATGAGTGGG -3'
(R):5'- ATCCTGTGCATTCAGATTGTCC -3'

Sequencing Primer
(F):5'- GTGGGTTTAACATAGGAATCACAAC -3'
(R):5'- CCTTCTGCAATTCAAATGTCATCAAC -3'
Posted On 2020-09-15