Incidental Mutation 'R7963:Ptp4a2'
ID 650215
Institutional Source Beutler Lab
Gene Symbol Ptp4a2
Ensembl Gene ENSMUSG00000028788
Gene Name protein tyrosine phosphatase 4a2
Synonyms Prl-2
MMRRC Submission 046006-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7963 (G1)
Quality Score 201.009
Status Not validated
Chromosome 4
Chromosomal Location 129714262-129743796 bp(+) (GRCm39)
Type of Mutation start gained
DNA Base Change (assembly) A to G at 129733237 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000125901 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030578] [ENSMUST00000165853]
AlphaFold O70274
Predicted Effect probably benign
Transcript: ENSMUST00000030578
SMART Domains Protein: ENSMUSP00000030578
Gene: ENSMUSG00000028788

DomainStartEndE-ValueType
Pfam:Y_phosphatase 10 148 2e-9 PFAM
Pfam:DSPc 22 150 7.8e-9 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000165853
SMART Domains Protein: ENSMUSP00000125901
Gene: ENSMUSG00000028788

DomainStartEndE-ValueType
Pfam:DSPc 22 151 2.9e-10 PFAM
Pfam:Y_phosphatase 47 149 1e-10 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 11, 12 and 17. [provided by RefSeq, Aug 2010]
PHENOTYPE: Mice homozygous for a gene trap allele exhibit growth retardation associated with reduced decidual, spongiotrophoblast (due to reduced cell proliferation) and placental labyrinth. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2210408I21Rik A G 13: 77,340,673 (GRCm39) K101E probably benign Het
4930407I10Rik A G 15: 81,948,137 (GRCm39) K678R possibly damaging Het
Akr1b10 G C 6: 34,364,643 (GRCm39) A35P possibly damaging Het
Arhgef10l T C 4: 140,306,736 (GRCm39) E106G probably damaging Het
Atp9a T C 2: 168,516,732 (GRCm39) Y445C probably damaging Het
Btbd18 T C 2: 84,498,239 (GRCm39) S626P probably benign Het
Cdh23 A T 10: 60,171,967 (GRCm39) N1738K probably damaging Het
Cdv3 T C 9: 103,241,210 (GRCm39) D119G probably damaging Het
Cep295 A G 9: 15,244,737 (GRCm39) F1240L possibly damaging Het
Cmtm1 CGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGT CGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGT 8: 105,036,102 (GRCm39) probably benign Het
Ctsr C A 13: 61,310,276 (GRCm39) V127L probably damaging Het
Dlg1 G A 16: 31,609,119 (GRCm39) R271Q probably null Het
Dnaaf11 A T 15: 66,252,366 (GRCm39) D433E probably damaging Het
Dnajc1 G A 2: 18,227,535 (GRCm39) T377I possibly damaging Het
F2rl3 T C 8: 73,489,333 (GRCm39) Y187H probably damaging Het
Fgf1 A T 18: 38,980,167 (GRCm39) V69E probably damaging Het
Garem1 T C 18: 21,281,844 (GRCm39) K171E probably damaging Het
H3c13 C A 3: 96,176,309 (GRCm39) Y100* probably null Het
Il2ra G A 2: 11,679,235 (GRCm39) R65H probably benign Het
Lrp1b T C 2: 40,817,947 (GRCm39) I2428V Het
Lrp3 G A 7: 34,902,404 (GRCm39) Q579* probably null Het
Ncoa6 G A 2: 155,247,916 (GRCm39) T1796I probably benign Het
Ncor1 T C 11: 62,225,359 (GRCm39) I747V probably benign Het
Nfkb2 C T 19: 46,298,358 (GRCm39) T554M possibly damaging Het
Nrde2 T C 12: 100,116,127 (GRCm39) D119G probably damaging Het
Odf2 C A 2: 29,816,112 (GRCm39) Q720K probably benign Het
Or4c52 T C 2: 89,846,003 (GRCm39) V243A possibly damaging Het
Or4k41 T A 2: 111,279,971 (GRCm39) L162Q possibly damaging Het
Or5w1b C T 2: 87,475,769 (GRCm39) E233K probably benign Het
Or8k33 T C 2: 86,383,639 (GRCm39) I276M possibly damaging Het
Pcx T C 19: 4,652,034 (GRCm39) V94A probably damaging Het
Pdxdc1 A T 16: 13,694,030 (GRCm39) Y131N possibly damaging Het
Peg10 GC GCTCC 6: 4,756,452 (GRCm39) probably benign Het
Plod2 A G 9: 92,487,499 (GRCm39) H606R probably benign Het
Rsl1 A G 13: 67,330,173 (GRCm39) E207G probably damaging Het
Slc28a3 A G 13: 58,724,580 (GRCm39) Y225H probably damaging Het
Spag17 T A 3: 99,929,954 (GRCm39) M551K probably benign Het
Ssh2 C A 11: 77,312,182 (GRCm39) A231D possibly damaging Het
Stab2 A G 10: 86,683,887 (GRCm39) probably null Het
Stac2 T C 11: 97,932,403 (GRCm39) T197A probably benign Het
Syne2 T A 12: 76,067,174 (GRCm39) L4291Q probably benign Het
Vmn2r38 A T 7: 9,095,854 (GRCm39) D179E probably benign Het
Zfp597 T C 16: 3,689,022 (GRCm39) D51G probably benign Het
Zfp64 A T 2: 168,793,538 (GRCm39) F69L probably benign Het
Other mutations in Ptp4a2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02942:Ptp4a2 APN 4 129,738,986 (GRCm39) critical splice donor site probably null
R1082:Ptp4a2 UTSW 4 129,741,580 (GRCm39) missense probably benign
R1405:Ptp4a2 UTSW 4 129,738,851 (GRCm39) splice site probably benign
R4591:Ptp4a2 UTSW 4 129,740,308 (GRCm39) missense probably benign 0.16
R8208:Ptp4a2 UTSW 4 129,736,485 (GRCm39) missense probably benign 0.11
R8312:Ptp4a2 UTSW 4 129,733,427 (GRCm39) missense probably benign 0.06
R8768:Ptp4a2 UTSW 4 129,740,299 (GRCm39) missense probably damaging 0.98
R8919:Ptp4a2 UTSW 4 129,738,945 (GRCm39) missense possibly damaging 0.90
RF017:Ptp4a2 UTSW 4 129,733,237 (GRCm39) start gained probably benign
Predicted Primers PCR Primer
(F):5'- ACTTGTCTCACTAGTGCCTAAATG -3'
(R):5'- GGTTGTGAGTTATCAGAAAACGC -3'

Sequencing Primer
(F):5'- TGCCTAAATGTAGTAAAAAGGCTGC -3'
(R):5'- GTGAGTTATCAGAAAACGCATGTTC -3'
Posted On 2020-09-15