Mutagenetix > Incidental Mutation

Incidental Mutation 'R7964:Dcdc2c'

650288

Institutional Source

Beutler Lab

Gene Symbol

Dcdc2c

Ensembl Gene

ENSMUSG00000020633

Gene Name

doublecortin domain containing 2C

Synonyms

1110015M06Rik

MMRRC Submission

046007-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R7964 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

28487794-28602398 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 28520318 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 586 (I586T)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000189735] [ENSMUST00000221349]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000189735

SMART Domains

Protein: ENSMUSP00000140603
Gene: ENSMUSG00000020633

Domain	Start	End	E-Value	Type
Pfam:DCX	1	44	1.5e-9	PFAM
low complexity region	134	148	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000221349

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.8%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 52 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca13	A	T	11: 9,266,146 (GRCm39)	M3042L	probably benign	Het
Abca3	T	A	17: 24,621,410 (GRCm39)	L1345Q	probably benign	Het
Adam20	G	T	8: 41,249,944 (GRCm39)	V685F	probably damaging	Het
Adam25	T	A	8: 41,208,576 (GRCm39)	I614N	probably damaging	Het
Aldh1a7	C	T	19: 20,677,371 (GRCm39)	V417M	probably damaging	Het
Aldh1a7	C	T	19: 20,693,406 (GRCm39)	G171D	probably benign	Het
Aloxe3	T	C	11: 69,017,362 (GRCm39)	F45S	probably damaging	Het
Ankrd26	T	C	6: 118,500,160 (GRCm39)	I1104V	probably benign	Het
Ap3d1	C	A	10: 80,565,891 (GRCm39)	R92L	probably damaging	Het
Aspm	A	G	1: 139,408,424 (GRCm39)	Q2437R	probably damaging	Het
Bcl11a	T	C	11: 24,113,353 (GRCm39)	I232T	probably benign	Het
Cdcp3	G	T	7: 130,899,963 (GRCm39)	R2102L	unknown	Het
Cemip2	T	C	19: 21,775,794 (GRCm39)		probably null	Het
Cfap97	A	G	8: 46,623,237 (GRCm39)	D209G	possibly damaging	Het
Csmd2	A	G	4: 128,417,303 (GRCm39)	M2754V		Het
Dkk4	T	C	8: 23,115,368 (GRCm39)	C73R	probably damaging	Het
Dnai3	T	C	3: 145,774,531 (GRCm39)	N439D	probably benign	Het
Dzip3	T	C	16: 48,772,268 (GRCm39)	D467G	probably damaging	Het
Eif5	T	C	12: 111,506,608 (GRCm39)	F67L	probably benign	Het
Elmod1	A	G	9: 53,838,860 (GRCm39)	I100T	probably benign	Het
Gm9837	A	G	11: 53,361,001 (GRCm39)	L71P	unknown	Het
Hpse	A	G	5: 100,846,777 (GRCm39)		probably null	Het
Insc	T	C	7: 114,445,708 (GRCm39)	L472P	probably damaging	Het
Itgax	A	C	7: 127,739,590 (GRCm39)		probably null	Het
Lair1	A	G	7: 4,013,803 (GRCm39)	V148A	probably benign	Het
Lama2	A	G	10: 27,099,977 (GRCm39)		probably null	Het
Ldlrad1	G	A	4: 107,066,688 (GRCm39)	A8T	probably benign	Het
Lgr5	T	C	10: 115,288,079 (GRCm39)	D855G	probably benign	Het
Lrp1	C	A	10: 127,410,913 (GRCm39)	R1425L	possibly damaging	Het
Lrp1b	A	G	2: 40,488,523 (GRCm39)	S4521P		Het
Nbas	A	G	12: 13,406,896 (GRCm39)	Y831C	probably damaging	Het
Nek9	C	A	12: 85,385,787 (GRCm39)	R70L	probably benign	Het
Nlrp2	A	C	7: 5,331,527 (GRCm39)	L290V	probably damaging	Het
Nos1	T	A	5: 118,038,607 (GRCm39)	I480N	probably damaging	Het
Or4a80	T	C	2: 89,583,158 (GRCm39)	N5D	possibly damaging	Het
Pcdhb13	C	A	18: 37,577,871 (GRCm39)	Q750K	possibly damaging	Het
Pik3c2g	C	T	6: 139,827,786 (GRCm39)	T727I		Het
Pik3r6	C	A	11: 68,424,565 (GRCm39)	P390Q	probably benign	Het
Pramel1	T	C	4: 143,123,810 (GRCm39)	S162P	probably benign	Het
Psg21	A	G	7: 18,381,136 (GRCm39)	M469T	probably benign	Het
Psg27	A	T	7: 18,299,124 (GRCm39)	W66R	probably damaging	Het
Sbno2	A	G	10: 79,904,185 (GRCm39)	C371R	probably damaging	Het
Shroom1	G	T	11: 53,355,149 (GRCm39)	K329N	possibly damaging	Het
Slc35a3	A	G	3: 116,480,984 (GRCm39)	I93T	possibly damaging	Het
Slc38a2	G	A	15: 96,590,453 (GRCm39)	T297M	probably benign	Het
Sorl1	T	A	9: 41,902,697 (GRCm39)	D1620V	probably damaging	Het
Srsf4	T	A	4: 131,618,544 (GRCm39)	L45Q	probably benign	Het
Tcaf2	G	A	6: 42,606,640 (GRCm39)	S438L	probably benign	Het
Trappc11	T	A	8: 47,979,979 (GRCm39)	I186L	possibly damaging	Het
Usp9y	A	T	Y: 1,316,914 (GRCm39)	N1878K	probably benign	Het
Zfp280d	T	A	9: 72,229,740 (GRCm39)	M349K	probably damaging	Het
Zgpat	A	G	2: 181,020,274 (GRCm39)	H227R	probably benign	Het

Other mutations in Dcdc2c

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02892:Dcdc2c	APN	12	28,585,544 (GRCm39)	missense	probably benign	0.03
R1214:Dcdc2c	UTSW	12	28,580,429 (GRCm39)	nonsense	probably null
R3040:Dcdc2c	UTSW	12	28,602,181 (GRCm39)	missense	probably damaging	1.00
R4937:Dcdc2c	UTSW	12	28,580,472 (GRCm39)	missense	possibly damaging	0.69
R5268:Dcdc2c	UTSW	12	28,566,656 (GRCm39)	missense	possibly damaging	0.83
R5920:Dcdc2c	UTSW	12	28,585,536 (GRCm39)	missense	possibly damaging	0.67
R5921:Dcdc2c	UTSW	12	28,574,774 (GRCm39)	missense	possibly damaging	0.90
R6444:Dcdc2c	UTSW	12	28,585,475 (GRCm39)	missense	probably damaging	1.00
R6939:Dcdc2c	UTSW	12	28,591,496 (GRCm39)	missense	probably benign	0.09
R7044:Dcdc2c	UTSW	12	28,520,493 (GRCm39)	utr 3 prime	probably benign
R7235:Dcdc2c	UTSW	12	28,520,718 (GRCm39)	missense
R7287:Dcdc2c	UTSW	12	28,566,685 (GRCm39)	missense	probably benign
R7767:Dcdc2c	UTSW	12	28,520,256 (GRCm39)	missense
R7896:Dcdc2c	UTSW	12	28,520,619 (GRCm39)	nonsense	probably null
R8802:Dcdc2c	UTSW	12	28,576,720 (GRCm39)	missense	probably benign
R9111:Dcdc2c	UTSW	12	28,585,488 (GRCm39)	missense	probably damaging	1.00
R9545:Dcdc2c	UTSW	12	28,602,295 (GRCm39)	missense	possibly damaging	0.91
R9578:Dcdc2c	UTSW	12	28,602,234 (GRCm39)	missense	probably damaging	1.00
R9694:Dcdc2c	UTSW	12	28,585,553 (GRCm39)	missense
Z1176:Dcdc2c	UTSW	12	28,574,706 (GRCm39)	missense	probably benign	0.09

Predicted Primers

PCR Primer
(F):5'- CCCAGAGTCACCTGTTTCTAAG -3'
(R):5'- AACGGTACCTGTACAGTTGTCC -3'

Sequencing Primer
(F):5'- CAAGGATGACTGTCATTGGGATC -3'
(R):5'- GTACCTGTACAGTTGTCCTTGGGAC -3'

Posted On

2020-09-15