Incidental Mutation 'R7965:Or5t16'
ID 650304
Institutional Source Beutler Lab
Gene Symbol Or5t16
Ensembl Gene ENSMUSG00000075167
Gene Name olfactory receptor family 5 subfamily T member 16
Synonyms GA_x6K02T2Q125-48475870-48474938, MOR179-3, Olfr1101
MMRRC Submission 046008-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.101) question?
Stock # R7965 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 86818586-86819518 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 86818707 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 271 (V271A)
Ref Sequence ENSEMBL: ENSMUSP00000151171 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099870] [ENSMUST00000214411]
AlphaFold Q7TR59
Predicted Effect probably benign
Transcript: ENSMUST00000099870
AA Change: V271A

PolyPhen 2 Score 0.115 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000097455
Gene: ENSMUSG00000075167
AA Change: V271A

DomainStartEndE-ValueType
Pfam:7tm_4 28 305 1.7e-51 PFAM
Pfam:7tm_1 38 287 5.1e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214411
AA Change: V271A

PolyPhen 2 Score 0.115 (Sensitivity: 0.93; Specificity: 0.86)
Meta Mutation Damage Score 0.2315 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 100% (45/45)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankhd1 A G 18: 36,791,465 (GRCm39) T154A Het
Arhgap21 A G 2: 20,854,007 (GRCm39) I1795T probably damaging Het
Arhgef4 T C 1: 34,850,762 (GRCm39) V436A probably benign Het
Bche A T 3: 73,609,149 (GRCm39) N92K probably damaging Het
Bmp2 C T 2: 133,403,105 (GRCm39) H219Y probably benign Het
Cables1 T G 18: 11,973,269 (GRCm39) V136G probably benign Het
Cacna1d G A 14: 29,769,270 (GRCm39) R1887* probably null Het
Chrd A G 16: 20,557,903 (GRCm39) E774G probably benign Het
Chrna2 A G 14: 66,388,525 (GRCm39) *513W probably null Het
Cracr2b T C 7: 141,044,161 (GRCm39) F131S probably damaging Het
Ctsf T G 19: 4,906,567 (GRCm39) F165V probably damaging Het
Cyfip1 T A 7: 55,546,523 (GRCm39) I545N possibly damaging Het
Enpp3 T A 10: 24,654,717 (GRCm39) T654S possibly damaging Het
Glce A G 9: 61,968,228 (GRCm39) S308P probably damaging Het
H3c13 C A 3: 96,176,309 (GRCm39) Y100* probably null Het
Hmmr A C 11: 40,606,256 (GRCm39) probably null Het
Hoxb9 A G 11: 96,165,464 (GRCm39) N178D probably benign Het
Igkv10-94 A T 6: 68,681,595 (GRCm39) F82I probably damaging Het
Igkv1-133 A T 6: 67,702,578 (GRCm39) K99* probably null Het
Il4i1 A G 7: 44,489,819 (GRCm39) Q528R probably benign Het
Inhba G T 13: 16,201,572 (GRCm39) G378V possibly damaging Het
Katna1 T C 10: 7,614,623 (GRCm39) S44P probably benign Het
Ldlrad1 G A 4: 107,066,688 (GRCm39) A8T probably benign Het
Mgat4d T C 8: 84,084,722 (GRCm39) V155A possibly damaging Het
Morc2b C T 17: 33,354,746 (GRCm39) E1009K possibly damaging Het
Myo9a T A 9: 59,695,721 (GRCm39) L341H probably damaging Het
Nell2 C T 15: 95,129,216 (GRCm39) D716N probably damaging Het
Or1n2 A G 2: 36,796,953 (GRCm39) probably benign Het
Or8g36 C T 9: 39,422,810 (GRCm39) V69I probably benign Het
Or8k30 A G 2: 86,338,815 (GRCm39) H4R probably benign Het
Ppp1r37 T C 7: 19,265,868 (GRCm39) T633A probably damaging Het
Prdm10 A G 9: 31,258,302 (GRCm39) K576E probably damaging Het
Prl2c5 G T 13: 13,360,469 (GRCm39) M45I probably benign Het
Rigi C A 4: 40,223,824 (GRCm39) G397* probably null Het
Rnf44 A G 13: 54,830,667 (GRCm39) S247P probably benign Het
Scn3a A G 2: 65,336,555 (GRCm39) F684L probably damaging Het
Skint2 T A 4: 112,502,648 (GRCm39) M286K probably benign Het
Slc39a9 G A 12: 80,713,450 (GRCm39) G116D probably damaging Het
Smchd1 G A 17: 71,762,621 (GRCm39) T206I possibly damaging Het
Tmem161a C T 8: 70,630,154 (GRCm39) probably benign Het
Trpm6 T A 19: 18,853,474 (GRCm39) H1831Q probably damaging Het
Trpm7 A T 2: 126,667,614 (GRCm39) H792Q probably damaging Het
Ttc6 A G 12: 57,720,542 (GRCm39) Q936R possibly damaging Het
Usp53 A T 3: 122,756,531 (GRCm39) probably null Het
Vmn1r236 T A 17: 21,507,696 (GRCm39) C271* probably null Het
Vmn2r70 T A 7: 85,211,071 (GRCm39) M547L probably damaging Het
Vwa5b1 G A 4: 138,332,800 (GRCm39) T254M probably damaging Het
Zc3h4 T C 7: 16,163,770 (GRCm39) F655S unknown Het
Zfp605 G A 5: 110,275,316 (GRCm39) G145S probably benign Het
Other mutations in Or5t16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01288:Or5t16 APN 2 86,818,598 (GRCm39) missense probably benign
IGL03018:Or5t16 APN 2 86,819,349 (GRCm39) missense probably damaging 1.00
IGL03265:Or5t16 APN 2 86,819,424 (GRCm39) missense probably damaging 1.00
R0627:Or5t16 UTSW 2 86,819,358 (GRCm39) missense probably benign 0.21
R2871:Or5t16 UTSW 2 86,819,192 (GRCm39) nonsense probably null
R2871:Or5t16 UTSW 2 86,819,192 (GRCm39) nonsense probably null
R7012:Or5t16 UTSW 2 86,819,051 (GRCm39) missense possibly damaging 0.50
R7144:Or5t16 UTSW 2 86,819,164 (GRCm39) missense probably damaging 1.00
R7151:Or5t16 UTSW 2 86,819,385 (GRCm39) missense probably benign 0.16
R7521:Or5t16 UTSW 2 86,818,954 (GRCm39) missense probably damaging 1.00
R7672:Or5t16 UTSW 2 86,818,663 (GRCm39) missense possibly damaging 0.93
R7725:Or5t16 UTSW 2 86,819,323 (GRCm39) missense probably benign 0.00
R7863:Or5t16 UTSW 2 86,819,424 (GRCm39) missense probably damaging 1.00
R8447:Or5t16 UTSW 2 86,818,885 (GRCm39) missense probably benign 0.01
R8500:Or5t16 UTSW 2 86,818,822 (GRCm39) missense probably damaging 1.00
R8899:Or5t16 UTSW 2 86,818,710 (GRCm39) missense probably benign 0.03
R9776:Or5t16 UTSW 2 86,819,055 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- CAATGGGCATATAACTGTTCCC -3'
(R):5'- CATCTTTGTGAGCTCCATTGAG -3'

Sequencing Primer
(F):5'- CTCTTATATCCAGTTCAATGTGTGTG -3'
(R):5'- GCTCCATTGAGGTAGTCACTATC -3'
Posted On 2020-09-15