Incidental Mutation 'R7965:H3c13'
ID 650308
Institutional Source Beutler Lab
Gene Symbol H3c13
Ensembl Gene ENSMUSG00000074403
Gene Name H3 clustered histone 13
Synonyms Hist2h3b, H3-616
MMRRC Submission 046008-MU
Accession Numbers
Essential gene? Not available question?
Stock # R7965 (G1)
Quality Score 163.009
Status Not validated
Chromosome 3
Chromosomal Location 96175970-96176457 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to A at 96176309 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 100 (Y100*)
Ref Sequence ENSEMBL: ENSMUSP00000096442 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098843] [ENSMUST00000177113]
AlphaFold no structure available at present
Predicted Effect probably null
Transcript: ENSMUST00000098843
AA Change: Y100*
SMART Domains Protein: ENSMUSP00000096442
Gene: ENSMUSG00000074403
AA Change: Y100*

DomainStartEndE-ValueType
H3 34 136 2.12e-75 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000177113
SMART Domains Protein: ENSMUSP00000135427
Gene: ENSMUSG00000105827

DomainStartEndE-ValueType
H2B 28 124 1.43e-72 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 100% (45/45)
MGI Phenotype FUNCTION: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. [provided by RefSeq, Aug 2015]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankhd1 A G 18: 36,791,465 (GRCm39) T154A Het
Arhgap21 A G 2: 20,854,007 (GRCm39) I1795T probably damaging Het
Arhgef4 T C 1: 34,850,762 (GRCm39) V436A probably benign Het
Bche A T 3: 73,609,149 (GRCm39) N92K probably damaging Het
Bmp2 C T 2: 133,403,105 (GRCm39) H219Y probably benign Het
Cables1 T G 18: 11,973,269 (GRCm39) V136G probably benign Het
Cacna1d G A 14: 29,769,270 (GRCm39) R1887* probably null Het
Chrd A G 16: 20,557,903 (GRCm39) E774G probably benign Het
Chrna2 A G 14: 66,388,525 (GRCm39) *513W probably null Het
Cracr2b T C 7: 141,044,161 (GRCm39) F131S probably damaging Het
Ctsf T G 19: 4,906,567 (GRCm39) F165V probably damaging Het
Cyfip1 T A 7: 55,546,523 (GRCm39) I545N possibly damaging Het
Enpp3 T A 10: 24,654,717 (GRCm39) T654S possibly damaging Het
Glce A G 9: 61,968,228 (GRCm39) S308P probably damaging Het
Hmmr A C 11: 40,606,256 (GRCm39) probably null Het
Hoxb9 A G 11: 96,165,464 (GRCm39) N178D probably benign Het
Igkv10-94 A T 6: 68,681,595 (GRCm39) F82I probably damaging Het
Igkv1-133 A T 6: 67,702,578 (GRCm39) K99* probably null Het
Il4i1 A G 7: 44,489,819 (GRCm39) Q528R probably benign Het
Inhba G T 13: 16,201,572 (GRCm39) G378V possibly damaging Het
Katna1 T C 10: 7,614,623 (GRCm39) S44P probably benign Het
Ldlrad1 G A 4: 107,066,688 (GRCm39) A8T probably benign Het
Mgat4d T C 8: 84,084,722 (GRCm39) V155A possibly damaging Het
Morc2b C T 17: 33,354,746 (GRCm39) E1009K possibly damaging Het
Myo9a T A 9: 59,695,721 (GRCm39) L341H probably damaging Het
Nell2 C T 15: 95,129,216 (GRCm39) D716N probably damaging Het
Or1n2 A G 2: 36,796,953 (GRCm39) probably benign Het
Or5t16 A G 2: 86,818,707 (GRCm39) V271A probably benign Het
Or8g36 C T 9: 39,422,810 (GRCm39) V69I probably benign Het
Or8k30 A G 2: 86,338,815 (GRCm39) H4R probably benign Het
Ppp1r37 T C 7: 19,265,868 (GRCm39) T633A probably damaging Het
Prdm10 A G 9: 31,258,302 (GRCm39) K576E probably damaging Het
Prl2c5 G T 13: 13,360,469 (GRCm39) M45I probably benign Het
Rigi C A 4: 40,223,824 (GRCm39) G397* probably null Het
Rnf44 A G 13: 54,830,667 (GRCm39) S247P probably benign Het
Scn3a A G 2: 65,336,555 (GRCm39) F684L probably damaging Het
Skint2 T A 4: 112,502,648 (GRCm39) M286K probably benign Het
Slc39a9 G A 12: 80,713,450 (GRCm39) G116D probably damaging Het
Smchd1 G A 17: 71,762,621 (GRCm39) T206I possibly damaging Het
Tmem161a C T 8: 70,630,154 (GRCm39) probably benign Het
Trpm6 T A 19: 18,853,474 (GRCm39) H1831Q probably damaging Het
Trpm7 A T 2: 126,667,614 (GRCm39) H792Q probably damaging Het
Ttc6 A G 12: 57,720,542 (GRCm39) Q936R possibly damaging Het
Usp53 A T 3: 122,756,531 (GRCm39) probably null Het
Vmn1r236 T A 17: 21,507,696 (GRCm39) C271* probably null Het
Vmn2r70 T A 7: 85,211,071 (GRCm39) M547L probably damaging Het
Vwa5b1 G A 4: 138,332,800 (GRCm39) T254M probably damaging Het
Zc3h4 T C 7: 16,163,770 (GRCm39) F655S unknown Het
Zfp605 G A 5: 110,275,316 (GRCm39) G145S probably benign Het
Other mutations in H3c13
AlleleSourceChrCoordTypePredicted EffectPPH Score
R4698:H3c13 UTSW 3 96,176,394 (GRCm39) missense probably damaging 1.00
R4885:H3c13 UTSW 3 96,176,277 (GRCm39) missense possibly damaging 0.77
R7152:H3c13 UTSW 3 96,176,254 (GRCm39) missense probably benign 0.13
R7702:H3c13 UTSW 3 96,176,309 (GRCm39) nonsense probably null
R7703:H3c13 UTSW 3 96,176,309 (GRCm39) nonsense probably null
R7758:H3c13 UTSW 3 96,176,203 (GRCm39) missense possibly damaging 0.91
R7962:H3c13 UTSW 3 96,176,309 (GRCm39) nonsense probably null
R7963:H3c13 UTSW 3 96,176,309 (GRCm39) nonsense probably null
R8081:H3c13 UTSW 3 96,176,309 (GRCm39) nonsense probably null
R8082:H3c13 UTSW 3 96,176,309 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- AATATGGCCCGTACGAAGC -3'
(R):5'- TCATCGACAACGTAGGTGGC -3'

Sequencing Primer
(F):5'- AGCAGCTGGCCACCAAG -3'
(R):5'- CTCTGAAAAGAGCCTTTGTGG -3'
Posted On 2020-09-15