Incidental Mutation 'R7969:Dao'
ID 650497
Institutional Source Beutler Lab
Gene Symbol Dao
Ensembl Gene ENSMUSG00000042096
Gene Name D-amino acid oxidase
Synonyms Dao-1, DAO, Dao1
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.052) question?
Stock # R7969 (G1)
Quality Score 215.468
Status Not validated
Chromosome 5
Chromosomal Location 114003703-114025682 bp(+) (GRCm38)
Type of Mutation critical splice donor site
DNA Base Change (assembly) AGG to AG at 114015209 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000107911 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086599] [ENSMUST00000112292] [ENSMUST00000161610]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000086599
SMART Domains Protein: ENSMUSP00000083792
Gene: ENSMUSG00000042096

DomainStartEndE-ValueType
Pfam:DAO 2 245 1.8e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000112292
SMART Domains Protein: ENSMUSP00000107911
Gene: ENSMUSG00000042096

DomainStartEndE-ValueType
Pfam:DAO 2 327 1.8e-39 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000161610
SMART Domains Protein: ENSMUSP00000125588
Gene: ENSMUSG00000042096

DomainStartEndE-ValueType
Pfam:DAO 2 327 4.5e-33 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000199175
Meta Mutation Damage Score 0.0846 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the peroxisomal enzyme D-amino acid oxidase. The enzyme is a flavoprotein which uses flavin adenine dinucleotide (FAD) as its prosthetic group. Its substrates include a wide variety of D-amino acids, but it is inactive on the naturally occurring L-amino acids. Its biological function is not known; it may act as a detoxifying agent which removes D-amino acids that accumulate during aging. In mice, it degrades D-serine, a co-agonist of the NMDA receptor. This gene may play a role in the pathophysiology of schizophrenia. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mice display increased levels of D-serine and a decrease in the severity of behavioral effects induced by NMDA receptor antagonists. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrv1 A T 13: 81,440,225 V4414E possibly damaging Het
Ahcyl2 T A 6: 29,870,664 I193N probably damaging Het
Amotl2 C T 9: 102,723,769 T345I probably benign Het
Atf6b A T 17: 34,648,575 probably null Het
Cacna1s T G 1: 136,076,732 F337C probably damaging Het
Cep85l T C 10: 53,298,184 I488V probably damaging Het
Cmas T A 6: 142,775,166 D375E probably damaging Het
Cnga4 T C 7: 105,406,046 F279S probably damaging Het
Cyp4f37 T C 17: 32,625,207 V95A probably benign Het
Dlg2 T C 7: 92,417,258 F235S probably benign Het
Dmxl2 T C 9: 54,446,881 D427G possibly damaging Het
Efl1 T C 7: 82,692,970 Y529H probably benign Het
Epx C T 11: 87,872,721 M224I probably benign Het
Fetub A G 16: 22,929,699 R101G possibly damaging Het
Fubp1 T A 3: 152,222,246 probably null Het
Impdh2 C T 9: 108,562,306 R153* probably null Het
Kcnj12 C T 11: 61,069,604 Q243* probably null Het
Lrrn1 T A 6: 107,567,850 V203E probably damaging Het
Meikin T C 11: 54,409,710 S338P possibly damaging Het
Myl10 A T 5: 136,700,853 probably null Het
Nt5c3b T C 11: 100,434,741 K120E possibly damaging Het
Olfr118 T A 17: 37,672,656 L211H probably damaging Het
Olfr790 T C 10: 129,501,847 L313S probably benign Het
Olfr802 G A 10: 129,681,830 T303I probably benign Het
Olfr93 T A 17: 37,151,186 N262I possibly damaging Het
Pdzd7 A G 19: 45,036,225 S452P probably benign Het
Prune2 A G 19: 17,201,670 I2982V probably damaging Het
Ptpdc1 G A 13: 48,587,101 R285C probably damaging Het
Raf1 T C 6: 115,620,288 D486G probably damaging Het
Rbm27 A T 18: 42,275,480 probably benign Het
Slit2 A G 5: 48,304,036 Y1475C possibly damaging Het
Snx14 G A 9: 88,413,560 T184M probably damaging Het
Tgm5 G T 2: 121,075,169 N168K probably damaging Het
Ugt2b38 A G 5: 87,424,032 V47A probably benign Het
Ush2a A G 1: 188,826,371 H3599R probably benign Het
Veph1 T C 3: 66,215,475 E211G possibly damaging Het
Wapl T A 14: 34,730,647 H832Q probably damaging Het
Zfp281 T A 1: 136,626,034 V250D probably benign Het
Zfp36l2 A G 17: 84,185,824 S462P unknown Het
Other mutations in Dao
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01420:Dao APN 5 114023820 splice site probably benign
IGL02499:Dao APN 5 114013941 missense possibly damaging 0.77
IGL03063:Dao APN 5 114021015 missense probably damaging 1.00
IGL03054:Dao UTSW 5 114024902 missense probably damaging 1.00
R0127:Dao UTSW 5 114019963 missense probably damaging 1.00
R4461:Dao UTSW 5 114019926 missense probably damaging 1.00
R4747:Dao UTSW 5 114012632 missense probably benign 0.12
R5176:Dao UTSW 5 114020009 critical splice donor site probably null
R5226:Dao UTSW 5 114021033 missense probably benign 0.00
R7388:Dao UTSW 5 114015212 makesense probably null
R7968:Dao UTSW 5 114015209 critical splice donor site probably benign
R7970:Dao UTSW 5 114015209 critical splice donor site probably benign
R7971:Dao UTSW 5 114015209 critical splice donor site probably benign
R7972:Dao UTSW 5 114015209 critical splice donor site probably benign
R7973:Dao UTSW 5 114015209 critical splice donor site probably benign
R8018:Dao UTSW 5 114015209 critical splice donor site probably benign
R8020:Dao UTSW 5 114015209 critical splice donor site probably benign
R8045:Dao UTSW 5 114015209 critical splice donor site probably benign
R8123:Dao UTSW 5 114015209 critical splice donor site probably benign
R8124:Dao UTSW 5 114015209 critical splice donor site probably benign
R9376:Dao UTSW 5 114009840 start codon destroyed probably null 1.00
R9614:Dao UTSW 5 114013999 missense probably benign 0.04
Predicted Primers PCR Primer
(F):5'- AGAGCTAACCCTCACTGTTACC -3'
(R):5'- TGCCAAGTGGGTTGATGCTC -3'

Sequencing Primer
(F):5'- AATGCTACCTAGTGGCTCAGC -3'
(R):5'- TGATGCTCTGCAGGATGC -3'
Posted On 2020-09-15