Incidental Mutation 'R7969:Olfr802'
ID 650512
Institutional Source Beutler Lab
Gene Symbol Olfr802
Ensembl Gene ENSMUSG00000093866
Gene Name olfactory receptor 802
Synonyms GA_x6K02T2PULF-11361362-11360424, MOR111-1
MMRRC Submission
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7969 (G1)
Quality Score 225.009
Status Not validated
Chromosome 10
Chromosomal Location 129677683-129688169 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) G to A at 129681830 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 303 (T303I)
Ref Sequence ENSEMBL: ENSMUSP00000144741 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074713] [ENSMUST00000203785] [ENSMUST00000217576]
AlphaFold Q8VGJ2
Predicted Effect probably benign
Transcript: ENSMUST00000074713
AA Change: T303I

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000074275
Gene: ENSMUSG00000093866
AA Change: T303I

DomainStartEndE-ValueType
Pfam:7tm_4 28 305 6.8e-56 PFAM
Pfam:7tm_1 39 288 2.5e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000203785
AA Change: T303I

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000144741
Gene: ENSMUSG00000093866
AA Change: T303I

DomainStartEndE-ValueType
Pfam:7tm_4 28 305 6.8e-56 PFAM
Pfam:7tm_1 39 288 2.5e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000217576
AA Change: T303I

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrv1 A T 13: 81,440,225 V4414E possibly damaging Het
Ahcyl2 T A 6: 29,870,664 I193N probably damaging Het
Amotl2 C T 9: 102,723,769 T345I probably benign Het
Atf6b A T 17: 34,648,575 probably null Het
Cacna1s T G 1: 136,076,732 F337C probably damaging Het
Cep85l T C 10: 53,298,184 I488V probably damaging Het
Cmas T A 6: 142,775,166 D375E probably damaging Het
Cnga4 T C 7: 105,406,046 F279S probably damaging Het
Cyp4f37 T C 17: 32,625,207 V95A probably benign Het
Dao AGG AG 5: 114,015,209 probably benign Het
Dlg2 T C 7: 92,417,258 F235S probably benign Het
Dmxl2 T C 9: 54,446,881 D427G possibly damaging Het
Efl1 T C 7: 82,692,970 Y529H probably benign Het
Epx C T 11: 87,872,721 M224I probably benign Het
Fetub A G 16: 22,929,699 R101G possibly damaging Het
Fubp1 T A 3: 152,222,246 probably null Het
Impdh2 C T 9: 108,562,306 R153* probably null Het
Kcnj12 C T 11: 61,069,604 Q243* probably null Het
Lrrn1 T A 6: 107,567,850 V203E probably damaging Het
Meikin T C 11: 54,409,710 S338P possibly damaging Het
Myl10 A T 5: 136,700,853 probably null Het
Nt5c3b T C 11: 100,434,741 K120E possibly damaging Het
Olfr118 T A 17: 37,672,656 L211H probably damaging Het
Olfr790 T C 10: 129,501,847 L313S probably benign Het
Olfr93 T A 17: 37,151,186 N262I possibly damaging Het
Pdzd7 A G 19: 45,036,225 S452P probably benign Het
Prune2 A G 19: 17,201,670 I2982V probably damaging Het
Ptpdc1 G A 13: 48,587,101 R285C probably damaging Het
Raf1 T C 6: 115,620,288 D486G probably damaging Het
Rbm27 A T 18: 42,275,480 probably benign Het
Slit2 A G 5: 48,304,036 Y1475C possibly damaging Het
Snx14 G A 9: 88,413,560 T184M probably damaging Het
Tgm5 G T 2: 121,075,169 N168K probably damaging Het
Ugt2b38 A G 5: 87,424,032 V47A probably benign Het
Ush2a A G 1: 188,826,371 H3599R probably benign Het
Veph1 T C 3: 66,215,475 E211G possibly damaging Het
Wapl T A 14: 34,730,647 H832Q probably damaging Het
Zfp281 T A 1: 136,626,034 V250D probably benign Het
Zfp36l2 A G 17: 84,185,824 S462P unknown Het
Other mutations in Olfr802
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02939:Olfr802 APN 10 129681988 nonsense probably null
IGL03112:Olfr802 APN 10 129681923 missense probably benign 0.08
R0366:Olfr802 UTSW 10 129681971 missense possibly damaging 0.72
R0463:Olfr802 UTSW 10 129681839 missense probably benign 0.11
R0579:Olfr802 UTSW 10 129682237 nonsense probably null
R1769:Olfr802 UTSW 10 129682212 missense probably benign 0.15
R2128:Olfr802 UTSW 10 129682532 missense possibly damaging 0.78
R2375:Olfr802 UTSW 10 129682163 missense probably benign 0.04
R3888:Olfr802 UTSW 10 129682218 missense possibly damaging 0.94
R3888:Olfr802 UTSW 10 129682219 missense probably benign 0.43
R4956:Olfr802 UTSW 10 129682099 missense probably benign 0.00
R5471:Olfr802 UTSW 10 129682056 missense probably damaging 1.00
R5588:Olfr802 UTSW 10 129681836 missense possibly damaging 0.72
R7305:Olfr802 UTSW 10 129682280 missense probably damaging 0.99
R7995:Olfr802 UTSW 10 129682640 missense probably damaging 1.00
R9142:Olfr802 UTSW 10 129682416 missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- GCATCAGCTAACATGTCTTGGC -3'
(R):5'- GTCAAAGGCCTTTTCCACATG -3'

Sequencing Primer
(F):5'- CCTTAAATTTCATTCATGGGTAGGC -3'
(R):5'- ATGATTGTCATCTCCATCTCTTATGG -3'
Posted On 2020-09-15