Incidental Mutation 'R7969:Meikin'
ID 650513
Institutional Source Beutler Lab
Gene Symbol Meikin
Ensembl Gene ENSMUSG00000020332
Gene Name meiotic kinetochore factor
Synonyms 4930404A10Rik
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.122) question?
Stock # R7969 (G1)
Quality Score 225.009
Status Not validated
Chromosome 11
Chromosomal Location 54370652-54426790 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 54409710 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 338 (S338P)
Ref Sequence ENSEMBL: ENSMUSP00000091745 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094193]
AlphaFold Q5F2C3
Predicted Effect possibly damaging
Transcript: ENSMUST00000094193
AA Change: S338P

PolyPhen 2 Score 0.827 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000091745
Gene: ENSMUSG00000020332
AA Change: S338P

DomainStartEndE-ValueType
low complexity region 91 104 N/A INTRINSIC
low complexity region 361 386 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a null mutation display male and female infertility with defects in sister kinetochore pairing in meiosis I. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrv1 A T 13: 81,440,225 V4414E possibly damaging Het
Ahcyl2 T A 6: 29,870,664 I193N probably damaging Het
Amotl2 C T 9: 102,723,769 T345I probably benign Het
Atf6b A T 17: 34,648,575 probably null Het
Cacna1s T G 1: 136,076,732 F337C probably damaging Het
Cep85l T C 10: 53,298,184 I488V probably damaging Het
Cmas T A 6: 142,775,166 D375E probably damaging Het
Cnga4 T C 7: 105,406,046 F279S probably damaging Het
Cyp4f37 T C 17: 32,625,207 V95A probably benign Het
Dao AGG AG 5: 114,015,209 probably benign Het
Dlg2 T C 7: 92,417,258 F235S probably benign Het
Dmxl2 T C 9: 54,446,881 D427G possibly damaging Het
Efl1 T C 7: 82,692,970 Y529H probably benign Het
Epx C T 11: 87,872,721 M224I probably benign Het
Fetub A G 16: 22,929,699 R101G possibly damaging Het
Fubp1 T A 3: 152,222,246 probably null Het
Impdh2 C T 9: 108,562,306 R153* probably null Het
Kcnj12 C T 11: 61,069,604 Q243* probably null Het
Lrrn1 T A 6: 107,567,850 V203E probably damaging Het
Myl10 A T 5: 136,700,853 probably null Het
Nt5c3b T C 11: 100,434,741 K120E possibly damaging Het
Olfr118 T A 17: 37,672,656 L211H probably damaging Het
Olfr790 T C 10: 129,501,847 L313S probably benign Het
Olfr802 G A 10: 129,681,830 T303I probably benign Het
Olfr93 T A 17: 37,151,186 N262I possibly damaging Het
Pdzd7 A G 19: 45,036,225 S452P probably benign Het
Prune2 A G 19: 17,201,670 I2982V probably damaging Het
Ptpdc1 G A 13: 48,587,101 R285C probably damaging Het
Raf1 T C 6: 115,620,288 D486G probably damaging Het
Rbm27 A T 18: 42,275,480 probably benign Het
Slit2 A G 5: 48,304,036 Y1475C possibly damaging Het
Snx14 G A 9: 88,413,560 T184M probably damaging Het
Tgm5 G T 2: 121,075,169 N168K probably damaging Het
Ugt2b38 A G 5: 87,424,032 V47A probably benign Het
Ush2a A G 1: 188,826,371 H3599R probably benign Het
Veph1 T C 3: 66,215,475 E211G possibly damaging Het
Wapl T A 14: 34,730,647 H832Q probably damaging Het
Zfp281 T A 1: 136,626,034 V250D probably benign Het
Zfp36l2 A G 17: 84,185,824 S462P unknown Het
Other mutations in Meikin
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00493:Meikin APN 11 54398494 missense probably damaging 0.96
IGL02893:Meikin APN 11 54417758 missense possibly damaging 0.83
IGL03224:Meikin APN 11 54398460 missense probably benign 0.01
R0153:Meikin UTSW 11 54409642 splice site probably benign
R0634:Meikin UTSW 11 54390483 missense probably benign 0.22
R1374:Meikin UTSW 11 54398444 splice site probably benign
R1457:Meikin UTSW 11 54370941 nonsense probably null
R1659:Meikin UTSW 11 54390566 nonsense probably null
R1799:Meikin UTSW 11 54417787 missense probably benign 0.27
R2869:Meikin UTSW 11 54373507 missense possibly damaging 0.46
R2869:Meikin UTSW 11 54373507 missense possibly damaging 0.46
R3801:Meikin UTSW 11 54399871 splice site probably null
R4384:Meikin UTSW 11 54417787 nonsense probably null
R6343:Meikin UTSW 11 54370766 missense probably damaging 0.97
R6523:Meikin UTSW 11 54398501 nonsense probably null
R6878:Meikin UTSW 11 54411886 missense possibly damaging 0.83
R7214:Meikin UTSW 11 54411912 missense probably benign 0.40
R8462:Meikin UTSW 11 54399840 missense probably benign 0.01
R8680:Meikin UTSW 11 54426651 missense possibly damaging 0.46
R9136:Meikin UTSW 11 54394638 missense possibly damaging 0.82
R9169:Meikin UTSW 11 54394691 missense possibly damaging 0.66
Predicted Primers PCR Primer
(F):5'- CAGTTCAGAAAATTCTTCAGTTTCC -3'
(R):5'- AAAATTTGTGACCTGGCAAGTT -3'

Sequencing Primer
(F):5'- AAATTCTTCAGTTTCCTATCAGATGG -3'
(R):5'- CTCCTGCAAAGGACCTGAGTTTAG -3'
Posted On 2020-09-15