Incidental Mutation 'R7971:Npy2r'
ID 650594
Institutional Source Beutler Lab
Gene Symbol Npy2r
Ensembl Gene ENSMUSG00000028004
Gene Name neuropeptide Y receptor Y2
Synonyms NPY-Y2 receptor
MMRRC Submission 046014-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.080) question?
Stock # R7971 (G1)
Quality Score 225.009
Status Validated
Chromosome 3
Chromosomal Location 82445690-82455391 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 82448175 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 200 (I200N)
Ref Sequence ENSEMBL: ENSMUSP00000096595 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029633] [ENSMUST00000098997] [ENSMUST00000182181] [ENSMUST00000182831]
AlphaFold P97295
Predicted Effect probably damaging
Transcript: ENSMUST00000029633
AA Change: I200N

PolyPhen 2 Score 0.986 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000029633
Gene: ENSMUSG00000028004
AA Change: I200N

DomainStartEndE-ValueType
low complexity region 35 44 N/A INTRINSIC
Pfam:7TM_GPCR_Srsx 65 344 1.7e-13 PFAM
Pfam:7tm_1 71 329 7.9e-52 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000098997
AA Change: I200N

PolyPhen 2 Score 0.986 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000096595
Gene: ENSMUSG00000028004
AA Change: I200N

DomainStartEndE-ValueType
Pfam:7tm_1 27 212 1.2e-26 PFAM
Pfam:7TM_GPCR_Srsx 30 227 8.5e-6 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000182181
AA Change: I87N

PolyPhen 2 Score 0.970 (Sensitivity: 0.77; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000138559
Gene: ENSMUSG00000028004
AA Change: I87N

DomainStartEndE-ValueType
Pfam:7tm_1 27 212 1.2e-26 PFAM
Pfam:7TM_GPCR_Srsx 30 227 8.5e-6 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000182831
AA Change: I200N

PolyPhen 2 Score 0.986 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000138282
Gene: ENSMUSG00000028004
AA Change: I200N

DomainStartEndE-ValueType
low complexity region 31 40 N/A INTRINSIC
Pfam:7TM_GPCR_Srsx 61 340 7.1e-15 PFAM
Pfam:7tm_1 67 325 4.4e-54 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 98% (46/47)
MGI Phenotype PHENOTYPE: Homozygotes for targeted null mutations exhibit reduced food intake, body weight, and adiposity, elevated plasma pancreatic polypeptide levels, increased cancellous bone volume, and heightened sensitivity to pentobarbital-induced sedation. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5530401A14Rik G A 11: 81,754,526 (GRCm39) A16T unknown Het
Abcc1 T A 16: 14,266,443 (GRCm39) D880E probably benign Het
Adamts2 G A 11: 50,647,523 (GRCm39) V299I probably damaging Het
Akap6 T C 12: 53,186,578 (GRCm39) S1331P probably damaging Het
Alms1 T C 6: 85,605,661 (GRCm39) L1968S probably benign Het
Amotl2 C T 9: 102,600,968 (GRCm39) T345I probably benign Het
Cacnb2 A T 2: 14,976,409 (GRCm39) M277L possibly damaging Het
Cd80 T A 16: 38,294,391 (GRCm39) Y91* probably null Het
Cfap46 A G 7: 139,215,043 (GRCm39) S1561P unknown Het
Clasp1 C T 1: 118,449,559 (GRCm39) R647W probably damaging Het
Creld1 T C 6: 113,468,933 (GRCm39) V299A probably benign Het
Csk C A 9: 57,535,970 (GRCm39) G260V probably benign Het
Dao AGG AG 5: 114,153,270 (GRCm39) probably benign Het
Dgkg G A 16: 22,388,966 (GRCm39) Q403* probably null Het
Dnaaf2 T C 12: 69,244,119 (GRCm39) D314G probably damaging Het
Dsp T A 13: 38,376,499 (GRCm39) L1428Q probably damaging Het
Fastkd1 A G 2: 69,537,703 (GRCm39) V293A probably benign Het
Gm4353 C A 7: 115,682,747 (GRCm39) S278I possibly damaging Het
Hmgb2 A G 8: 57,966,168 (GRCm39) M75V possibly damaging Het
Hoxa4 G A 6: 52,168,711 (GRCm39) probably benign Het
Ifi206 A T 1: 173,298,976 (GRCm39) W877R unknown Het
Ifi44 T A 3: 151,454,857 (GRCm39) I123F possibly damaging Het
Kcnh6 A G 11: 105,908,353 (GRCm39) Y323C probably damaging Het
Lars1 T C 18: 42,351,631 (GRCm39) T858A probably benign Het
Mest T A 6: 30,740,734 (GRCm39) I38N Het
Olfm4 T A 14: 80,259,240 (GRCm39) M496K probably damaging Het
Olfml2a A T 2: 38,831,794 (GRCm39) probably null Het
Omd A T 13: 49,743,730 (GRCm39) H260L probably benign Het
Or8c16 G T 9: 38,130,843 (GRCm39) L238F probably benign Het
Pigk C A 3: 152,450,176 (GRCm39) Q274K probably benign Het
Pmpca G A 2: 26,283,164 (GRCm39) G352R probably damaging Het
Prex1 C T 2: 166,423,859 (GRCm39) S1181N probably damaging Het
Prkg2 A T 5: 99,079,873 (GRCm39) F762Y probably damaging Het
Rcc1l A G 5: 134,194,208 (GRCm39) S250P probably damaging Het
Rufy1 A T 11: 50,312,498 (GRCm39) F152Y probably damaging Het
Scaf1 T A 7: 44,652,965 (GRCm39) T1179S unknown Het
Sh3d19 A G 3: 86,022,103 (GRCm39) D511G probably benign Het
Shroom3 C T 5: 93,098,933 (GRCm39) S1471L probably damaging Het
Slc12a4 G A 8: 106,678,237 (GRCm39) R319W possibly damaging Het
Slc13a4 A G 6: 35,248,695 (GRCm39) L484P probably damaging Het
Slc35a1 T C 4: 34,664,161 (GRCm39) D319G probably benign Het
Synm T C 7: 67,384,983 (GRCm39) E893G possibly damaging Het
Tatdn2 A G 6: 113,687,235 (GRCm39) probably null Het
Thada T A 17: 84,580,197 (GRCm39) D1419V possibly damaging Het
Tmem87b A G 2: 128,692,250 (GRCm39) D535G probably null Het
Tnfrsf25 A C 4: 152,204,193 (GRCm39) Q378P probably damaging Het
Trim34a T C 7: 103,897,025 (GRCm39) C30R probably damaging Het
Triml2 T C 8: 43,643,313 (GRCm39) S212P probably damaging Het
Tubg1 G T 11: 101,014,854 (GRCm39) A199S probably benign Het
Other mutations in Npy2r
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02705:Npy2r APN 3 82,448,056 (GRCm39) missense probably benign 0.07
IGL03013:Npy2r APN 3 82,447,819 (GRCm39) missense probably damaging 1.00
R0616:Npy2r UTSW 3 82,448,670 (GRCm39) missense possibly damaging 0.84
R1460:Npy2r UTSW 3 82,448,251 (GRCm39) missense probably benign
R2013:Npy2r UTSW 3 82,448,487 (GRCm39) missense probably damaging 1.00
R2107:Npy2r UTSW 3 82,448,436 (GRCm39) splice site probably null
R2171:Npy2r UTSW 3 82,447,708 (GRCm39) missense possibly damaging 0.65
R2259:Npy2r UTSW 3 82,448,661 (GRCm39) missense possibly damaging 0.82
R2261:Npy2r UTSW 3 82,448,346 (GRCm39) missense possibly damaging 0.90
R4604:Npy2r UTSW 3 82,448,365 (GRCm39) missense probably damaging 1.00
R5935:Npy2r UTSW 3 82,448,068 (GRCm39) missense possibly damaging 0.83
R7124:Npy2r UTSW 3 82,448,490 (GRCm39) missense probably damaging 1.00
R7143:Npy2r UTSW 3 82,448,250 (GRCm39) missense probably benign 0.02
R7709:Npy2r UTSW 3 82,447,689 (GRCm39) missense probably benign
R7986:Npy2r UTSW 3 82,448,803 (GRCm39) critical splice acceptor site probably null
R9323:Npy2r UTSW 3 82,447,728 (GRCm39) missense possibly damaging 0.93
R9331:Npy2r UTSW 3 82,448,068 (GRCm39) missense probably damaging 1.00
R9381:Npy2r UTSW 3 82,448,356 (GRCm39) missense probably damaging 1.00
X0018:Npy2r UTSW 3 82,447,690 (GRCm39) missense probably benign 0.00
X0062:Npy2r UTSW 3 82,447,900 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CACGCACACCAGCATTTTGG -3'
(R):5'- CTTTGACAGTCATTGCTCTGGAC -3'

Sequencing Primer
(F):5'- ATGGTAATGGTCACTTGCAGCTC -3'
(R):5'- GACCGCCATCGTTGCATTG -3'
Posted On 2020-09-15