Incidental Mutation 'R7972:Or4c107'
ID 650641
Institutional Source Beutler Lab
Gene Symbol Or4c107
Ensembl Gene ENSMUSG00000048226
Gene Name olfactory receptor family 4 subfamily C member 107
Synonyms Olfr1212, MOR233-17, GA_x6K02T2Q125-50437014-50437949, MOR233-20
MMRRC Submission 046015-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.071) question?
Stock # R7972 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 88788812-88789747 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 88789177 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 122 (Y122*)
Ref Sequence ENSEMBL: ENSMUSP00000149781 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055895] [ENSMUST00000215781]
AlphaFold Q7TR08
Predicted Effect probably null
Transcript: ENSMUST00000055895
AA Change: Y122*
SMART Domains Protein: ENSMUSP00000052837
Gene: ENSMUSG00000048226
AA Change: Y122*

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 1.9e-46 PFAM
Pfam:7tm_1 39 286 7.1e-15 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000215781
AA Change: Y122*
Meta Mutation Damage Score 0.9718 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 98% (48/49)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd16a T A 17: 35,320,287 (GRCm39) V384E probably damaging Het
Acacb C T 5: 114,364,918 (GRCm39) R1533* probably null Het
Alox12 T A 11: 70,133,513 (GRCm39) M604L probably benign Het
Amotl2 C T 9: 102,600,968 (GRCm39) T345I probably benign Het
Brdt A T 5: 107,496,415 (GRCm39) I176F possibly damaging Het
Cdk5 G T 5: 24,624,656 (GRCm39) T245K probably benign Het
Chd9 A T 8: 91,732,395 (GRCm39) R1304S unknown Het
Clpsl2 G A 17: 28,769,702 (GRCm39) G55R probably damaging Het
Cyp2j11 T A 4: 96,185,871 (GRCm39) E438V probably damaging Het
Dao AGG AG 5: 114,153,270 (GRCm39) probably benign Het
Dnah10 T C 5: 124,803,949 (GRCm39) V92A probably benign Het
Evl C T 12: 108,647,783 (GRCm39) R295* probably null Het
Fam184a A T 10: 53,514,355 (GRCm39) L1022Q probably damaging Het
Foxd4 T C 19: 24,877,594 (GRCm39) H202R probably damaging Het
Fry T C 5: 150,233,861 (GRCm39) V16A probably benign Het
Gstcd A T 3: 132,777,894 (GRCm39) F306I probably benign Het
H2bc13 A G 13: 21,899,977 (GRCm39) S113P possibly damaging Het
Hivep3 T C 4: 119,954,711 (GRCm39) V1009A possibly damaging Het
Hoxd12 G T 2: 74,506,269 (GRCm39) R227L probably damaging Het
Ifi208 T A 1: 173,506,556 (GRCm39) M113K possibly damaging Het
Ift70a1 A T 2: 75,810,802 (GRCm39) M427K probably damaging Het
Kcnh4 T G 11: 100,643,278 (GRCm39) T330P probably damaging Het
Kctd17 CAGCTGGAGGAGC CAGC 15: 78,321,113 (GRCm39) probably benign Het
Lin28a G A 4: 133,733,574 (GRCm39) P158S probably damaging Het
Muc16 C A 9: 18,557,060 (GRCm39) E3078* probably null Het
Naaladl1 A G 19: 6,156,274 (GRCm39) N120S probably damaging Het
Nol10 G A 12: 17,402,648 (GRCm39) R40H probably benign Het
Ntng1 G A 3: 110,042,802 (GRCm39) S8L probably benign Het
Or4a71 T G 2: 89,357,948 (GRCm39) I269L probably benign Het
Pacsin1 T A 17: 27,927,613 (GRCm39) F319I unknown Het
Pla2g4d G A 2: 120,109,413 (GRCm39) T212I probably benign Het
Ppp4r1 T A 17: 66,140,093 (GRCm39) C664S possibly damaging Het
Prodh2 T C 7: 30,210,580 (GRCm39) I377T probably damaging Het
Prss57 A T 10: 79,619,230 (GRCm39) L243H probably benign Het
Pxdn C T 12: 30,056,601 (GRCm39) L1271F probably damaging Het
Ros1 G A 10: 52,030,926 (GRCm39) R581* probably null Het
Rps6kc1 C T 1: 190,531,321 (GRCm39) G894S probably benign Het
Sirt7 A G 11: 120,510,016 (GRCm39) S183P unknown Het
Slc12a4 G A 8: 106,678,237 (GRCm39) R319W possibly damaging Het
Son AGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCG AGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCG 16: 91,457,222 (GRCm39) probably benign Het
Styxl2 T A 1: 165,926,708 (GRCm39) E968V probably damaging Het
Tbc1d8 A G 1: 39,431,250 (GRCm39) F374S probably damaging Het
Tdrd1 T A 19: 56,837,134 (GRCm39) D489E probably damaging Het
Tiprl T A 1: 165,064,543 (GRCm39) probably benign Het
Tpt1 T C 14: 76,085,539 (GRCm39) *173Q probably null Het
Trim17 A G 11: 58,859,394 (GRCm39) I203V probably benign Het
Trim43b T A 9: 88,973,361 (GRCm39) H124L probably damaging Het
Triobp T C 15: 78,852,186 (GRCm39) I780T probably damaging Het
Tyrobp G A 7: 30,114,063 (GRCm39) G101R Het
Vmn1r181 A T 7: 23,683,871 (GRCm39) H112L probably benign Het
Wdr19 A G 5: 65,381,193 (GRCm39) N406D probably damaging Het
Zc3h12a T C 4: 125,013,728 (GRCm39) K379E probably benign Het
Zcwpw1 T C 5: 137,799,323 (GRCm39) I230T probably benign Het
Zfhx4 A G 3: 5,477,533 (GRCm39) T3383A probably benign Het
Other mutations in Or4c107
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00089:Or4c107 APN 2 88,789,110 (GRCm39) missense probably damaging 0.98
IGL01398:Or4c107 APN 2 88,789,193 (GRCm39) missense probably damaging 1.00
IGL01537:Or4c107 APN 2 88,788,885 (GRCm39) missense probably benign 0.00
IGL02197:Or4c107 APN 2 88,789,028 (GRCm39) missense probably benign 0.05
IGL02557:Or4c107 APN 2 88,789,025 (GRCm39) missense probably benign 0.00
R0276:Or4c107 UTSW 2 88,789,099 (GRCm39) nonsense probably null
R0568:Or4c107 UTSW 2 88,789,387 (GRCm39) nonsense probably null
R0699:Or4c107 UTSW 2 88,788,960 (GRCm39) missense probably benign 0.31
R1101:Or4c107 UTSW 2 88,789,328 (GRCm39) missense possibly damaging 0.60
R1205:Or4c107 UTSW 2 88,788,932 (GRCm39) missense probably benign 0.00
R1468:Or4c107 UTSW 2 88,789,387 (GRCm39) nonsense probably null
R1468:Or4c107 UTSW 2 88,789,387 (GRCm39) nonsense probably null
R1845:Or4c107 UTSW 2 88,789,211 (GRCm39) missense probably damaging 0.99
R2031:Or4c107 UTSW 2 88,789,643 (GRCm39) missense probably benign 0.19
R2418:Or4c107 UTSW 2 88,789,380 (GRCm39) missense probably benign 0.01
R2419:Or4c107 UTSW 2 88,789,380 (GRCm39) missense probably benign 0.01
R3781:Or4c107 UTSW 2 88,789,091 (GRCm39) nonsense probably null
R4049:Or4c107 UTSW 2 88,789,617 (GRCm39) missense probably benign 0.09
R4440:Or4c107 UTSW 2 88,789,685 (GRCm39) missense probably benign 0.22
R4583:Or4c107 UTSW 2 88,789,556 (GRCm39) missense probably damaging 0.99
R4646:Or4c107 UTSW 2 88,789,556 (GRCm39) missense probably damaging 0.99
R4648:Or4c107 UTSW 2 88,789,556 (GRCm39) missense probably damaging 0.99
R4674:Or4c107 UTSW 2 88,789,216 (GRCm39) missense probably damaging 0.98
R4851:Or4c107 UTSW 2 88,788,930 (GRCm39) missense probably damaging 1.00
R4971:Or4c107 UTSW 2 88,788,863 (GRCm39) missense probably damaging 1.00
R5610:Or4c107 UTSW 2 88,789,170 (GRCm39) missense probably damaging 1.00
R5805:Or4c107 UTSW 2 88,788,985 (GRCm39) missense possibly damaging 0.50
R5887:Or4c107 UTSW 2 88,789,098 (GRCm39) missense possibly damaging 0.60
R6023:Or4c107 UTSW 2 88,789,059 (GRCm39) missense possibly damaging 0.76
R6118:Or4c107 UTSW 2 88,789,462 (GRCm39) nonsense probably null
R7490:Or4c107 UTSW 2 88,789,392 (GRCm39) missense probably benign 0.00
R7542:Or4c107 UTSW 2 88,789,119 (GRCm39) missense probably benign 0.01
R7612:Or4c107 UTSW 2 88,788,849 (GRCm39) missense probably damaging 1.00
R8422:Or4c107 UTSW 2 88,789,341 (GRCm39) missense probably benign 0.05
R9111:Or4c107 UTSW 2 88,789,055 (GRCm39) missense probably benign 0.00
Z1177:Or4c107 UTSW 2 88,789,721 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- CTGCTTGGATCACCCATGTAC -3'
(R):5'- ATGCCAACTCCAGTAATGGG -3'

Sequencing Primer
(F):5'- GGATCACCCATGTACTTCTTCTTGG -3'
(R):5'- TCCAGTAATGGGAACAAGTCACAC -3'
Posted On 2020-09-15