Incidental Mutation 'R7972:Nol10'
ID 650674
Institutional Source Beutler Lab
Gene Symbol Nol10
Ensembl Gene ENSMUSG00000061458
Gene Name nucleolar protein 10
Synonyms LOC217431
MMRRC Submission 046015-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.969) question?
Stock # R7972 (G1)
Quality Score 225.009
Status Validated
Chromosome 12
Chromosomal Location 17398459-17480096 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 17402648 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Histidine at position 40 (R40H)
Ref Sequence ENSEMBL: ENSMUSP00000035930 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000046011]
AlphaFold Q5RJG1
Predicted Effect probably benign
Transcript: ENSMUST00000046011
AA Change: R40H

PolyPhen 2 Score 0.154 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000035930
Gene: ENSMUSG00000061458
AA Change: R40H

DomainStartEndE-ValueType
WD40 42 81 1.1e1 SMART
Blast:WD40 84 123 1e-8 BLAST
WD40 165 204 3.3e1 SMART
WD40 223 257 4.42e1 SMART
WD40 260 299 1.19e1 SMART
WD40 302 340 1.97e2 SMART
low complexity region 451 476 N/A INTRINSIC
Pfam:NUC153 482 509 1.4e-15 PFAM
low complexity region 515 536 N/A INTRINSIC
low complexity region 542 553 N/A INTRINSIC
coiled coil region 557 588 N/A INTRINSIC
low complexity region 650 660 N/A INTRINSIC
Meta Mutation Damage Score 0.1177 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 98% (48/49)
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd16a T A 17: 35,320,287 (GRCm39) V384E probably damaging Het
Acacb C T 5: 114,364,918 (GRCm39) R1533* probably null Het
Alox12 T A 11: 70,133,513 (GRCm39) M604L probably benign Het
Amotl2 C T 9: 102,600,968 (GRCm39) T345I probably benign Het
Brdt A T 5: 107,496,415 (GRCm39) I176F possibly damaging Het
Cdk5 G T 5: 24,624,656 (GRCm39) T245K probably benign Het
Chd9 A T 8: 91,732,395 (GRCm39) R1304S unknown Het
Clpsl2 G A 17: 28,769,702 (GRCm39) G55R probably damaging Het
Cyp2j11 T A 4: 96,185,871 (GRCm39) E438V probably damaging Het
Dao AGG AG 5: 114,153,270 (GRCm39) probably benign Het
Dnah10 T C 5: 124,803,949 (GRCm39) V92A probably benign Het
Evl C T 12: 108,647,783 (GRCm39) R295* probably null Het
Fam184a A T 10: 53,514,355 (GRCm39) L1022Q probably damaging Het
Foxd4 T C 19: 24,877,594 (GRCm39) H202R probably damaging Het
Fry T C 5: 150,233,861 (GRCm39) V16A probably benign Het
Gstcd A T 3: 132,777,894 (GRCm39) F306I probably benign Het
H2bc13 A G 13: 21,899,977 (GRCm39) S113P possibly damaging Het
Hivep3 T C 4: 119,954,711 (GRCm39) V1009A possibly damaging Het
Hoxd12 G T 2: 74,506,269 (GRCm39) R227L probably damaging Het
Ifi208 T A 1: 173,506,556 (GRCm39) M113K possibly damaging Het
Ift70a1 A T 2: 75,810,802 (GRCm39) M427K probably damaging Het
Kcnh4 T G 11: 100,643,278 (GRCm39) T330P probably damaging Het
Kctd17 CAGCTGGAGGAGC CAGC 15: 78,321,113 (GRCm39) probably benign Het
Lin28a G A 4: 133,733,574 (GRCm39) P158S probably damaging Het
Muc16 C A 9: 18,557,060 (GRCm39) E3078* probably null Het
Naaladl1 A G 19: 6,156,274 (GRCm39) N120S probably damaging Het
Ntng1 G A 3: 110,042,802 (GRCm39) S8L probably benign Het
Or4a71 T G 2: 89,357,948 (GRCm39) I269L probably benign Het
Or4c107 T A 2: 88,789,177 (GRCm39) Y122* probably null Het
Pacsin1 T A 17: 27,927,613 (GRCm39) F319I unknown Het
Pla2g4d G A 2: 120,109,413 (GRCm39) T212I probably benign Het
Ppp4r1 T A 17: 66,140,093 (GRCm39) C664S possibly damaging Het
Prodh2 T C 7: 30,210,580 (GRCm39) I377T probably damaging Het
Prss57 A T 10: 79,619,230 (GRCm39) L243H probably benign Het
Pxdn C T 12: 30,056,601 (GRCm39) L1271F probably damaging Het
Ros1 G A 10: 52,030,926 (GRCm39) R581* probably null Het
Rps6kc1 C T 1: 190,531,321 (GRCm39) G894S probably benign Het
Sirt7 A G 11: 120,510,016 (GRCm39) S183P unknown Het
Slc12a4 G A 8: 106,678,237 (GRCm39) R319W possibly damaging Het
Son AGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCG AGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCG 16: 91,457,222 (GRCm39) probably benign Het
Styxl2 T A 1: 165,926,708 (GRCm39) E968V probably damaging Het
Tbc1d8 A G 1: 39,431,250 (GRCm39) F374S probably damaging Het
Tdrd1 T A 19: 56,837,134 (GRCm39) D489E probably damaging Het
Tiprl T A 1: 165,064,543 (GRCm39) probably benign Het
Tpt1 T C 14: 76,085,539 (GRCm39) *173Q probably null Het
Trim17 A G 11: 58,859,394 (GRCm39) I203V probably benign Het
Trim43b T A 9: 88,973,361 (GRCm39) H124L probably damaging Het
Triobp T C 15: 78,852,186 (GRCm39) I780T probably damaging Het
Tyrobp G A 7: 30,114,063 (GRCm39) G101R Het
Vmn1r181 A T 7: 23,683,871 (GRCm39) H112L probably benign Het
Wdr19 A G 5: 65,381,193 (GRCm39) N406D probably damaging Het
Zc3h12a T C 4: 125,013,728 (GRCm39) K379E probably benign Het
Zcwpw1 T C 5: 137,799,323 (GRCm39) I230T probably benign Het
Zfhx4 A G 3: 5,477,533 (GRCm39) T3383A probably benign Het
Other mutations in Nol10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00916:Nol10 APN 12 17,411,130 (GRCm39) splice site probably benign
R1769:Nol10 UTSW 12 17,466,709 (GRCm39) splice site probably benign
R1884:Nol10 UTSW 12 17,418,390 (GRCm39) critical splice donor site probably null
R1930:Nol10 UTSW 12 17,398,555 (GRCm39) start codon destroyed probably null 0.99
R1931:Nol10 UTSW 12 17,398,555 (GRCm39) start codon destroyed probably null 0.99
R2010:Nol10 UTSW 12 17,466,102 (GRCm39) missense probably benign 0.00
R2037:Nol10 UTSW 12 17,411,152 (GRCm39) missense probably benign 0.01
R2168:Nol10 UTSW 12 17,423,585 (GRCm39) missense probably damaging 1.00
R3729:Nol10 UTSW 12 17,474,674 (GRCm39) missense probably benign 0.42
R3731:Nol10 UTSW 12 17,474,674 (GRCm39) missense probably benign 0.42
R4368:Nol10 UTSW 12 17,429,293 (GRCm39) missense probably damaging 1.00
R4618:Nol10 UTSW 12 17,398,562 (GRCm39) missense probably damaging 0.98
R4736:Nol10 UTSW 12 17,405,288 (GRCm39) missense probably damaging 1.00
R5342:Nol10 UTSW 12 17,419,621 (GRCm39) splice site probably null
R5451:Nol10 UTSW 12 17,409,103 (GRCm39) nonsense probably null
R5536:Nol10 UTSW 12 17,466,138 (GRCm39) nonsense probably null
R5586:Nol10 UTSW 12 17,466,829 (GRCm39) missense possibly damaging 0.73
R6045:Nol10 UTSW 12 17,398,479 (GRCm39) start gained probably benign
R6833:Nol10 UTSW 12 17,402,728 (GRCm39) missense probably benign 0.03
R7039:Nol10 UTSW 12 17,479,185 (GRCm39) missense possibly damaging 0.94
R7189:Nol10 UTSW 12 17,423,562 (GRCm39) critical splice acceptor site probably null
R7251:Nol10 UTSW 12 17,452,108 (GRCm39) missense probably damaging 1.00
R7399:Nol10 UTSW 12 17,452,174 (GRCm39) missense probably damaging 1.00
R7600:Nol10 UTSW 12 17,419,481 (GRCm39) missense probably damaging 0.99
R7650:Nol10 UTSW 12 17,412,683 (GRCm39) critical splice donor site probably null
R7729:Nol10 UTSW 12 17,474,676 (GRCm39) missense possibly damaging 0.62
R7772:Nol10 UTSW 12 17,398,586 (GRCm39) missense probably damaging 1.00
R7869:Nol10 UTSW 12 17,408,239 (GRCm39) missense probably null 0.93
R8686:Nol10 UTSW 12 17,419,772 (GRCm39) intron probably benign
R8926:Nol10 UTSW 12 17,466,871 (GRCm39) missense probably benign 0.00
R8936:Nol10 UTSW 12 17,466,863 (GRCm39) missense probably benign 0.08
R8966:Nol10 UTSW 12 17,419,507 (GRCm39) missense possibly damaging 0.64
R8994:Nol10 UTSW 12 17,402,717 (GRCm39) missense probably damaging 1.00
R9002:Nol10 UTSW 12 17,408,134 (GRCm39) missense probably damaging 1.00
R9096:Nol10 UTSW 12 17,466,199 (GRCm39) missense probably benign
R9196:Nol10 UTSW 12 17,455,316 (GRCm39) missense probably benign 0.04
R9548:Nol10 UTSW 12 17,466,144 (GRCm39) missense possibly damaging 0.49
Z1177:Nol10 UTSW 12 17,409,089 (GRCm39) critical splice acceptor site probably null
Predicted Primers PCR Primer
(F):5'- TGGACTTTTCAGTTAAAGAACATGTTC -3'
(R):5'- GTGACCTACTCCGAAAACTCATTTT -3'

Sequencing Primer
(F):5'- ATCCAAACTGTTGCCTGGTAG -3'
(R):5'- TCAGTGCAGAATCTAGGTCAC -3'
Posted On 2020-09-15