Incidental Mutation 'R7973:Neo1'
ID 650720
Institutional Source Beutler Lab
Gene Symbol Neo1
Ensembl Gene ENSMUSG00000032340
Gene Name neogenin
Synonyms 2610028H22Rik, D930014N22Rik, Igdcc2
MMRRC Submission 046016-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R7973 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 58781970-58943724 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 58897476 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Glutamic Acid at position 160 (A160E)
Ref Sequence ENSEMBL: ENSMUSP00000063656 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000068664] [ENSMUST00000214547]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000068664
AA Change: A160E

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000063656
Gene: ENSMUSG00000032340
AA Change: A160E

DomainStartEndE-ValueType
signal peptide 1 41 N/A INTRINSIC
IGc2 76 147 9.49e-5 SMART
IGc2 175 239 4.43e-5 SMART
IGc2 272 338 6.15e-13 SMART
IGc2 364 428 7.76e-10 SMART
low complexity region 446 458 N/A INTRINSIC
FN3 470 553 8.23e-12 SMART
FN3 570 649 1.78e-16 SMART
FN3 665 749 1.54e-11 SMART
FN3 770 849 5.27e-10 SMART
FN3 885 970 7.63e-7 SMART
FN3 986 1072 2.78e-9 SMART
transmembrane domain 1136 1158 N/A INTRINSIC
Pfam:Neogenin_C 1189 1492 1.9e-122 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214547
AA Change: A160E

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 98% (53/54)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. This protein may be involved in cell growth and differentiation and in cell-cell adhesion. Defects in this gene are associated with cell proliferation in certain cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
PHENOTYPE: Mice homozygous for a gene trap allele display perinatal lethality and abnormal trigeminal nerve development. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2210016L21Rik A G 5: 115,084,112 (GRCm39) D76G probably benign Het
Abcg1 T C 17: 31,323,132 (GRCm39) V237A probably damaging Het
Adgrv1 A T 13: 81,588,344 (GRCm39) V4414E possibly damaging Het
Akap11 A T 14: 78,752,506 (GRCm39) H122Q Het
Amotl2 C T 9: 102,600,968 (GRCm39) T345I probably benign Het
Arhgef4 C T 1: 34,763,518 (GRCm39) R925W possibly damaging Het
Arid1a C T 4: 133,480,381 (GRCm39) G181D probably damaging Het
Ash1l T A 3: 88,960,164 (GRCm39) S2299T probably benign Het
Atf7ip C T 6: 136,538,062 (GRCm39) Q432* probably null Het
B430306N03Rik T A 17: 48,623,483 (GRCm39) S10T probably benign Het
Bckdk A G 7: 127,505,539 (GRCm39) I221V probably benign Het
Brinp2 T C 1: 158,074,057 (GRCm39) Y688C probably damaging Het
Caml C T 13: 55,779,784 (GRCm39) L286F probably benign Het
Ccdc125 C T 13: 100,806,331 (GRCm39) probably benign Het
Cdh24 A T 14: 54,876,477 (GRCm39) V116E possibly damaging Het
Cenpe T A 3: 134,929,011 (GRCm39) I305N probably damaging Het
Cep41 C T 6: 30,680,130 (GRCm39) G33S probably damaging Het
Clec4b2 A T 6: 123,181,148 (GRCm39) I178L probably benign Het
Dao AGG AG 5: 114,153,270 (GRCm39) probably benign Het
Dapk1 T A 13: 60,909,377 (GRCm39) L1330Q probably damaging Het
Evl C T 12: 108,647,783 (GRCm39) R295* probably null Het
Fmnl1 G T 11: 103,061,984 (GRCm39) probably benign Het
Galk1 A G 11: 115,903,435 (GRCm39) F24L possibly damaging Het
Hyal4 T A 6: 24,755,785 (GRCm39) M1K probably null Het
Ighe T C 12: 113,236,677 (GRCm39) T64A Het
Iqch A G 9: 63,432,228 (GRCm39) I389T possibly damaging Het
Ism2 G T 12: 87,333,769 (GRCm39) T92K possibly damaging Het
Kctd17 CAGCTGGAGGAGC CAGC 15: 78,321,113 (GRCm39) probably benign Het
Kdm1b T C 13: 47,230,922 (GRCm39) S650P probably benign Het
Mapkapk5 T G 5: 121,663,776 (GRCm39) N426T possibly damaging Het
Mroh5 G T 15: 73,664,614 (GRCm39) Y90* probably null Het
Ncan T G 8: 70,550,225 (GRCm39) I1184L probably benign Het
Nectin3 T C 16: 46,216,484 (GRCm39) T439A probably benign Het
Nosip T C 7: 44,726,784 (GRCm39) S295P possibly damaging Het
Nup205 T A 6: 35,222,274 (GRCm39) F1979L probably benign Het
Nxpe2 A T 9: 48,231,168 (GRCm39) D400E probably damaging Het
Or4a73 T A 2: 89,421,331 (GRCm39) I43F probably damaging Het
Pfkfb4 G A 9: 108,854,179 (GRCm39) R351Q probably damaging Het
Psg29 T C 7: 16,944,462 (GRCm39) I324T probably benign Het
Ptprh G T 7: 4,583,887 (GRCm39) T235N possibly damaging Het
Ralgapa2 T A 2: 146,230,481 (GRCm39) N981I possibly damaging Het
Ralgps1 T C 2: 33,036,651 (GRCm39) Y421C probably damaging Het
Sf3b3 T C 8: 111,542,922 (GRCm39) E845G possibly damaging Het
Sgk1 G T 10: 21,870,054 (GRCm39) S31I probably benign Het
Sim1 T G 10: 50,857,419 (GRCm39) Y390D probably damaging Het
Slain2 T A 5: 73,112,779 (GRCm39) Y271* probably null Het
Slc12a4 G A 8: 106,678,237 (GRCm39) R319W possibly damaging Het
St6gal1 G A 16: 23,176,585 (GRCm39) A393T probably benign Het
Stab1 A T 14: 30,881,590 (GRCm39) probably null Het
Supv3l1 A T 10: 62,285,202 (GRCm39) L88Q probably damaging Het
Syt2 C A 1: 134,668,570 (GRCm39) probably null Het
Tpr C T 1: 150,279,638 (GRCm39) R256C probably damaging Het
Tubg1 G T 11: 101,014,854 (GRCm39) A199S probably benign Het
Usp32 A G 11: 84,913,634 (GRCm39) I899T probably damaging Het
Usp6nl G T 2: 6,413,762 (GRCm39) R96M probably damaging Het
Vmn1r75 A G 7: 11,614,961 (GRCm39) D231G probably benign Het
Vmn2r42 T C 7: 8,197,872 (GRCm39) E249G probably benign Het
Zbtb34 C T 2: 33,301,531 (GRCm39) G337R probably benign Het
Zfp457 T A 13: 67,441,882 (GRCm39) H231L probably benign Het
Zfp715 C T 7: 42,949,321 (GRCm39) G213D possibly damaging Het
Zfp760 T G 17: 21,941,084 (GRCm39) H86Q probably benign Het
Other mutations in Neo1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00514:Neo1 APN 9 58,829,202 (GRCm39) splice site probably benign
IGL00885:Neo1 APN 9 58,795,746 (GRCm39) missense probably damaging 1.00
IGL01103:Neo1 APN 9 58,788,082 (GRCm39) missense possibly damaging 0.60
IGL01322:Neo1 APN 9 58,814,368 (GRCm39) missense possibly damaging 0.68
IGL02216:Neo1 APN 9 58,824,336 (GRCm39) missense probably damaging 0.96
IGL02327:Neo1 APN 9 58,810,371 (GRCm39) missense probably benign 0.08
IGL02392:Neo1 APN 9 58,833,094 (GRCm39) missense possibly damaging 0.49
IGL02458:Neo1 APN 9 58,801,150 (GRCm39) splice site probably benign
IGL03057:Neo1 APN 9 58,785,342 (GRCm39) missense probably damaging 1.00
IGL03091:Neo1 APN 9 58,885,951 (GRCm39) missense probably damaging 0.98
IGL03193:Neo1 APN 9 58,815,767 (GRCm39) missense probably damaging 1.00
R0097:Neo1 UTSW 9 58,882,021 (GRCm38) intron probably benign
R0419:Neo1 UTSW 9 58,897,463 (GRCm39) splice site probably benign
R0571:Neo1 UTSW 9 58,893,069 (GRCm39) missense probably benign
R0646:Neo1 UTSW 9 58,838,317 (GRCm39) missense probably damaging 1.00
R0736:Neo1 UTSW 9 58,824,364 (GRCm39) missense possibly damaging 0.78
R0739:Neo1 UTSW 9 58,829,160 (GRCm39) missense probably benign 0.22
R1636:Neo1 UTSW 9 58,820,560 (GRCm39) missense probably damaging 1.00
R1694:Neo1 UTSW 9 58,787,886 (GRCm39) missense probably damaging 1.00
R1827:Neo1 UTSW 9 58,824,314 (GRCm39) nonsense probably null
R1927:Neo1 UTSW 9 58,897,668 (GRCm39) missense probably benign 0.12
R2354:Neo1 UTSW 9 58,892,917 (GRCm39) missense probably benign
R2365:Neo1 UTSW 9 58,863,286 (GRCm39) missense probably benign
R3156:Neo1 UTSW 9 58,796,262 (GRCm39) splice site probably null
R3552:Neo1 UTSW 9 58,801,161 (GRCm39) missense probably damaging 1.00
R3829:Neo1 UTSW 9 58,820,452 (GRCm39) missense possibly damaging 0.58
R4477:Neo1 UTSW 9 58,784,582 (GRCm39) missense probably damaging 0.99
R4613:Neo1 UTSW 9 58,796,324 (GRCm39) missense possibly damaging 0.94
R5023:Neo1 UTSW 9 58,897,554 (GRCm39) missense probably damaging 1.00
R5046:Neo1 UTSW 9 58,801,194 (GRCm39) missense possibly damaging 0.77
R5057:Neo1 UTSW 9 58,897,554 (GRCm39) missense probably damaging 1.00
R5323:Neo1 UTSW 9 58,813,931 (GRCm39) critical splice donor site probably null
R5394:Neo1 UTSW 9 58,897,517 (GRCm39) missense probably benign 0.10
R5470:Neo1 UTSW 9 58,838,350 (GRCm39) missense probably damaging 1.00
R5473:Neo1 UTSW 9 58,788,126 (GRCm39) missense possibly damaging 0.88
R5500:Neo1 UTSW 9 58,824,337 (GRCm39) missense possibly damaging 0.94
R5503:Neo1 UTSW 9 58,892,933 (GRCm39) missense possibly damaging 0.67
R6122:Neo1 UTSW 9 58,824,291 (GRCm39) missense probably benign
R6191:Neo1 UTSW 9 58,796,312 (GRCm39) missense probably damaging 1.00
R6431:Neo1 UTSW 9 58,814,354 (GRCm39) missense probably benign 0.27
R6560:Neo1 UTSW 9 58,787,884 (GRCm39) missense possibly damaging 0.95
R6658:Neo1 UTSW 9 58,829,132 (GRCm39) missense probably benign 0.14
R6772:Neo1 UTSW 9 58,810,259 (GRCm39) missense probably damaging 1.00
R6912:Neo1 UTSW 9 58,824,335 (GRCm39) missense probably benign 0.00
R7061:Neo1 UTSW 9 58,897,724 (GRCm39) missense possibly damaging 0.95
R7145:Neo1 UTSW 9 58,796,462 (GRCm39) missense probably damaging 1.00
R7156:Neo1 UTSW 9 58,810,206 (GRCm39) missense probably damaging 1.00
R7485:Neo1 UTSW 9 58,791,826 (GRCm39) missense probably benign 0.04
R7519:Neo1 UTSW 9 58,785,348 (GRCm39) missense probably benign 0.13
R7615:Neo1 UTSW 9 58,791,786 (GRCm39) missense probably benign 0.07
R7665:Neo1 UTSW 9 58,833,078 (GRCm39) missense probably damaging 1.00
R7695:Neo1 UTSW 9 58,810,212 (GRCm39) missense possibly damaging 0.81
R7753:Neo1 UTSW 9 58,863,288 (GRCm39) missense probably benign 0.00
R7807:Neo1 UTSW 9 58,897,777 (GRCm39) missense probably benign 0.01
R7915:Neo1 UTSW 9 58,838,264 (GRCm39) missense probably benign 0.42
R8356:Neo1 UTSW 9 58,785,402 (GRCm39) missense probably damaging 1.00
R8505:Neo1 UTSW 9 58,820,566 (GRCm39) missense probably benign 0.02
R8700:Neo1 UTSW 9 58,825,913 (GRCm39) missense probably benign 0.28
R8798:Neo1 UTSW 9 58,820,449 (GRCm39) missense probably damaging 1.00
R8952:Neo1 UTSW 9 58,897,545 (GRCm39) missense probably benign 0.01
R9779:Neo1 UTSW 9 58,886,009 (GRCm39) nonsense probably null
R9784:Neo1 UTSW 9 58,889,503 (GRCm39) missense probably benign
R9789:Neo1 UTSW 9 58,801,307 (GRCm39) critical splice acceptor site probably null
X0063:Neo1 UTSW 9 58,897,581 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- CACCAGTTTCTTCAGCATAACCCTAAG -3'
(R):5'- TCGGCATATTCTGAGCCCTC -3'

Sequencing Primer
(F):5'- CCCTAAGCAAATGAGTGTAGTCTC -3'
(R):5'- TGAGCCCTCTCCAAACATTGAATG -3'
Posted On 2020-09-15