Mutagenetix > Incidental Mutation

Incidental Mutation 'R7974:Olfr761'

650807

Institutional Source

Beutler Lab

Gene Symbol

Olfr761

Ensembl Gene

ENSMUSG00000109376

Gene Name

olfactory receptor 761

Synonyms

MOR218-5P, MOR218-6P, MOR218-12, Olfr1552-ps1, GA_x6K02T2PSCP-2403971-2403000, MOR218-6P

MMRRC Submission

Accession Numbers

Essential gene?

Probably essential (E-score: 0.794) question?

Stock #

R7974 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

37952051-37953079 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 37952781 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 81 (Y81C)

Ref Sequence

ENSEMBL: ENSMUSP00000092917 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000049620]

AlphaFold

Q7TRJ0

Predicted Effect

probably damaging
Transcript: ENSMUST00000049620
AA Change: Y81C

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000092917
Gene: ENSMUSG00000109376
AA Change: Y81C

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	6.8e-45	PFAM
Pfam:7TM_GPCR_Srsx	35	305	2.1e-6	PFAM
Pfam:7tm_1	41	290	3.7e-22	PFAM

Meta Mutation Damage Score

0.6329

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.0%

Validation Efficiency

100% (64/64)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 69 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ablim1	C	T	19: 57,044,973		probably null	Het
Adamts19	A	T	18: 59,011,022	Q892L	possibly damaging	Het
Adamts9	A	G	6: 92,909,687		probably null	Het
Aftph	T	C	11: 20,698,233	*686W	probably null	Het
AI661453	T	C	17: 47,466,081	L244P	unknown	Het
Ankar	C	A	1: 72,698,979	E15*	probably null	Het
Ankrd39	A	G	1: 36,546,918		probably benign	Het
Arsi	A	G	18: 60,912,406	D56G	probably damaging	Het
Blmh	T	C	11: 76,965,903	I245T	possibly damaging	Het
Ccr6	T	C	17: 8,256,224	F87S	probably damaging	Het
Cdc42ep2	T	C	19: 5,918,495	K61E	probably damaging	Het
Celsr1	C	T	15: 86,031,030	G914D	probably damaging	Het
Cep126	T	A	9: 8,120,763	K86N	probably benign	Het
Cfap70	A	T	14: 20,420,750	F532I	probably damaging	Het
Cpsf3	T	A	12: 21,308,005	L506Q	probably damaging	Het
Dct	A	C	14: 118,039,655	I273S	probably damaging	Het
Dsel	T	C	1: 111,860,499	I769V	probably benign	Het
Dus2	G	A	8: 106,036,020	E138K	probably benign	Het
Emsy	A	G	7: 98,630,218	S305P	possibly damaging	Het
Erp27	A	T	6: 136,908,065	V245D	probably damaging	Het
Fez1	C	A	9: 36,843,948	T81K	probably damaging	Het
Gli3	A	C	13: 15,726,256	Q1409H	probably benign	Het
Gm10696	T	C	3: 94,175,541	K321R	probably benign	Het
Hdac9	T	C	12: 34,303,220	S664G	possibly damaging	Het
Hibadh	A	G	6: 52,557,895	S167P	probably benign	Het
Hsdl1	A	G	8: 119,566,333	V121A	probably benign	Het
Ighv1-18	A	C	12: 114,683,049	I6S	possibly damaging	Het
Iqcm	T	A	8: 75,554,892	M1K	probably null	Het
Itch	T	C	2: 155,192,159	F417S	probably damaging	Het
Itpr1	C	T	6: 108,523,405	T2653I	possibly damaging	Het
Kank1	T	G	19: 25,424,220	Y1064D	probably damaging	Het
Kmt2c	T	C	5: 25,300,563	Q3249R	probably damaging	Het
Lefty1	T	C	1: 180,937,820	C318R	probably damaging	Het
Lmbr1l	C	T	15: 98,911,619	V147I	probably benign	Het
Meig1	C	A	2: 3,411,874	E37*	probably null	Het
Mpp3	A	G	11: 102,008,354		probably null	Het
Muc3	T	C	5: 137,146,816	N2S		Het
Mup7	T	C	4: 60,067,518	E199G	possibly damaging	Het
Nol4	G	C	18: 22,719,025	Y275*	probably null	Het
Nrxn1	G	A	17: 90,700,779	P429S	probably damaging	Het
Pfkl	A	T	10: 77,994,162	F367L	probably damaging	Het
Pik3cg	T	C	12: 32,204,032	E652G	probably benign	Het
Prkag3	A	G	1: 74,744,821	I301T	probably benign	Het
Rcn1	G	A	2: 105,393,710	P163L	probably benign	Het
Slc1a7	G	A	4: 108,012,276	V513M	probably benign	Het
Slc37a2	A	T	9: 37,239,125		probably null	Het
Slc9b1	C	T	3: 135,394,030	T437I	possibly damaging	Het
Smap1	T	G	1: 23,849,441	T248P	probably benign	Het
Smpd3	A	C	8: 106,255,622	C617G	probably benign	Het
Spata20	T	C	11: 94,484,140	N212S	possibly damaging	Het
Sphkap	A	C	1: 83,278,962	C355W	probably damaging	Het
Spsb1	T	A	4: 149,907,109	M1L	probably damaging	Het
Srebf2	C	T	15: 82,178,765	R468C	probably damaging	Het
Stxbp5	A	C	10: 9,770,695		probably null	Het
Taar5	G	C	10: 23,971,222	D173H	possibly damaging	Het
Tfrc	A	G	16: 32,621,283	D438G	probably null	Het
Tinag	A	T	9: 76,999,849	I368K	probably benign	Het
Tm9sf1	A	G	14: 55,636,449	W531R	probably damaging	Het
Tnc	G	T	4: 64,000,724	P1154Q	possibly damaging	Het
Toporsl	A	G	4: 52,611,645	R513G	probably damaging	Het
Ttc30a1	T	C	2: 75,980,344	H465R	probably damaging	Het
Vat1	A	G	11: 101,466,130	S2P	probably benign	Het
Vmn2r107	C	G	17: 20,357,008	P423A	probably benign	Het
Vmn2r2	T	A	3: 64,117,387	E591V	probably damaging	Het
Vmn2r62	G	A	7: 42,764,607	T804I	probably damaging	Het
Vmn2r62	T	A	7: 42,787,857	Y401F	probably damaging	Het
Vmn2r89	A	T	14: 51,456,002	I270F	probably damaging	Het
Zfp418	T	C	7: 7,182,168	F377L	possibly damaging	Het
Zkscan5	T	C	5: 145,207,692	S182P	unknown	Het

Other mutations in Olfr761

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01557:Olfr761	APN	17	37952851	missense	probably damaging	1.00
IGL02104:Olfr761	APN	17	37952291	missense	probably damaging	1.00
IGL02431:Olfr761	APN	17	37952522	missense	probably benign	0.06
IGL02649:Olfr761	APN	17	37952973	missense	probably damaging	1.00
IGL03109:Olfr761	APN	17	37952487	missense	probably damaging	1.00
IGL03261:Olfr761	APN	17	37952806	missense	possibly damaging	0.76
R0898:Olfr761	UTSW	17	37952236	missense	probably benign	0.17
R1373:Olfr761	UTSW	17	37952360	missense	probably damaging	1.00
R1527:Olfr761	UTSW	17	37952829	missense	possibly damaging	0.88
R1664:Olfr761	UTSW	17	37952893	missense	probably benign	0.44
R1835:Olfr761	UTSW	17	37952385	missense	possibly damaging	0.79
R4124:Olfr761	UTSW	17	37952790	missense	probably benign	0.16
R4125:Olfr761	UTSW	17	37952790	missense	probably benign	0.16
R4128:Olfr761	UTSW	17	37952790	missense	probably benign	0.16
R4534:Olfr761	UTSW	17	37952722	missense	probably benign
R4557:Olfr761	UTSW	17	37952251	missense	probably benign	0.10
R4790:Olfr761	UTSW	17	37952742	missense	probably damaging	0.99
R4856:Olfr761	UTSW	17	37952071	missense	probably benign	0.15
R4886:Olfr761	UTSW	17	37952071	missense	probably benign	0.15
R4955:Olfr761	UTSW	17	37952898	missense	probably damaging	1.00
R5162:Olfr761	UTSW	17	37952364	missense	probably benign	0.00
R6016:Olfr761	UTSW	17	37952076	missense	probably benign	0.13
R6282:Olfr761	UTSW	17	37952424	missense	possibly damaging	0.80
R7018:Olfr761	UTSW	17	37952502	missense	probably damaging	1.00
R7199:Olfr761	UTSW	17	37952157	missense	probably damaging	1.00
R7340:Olfr761	UTSW	17	37952522	missense	probably benign	0.06
R7360:Olfr761	UTSW	17	37953009	missense	probably damaging	1.00
R7464:Olfr761	UTSW	17	37952280	missense	probably damaging	1.00
R8719:Olfr761	UTSW	17	37953004	missense	probably damaging	0.97
R8738:Olfr761	UTSW	17	37952782	missense	possibly damaging	0.79
R8817:Olfr761	UTSW	17	37952382	missense	probably damaging	0.99
R8856:Olfr761	UTSW	17	37952200	missense	possibly damaging	0.87
R9006:Olfr761	UTSW	17	37952654	nonsense	probably null
R9432:Olfr761	UTSW	17	37952668	missense	probably damaging	1.00
X0064:Olfr761	UTSW	17	37952814	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- AAGTGCACTTTCTGGGACTC -3'
(R):5'- TGAGTGGATTCCTCCTCGTG -3'

Sequencing Primer
(F):5'- GGGACTCATTATGACCTCATAGTGC -3'
(R):5'- CCATGAGCTGCAGATCTTACAGG -3'

Posted On

2020-09-15