Incidental Mutation 'R7976:Dennd4a'
ID 650920
Institutional Source Beutler Lab
Gene Symbol Dennd4a
Ensembl Gene ENSMUSG00000053641
Gene Name DENN/MADD domain containing 4A
Synonyms F730015K02Rik
MMRRC Submission 046019-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.432) question?
Stock # R7976 (G1)
Quality Score 225.009
Status Not validated
Chromosome 9
Chromosomal Location 64811340-64919667 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) G to T at 64852512 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Glycine to Tryptophan at position 300 (G300W)
Ref Sequence ENSEMBL: ENSMUSP00000037915 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000038890]
AlphaFold E9Q8V6
Predicted Effect possibly damaging
Transcript: ENSMUST00000038890
AA Change: G300W

PolyPhen 2 Score 0.954 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000037915
Gene: ENSMUSG00000053641
AA Change: G300W

DomainStartEndE-ValueType
internal_repeat_1 45 93 3.26e-5 PROSPERO
uDENN 169 276 1.71e-28 SMART
DENN 309 493 2.4e-73 SMART
dDENN 559 633 4.15e-27 SMART
low complexity region 724 735 N/A INTRINSIC
low complexity region 936 950 N/A INTRINSIC
low complexity region 1176 1191 N/A INTRINSIC
low complexity region 1249 1262 N/A INTRINSIC
low complexity region 1402 1417 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.2%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a DENN domain-containing protein that may function as a guanine nucleotide exchange factor that specifically activates ras-related protein Rab-10. This protein also contains a interferon stimulated response element-binding domain and may be involved in regulating the v-myc avian myelocytomatosis viral (MYC) oncogene. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 8. [provided by RefSeq, Mar 2016]
Allele List at MGI
Other mutations in this stock
Total: 70 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adss1 A C 12: 112,636,397 (GRCm38) I341L probably benign Het
Aldh1b1 T A 4: 45,803,092 (GRCm38) M210K possibly damaging Het
Ankrd17 G A 5: 90,283,592 (GRCm38) Q778* probably null Het
Bmper T C 9: 23,406,810 (GRCm38) V575A probably damaging Het
Brinp2 A G 1: 158,246,343 (GRCm38) V736A probably benign Het
Ccdc81 A T 7: 89,866,515 (GRCm38) L652* probably null Het
Cdt1 C T 8: 122,571,846 (GRCm38) R437W probably damaging Het
Ckb A C 12: 111,671,032 (GRCm38) L165R possibly damaging Het
Col25a1 G T 3: 130,496,426 (GRCm38) G255V probably damaging Het
Ddx17 A G 15: 79,535,955 (GRCm38) probably null Het
Dlg4 T A 11: 70,039,182 (GRCm38) I316N probably damaging Het
Dlgap2 C T 8: 14,743,410 (GRCm38) P467L probably benign Het
Dnah9 T C 11: 65,841,401 (GRCm38) I4226M possibly damaging Het
Drc1 G A 5: 30,364,485 (GRCm38) A734T probably benign Het
Entpd1 A G 19: 40,612,421 (GRCm38) M1V probably null Het
Exph5 T G 9: 53,376,635 (GRCm38) I1672S possibly damaging Het
Fam149b T A 14: 20,377,784 (GRCm38) D379E probably damaging Het
Fgfr2 T C 7: 130,185,344 (GRCm38) T461A probably damaging Het
Frem1 A G 4: 83,001,709 (GRCm38) V469A probably damaging Het
Frem3 A T 8: 80,611,602 (GRCm38) K175* probably null Het
Fsd2 C T 7: 81,559,881 (GRCm38) G71E probably benign Het
Gcat T C 15: 79,034,988 (GRCm38) I116T probably damaging Het
Gigyf2 G A 1: 87,403,736 (GRCm38) S202N unknown Het
Glra3 T G 8: 56,112,876 (GRCm38) probably null Het
Golga4 C T 9: 118,536,768 (GRCm38) T296I possibly damaging Het
Herc1 C T 9: 66,434,270 (GRCm38) T1816I possibly damaging Het
Igfbpl1 C A 4: 45,826,786 (GRCm38) R3L unknown Het
Ighv15-2 A T 12: 114,564,850 (GRCm38) S28T probably benign Het
Kat2b T A 17: 53,648,807 (GRCm38) M427K probably benign Het
Kdm4c A G 4: 74,377,669 (GRCm38) T882A probably damaging Het
Kif1a G T 1: 93,039,774 (GRCm38) F1138L probably damaging Het
Klhl20 A T 1: 161,106,737 (GRCm38) S237R probably benign Het
Lamc1 A T 1: 153,247,268 (GRCm38) N725K probably damaging Het
Lmtk3 A G 7: 45,795,466 (GRCm38) D1191G unknown Het
Ltbp1 C A 17: 75,363,363 (GRCm38) N1466K possibly damaging Het
Ly75 T C 2: 60,365,088 (GRCm38) E242G probably damaging Het
Lyrm1 T C 7: 119,916,226 (GRCm38) V113A probably benign Het
Mfsd13a G T 19: 46,372,007 (GRCm38) A333S probably benign Het
Mllt10 T C 2: 18,162,403 (GRCm38) S380P possibly damaging Het
Mrc2 A G 11: 105,348,003 (GRCm38) K1295E possibly damaging Het
Muc5ac A T 7: 141,809,791 (GRCm38) I2280F unknown Het
Neurod2 A C 11: 98,327,197 (GRCm38) F380L probably damaging Het
Ntrk3 G A 7: 78,356,206 (GRCm38) A469V probably damaging Het
Nup205 T C 6: 35,198,953 (GRCm38) F584L probably damaging Het
Oas1d A T 5: 120,919,147 (GRCm38) Y272F probably damaging Het
Olfm3 T C 3: 115,081,145 (GRCm38) V30A probably benign Het
Or4c110 T A 2: 89,001,629 (GRCm38) I220F probably damaging Het
Or5b117 A G 19: 13,454,199 (GRCm38) I106T probably benign Het
Or8k22 A G 2: 86,332,720 (GRCm38) V212A probably benign Het
Pcdhga12 A G 18: 37,768,374 (GRCm38) Y753C probably damaging Het
Phox2b A G 5: 67,096,171 (GRCm38) V294A unknown Het
Prdm2 A T 4: 143,133,242 (GRCm38) C1159* probably null Het
Ptpn12 G T 5: 21,002,633 (GRCm38) S275* probably null Het
Rigi T C 4: 40,209,894 (GRCm38) M725V probably damaging Het
Rnf223 A T 4: 156,132,319 (GRCm38) E50D probably damaging Het
Rrp12 A T 19: 41,891,109 (GRCm38) Y169N probably benign Het
Sgip1 T C 4: 102,900,539 (GRCm38) probably null Het
Shank2 T C 7: 144,411,061 (GRCm38) I802T probably damaging Het
Skint2 A T 4: 112,624,132 (GRCm38) N64I probably damaging Het
Smpd3 A C 8: 106,255,622 (GRCm38) C617G probably benign Het
Tmem106c G C 15: 97,968,104 (GRCm38) G192R probably damaging Het
Tmem72 T C 6: 116,696,839 (GRCm38) H106R probably damaging Het
Upf2 G C 2: 6,026,115 (GRCm38) V789L unknown Het
Vash1 A G 12: 86,679,984 (GRCm38) probably benign Het
Vmn1r201 T A 13: 22,474,705 (GRCm38) Y30N probably benign Het
Xpr1 A G 1: 155,290,289 (GRCm38) F571L possibly damaging Het
Yif1a T C 19: 5,089,787 (GRCm38) S87P probably damaging Het
Zer1 T C 2: 30,107,508 (GRCm38) Y462C probably damaging Het
Zfp597 G A 16: 3,866,511 (GRCm38) P127L possibly damaging Het
Zxdc T C 6: 90,398,767 (GRCm38) S742P probably benign Het
Other mutations in Dennd4a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00476:Dennd4a APN 9 64,911,762 (GRCm38) missense probably damaging 1.00
IGL01610:Dennd4a APN 9 64,906,884 (GRCm38) missense probably damaging 0.99
IGL01788:Dennd4a APN 9 64,842,621 (GRCm38) missense probably benign 0.00
IGL01827:Dennd4a APN 9 64,842,561 (GRCm38) nonsense probably null
IGL01828:Dennd4a APN 9 64,842,561 (GRCm38) nonsense probably null
IGL01829:Dennd4a APN 9 64,842,561 (GRCm38) nonsense probably null
IGL01979:Dennd4a APN 9 64,894,409 (GRCm38) missense probably benign 0.00
IGL02100:Dennd4a APN 9 64,909,706 (GRCm38) splice site probably benign
IGL02339:Dennd4a APN 9 64,842,561 (GRCm38) nonsense probably null
IGL02341:Dennd4a APN 9 64,842,561 (GRCm38) nonsense probably null
IGL02584:Dennd4a APN 9 64,851,298 (GRCm38) missense probably damaging 1.00
IGL02607:Dennd4a APN 9 64,862,327 (GRCm38) missense probably damaging 0.99
IGL02654:Dennd4a APN 9 64,910,191 (GRCm38) splice site probably benign
IGL02701:Dennd4a APN 9 64,897,353 (GRCm38) missense possibly damaging 0.50
IGL03051:Dennd4a APN 9 64,862,414 (GRCm38) missense probably damaging 1.00
IGL03257:Dennd4a APN 9 64,871,874 (GRCm38) missense possibly damaging 0.93
IGL03346:Dennd4a APN 9 64,888,526 (GRCm38) missense possibly damaging 0.47
IGL03349:Dennd4a APN 9 64,888,974 (GRCm38) missense probably damaging 1.00
IGL03398:Dennd4a APN 9 64,871,882 (GRCm38) missense probably benign 0.32
R0010:Dennd4a UTSW 9 64,896,715 (GRCm38) missense probably benign 0.00
R0010:Dennd4a UTSW 9 64,896,715 (GRCm38) missense probably benign 0.00
R0129:Dennd4a UTSW 9 64,893,294 (GRCm38) missense probably damaging 1.00
R0220:Dennd4a UTSW 9 64,852,445 (GRCm38) missense probably damaging 1.00
R0396:Dennd4a UTSW 9 64,862,391 (GRCm38) missense probably damaging 1.00
R0881:Dennd4a UTSW 9 64,851,383 (GRCm38) critical splice donor site probably null
R1225:Dennd4a UTSW 9 64,911,675 (GRCm38) missense probably benign 0.03
R1311:Dennd4a UTSW 9 64,910,004 (GRCm38) missense probably benign 0.34
R1448:Dennd4a UTSW 9 64,906,045 (GRCm38) missense possibly damaging 0.95
R1450:Dennd4a UTSW 9 64,911,665 (GRCm38) missense probably benign 0.03
R1630:Dennd4a UTSW 9 64,871,882 (GRCm38) missense probably benign 0.32
R1709:Dennd4a UTSW 9 64,889,605 (GRCm38) missense possibly damaging 0.92
R1824:Dennd4a UTSW 9 64,859,358 (GRCm38) critical splice donor site probably null
R1851:Dennd4a UTSW 9 64,862,030 (GRCm38) missense probably damaging 1.00
R1870:Dennd4a UTSW 9 64,897,234 (GRCm38) missense probably benign 0.00
R1900:Dennd4a UTSW 9 64,897,336 (GRCm38) missense probably damaging 0.99
R1911:Dennd4a UTSW 9 64,889,086 (GRCm38) missense probably damaging 1.00
R1938:Dennd4a UTSW 9 64,842,490 (GRCm38) missense probably damaging 1.00
R1954:Dennd4a UTSW 9 64,852,467 (GRCm38) missense probably benign 0.02
R1955:Dennd4a UTSW 9 64,852,467 (GRCm38) missense probably benign 0.02
R2049:Dennd4a UTSW 9 64,889,605 (GRCm38) missense possibly damaging 0.92
R2129:Dennd4a UTSW 9 64,905,974 (GRCm38) splice site probably null
R2138:Dennd4a UTSW 9 64,889,337 (GRCm38) missense probably damaging 1.00
R2929:Dennd4a UTSW 9 64,852,417 (GRCm38) missense possibly damaging 0.85
R3083:Dennd4a UTSW 9 64,906,081 (GRCm38) missense probably benign 0.03
R3108:Dennd4a UTSW 9 64,912,387 (GRCm38) missense probably benign 0.23
R3176:Dennd4a UTSW 9 64,888,993 (GRCm38) missense probably damaging 1.00
R3177:Dennd4a UTSW 9 64,888,993 (GRCm38) missense probably damaging 1.00
R3276:Dennd4a UTSW 9 64,888,993 (GRCm38) missense probably damaging 1.00
R3277:Dennd4a UTSW 9 64,888,993 (GRCm38) missense probably damaging 1.00
R3890:Dennd4a UTSW 9 64,872,028 (GRCm38) missense probably damaging 1.00
R3953:Dennd4a UTSW 9 64,852,575 (GRCm38) missense probably damaging 1.00
R3963:Dennd4a UTSW 9 64,862,331 (GRCm38) missense probably damaging 1.00
R4059:Dennd4a UTSW 9 64,911,892 (GRCm38) missense possibly damaging 0.92
R4499:Dennd4a UTSW 9 64,910,123 (GRCm38) missense possibly damaging 0.78
R4500:Dennd4a UTSW 9 64,910,123 (GRCm38) missense possibly damaging 0.78
R4501:Dennd4a UTSW 9 64,910,123 (GRCm38) missense possibly damaging 0.78
R4671:Dennd4a UTSW 9 64,894,407 (GRCm38) missense probably benign
R4701:Dennd4a UTSW 9 64,897,357 (GRCm38) missense possibly damaging 0.91
R4821:Dennd4a UTSW 9 64,897,249 (GRCm38) missense possibly damaging 0.92
R4829:Dennd4a UTSW 9 64,889,056 (GRCm38) missense probably damaging 1.00
R4876:Dennd4a UTSW 9 64,896,590 (GRCm38) missense probably benign
R4881:Dennd4a UTSW 9 64,838,844 (GRCm38) missense possibly damaging 0.77
R4962:Dennd4a UTSW 9 64,906,003 (GRCm38) missense probably benign 0.00
R5225:Dennd4a UTSW 9 64,888,928 (GRCm38) missense possibly damaging 0.94
R5557:Dennd4a UTSW 9 64,904,227 (GRCm38) missense probably benign 0.07
R5649:Dennd4a UTSW 9 64,851,209 (GRCm38) splice site probably null
R5868:Dennd4a UTSW 9 64,896,729 (GRCm38) missense probably benign 0.02
R5876:Dennd4a UTSW 9 64,911,755 (GRCm38) missense probably damaging 1.00
R6052:Dennd4a UTSW 9 64,886,945 (GRCm38) missense probably damaging 1.00
R6411:Dennd4a UTSW 9 64,871,899 (GRCm38) missense probably benign 0.04
R6596:Dennd4a UTSW 9 64,852,420 (GRCm38) missense probably damaging 1.00
R6668:Dennd4a UTSW 9 64,886,965 (GRCm38) missense probably damaging 1.00
R6915:Dennd4a UTSW 9 64,852,489 (GRCm38) nonsense probably null
R7056:Dennd4a UTSW 9 64,906,923 (GRCm38) missense possibly damaging 0.89
R7107:Dennd4a UTSW 9 64,894,399 (GRCm38) missense possibly damaging 0.79
R7203:Dennd4a UTSW 9 64,896,474 (GRCm38) missense probably benign 0.05
R7238:Dennd4a UTSW 9 64,861,956 (GRCm38) missense probably damaging 1.00
R7373:Dennd4a UTSW 9 64,897,269 (GRCm38) missense probably benign 0.01
R7454:Dennd4a UTSW 9 64,852,570 (GRCm38) missense probably damaging 1.00
R7546:Dennd4a UTSW 9 64,873,044 (GRCm38) missense probably damaging 1.00
R7590:Dennd4a UTSW 9 64,888,587 (GRCm38) missense probably benign 0.01
R7662:Dennd4a UTSW 9 64,852,431 (GRCm38) missense probably damaging 1.00
R7782:Dennd4a UTSW 9 64,906,920 (GRCm38) missense probably damaging 0.98
R7909:Dennd4a UTSW 9 64,872,993 (GRCm38) critical splice acceptor site probably null
R8026:Dennd4a UTSW 9 64,873,030 (GRCm38) missense probably damaging 1.00
R8034:Dennd4a UTSW 9 64,888,568 (GRCm38) missense probably benign 0.01
R8089:Dennd4a UTSW 9 64,849,175 (GRCm38) missense probably damaging 1.00
R8298:Dennd4a UTSW 9 64,906,875 (GRCm38) missense probably benign 0.00
R8397:Dennd4a UTSW 9 64,889,109 (GRCm38) missense probably benign
R8425:Dennd4a UTSW 9 64,838,974 (GRCm38) missense probably damaging 1.00
R8495:Dennd4a UTSW 9 64,886,879 (GRCm38) missense probably damaging 1.00
R8855:Dennd4a UTSW 9 64,912,390 (GRCm38) missense probably benign
R9219:Dennd4a UTSW 9 64,889,094 (GRCm38) missense probably damaging 0.96
R9275:Dennd4a UTSW 9 64,842,624 (GRCm38) missense probably damaging 1.00
R9376:Dennd4a UTSW 9 64,912,692 (GRCm38) missense probably benign 0.00
R9485:Dennd4a UTSW 9 64,907,106 (GRCm38) nonsense probably null
R9672:Dennd4a UTSW 9 64,893,358 (GRCm38) missense probably benign
R9746:Dennd4a UTSW 9 64,894,511 (GRCm38) missense probably benign
X0026:Dennd4a UTSW 9 64,897,320 (GRCm38) missense possibly damaging 0.67
Z1088:Dennd4a UTSW 9 64,872,022 (GRCm38) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CCGCTAAATACTCAGCTGATCATC -3'
(R):5'- CATCTTGGATTGTCAATGCTTTCTG -3'

Sequencing Primer
(F):5'- ATACTCAGCTGATCATCTGTTTTG -3'
(R):5'- TGGAACTCACTCTGTAGACCAGG -3'
Posted On 2020-09-15