Incidental Mutation 'R7981:Or55b3'
ID 651215
Institutional Source Beutler Lab
Gene Symbol Or55b3
Ensembl Gene ENSMUSG00000044814
Gene Name olfactory receptor family 55 subfamily B member 3
Synonyms GA_x6K02T2PBJ9-5199377-5198367, Olfr543, MOR42-2
MMRRC Submission 046022-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.084) question?
Stock # R7981 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 102125980-102127109 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 102127036 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Asparagine at position 14 (Y14N)
Ref Sequence ENSEMBL: ENSMUSP00000151487 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051201] [ENSMUST00000061482] [ENSMUST00000219647]
AlphaFold E9PWI5
Predicted Effect probably benign
Transcript: ENSMUST00000051201
SMART Domains Protein: ENSMUSP00000051280
Gene: ENSMUSG00000043925

DomainStartEndE-ValueType
Pfam:7tm_4 35 314 1.2e-73 PFAM
Pfam:7TM_GPCR_Srsx 39 311 6.3e-8 PFAM
Pfam:7tm_1 45 296 2.4e-14 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000061482
AA Change: Y14N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000051348
Gene: ENSMUSG00000044814
AA Change: Y14N

DomainStartEndE-ValueType
Pfam:7tm_4 36 315 1.5e-70 PFAM
Pfam:7TM_GPCR_Srsx 40 312 1.3e-8 PFAM
Pfam:7tm_1 46 332 1.5e-15 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000219647
AA Change: Y14N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl2fm3 T A 3: 59,784,360 (GRCm39) F278I probably damaging Het
Abca8a T C 11: 109,980,739 (GRCm39) T100A probably benign Het
Adam34l A G 8: 44,078,850 (GRCm39) F458S probably damaging Het
Agbl1 A G 7: 76,094,588 (GRCm39) T740A unknown Het
Aldh1a2 A T 9: 71,171,102 (GRCm39) I197F probably damaging Het
Ankrd28 T C 14: 31,424,114 (GRCm39) T1009A probably benign Het
Antxrl T C 14: 33,787,838 (GRCm39) V287A probably damaging Het
Baiap2l1 G A 5: 144,294,700 (GRCm39) probably benign Het
Catsperd T C 17: 56,938,562 (GRCm39) V30A possibly damaging Het
Ccdc150 A T 1: 54,407,551 (GRCm39) K1109M probably damaging Het
Ccdc28a A G 10: 18,094,127 (GRCm39) L164P probably benign Het
Cnot1 C T 8: 96,489,797 (GRCm39) V469M probably damaging Het
Col16a1 T G 4: 129,980,347 (GRCm39) probably null Het
Coq9 A G 8: 95,569,285 (GRCm39) H39R probably benign Het
Crh T A 3: 19,748,216 (GRCm39) E142V probably benign Het
Depdc1a A G 3: 159,226,488 (GRCm39) N265S probably benign Het
Dlg5 T C 14: 24,208,213 (GRCm39) T998A probably benign Het
Epg5 T C 18: 78,052,929 (GRCm39) probably null Het
Gcc1 G A 6: 28,419,140 (GRCm39) L398F probably benign Het
Gde1 T C 7: 118,288,264 (GRCm39) T320A probably damaging Het
Gemin5 T C 11: 58,036,231 (GRCm39) D704G probably damaging Het
Gfi1 G A 5: 107,873,543 (GRCm39) probably benign Het
Insc A G 7: 114,428,302 (GRCm39) T92A probably damaging Het
Krtap6-2 T C 16: 89,216,562 (GRCm39) Y135C unknown Het
Lpcat2 T C 8: 93,582,182 (GRCm39) S34P probably damaging Het
Mansc1 T C 6: 134,587,274 (GRCm39) D301G possibly damaging Het
Mbl2 C A 19: 30,216,737 (GRCm39) T183K probably damaging Het
Mri1 A C 8: 84,983,792 (GRCm39) V33G possibly damaging Het
Mrps7 T C 11: 115,497,687 (GRCm39) M184T possibly damaging Het
Mug1 A T 6: 121,858,723 (GRCm39) Y1147F probably damaging Het
N4bp2 C T 5: 65,969,485 (GRCm39) H1416Y probably benign Het
Naa15 T C 3: 51,366,092 (GRCm39) F487S probably damaging Het
Nin C T 12: 70,089,591 (GRCm39) V1275I Het
Or4c116 A G 2: 88,942,400 (GRCm39) F152S probably damaging Het
Pik3c2b A T 1: 133,003,547 (GRCm39) probably null Het
Pkn1 G T 8: 84,407,637 (GRCm39) N463K probably damaging Het
Pramel24 T G 4: 143,453,452 (GRCm39) F187V probably benign Het
Rab11fip3 C T 17: 26,216,963 (GRCm39) S816N probably damaging Het
Rassf4 G T 6: 116,617,218 (GRCm39) D262E probably damaging Het
Sec16a A G 2: 26,311,384 (GRCm39) probably null Het
Sspo A G 6: 48,445,428 (GRCm39) T2290A probably benign Het
Sumf1 A G 6: 108,129,186 (GRCm39) probably null Het
Syne1 T C 10: 5,179,248 (GRCm39) K4409E probably benign Het
Tasor T C 14: 27,168,373 (GRCm39) V305A possibly damaging Het
Tmco4 T G 4: 138,785,772 (GRCm39) L614R probably damaging Het
Tmem67 G T 4: 12,070,592 (GRCm39) N245K probably damaging Het
Trim58 T C 11: 58,542,138 (GRCm39) V366A probably benign Het
Vmn1r123 T C 7: 20,896,914 (GRCm39) S269P probably damaging Het
Vmn2r91 T A 17: 18,327,887 (GRCm39) S494T probably benign Het
Zbtb26 T A 2: 37,326,887 (GRCm39) I50L possibly damaging Het
Other mutations in Or55b3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01929:Or55b3 APN 7 102,126,373 (GRCm39) missense possibly damaging 0.57
IGL02074:Or55b3 APN 7 102,126,679 (GRCm39) missense probably benign 0.13
IGL02104:Or55b3 APN 7 102,126,544 (GRCm39) missense probably damaging 1.00
IGL02124:Or55b3 APN 7 102,126,742 (GRCm39) missense possibly damaging 0.63
R0014:Or55b3 UTSW 7 102,126,684 (GRCm39) missense probably damaging 1.00
R1694:Or55b3 UTSW 7 102,126,547 (GRCm39) missense probably benign 0.11
R1826:Or55b3 UTSW 7 102,126,720 (GRCm39) missense probably damaging 1.00
R1827:Or55b3 UTSW 7 102,126,720 (GRCm39) missense probably damaging 1.00
R1828:Or55b3 UTSW 7 102,126,720 (GRCm39) missense probably damaging 1.00
R2496:Or55b3 UTSW 7 102,126,354 (GRCm39) missense probably damaging 1.00
R5117:Or55b3 UTSW 7 102,126,709 (GRCm39) missense probably damaging 1.00
R5859:Or55b3 UTSW 7 102,126,957 (GRCm39) missense possibly damaging 0.89
R6344:Or55b3 UTSW 7 102,126,738 (GRCm39) missense probably damaging 1.00
R7031:Or55b3 UTSW 7 102,127,057 (GRCm39) missense probably benign 0.03
R7426:Or55b3 UTSW 7 102,126,883 (GRCm39) missense probably damaging 1.00
R7521:Or55b3 UTSW 7 102,126,402 (GRCm39) missense possibly damaging 0.75
R7621:Or55b3 UTSW 7 102,126,472 (GRCm39) missense possibly damaging 0.93
R9048:Or55b3 UTSW 7 102,126,684 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCAATGAGCACGTACATGGG -3'
(R):5'- TGAGACCACACCGATCTTGG -3'

Sequencing Primer
(F):5'- TACATGGGCTGGTGCAGACTC -3'
(R):5'- AATATCTTGTACAGGAGCTCCC -3'
Posted On 2020-09-15