Incidental Mutation 'R7982:Or10ac1'
ID 651261
Institutional Source Beutler Lab
Gene Symbol Or10ac1
Ensembl Gene ENSMUSG00000071494
Gene Name olfactory receptor family 10 subfamily AC member 1
Synonyms MORO-2, Olfr455, Olfr455-ps1, GA_x6K02T2P3E9-5021913-5022918, EG546896, MOR0-17_p, MOR0-2P
MMRRC Submission 046023-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.096) question?
Stock # R7982 (G1)
Quality Score 225.009
Status Not validated
Chromosome 6
Chromosomal Location 42515001-42515954 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 42515225 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 244 (T244S)
Ref Sequence ENSEMBL: ENSMUSP00000151418 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000171307] [ENSMUST00000217978]
AlphaFold A0A0B4J1M2
Predicted Effect probably damaging
Transcript: ENSMUST00000171307
AA Change: T244S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000130187
Gene: ENSMUSG00000071494
AA Change: T244S

DomainStartEndE-ValueType
Pfam:7tm_4 32 312 8.4e-41 PFAM
Pfam:7tm_1 42 265 5.8e-20 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000217978
AA Change: T244S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.9%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jun 2009]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb6 A G 1: 75,150,284 (GRCm39) S625P probably damaging Het
Actl6b A G 5: 137,561,424 (GRCm39) N142S probably benign Het
Ank1 A T 8: 23,609,397 (GRCm39) D1363V probably damaging Het
Aox4 A C 1: 58,296,400 (GRCm39) L1032F possibly damaging Het
Atosb T C 4: 43,034,483 (GRCm39) T371A probably damaging Het
Bcl2l15 T C 3: 103,740,158 (GRCm39) M4T probably damaging Het
Cand1 A T 10: 119,052,378 (GRCm39) S242R probably damaging Het
Cant1 A T 11: 118,300,968 (GRCm39) V229D probably benign Het
Ccdc117 A G 11: 5,481,460 (GRCm39) S224P possibly damaging Het
Cdc42ep4 T C 11: 113,619,402 (GRCm39) R330G possibly damaging Het
Cep164 T C 9: 45,690,162 (GRCm39) E527G probably benign Het
Cfap58 A G 19: 47,963,006 (GRCm39) D472G probably benign Het
Cln6 A C 9: 62,756,450 (GRCm39) K198T possibly damaging Het
Col4a4 G A 1: 82,549,162 (GRCm39) probably benign Het
Cyp1b1 T C 17: 80,017,919 (GRCm39) Y412C probably damaging Het
Dhx30 A T 9: 109,914,524 (GRCm39) L991Q probably damaging Het
Dst C T 1: 34,221,621 (GRCm39) T2475I possibly damaging Het
Exoc8 A T 8: 125,623,149 (GRCm39) V406E probably damaging Het
Grk6 T A 13: 55,599,519 (GRCm39) C201S probably damaging Het
Helz T C 11: 107,517,456 (GRCm39) V664A possibly damaging Het
Hsd17b11 A G 5: 104,151,090 (GRCm39) C215R possibly damaging Het
Ift25 T C 4: 107,132,480 (GRCm39) V89A probably benign Het
Kbtbd12 T C 6: 88,595,616 (GRCm39) I71M possibly damaging Het
Khdc1a A T 1: 21,421,130 (GRCm39) H105L probably benign Het
Klf6 T A 13: 5,911,822 (GRCm39) L62Q probably damaging Het
Mc1r A G 8: 124,134,879 (GRCm39) R211G probably damaging Het
Nt5m T A 11: 59,739,157 (GRCm39) W68R possibly damaging Het
Nufip1 T C 14: 76,363,679 (GRCm39) V301A probably benign Het
Or12d14-ps1 T G 17: 37,673,502 (GRCm39) F165V probably damaging Het
Or2b7 T C 13: 21,740,136 (GRCm39) N19D probably benign Het
Or51f5 A T 7: 102,424,310 (GRCm39) D193V probably damaging Het
Or5ac25 A G 16: 59,181,927 (GRCm39) I218T probably benign Het
Ostn T C 16: 27,140,189 (GRCm39) probably null Het
Pcdhb6 C T 18: 37,467,273 (GRCm39) R65* probably null Het
Pds5b T C 5: 150,693,406 (GRCm39) I706T probably damaging Het
Pgm2 T G 5: 64,258,302 (GRCm39) Y96D probably damaging Het
Pkd1l2 G A 8: 117,777,926 (GRCm39) T875I possibly damaging Het
Poc1b A G 10: 99,000,764 (GRCm39) S355G probably benign Het
Ppp6r1 A C 7: 4,646,157 (GRCm39) D181E probably benign Het
Pstpip2 G A 18: 77,967,073 (GRCm39) V325M probably benign Het
Rras2 A T 7: 113,658,186 (GRCm39) V92D probably damaging Het
Rsf1 CGGC CGGCGGCGGGGGC 7: 97,229,139 (GRCm39) probably benign Het
Ryr3 GTCTTCTTCTTCTTCTTC GTCTTCTTCTTCTTC 2: 112,499,594 (GRCm39) probably benign Het
Stac2 T A 11: 97,933,379 (GRCm39) M188L probably benign Het
Synrg G A 11: 83,910,644 (GRCm39) D859N probably damaging Het
Tarbp1 A T 8: 127,171,040 (GRCm39) S987T probably damaging Het
Tbx20 C A 9: 24,685,220 (GRCm39) probably benign Het
Trim30d G T 7: 104,121,817 (GRCm39) N309K possibly damaging Het
Ttc16 C T 2: 32,665,047 (GRCm39) probably benign Het
Ttc34 T A 4: 154,945,875 (GRCm39) I303N possibly damaging Het
Ubr4 T C 4: 139,155,519 (GRCm39) probably null Het
Uros A T 7: 133,294,278 (GRCm39) S168T unknown Het
Vmn2r6 C T 3: 64,467,241 (GRCm39) G86D probably damaging Het
Ybx2 C T 11: 69,831,448 (GRCm39) T295I possibly damaging Het
Zbed5 T A 5: 129,929,321 (GRCm39) C146S possibly damaging Het
Zcchc2 G A 1: 105,958,901 (GRCm39) C1124Y probably damaging Het
Zfp626 G A 7: 27,510,175 (GRCm39) probably null Het
Other mutations in Or10ac1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02110:Or10ac1 APN 6 42,515,113 (GRCm39) missense possibly damaging 0.85
PIT4519001:Or10ac1 UTSW 6 42,515,534 (GRCm39) missense probably damaging 0.98
R0931:Or10ac1 UTSW 6 42,515,020 (GRCm39) missense probably benign 0.00
R1696:Or10ac1 UTSW 6 42,515,537 (GRCm39) missense probably benign 0.04
R1774:Or10ac1 UTSW 6 42,515,453 (GRCm39) missense probably damaging 0.99
R4627:Or10ac1 UTSW 6 42,515,375 (GRCm39) missense possibly damaging 0.46
R4835:Or10ac1 UTSW 6 42,515,770 (GRCm39) missense probably damaging 1.00
R5140:Or10ac1 UTSW 6 42,515,449 (GRCm39) missense probably benign 0.00
R5322:Or10ac1 UTSW 6 42,515,950 (GRCm39) missense probably benign 0.06
R7237:Or10ac1 UTSW 6 42,515,581 (GRCm39) missense probably damaging 1.00
R7399:Or10ac1 UTSW 6 42,515,662 (GRCm39) missense possibly damaging 0.79
R7422:Or10ac1 UTSW 6 42,515,053 (GRCm39) missense possibly damaging 0.72
R8697:Or10ac1 UTSW 6 42,515,629 (GRCm39) missense probably damaging 1.00
R9120:Or10ac1 UTSW 6 42,515,583 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- TGAATGGCAGAAGTGATCTCC -3'
(R):5'- TAACGGTGGCAGTGTTCCAC -3'

Sequencing Primer
(F):5'- AGAAGTGATCTCCCGGTTGC -3'
(R):5'- GGTGCATTTCTTCTGCGACATCAC -3'
Posted On 2020-09-15