Incidental Mutation 'R7982:Rras2'
ID 651268
Institutional Source Beutler Lab
Gene Symbol Rras2
Ensembl Gene ENSMUSG00000055723
Gene Name related RAS viral (r-ras) oncogene 2
Synonyms TC21, 2610016H24Rik
MMRRC Submission 046023-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.320) question?
Stock # R7982 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 113646017-113717016 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 113658186 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Aspartic acid at position 92 (V92D)
Ref Sequence ENSEMBL: ENSMUSP00000069752 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000069449] [ENSMUST00000210075]
AlphaFold P62071
Predicted Effect probably damaging
Transcript: ENSMUST00000069449
AA Change: V92D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000069752
Gene: ENSMUSG00000055723
AA Change: V92D

DomainStartEndE-ValueType
RAS 12 178 1.02e-120 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000210075
AA Change: V92D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.9%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the R-Ras subfamily of Ras-like small GTPases. The encoded protein associates with the plasma membrane and may function as a signal transducer. This protein may play an important role in activating signal transduction pathways that control cell proliferation. Mutations in this gene are associated with the growth of certain tumors. Pseudogenes of this gene are found on chromosomes 1 and 2. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]
PHENOTYPE: Homozygote and heterozygote null mice are lymphopenic, resulting from diminished homeostatic proliferation and impaired T cell and B cell survival. Mice homozygous for a gene trap insertion exhibit retinal degeneration, and increased total body mass and total body fat. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb6 A G 1: 75,150,284 (GRCm39) S625P probably damaging Het
Actl6b A G 5: 137,561,424 (GRCm39) N142S probably benign Het
Ank1 A T 8: 23,609,397 (GRCm39) D1363V probably damaging Het
Aox4 A C 1: 58,296,400 (GRCm39) L1032F possibly damaging Het
Atosb T C 4: 43,034,483 (GRCm39) T371A probably damaging Het
Bcl2l15 T C 3: 103,740,158 (GRCm39) M4T probably damaging Het
Cand1 A T 10: 119,052,378 (GRCm39) S242R probably damaging Het
Cant1 A T 11: 118,300,968 (GRCm39) V229D probably benign Het
Ccdc117 A G 11: 5,481,460 (GRCm39) S224P possibly damaging Het
Cdc42ep4 T C 11: 113,619,402 (GRCm39) R330G possibly damaging Het
Cep164 T C 9: 45,690,162 (GRCm39) E527G probably benign Het
Cfap58 A G 19: 47,963,006 (GRCm39) D472G probably benign Het
Cln6 A C 9: 62,756,450 (GRCm39) K198T possibly damaging Het
Col4a4 G A 1: 82,549,162 (GRCm39) probably benign Het
Cyp1b1 T C 17: 80,017,919 (GRCm39) Y412C probably damaging Het
Dhx30 A T 9: 109,914,524 (GRCm39) L991Q probably damaging Het
Dst C T 1: 34,221,621 (GRCm39) T2475I possibly damaging Het
Exoc8 A T 8: 125,623,149 (GRCm39) V406E probably damaging Het
Grk6 T A 13: 55,599,519 (GRCm39) C201S probably damaging Het
Helz T C 11: 107,517,456 (GRCm39) V664A possibly damaging Het
Hsd17b11 A G 5: 104,151,090 (GRCm39) C215R possibly damaging Het
Ift25 T C 4: 107,132,480 (GRCm39) V89A probably benign Het
Kbtbd12 T C 6: 88,595,616 (GRCm39) I71M possibly damaging Het
Khdc1a A T 1: 21,421,130 (GRCm39) H105L probably benign Het
Klf6 T A 13: 5,911,822 (GRCm39) L62Q probably damaging Het
Mc1r A G 8: 124,134,879 (GRCm39) R211G probably damaging Het
Nt5m T A 11: 59,739,157 (GRCm39) W68R possibly damaging Het
Nufip1 T C 14: 76,363,679 (GRCm39) V301A probably benign Het
Or10ac1 T A 6: 42,515,225 (GRCm39) T244S probably damaging Het
Or12d14-ps1 T G 17: 37,673,502 (GRCm39) F165V probably damaging Het
Or2b7 T C 13: 21,740,136 (GRCm39) N19D probably benign Het
Or51f5 A T 7: 102,424,310 (GRCm39) D193V probably damaging Het
Or5ac25 A G 16: 59,181,927 (GRCm39) I218T probably benign Het
Ostn T C 16: 27,140,189 (GRCm39) probably null Het
Pcdhb6 C T 18: 37,467,273 (GRCm39) R65* probably null Het
Pds5b T C 5: 150,693,406 (GRCm39) I706T probably damaging Het
Pgm2 T G 5: 64,258,302 (GRCm39) Y96D probably damaging Het
Pkd1l2 G A 8: 117,777,926 (GRCm39) T875I possibly damaging Het
Poc1b A G 10: 99,000,764 (GRCm39) S355G probably benign Het
Ppp6r1 A C 7: 4,646,157 (GRCm39) D181E probably benign Het
Pstpip2 G A 18: 77,967,073 (GRCm39) V325M probably benign Het
Rsf1 CGGC CGGCGGCGGGGGC 7: 97,229,139 (GRCm39) probably benign Het
Ryr3 GTCTTCTTCTTCTTCTTC GTCTTCTTCTTCTTC 2: 112,499,594 (GRCm39) probably benign Het
Stac2 T A 11: 97,933,379 (GRCm39) M188L probably benign Het
Synrg G A 11: 83,910,644 (GRCm39) D859N probably damaging Het
Tarbp1 A T 8: 127,171,040 (GRCm39) S987T probably damaging Het
Tbx20 C A 9: 24,685,220 (GRCm39) probably benign Het
Trim30d G T 7: 104,121,817 (GRCm39) N309K possibly damaging Het
Ttc16 C T 2: 32,665,047 (GRCm39) probably benign Het
Ttc34 T A 4: 154,945,875 (GRCm39) I303N possibly damaging Het
Ubr4 T C 4: 139,155,519 (GRCm39) probably null Het
Uros A T 7: 133,294,278 (GRCm39) S168T unknown Het
Vmn2r6 C T 3: 64,467,241 (GRCm39) G86D probably damaging Het
Ybx2 C T 11: 69,831,448 (GRCm39) T295I possibly damaging Het
Zbed5 T A 5: 129,929,321 (GRCm39) C146S possibly damaging Het
Zcchc2 G A 1: 105,958,901 (GRCm39) C1124Y probably damaging Het
Zfp626 G A 7: 27,510,175 (GRCm39) probably null Het
Other mutations in Rras2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01688:Rras2 APN 7 113,659,632 (GRCm39) missense probably damaging 1.00
IGL02028:Rras2 APN 7 113,659,597 (GRCm39) missense probably benign 0.01
IGL02108:Rras2 APN 7 113,659,623 (GRCm39) missense probably damaging 1.00
R0017:Rras2 UTSW 7 113,647,490 (GRCm39) splice site probably benign
R0017:Rras2 UTSW 7 113,647,490 (GRCm39) splice site probably benign
R4718:Rras2 UTSW 7 113,649,584 (GRCm39) missense probably benign 0.00
R5371:Rras2 UTSW 7 113,649,572 (GRCm39) missense probably damaging 1.00
R5534:Rras2 UTSW 7 113,649,650 (GRCm39) missense possibly damaging 0.47
R7871:Rras2 UTSW 7 113,716,783 (GRCm39) start gained probably benign
R9731:Rras2 UTSW 7 113,659,593 (GRCm39) missense probably damaging 1.00
R9748:Rras2 UTSW 7 113,716,629 (GRCm39) critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- AACCTAGCACTGCTAACTTGAG -3'
(R):5'- TCTGCCTCTGGTGCTAGGAATG -3'

Sequencing Primer
(F):5'- ACTGCTAACTTGAGGTTTTTATTAGC -3'
(R):5'- GACAGGAATGCATTGCCTCTC -3'
Posted On 2020-09-15